Λεπτομέρειες βιβλιογραφικής εγγραφής
| Τίτλος: |
Modelling menstruation in the common mouse: a narrative review. |
| Συγγραφείς: |
Rogers LM; Department of Anatomy, School of Biomedical Sciences, University of Otago., Lash GE; Division of Uterine Vascular Biology, Guangdong Provincial Clinical Research Center for Child Health, Guangzhou Institute of Pediatrics, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, China., Anderson GM; Department of Anatomy, School of Biomedical Sciences, University of Otago., Girling JE; Department of Anatomy, School of Biomedical Sciences, University of Otago. |
| Πηγή: |
Reproduction, fertility, and development [Reprod Fertil Dev] 2025 Aug; Vol. 37. |
| Τύπος έκδοσης: |
Journal Article; Review |
| Γλώσσα: |
English |
| Στοιχεία περιοδικού: |
Publisher: Commonwealth Scientific and Industrial Research Organisation Country of Publication: Australia NLM ID: 8907465 Publication Model: Print Cited Medium: Internet ISSN: 1448-5990 (Electronic) Linking ISSN: 10313613 NLM ISO Abbreviation: Reprod Fertil Dev Subsets: MEDLINE |
| Imprint Name(s): |
Original Publication: East Melbourne, Vic., Australia : Commonwealth Scientific and Industrial Research Organisation, c1989- |
| Ιατρικοί όροι (MeSH): |
Menstruation*/physiology , Endometrium*/physiology , Models, Animal*, Pseudopregnancy/physiopathology ; Animals ; Female ; Mice ; Progesterone ; Ovariectomy ; Humans ; Disease Models, Animal |
| Περίληψη: |
Despite occurring in up to 50% of the human population, menstruation is a fundamentally understudied process with limited treatment options when menstrual pathologies arise. Reasons for this deficit include the inherent ethical and technical constraints associated with researching menstruation. The multifactorial nature of many menstrual-related pathologies means in vivo research is necessary; however, this type of research is difficult in humans, and non-human species that menstruate naturally are often not suitable as research models. Consequently, most menstrual research relies on an artificially induced menstrual-like process in the non-menstruating laboratory mouse. This review investigates mouse models of menstruation and how specific technical variables are used to produce or modulate a menstrual-like process. The review describes two key categories of models, those that are ovariectomy-based versus those that are pseudopregnancy-based. The menstrual-like process occurring in these models varied slightly;the underlying reason for the variation is likely to be the method of progesterone withdrawal. Models that withdrew progesterone specifically had a far less rapid endometrial breakdown in comparison to those that withdrew all ovarian input. These outcomes suggest that a loss of ovarian factors other than progesterone is likely impacting the breakdown process. The review highlights the gaps in our understanding of the mechanisms of endometrial breakdown and repair in these proxies for menstruation and the subsequent impacts on any conclusions drawn from these models. |
| Substance Nomenclature: |
4G7DS2Q64Y (Progesterone) |
| Entry Date(s): |
Date Created: 20250922 Date Completed: 20250922 Latest Revision: 20250922 |
| Update Code: |
20260130 |
| DOI: |
10.1071/RD25055 |
| PMID: |
40977194 |
| Βάση Δεδομένων: |
MEDLINE |