Academic Journal
Invasive neurophysiology and whole brain connectomics for neural decoding in patients with brain implants.
| Τίτλος: | Invasive neurophysiology and whole brain connectomics for neural decoding in patients with brain implants. |
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| Συγγραφείς: | Merk T; Movement Disorder and Neuromodulation Unit, Department of Neurology, Charité - Universitätsmedizin Berlin, Berlin, Germany. timon.merk95@gmail.com.; Department of Neurosurgery, Baylor College of Medicine, Houston, TX, USA. timon.merk95@gmail.com.; Department of Electrical & Computer Engineering, Rice University, Houston, TX, USA. timon.merk95@gmail.com., Köhler RM; Movement Disorder and Neuromodulation Unit, Department of Neurology, Charité - Universitätsmedizin Berlin, Berlin, Germany., Brotons TM; Movement Disorder and Neuromodulation Unit, Department of Neurology, Charité - Universitätsmedizin Berlin, Berlin, Germany., Vossberg SR; Movement Disorder and Neuromodulation Unit, Department of Neurology, Charité - Universitätsmedizin Berlin, Berlin, Germany., Peterson V; Department of Neurosurgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.; Instituto de Matemática Aplicada del Litoral IMAL, CONICET-UNL, Santa Fe, Argentina., Lyra LF; Movement Disorder and Neuromodulation Unit, Department of Neurology, Charité - Universitätsmedizin Berlin, Berlin, Germany., Vanhoecke J; Movement Disorder and Neuromodulation Unit, Department of Neurology, Charité - Universitätsmedizin Berlin, Berlin, Germany., Chikermane M; Movement Disorder and Neuromodulation Unit, Department of Neurology, Charité - Universitätsmedizin Berlin, Berlin, Germany., Binns TS; Movement Disorder and Neuromodulation Unit, Department of Neurology, Charité - Universitätsmedizin Berlin, Berlin, Germany.; Einstein Center for Neurosciences Berlin, Charité - Universitätsmedizin Berlin, Berlin, Germany., Li N; Movement Disorder and Neuromodulation Unit, Department of Neurology, Charité - Universitätsmedizin Berlin, Berlin, Germany., Walton A; Department of Neurosurgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA., Neudorfer C; Department of Neurosurgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA., Bush A; Department of Neurosurgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA., Sisterson N; Department of Neurosurgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA., Busch J; Movement Disorder and Neuromodulation Unit, Department of Neurology, Charité - Universitätsmedizin Berlin, Berlin, Germany., Lofredi R; Movement Disorder and Neuromodulation Unit, Department of Neurology, Charité - Universitätsmedizin Berlin, Berlin, Germany., Habets J; Movement Disorder and Neuromodulation Unit, Department of Neurology, Charité - Universitätsmedizin Berlin, Berlin, Germany., Huebl J; Movement Disorder and Neuromodulation Unit, Department of Neurology, Charité - Universitätsmedizin Berlin, Berlin, Germany., Zhu G; Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.; Beijing Key Laboratory of Neurostimulation, Beijing, China., Yin Z; Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.; Beijing Key Laboratory of Neurostimulation, Beijing, China., Zhao B; Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.; Beijing Key Laboratory of Neurostimulation, Beijing, China., Merkl A; Department of Psychology, Medical School Berlin (MSB), Berlin, Germany.; Department of Psychiatry, Charité - Universitätsmedizin Berlin, Berlin, Germany., Bajbouj M; Department of Psychiatry, Charité - Universitätsmedizin Berlin, Berlin, Germany., Krause P; Movement Disorder and Neuromodulation Unit, Department of Neurology, Charité - Universitätsmedizin Berlin, Berlin, Germany., Faust K; Department of Neurosurgery, Charité - Universitätsmedizin Berlin, Berlin, Germany., Schneider GH; Department of Neurosurgery, Charité - Universitätsmedizin Berlin, Berlin, Germany., Horn A; Network Stimulation Institute, Department of Stereotactic and Functional Neurosurgery, University Hospital Cologne, Cologne, Germany.; Center for Brain Circuit Therapeutics Department of Neurology, Brigham & Women's Hospital, Harvard Medical School, Boston, MA, USA.; MGH Neurosurgery & Center for Neurotechnology and Neurorecovery (CNTR) at MGH Neurology Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA., Zhang J; Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.; Beijing Key Laboratory of Neurostimulation, Beijing, China., Kühn AA; Movement Disorder and Neuromodulation Unit, Department of Neurology, Charité - Universitätsmedizin Berlin, Berlin, Germany.; Einstein Center for Neurosciences Berlin, Charité - Universitätsmedizin Berlin, Berlin, Germany., Mark Richardson R; Department of Neurosurgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA., Neumann WJ; Movement Disorder and Neuromodulation Unit, Department of Neurology, Charité - Universitätsmedizin Berlin, Berlin, Germany. julian.neumann@charite.de.; Einstein Center for Neurosciences Berlin, Charité - Universitätsmedizin Berlin, Berlin, Germany. julian.neumann@charite.de. |
| Πηγή: | Nature biomedical engineering [Nat Biomed Eng] 2026 May; Vol. 10 (5), pp. 852-869. Date of Electronic Publication: 2025 Sep 24. |
| Τύπος έκδοσης: | Journal Article |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: Springer Nature Country of Publication: England NLM ID: 101696896 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2157-846X (Electronic) Linking ISSN: 2157846X NLM ISO Abbreviation: Nat Biomed Eng Subsets: MEDLINE |
| Imprint Name(s): | Publication: London : Springer Nature Original Publication: [London] : Macmillan Publishers Limited, [2016]- |
| Ιατρικοί όροι (MeSH): | Connectome*/methods , Brain*/diagnostic imaging , Brain*/physiology , Brain*/physiopathology , Neurophysiology*/methods, Epilepsy/physiopathology ; Epilepsy/therapy ; Deep Brain Stimulation/methods ; Parkinson Disease/physiopathology ; Parkinson Disease/diagnostic imaging ; Major Depressive Disorder/physiopathology ; Humans ; Magnetic Resonance Imaging ; Male ; Female ; Brain-Computer Interfaces ; Middle Aged ; Adult ; Machine Learning |
| Περίληψη: | Brain-computer interface research can inspire closed-loop neuromodulation therapies, promising spatiotemporal precision for the treatment of brain disorders. Decoding dynamic patient states from brain signals with machine learning is required to leverage this precision, but a standardized framework for invasive brain signal decoding from neural implants does not exist. Here we develop a platform that integrates brain signal decoding with magnetic resonance imaging connectomics and demonstrate its use across 123 h of invasively recorded brain data from 73 neurosurgical patients treated with brain implants for movement disorders, depression and epilepsy. We introduce connectomics-informed movement decoders that generalize across cohorts with Parkinson's disease and epilepsy from the United States, Europe and China. We reveal network targets for emotion decoding in left prefrontal and cingulate circuits in deep brain stimulation patients with major depression. Finally, we showcase opportunities to improve seizure detection in responsive neurostimulation for epilepsy. Our study highlights the clinical use of brain signal decoding for deep brain stimulation and provides methods that allow for rapid, high-accuracy decoding for precision medicine approaches that can dynamically adapt neurotherapies in response to the individual needs of patients. (© 2025. The Author(s).) |
| Competing Interests: | Competing interests: R.M.R. has served as a consultant for NeuroPace. R.L. reports personal fees from Medtronic. A.A.K. reports personal fees from Medtronic and Boston Scientific. G.-H.S. reports personal fees from Medtronic, Boston Scientific and Abbott. W.-J.N. serves as consultant to InBrain and reports personal fees from Medtronic. A.H. reports lecture fees for Boston Scientific, is a consultant for Modulight.bio, was a consultant for FxNeuromodulation and Abbott in recent years and serves as a co-inventor on a patent granted to Charité University Medicine Berlin that covers multisymptom DBS fibre filtering and an automated DBS parameter suggestion algorithm unrelated to this work (patent LU103178). The remaining authors declare no competing interests. |
| Σχόλια: | Update of: Res Sq. 2023 Sep 20:rs.3.rs-3212709. doi: 10.21203/rs.3.rs-3212709/v1.. (PMID: 37790428) |
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| Grant Information: | R01NS110424 Bundesministerium fr Bildung und Forschung (Federal Ministry of Education and Research); 424778381 Deutsche Forschungsgemeinschaft (German Research Foundation); R01NS110424 Deutsche Forschungsgemeinschaft (German Research Foundation); R01 13478451 U.S. Department of Health Human Services | National Institutes of Health (NIH); 1R01NS127892-01 U.S. Department of Health Human Services | National Institutes of Health (NIH); UM1NS132358 U.S. Department of Health Human Services | National Institutes of Health (NIH); 101077060 European Commission (EC) |
| Entry Date(s): | Date Created: 20250924 Date Completed: 20260520 Latest Revision: 20260813 |
| Update Code: | 20260813 |
| PubMed Central ID: | PMC13190260 |
| DOI: | 10.1038/s41551-025-01467-9 |
| PMID: | 40993190 |
| Βάση Δεδομένων: | MEDLINE |
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