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Anti-Helicobacter pylori Activity and Gastroprotective Effects of Diacetylcurcumin and Four Metal Derivatives.

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Τίτλος: Anti-Helicobacter pylori Activity and Gastroprotective Effects of Diacetylcurcumin and Four Metal Derivatives.
Συγγραφείς: Agabo-Martínez A; Departamento de Bioquímica, Facultad de Medicina, Universidad Nacional Autónoma de México (UNAM), Ciudad Universitaria, Ciudad de México 04510, Mexico., Gomez-Chang E; Departamento de Bioquímica, Facultad de Medicina, Universidad Nacional Autónoma de México (UNAM), Ciudad Universitaria, Ciudad de México 04510, Mexico., Hernández-Hipólito E; Departamento de Bioquímica, Facultad de Medicina, Universidad Nacional Autónoma de México (UNAM), Ciudad Universitaria, Ciudad de México 04510, Mexico., Estrada-Muñiz E; Departamento de Toxicología, Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional, Zacatenco, Ciudad de México 07360, Mexico., Escobedo-Martínez C; Departamento de Farmacia, División de Ciencias Naturales y Exactas, Universidad de Guanajuato, Campus Guanajuato, Guanajuato 36050, Mexico., Obregón-Mendoza MA; Instituto de Química, Universidad Nacional Autónoma de México (UNAM), Ciudad Universitaria, Ciudad de México 04510, Mexico., Enríquez RG; Instituto de Química, Universidad Nacional Autónoma de México (UNAM), Ciudad Universitaria, Ciudad de México 04510, Mexico., Vega L; Departamento de Toxicología, Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional, Zacatenco, Ciudad de México 07360, Mexico., Romero I; Departamento de Bioquímica, Facultad de Medicina, Universidad Nacional Autónoma de México (UNAM), Ciudad Universitaria, Ciudad de México 04510, Mexico.
Πηγή: Molecules (Basel, Switzerland) [Molecules] 2025 Sep 23; Vol. 30 (19). Date of Electronic Publication: 2025 Sep 23.
Τύπος έκδοσης: Journal Article
Γλώσσα: English
Στοιχεία περιοδικού: Publisher: MDPI Country of Publication: Switzerland NLM ID: 100964009 Publication Model: Electronic Cited Medium: Internet ISSN: 1420-3049 (Electronic) Linking ISSN: 14203049 NLM ISO Abbreviation: Molecules Subsets: MEDLINE
Imprint Name(s): Original Publication: Basel, Switzerland : MDPI, c1995-
Ιατρικοί όροι (MeSH): Curcumin*/analogs & derivatives , Curcumin*/chemistry , Curcumin*/pharmacology , Curcumin*/therapeutic use , Curcumin*/analogs & derivatives , Helicobacter pylori*/drug effects , Helicobacter pylori*/enzymology , Anti-Bacterial Agents*/chemistry , Anti-Bacterial Agents*/pharmacology , Anti-Bacterial Agents*/therapeutic use , Helicobacter Infections*/drug therapy , Helicobacter Infections*/microbiology , Stomach Ulcer*/chemically induced , Stomach Ulcer*/pathology , Stomach Ulcer*/prevention & control , Protective Agents*/chemistry , Protective Agents*/pharmacology , Protective Agents*/therapeutic use, Metals/chemistry ; Ethanol/toxicity ; Urease/antagonists & inhibitors ; Topoisomerase II Inhibitors/chemistry ; Topoisomerase II Inhibitors/pharmacology ; Topoisomerase II Inhibitors/therapeutic use ; Biological Availability ; Microbial Sensitivity Tests ; Disease Models, Animal ; Toxicity Tests, Subacute ; Animals ; Mice ; Male
Περίληψη: Helicobacter pylori is the main etiological factor of gastritis, peptic ulcers, and gastric cancer. This bacterium's antibiotic resistance has led to a lower eradication rate; therefore, new drugs with anti-H. pylori activity are needed. Curcumin exhibits multiple biological activities, but it has low stability and poor bioavailability. To overcome these disadvantages, different metal complexes have been synthesized. The objective of this study was to determine the in vitro anti-H. pylori activity of diacetylcurcumin (DAC), DAC2-Cu, DAC2-Zn, DAC2-Mn, and DAC2-Mg by obtaining the minimum inhibitory concentration of bacterial growth, and to investigate some mechanisms by which they could affect the bacteria (urease and DNA gyrase activities). Moreover, their gastroprotective potential was assayed in an ethanol-induced gastric ulcer model in mice. The results showed that DAC2-Cu and DAC2-Zn have good anti-H. pylori activity, exhibit specific activity against this bacterium, inhibit the urease activity, and provide 70% gastroprotection at a dose of 200 mg/kg of body weight. In a subacute toxicity study in mice, DAC2-Cu and DAC2-Zn did not cause death or any deleterious symptoms, nor did they have a significant effect on serum and urine biochemical parameters compared to control mice. These compounds are promising candidates for use in H. pylori eradication schemes.
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Grant Information: IN207622 Universidad Nacional Autónoma de México
Contributed Indexing: Keywords: Helicobacter pylori; MIC; diacetylcurcumin complexes; gastroprotection; subacute toxicity; urease
Substance Nomenclature: 5PUQ5907YX (diacetylcurcumin)
IT942ZTH98 (Curcumin)
0 (Anti-Bacterial Agents)
0 (Metals)
3K9958V90M (Ethanol)
0 (Protective Agents)
EC 3.5.1.5 (Urease)
0 (Topoisomerase II Inhibitors)
Entry Date(s): Date Created: 20251016 Date Completed: 20260306 Latest Revision: 20260306
Update Code: 20260307
PubMed Central ID: PMC12525688
DOI: 10.3390/molecules30193849
PMID: 41097273
Βάση Δεδομένων: MEDLINE
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