Academic Journal
Analgesic Effect of Vibratory Devices Associated with Carboxytherapy for Cellulite: Randomized Controlled Trial.
| Τίτλος: | Analgesic Effect of Vibratory Devices Associated with Carboxytherapy for Cellulite: Randomized Controlled Trial. |
|---|---|
| Συγγραφείς: | Sadala AY; Physioterapeutics Resources Laboratory, Department of Physical Therapy, Federal University of São Carlos (UFSCar), São Carlos, Brazil., Rampazo ÉP; Physioterapeutics Resources Laboratory, Department of Physical Therapy, Federal University of São Carlos (UFSCar), São Carlos, Brazil., Righi NC; Postgraduate Program in Rehabilitation Sciences, Federal University of Health Sciences of Porto Alegre (UFCSPA), Porto Alegre, Brazil., Liebano RE; Department of Rehabilitation Sciences, University of Hartford, 200 Bloomfield Ave, West Hartford, CT, 06117, USA. liebano@hartford.edu. |
| Πηγή: | Aesthetic plastic surgery [Aesthetic Plast Surg] 2025 Dec; Vol. 49 (23), pp. 6720-6726. Date of Electronic Publication: 2025 Oct 06. |
| Τύπος έκδοσης: | Journal Article; Randomized Controlled Trial |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: Springer-Verlag Country of Publication: United States NLM ID: 7701756 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1432-5241 (Electronic) Linking ISSN: 0364216X NLM ISO Abbreviation: Aesthetic Plast Surg Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: New York, Springer-Verlag. |
| Ιατρικοί όροι (MeSH): | Vibration*/therapeutic use , Cellulite*/therapy , Pain Management*/methods , Analgesia*/methods, Humans ; Female ; Adult ; Middle Aged ; Young Adult ; Pain Measurement ; Adolescent ; Treatment Outcome ; Buttocks ; Procedural Pain |
| Περίληψη: | Introduction: Vibrational stimulation analgesia has been shown to be effective during injectable procedures in dermatology, but its analgesic effect associated with carboxytherapy has not yet been studied. Objective: To investigate the analgesic effect of two vibratory devices during carboxytherapy in women with gluteal cellulite. Methods: Seventy-eight women, aged 18 to 49 years, with moderate and/or severe gluteal cellulite, were randomly assigned to three groups: Vibratory Device Group 1-VDG1 (Carboxytherapy and vibratory device Vibrata®) (n = 26), Vibratory Device Group 2-VDG2 (Carboxytherapy and vibratory device BlaineLabs®) (n = 26), and a control group (Carboxytherapy only) (n = 26). Pain intensity was measured immediately after each puncture in a single session using the numeric pain rating scale (0-10). Results: There was no significant difference in pain intensity among the groups: VDG1 (4.95 ± 2.35); VDG2 (4.90 ± 2.22); and control (4.97 ± 2.43) (p =.997). Conclusion: Vibratory devices did not decrease pain intensity during carboxytherapy in women with gluteal cellulite. Despite this, the study addresses an important gap and lays the foundation for future clinical trials on pain management in aesthetic body procedures. Level of Evidence I: This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266 . (© 2025. Springer Science+Business Media, LLC, part of Springer Nature and International Society of Aesthetic Plastic Surgery.) |
| Competing Interests: | Declarations. Conflict of interest: The authors declare that they have no conflicts of interest to disclose. Ethical Approval: This study was approved by the Research Ethics Committee of the Federal University of São Carlos (CAAE: 16390719.0.0000.5504). Informed Consent: All participants gave informed consent prior to their participation in the study. |
| References: | Hernandes ASN, dos Santos GF, Vila MMDC. Cellulite: a brief review. Braz J Dev. 2022;8(1):4201–12. (PMID: 10.34117/bjdv8n1-277) Kołodziejczak A, Podgórna K, Rotsztejn H. Is carboxytherapy a good alternative method in the removal of various skin defects? Dermatol Ther. 2018;31(5). Bass LS, Kaminer MS. Insights into the pathophysiology of cellulite: a review. Dermatol Surg. 2020;1(46):S77-85. (PMID: 10.1097/DSS.0000000000002388) Sadowski T, Bielfeldt S, Wilhelm KP, Sukopp S, Gordon C. Objective and subjective reduction of cellulite volume using a localized vibrational massage device in a 24-week randomized intra-individual single-blind regression study. Int J Cosmet Sci. 2020;42(3):277–88. (PMID: 10.1111/ics.12613321814997317706) Machado AFP, Tacani RE, Schwartz J, Liebano RE, Ramos JdeLA, Frare T. Incidência de fibro edema geloide em mulheres caucasianas jovens. Arq Bras Cienc Saude. 2009;34(2):80–6. Lee GSK. Carbon dioxide therapy in the treatment of cellulite: an audit of clinical practice. Aesthet Plast Surg. 2010;34(2):239–43. (PMID: 10.1007/s00266-009-9459-0) Pianez LR, Custódio FS, Guidi RM, de Freitas JN, Sant’Ana E. Effectiveness of carboxytherapy in the treatment of cellulite in healthy women: a pilot study. Clin Cosmet Investig Dermatol. 2016;9:183–90. (PMID: 10.2147/CCID.S102503275789945001663) Brandi C, D’Aniello C, Grimaldi L, Caiazzo E, Stanghellini E. Carbon dioxide therapy: effects on skin irregularity and its use as a complement to liposuction. Aesthet Plast Surg. 2004;28(4):222–5. (PMID: 10.1007/s00266-004-2068-z) Koutná N. Carboxytherapy in aesthetic medicine. In: Prendergast P, Shiffman M, editors. Aesthetic medicine. Heidelberg: Springer; 2012. https://doi.org/10.1007/978-3-642-20113-4_43 . (PMID: 10.1007/978-3-642-20113-4_43) Kroumpouzos G, Arora G, Kassir M, Galadari H, Wollina U, Lotti T, et al. Carboxytherapy in dermatology. Clin Dermatol. 2022;40(3):305–9. (PMID: 10.1016/j.clindermatol.2021.08.02035667826) Costa CS, Otoch JP, Seelaender MCL, Das Neves RX, Martinez CAR, Margarido NF. Avaliação citométrica dos adipócitos localizados no tecido subcutâneo da parede anterior do abdome após infiltração percutânea de CO<sub>2</sub>. Rev Col Bras Cir. 2011;38(1):15–23. (PMID: 10.1590/S0100-6991201100010000421537738) Atamoros FMP, Pérez DA, Sigall DA, Romay AAÁ, Gastelum JAB, de la Salcedo JA P, et al. Evidence-based treatment for gynoid lipodystrophy: a review of the recent literature. J Cosmet Dermatol. 2018;17(6):977–83. (PMID: 10.1111/jocd.12555) Brandt F, Bank D, Cross SL, Weiss R. A lidocaine-containing formulation of large-gel particle hyaluronic acid alleviates pain. Dermatol Surg. 2010;36(SUPPL. 3):1876–85. (PMID: 10.1111/j.1524-4725.2010.01777.x20969665) Sadala AY, Machado AFP, Liebano RE. Effects of transcutaneous electrical nerve stimulation on pain intensity during application of carboxytherapy in patients with cellulite: a randomized placebo-controlled trial. J Cosmet Dermatol. 2018;17(6):1175–81. (PMID: 10.1111/jocd.1248929337405) Aimonetti JM, Ribot-Ciscar E. Pain management in photoepilation. J Cosmet Dermatol. 2015;15:194–9. (PMID: 10.1111/jocd.1219626589969) Irkoren S, Ozkan HS, Karaca H. A clinical comparison of EMLA cream and ethyl chloride spray application for pain relief of forehead botulinum toxin injection. Ann Plast Surg. 2015;75(3):272–4. (PMID: 10.1097/SAP.000000000000012125536197) Ballard A, Khadra C, Adler S, Trottier ED, Le May S. Efficacy of the buzzy device for pain management during needle-related procedures: a systematic review and meta-analysis. Clin J Pain. 2019;35(6):532–43. (PMID: 10.1097/AJP.000000000000069030829735) Benjamin AL, Hendrix TJ, Woody JL. Effects of vibration therapy in pediatric immunizations. Pediatr Nurs. 2016;42(3):124–30. (PMID: 27468514) Kuwahara H, Ogawa R. Using a vibration device to ease pain during facial needling and injection. Eplasty. 2016;4:65–72. Sharma P, Czyz CN, Wulc AE. Investigating the efficacy of vibration anesthesia to reduce pain from cosmetic botulinum toxin injections. Aesthet Surg J. 2011;31(8):966–71. (PMID: 10.1177/1090820X1142280922001341) Melzack R, Wall PD. Pain mechanisms: a new theory. Science (1979). 1965;150(3699):971–9. Guney K, Sezgin B, Yavuzer R. The efficacy of vibration anesthesia on reducing pain levels during lip augmentation: Worth the buzz? Aesthet Surg J. 2017;37(9):1044–8. (PMID: 10.1093/asj/sjx07329025227) Smith KC, Comite SL, Balasubramanian S, Carver A, Liu JF. Vibration anesthesia: a noninvasive method of reducing discomfort prior to dermatologic procedures. Dermatol Online J. 2004;10(2). Kazi R, Govas P, Slaugenhaupt RM, Carroll BT. Differential analgesia from vibratory stimulation during local injection of anesthetic: a randomized clinical trial. Dermatol Surg. 2020;46(10):1286–93. (PMID: 10.1097/DSS.0000000000002314318952578388110) Song S, Choi DH, Oh TS. The use of locally applied vibration to minimize pain during fractional CO<sub>2</sub> laser therapy in living liver-donor scar management. Arch Plast Surg. 2016;43(6):570–4. (PMID: 10.5999/aps.2016.43.6.570278961905122548) Altman DG, Schulz KF, Moher D, Egger M, Davidoff F, Elbourne D, et al. The revised CONSORT statement for reporting randomized trials: explanation and elaboration. Ann Intern Med. 2001;134(8):663–94. (PMID: 10.7326/0003-4819-134-8-200104170-0001211304107) Sadala AY, Rampazo ÉP, Liebano RE. Vibration anesthesia during carboxytherapy for cellulite: a study protocol. Pain Manag. 2022;12(4):401–8. (PMID: 10.2217/pmt-2021-008035001651) Hexsel DM, Dal’Forno T, Hexsel CL. A validated photonumeric cellulite severity scale. J Eur Acad Dermatol Venereol. 2009;23(5):523–8. (PMID: 10.1111/j.1468-3083.2009.03101.x19220646) Farrar JT, Young JPB, Lamoreaux L, Werth JL, Poole RM. Clinical importance of changes in chronic pain intensity measured on an 11-point numerical pain rating scale. Pain. 2001;149–58. Available from: www.elsevier.com/locate/pain . Abramo AC, Teixeira TT, Ledo-Silva MC, de Oliveira EL. Elevação da temperatura cutânea após a infusão controlada de dióxido de carbono. Revista Brasileira de Cirurgia Plástica. 2009;24(3):257–61. Jensen MP, Mcfarland CA. Increasing the reliability and validity of pain intensity measurement in chronic pain patients. Pain. 1993;55(2):195–203. (PMID: 10.1016/0304-3959(93)90148-I8309709) Comite SL, Malkowiak M. Vibration anesthesia during invasive procedures: a meta-analysis. J Clin Aesthet Dermatol. 2024;17(10):29–40. (PMID: 3944532311495163) Fayers T, Morris DS, Dolman PJ. Vibration-assisted anesthesia in eyelid surgery. Ophthalmology. 2010;117(7):1453–57. (PMID: 10.1016/j.ophtha.2009.11.02520303597) Nanitsos E, Vartuli R, Forte A, Dennison PJ, Peck CC. The effect of vibration on pain during local anaesthesia injections. Aust Dent J. 2009;54(2):94–100. (PMID: 10.1111/j.1834-7819.2009.01100.x19473149) Mally P, Czyz CN, Chan NJ, Wulc AE. Vibration anesthesia for the reduction of pain with facial dermal filler injections. Aesthetic Plast Surg. 2014;38(2):413–18. (PMID: 10.1007/s00266-013-0264-424464122) Bunyatyan ND, Drogovoz SM, Kononenko AV, Prokofiev AB. Carboxytherapy—an innovative trend in resort medicine. Vopr Kurortol Fizioter Lech Fiz Kult. 2018;95(5):72–6. (PMID: 10.17116/kurort2018950517230412151) Rahrovan S, Fanian F, Mehryan P, Humbert P, Firooz A. Male versus female skin: what dermatologists and cosmeticians should know. Int J Womens Dermatol. 2018;4(3):122–30. (PMID: 10.1016/j.ijwd.2018.03.002301752136116811) |
| Contributed Indexing: | Keywords: Analgesia; Carboxytherapy; Cellulite; Pain; Vibration |
| Entry Date(s): | Date Created: 20251006 Date Completed: 20251224 Latest Revision: 20260511 |
| Update Code: | 20260511 |
| DOI: | 10.1007/s00266-025-05280-2 |
| PMID: | 41053479 |
| Βάση Δεδομένων: | MEDLINE |
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