Periodical
Cellular Reprogramming and Microfluidics Enable Large-Scale Blastoid Production from Aged Donors.
| Title: | Cellular Reprogramming and Microfluidics Enable Large-Scale Blastoid Production from Aged Donors. |
|---|---|
| Authors: | Moura MT; Departamento de Biologia Celular e Molecular, Centro de Biotecnologia, Universidade Federal da Paraíba (UFPB), João Pessoa, Brasil. |
| Source: | Cellular reprogramming [Cell Reprogram] 2025 Dec; Vol. 27 (6), pp. 213-215. Date of Electronic Publication: 2025 Oct 22. |
| Publication Type: | News |
| Language: | English |
| Journal Info: | Publisher: Mary Ann Liebert, Inc Country of Publication: United States NLM ID: 101528176 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2152-4998 (Electronic) Linking ISSN: 21524971 NLM ISO Abbreviation: Cell Reprogram Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: New Rochelle, NY : Mary Ann Liebert, Inc. |
| MeSH Terms: | Microfluidics*/methods , Blastocyst*/cytology , Cellular Reprogramming Techniques*/methods , Cellular Reprogramming* , Aging*, Animals ; Macaca mulatta ; Humans |
| Abstract: | Blastoids are stem cell-based cellular models that resemble preimplantation embryos and have the potential to ease the investigation of developmental processes and associated diseases. Despite the fast-paced progress of blastoid technology in mice and humans, there was limited evidence of its potential for nonhuman primates. Wu et al. developed a highly efficient protocol for blastoid production in rhesus monkeys and performed standard assays for blastoid characterization at the cellular and molecular levels. By applying cellular reprogramming, Wu et al. generated blastoids from young and aged monkeys. The integration of blastoid protocol with microfluidics allowed their production at scale. If follow-up reports describe blastoid differentiation to peri- and post-implantation stages, it may place rhesus monkeys as an attractive model species for exploring mammalian development ex vivo. |
| Contributed Indexing: | Keywords: Macaca mulatta; embryo models; induced pluripotency; microfluidics; nuclear transplantation |
| Entry Date(s): | Date Created: 20251022 Date Completed: 20251129 Latest Revision: 20260120 |
| Update Code: | 20260130 |
| DOI: | 10.1177/21524971251391914 |
| PMID: | 41123470 |
| Database: | MEDLINE |
Be the first to leave a comment!