Academic Journal
Moxifloxacin-induced insomnia with psychotic episodes in a toddler: a case report.
| Τίτλος: | Moxifloxacin-induced insomnia with psychotic episodes in a toddler: a case report. |
|---|---|
| Συγγραφείς: | Getova-Kolarova V; Faculty of Pharmacy, Medical University - Sofia, Sofia, Bulgaria v.getova@pharmfac.mu-sofia.bg., Hababa-Ivanova I; Faculty of Pharmacy, Medical University - Sofia, Sofia, Bulgaria., Georgieva N; Acibadem City Clinic MHAT Tokuda Hospital, Sofia, Bulgaria. |
| Πηγή: | European journal of hospital pharmacy : science and practice [Eur J Hosp Pharm] 2026 Aug 19; Vol. 33 (5), pp. 483-485. Date of Electronic Publication: 2026 Aug 19. |
| Τύπος έκδοσης: | Case Reports; Journal Article |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: BMJ Publishing Group Country of Publication: England NLM ID: 101578294 Publication Model: Electronic Cited Medium: Print ISSN: 2047-9956 (Print) Linking ISSN: 20479956 NLM ISO Abbreviation: Eur J Hosp Pharm Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: London : BMJ Publishing Group |
| Ιατρικοί όροι (MeSH): | Moxifloxacin*/adverse effects , Anti-Bacterial Agents*/adverse effects , Anti-Bacterial Agents*/administration & dosage , Sleep Initiation and Maintenance Disorders*/chemically induced , Sleep Initiation and Maintenance Disorders*/diagnosis , Fluoroquinolones*/adverse effects , Fluoroquinolones*/administration & dosage , Psychoses, Substance-Induced*/etiology , Psychoses, Substance-Induced*/diagnosis, Humans ; Off-Label Use ; Male ; Child, Preschool ; Female |
| Περίληψη: | Moxifloxacin is a fourth-generation fluoroquinolone with a broad spectrum of antibacterial activity. It is commonly used for both local and systemic applications. Data on the safety profile of fluoroquinolones indicate the potential for serious adverse reactions including neurological and psychiatric disturbances. The current case describes the off-label use of moxifloxacin eye drops for nasal administration in a toddler which led to insomnia and symptoms of severe psychosis. Notably, these adverse events resolved completely shortly after discontinuation of treatment. This case highlights a rare and potentially debilitating adverse reaction and underscores the critical importance of clinical judgement when prescribing off-label medicines in the paediatric population. (© European Association of Hospital Pharmacists 2026. No commercial re-use. See rights and permissions. Published by BMJ Group.) |
| Competing Interests: | Competing interests: None declared. |
| Contributed Indexing: | Keywords: Case Reports; DRUG-RELATED SIDE EFFECTS AND ADVERSE REACTIONS; NEUROLOGY; PATIENT SAFETY; Public Health |
| Substance Nomenclature: | U188XYD42P (Moxifloxacin) 0 (Anti-Bacterial Agents) 0 (Fluoroquinolones) |
| Entry Date(s): | Date Created: 20250917 Date Completed: 20260819 Latest Revision: 20260825 |
| Update Code: | 20260825 |
| DOI: | 10.1136/ejhpharm-2025-004600 |
| PMID: | 40962481 |
| Βάση Δεδομένων: | MEDLINE |
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