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Selective SERS detection of dopamine in human urine using catechol oxidase-mimicking AgNPs@MOF-818.

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Τίτλος: Selective SERS detection of dopamine in human urine using catechol oxidase-mimicking AgNPs@MOF-818.
Συγγραφείς: Liu S; School of Chemistry, Institute of Green Chemistry and Molecular Engineering, Sun Yat-sen University, Guangzhou, 510006, China., Li G; School of Chemistry, Institute of Green Chemistry and Molecular Engineering, Sun Yat-sen University, Guangzhou, 510006, China., Hu Y; School of Chemistry, Institute of Green Chemistry and Molecular Engineering, Sun Yat-sen University, Guangzhou, 510006, China. Electronic address: ceshyl@mail.sysu.edu.cn.
Πηγή: Talanta [Talanta] 2026 Feb 01; Vol. 298 (Pt A), pp. 128907. Date of Electronic Publication: 2025 Sep 24.
Τύπος έκδοσης: Journal Article
Γλώσσα: English
Στοιχεία περιοδικού: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 2984816R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-3573 (Electronic) Linking ISSN: 00399140 NLM ISO Abbreviation: Talanta Subsets: MEDLINE
Imprint Name(s): Publication: Amsterdam : Elsevier
Original Publication: Oxford : Pergamon Press
Ιατρικοί όροι (MeSH): Dopamine*/urine , Dopamine*/chemistry , Metal Nanoparticles*/chemistry , Spectrum Analysis, Raman*/methods , Silver*/chemistry , Catechol Oxidase*/chemistry , Catechol Oxidase*/metabolism , Metal-Organic Frameworks*/chemistry, Humans ; Limit of Detection
Περίληψη: The integration of surface-enhanced Raman scattering (SERS) and nanozymes has proven to be a highly effective strategy in bioanalytical applications, owing to its superior capabilities in signal transduction and amplification. Nevertheless, clinical applications still face obstacles, particularly in achieving sufficient selectivity. In this work, we have presented a SERS strategy for the selective detection of dopamine in human urine with MOF-818 which exhibits selective catechol oxidase-like activities. AgNPs@MOF-818 catalyze the oxidation of o-phenylenediamine (OPD) to diaminobenzazine (DAP) molecules, when dopamine (DA) is present, the oxidation of OPD is inhibited while DA is catalyzed into o-quinones, thereby suppressing the SERS signal intensity. An indirect SERS detection strategy of dopamine with high sensitivity and selectivity was established. The catechol oxidase-like activity of MOF-818 provides ideal selectivity to dopamine, while the OPD-dopamine catalytic system induces significant changes in SERS intensity. The detection protocol was subsequently optimized to achieve high sensitivity for dopamine, yielding a linear response range of 0.1-30 μmol/L and a low limit of detection (LOD) of 0.04 μmol/L. The method was successfully applied to the quantitative analysis of dopamine in human urine samples, demonstrating excellent recovery rates and minimal relative error in comparison with results obtained by commercial dopamine ELISA kit. This strategy presents a cost-effective, efficient, and accurate approach for dopamine detection while delivering insights into the integration of selective multifunctional nanozymes with sensitive SERS technique.
(Copyright © 2025 Elsevier B.V. All rights reserved.)
Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
Contributed Indexing: Keywords: Catechol oxidase-like nanozyme; Dopamine; Metal-organic frameworks; Surface-enhanced Raman scattering
Substance Nomenclature: VTD58H1Z2X (Dopamine)
3M4G523W1G (Silver)
EC 1.10.3.1 (Catechol Oxidase)
0 (Metal-Organic Frameworks)
Entry Date(s): Date Created: 20250926 Date Completed: 20251204 Latest Revision: 20251204
Update Code: 20260130
DOI: 10.1016/j.talanta.2025.128907
PMID: 41004945
Βάση Δεδομένων: MEDLINE
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  Data: Selective SERS detection of dopamine in human urine using catechol oxidase-mimicking AgNPs@MOF-818.
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  Data: <searchLink fieldCode="AU" term="%22Liu+S%22">Liu S</searchLink>; School of Chemistry, Institute of Green Chemistry and Molecular Engineering, Sun Yat-sen University, Guangzhou, 510006, China.<br /><searchLink fieldCode="AU" term="%22Li+G%22">Li G</searchLink>; School of Chemistry, Institute of Green Chemistry and Molecular Engineering, Sun Yat-sen University, Guangzhou, 510006, China.<br /><searchLink fieldCode="AU" term="%22Hu+Y%22">Hu Y</searchLink>; School of Chemistry, Institute of Green Chemistry and Molecular Engineering, Sun Yat-sen University, Guangzhou, 510006, China. Electronic address: ceshyl@mail.sysu.edu.cn.
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  Data: <searchLink fieldCode="JN" term="%222984816R%22">Talanta</searchLink> [Talanta] 2026 Feb 01; Vol. 298 (Pt A), pp. 128907. <i>Date of Electronic Publication: </i>2025 Sep 24.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Elsevier%22">Elsevier </searchLink><i>Country of Publication: </i>Netherlands <i>NLM ID: </i>2984816R <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1873-3573 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2200399140%22">00399140 </searchLink><i>NLM ISO Abbreviation: </i>Talanta <i>Subsets: </i>MEDLINE
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  Data: <i>Publication</i>: Amsterdam : Elsevier<br /><i>Original Publication</i>: Oxford : Pergamon Press
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  Data: <searchLink fieldCode="MM" term="%22Dopamine%22">Dopamine*</searchLink>/<searchLink fieldCode="MM" term="%22Dopamine+urine%22">urine</searchLink> <br /><searchLink fieldCode="MM" term="%22Dopamine%22">Dopamine*</searchLink>/<searchLink fieldCode="MM" term="%22Dopamine+chemistry%22">chemistry</searchLink> <br /><searchLink fieldCode="MM" term="%22Metal+Nanoparticles%22">Metal Nanoparticles*</searchLink>/<searchLink fieldCode="MM" term="%22Metal+Nanoparticles+chemistry%22">chemistry</searchLink> <br /><searchLink fieldCode="MM" term="%22Spectrum+Analysis%2C+Raman%22">Spectrum Analysis, Raman*</searchLink>/<searchLink fieldCode="MM" term="%22Spectrum+Analysis%2C+Raman+methods%22">methods</searchLink> <br /><searchLink fieldCode="MM" term="%22Silver%22">Silver*</searchLink>/<searchLink fieldCode="MM" term="%22Silver+chemistry%22">chemistry</searchLink> <br /><searchLink fieldCode="MM" term="%22Catechol+Oxidase%22">Catechol Oxidase*</searchLink>/<searchLink fieldCode="MM" term="%22Catechol+Oxidase+chemistry%22">chemistry</searchLink> <br /><searchLink fieldCode="MM" term="%22Catechol+Oxidase%22">Catechol Oxidase*</searchLink>/<searchLink fieldCode="MM" term="%22Catechol+Oxidase+metabolism%22">metabolism</searchLink> <br /><searchLink fieldCode="MM" term="%22Metal-Organic+Frameworks%22">Metal-Organic Frameworks*</searchLink>/<searchLink fieldCode="MM" term="%22Metal-Organic+Frameworks+chemistry%22">chemistry</searchLink><br /><searchLink fieldCode="MH" term="%22Humans%22">Humans</searchLink> ; <searchLink fieldCode="MH" term="%22Limit+of+Detection%22">Limit of Detection</searchLink>
– Name: Abstract
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  Group: Ab
  Data: The integration of surface-enhanced Raman scattering (SERS) and nanozymes has proven to be a highly effective strategy in bioanalytical applications, owing to its superior capabilities in signal transduction and amplification. Nevertheless, clinical applications still face obstacles, particularly in achieving sufficient selectivity. In this work, we have presented a SERS strategy for the selective detection of dopamine in human urine with MOF-818 which exhibits selective catechol oxidase-like activities. AgNPs@MOF-818 catalyze the oxidation of o-phenylenediamine (OPD) to diaminobenzazine (DAP) molecules, when dopamine (DA) is present, the oxidation of OPD is inhibited while DA is catalyzed into o-quinones, thereby suppressing the SERS signal intensity. An indirect SERS detection strategy of dopamine with high sensitivity and selectivity was established. The catechol oxidase-like activity of MOF-818 provides ideal selectivity to dopamine, while the OPD-dopamine catalytic system induces significant changes in SERS intensity. The detection protocol was subsequently optimized to achieve high sensitivity for dopamine, yielding a linear response range of 0.1-30 μmol/L and a low limit of detection (LOD) of 0.04 μmol/L. The method was successfully applied to the quantitative analysis of dopamine in human urine samples, demonstrating excellent recovery rates and minimal relative error in comparison with results obtained by commercial dopamine ELISA kit. This strategy presents a cost-effective, efficient, and accurate approach for dopamine detection while delivering insights into the integration of selective multifunctional nanozymes with sensitive SERS technique.<br /> (Copyright © 2025 Elsevier B.V. All rights reserved.)
– Name: Abstract
  Label: Competing Interests
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  Data: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
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  Data: <i>Keywords: </i>Catechol oxidase-like nanozyme; Dopamine; Metal-organic frameworks; Surface-enhanced Raman scattering
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  Data: VTD58H1Z2X (Dopamine)<br />3M4G523W1G (Silver)<br />EC 1.10.3.1 (Catechol Oxidase)<br />0 (Metal-Organic Frameworks)
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  Data: 10.1016/j.talanta.2025.128907
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        Text: English
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        StartPage: 128907
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      – SubjectFull: Humans
        Type: general
      – SubjectFull: Limit of Detection
        Type: general
      – SubjectFull: Dopamine urine
        Type: general
      – SubjectFull: Dopamine chemistry
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      – TitleFull: Selective SERS detection of dopamine in human urine using catechol oxidase-mimicking AgNPs@MOF-818.
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