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Social experience shapes fighting strategies in Drosophila.

Λεπτομέρειες βιβλιογραφικής εγγραφής
Τίτλος: Social experience shapes fighting strategies in Drosophila.
Συγγραφείς: Gao C; The Key Laboratory of Developmental Genes and Human Disease, Jiangsu Key Laboratory of Brain Science and Medicine, School of Life Science and Technology, Southeast University, Nanjing, China., Ma M; The Key Laboratory of Developmental Genes and Human Disease, Jiangsu Key Laboratory of Brain Science and Medicine, School of Life Science and Technology, Southeast University, Nanjing, China., Chen J; The Key Laboratory of Developmental Genes and Human Disease, Jiangsu Key Laboratory of Brain Science and Medicine, School of Life Science and Technology, Southeast University, Nanjing, China., Ji X; The Key Laboratory of Developmental Genes and Human Disease, Jiangsu Key Laboratory of Brain Science and Medicine, School of Life Science and Technology, Southeast University, Nanjing, China., Peng Q; The Key Laboratory of Developmental Genes and Human Disease, Jiangsu Key Laboratory of Brain Science and Medicine, School of Life Science and Technology, Southeast University, Nanjing, China., Pan Y; The Key Laboratory of Developmental Genes and Human Disease, Jiangsu Key Laboratory of Brain Science and Medicine, School of Life Science and Technology, Southeast University, Nanjing, China.; Co-innovation Center of Neuroregeneration, Nantong University, Nantong, China.
Πηγή: ELife [Elife] 2025 Oct 07; Vol. 13. Date of Electronic Publication: 2025 Oct 07.
Τύπος έκδοσης: Journal Article
Γλώσσα: English
Στοιχεία περιοδικού: Publisher: eLife Sciences Publications, Ltd Country of Publication: England NLM ID: 101579614 Publication Model: Electronic Cited Medium: Internet ISSN: 2050-084X (Electronic) Linking ISSN: 2050084X NLM ISO Abbreviation: Elife Subsets: MEDLINE
Imprint Name(s): Original Publication: Cambridge, UK : eLife Sciences Publications, Ltd., 2012-
Ιατρικοί όροι (MeSH): Aggression*/physiology , Drosophila melanogaster*/physiology , Social Behavior* , Behavior, Animal*, Olfactory Receptor Neurons/physiology ; Animals ; Male ; Sexual Behavior, Animal ; Female
Περίληψη: Social isolation generally increases aggression but decreases mating competition, resulting in an intricate and ambiguous relationship between social experience, aggression, and reproductive success. In male Drosophila, aggression is often characterized by lunging, a frequent and comparatively low-intensity combat behavior. Here, we provide a behavioral paradigm for studying a less frequent but more vigorous fighting form known as tussling. While social enrichment decreases lunging, aligning with past observations, it heightens the more forceful tussling behavior. These two forms of aggression rely on different olfactory receptor neurons, specifically Or67d for lunging and Or47b for tussling. We further identify three pairs of central pC1 neurons that specifically promote tussling. Moreover, shifting from lunging to tussling in socially enriched males is accompanied by better territory control and mating success. Our findings identify distinct sensory and central neurons for two fighting forms and suggest that social experience may shape fighting strategies to optimize reproductive success.
(© 2024, Gao, Ma et al.)
Competing Interests: CG, MM, JC, XJ, QP, YP No competing interests declared
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Grant Information: 32371067 National Natural Science Foundation of China; 2021YFA1101300 National Key R&D Program of China; B2402005 Shenzhen Medical Academy of Research and Translation; BK20231418 Natural Science Foundation from Jiangsu Province; 2242023R40054 Fundamental Research Funds for the Central Universities
Contributed Indexing: Keywords: D. melanogaster; Or47b ORNs; aggression; fighting strategies; neuroscience; pC1 neurons; reproductive competition; social experience
Entry Date(s): Date Created: 20251007 Date Completed: 20251007 Latest Revision: 20251009
Update Code: 20260130
PubMed Central ID: PMC12503488
DOI: 10.7554/eLife.104212
PMID: 41055639
Βάση Δεδομένων: MEDLINE
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  Data: Social experience shapes fighting strategies in Drosophila.
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  Data: <searchLink fieldCode="AU" term="%22Gao+C%22">Gao C</searchLink>; The Key Laboratory of Developmental Genes and Human Disease, Jiangsu Key Laboratory of Brain Science and Medicine, School of Life Science and Technology, Southeast University, Nanjing, China.<br /><searchLink fieldCode="AU" term="%22Ma+M%22">Ma M</searchLink>; The Key Laboratory of Developmental Genes and Human Disease, Jiangsu Key Laboratory of Brain Science and Medicine, School of Life Science and Technology, Southeast University, Nanjing, China.<br /><searchLink fieldCode="AU" term="%22Chen+J%22">Chen J</searchLink>; The Key Laboratory of Developmental Genes and Human Disease, Jiangsu Key Laboratory of Brain Science and Medicine, School of Life Science and Technology, Southeast University, Nanjing, China.<br /><searchLink fieldCode="AU" term="%22Ji+X%22">Ji X</searchLink>; The Key Laboratory of Developmental Genes and Human Disease, Jiangsu Key Laboratory of Brain Science and Medicine, School of Life Science and Technology, Southeast University, Nanjing, China.<br /><searchLink fieldCode="AU" term="%22Peng+Q%22">Peng Q</searchLink>; The Key Laboratory of Developmental Genes and Human Disease, Jiangsu Key Laboratory of Brain Science and Medicine, School of Life Science and Technology, Southeast University, Nanjing, China.<br /><searchLink fieldCode="AU" term="%22Pan+Y%22">Pan Y</searchLink>; The Key Laboratory of Developmental Genes and Human Disease, Jiangsu Key Laboratory of Brain Science and Medicine, School of Life Science and Technology, Southeast University, Nanjing, China.; Co-innovation Center of Neuroregeneration, Nantong University, Nantong, China.
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  Data: Social isolation generally increases aggression but decreases mating competition, resulting in an intricate and ambiguous relationship between social experience, aggression, and reproductive success. In male Drosophila, aggression is often characterized by lunging, a frequent and comparatively low-intensity combat behavior. Here, we provide a behavioral paradigm for studying a less frequent but more vigorous fighting form known as tussling. While social enrichment decreases lunging, aligning with past observations, it heightens the more forceful tussling behavior. These two forms of aggression rely on different olfactory receptor neurons, specifically Or67d for lunging and Or47b for tussling. We further identify three pairs of central pC1 neurons that specifically promote tussling. Moreover, shifting from lunging to tussling in socially enriched males is accompanied by better territory control and mating success. Our findings identify distinct sensory and central neurons for two fighting forms and suggest that social experience may shape fighting strategies to optimize reproductive success.<br /> (© 2024, Gao, Ma et al.)
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  Label: Competing Interests
  Group: Ab
  Data: CG, MM, JC, XJ, QP, YP No competing interests declared
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  Data: 32371067 National Natural Science Foundation of China; 2021YFA1101300 National Key R&D Program of China; B2402005 Shenzhen Medical Academy of Research and Translation; BK20231418 Natural Science Foundation from Jiangsu Province; 2242023R40054 Fundamental Research Funds for the Central Universities
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  Data: <i>Keywords: </i>D. melanogaster; Or47b ORNs; aggression; fighting strategies; neuroscience; pC1 neurons; reproductive competition; social experience
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        Text: English
    Subjects:
      – SubjectFull: Olfactory Receptor Neurons physiology
        Type: general
      – SubjectFull: Animals
        Type: general
      – SubjectFull: Male
        Type: general
      – SubjectFull: Sexual Behavior, Animal
        Type: general
      – SubjectFull: Female
        Type: general
      – SubjectFull: Aggression physiology
        Type: general
      – SubjectFull: Drosophila melanogaster physiology
        Type: general
      – SubjectFull: Social Behavior
        Type: general
      – SubjectFull: Behavior, Animal
        Type: general
    Titles:
      – TitleFull: Social experience shapes fighting strategies in Drosophila.
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: Gao C
      – PersonEntity:
          Name:
            NameFull: Ma M
      – PersonEntity:
          Name:
            NameFull: Chen J
      – PersonEntity:
          Name:
            NameFull: Ji X
      – PersonEntity:
          Name:
            NameFull: Peng Q
      – PersonEntity:
          Name:
            NameFull: Pan Y
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 07
              M: 10
              Text: 2025 Oct 07
              Type: published
              Y: 2025
          Identifiers:
            – Type: issn-electronic
              Value: 2050-084X
          Numbering:
            – Type: volume
              Value: 13
          Titles:
            – TitleFull: ELife
              Type: main
ResultId 1