Academic Journal
Distribution of Prohormone Convertase 1/3 in β and α Cells of the Human Fetal Pancreas at Gestational Weeks 8-20.
| Τίτλος: | Distribution of Prohormone Convertase 1/3 in β and α Cells of the Human Fetal Pancreas at Gestational Weeks 8-20. |
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| Συγγραφείς: | Krivova YS; Avtsyn Research Institute of Human Morphology, Petrovsky National Research Centre of Surgery, Moscow, Russia. homulkina@gmail.com., Proshchina AE; Avtsyn Research Institute of Human Morphology, Petrovsky National Research Centre of Surgery, Moscow, Russia., Godovalova OS; Avtsyn Research Institute of Human Morphology, Petrovsky National Research Centre of Surgery, Moscow, Russia., Otlyga EG; Avtsyn Research Institute of Human Morphology, Petrovsky National Research Centre of Surgery, Moscow, Russia., Saveliev SV; Avtsyn Research Institute of Human Morphology, Petrovsky National Research Centre of Surgery, Moscow, Russia. |
| Πηγή: | Bulletin of experimental biology and medicine [Bull Exp Biol Med] 2025 Jun; Vol. 179 (2), pp. 260-265. Date of Electronic Publication: 2025 Aug 30. |
| Τύπος έκδοσης: | Journal Article |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: Springer Country of Publication: United States NLM ID: 0372557 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1573-8221 (Electronic) Linking ISSN: 00074888 NLM ISO Abbreviation: Bull Exp Biol Med Subsets: MEDLINE |
| Imprint Name(s): | Publication: New York : Springer Original Publication: New York, Consultants Bureau. |
| Ιατρικοί όροι (MeSH): | Proprotein Convertase 1*/metabolism , Proprotein Convertase 1*/genetics , Insulin-Secreting Cells*/metabolism , Insulin-Secreting Cells*/enzymology , Insulin-Secreting Cells*/cytology , Glucagon-Secreting Cells*/metabolism , Glucagon-Secreting Cells*/enzymology , Glucagon-Secreting Cells*/cytology , Pancreas*/embryology , Pancreas*/cytology , Pancreas*/metabolism, Fetus/cytology ; Fetus/metabolism ; Glucagon/metabolism ; Insulin/metabolism ; Humans ; Gestational Age ; Female ; Pregnancy |
| Περίληψη: | Data on the distribution of insulin biosynthesis enzymes in the developing human pancreas are limited and do not provide comprehensive understanding of mechanisms of β-cell maturation. In this study, the distribution of prohormone convertase 1/3 (PC1/3) in β and α cells of the pancreas of 15 fetuses (gestational age 8-20 weeks) was analyzed using double immunofluorescence staining. It has been demonstrated that numerous cells positively stained for PC1/3 but not containing insulin are present in the pancreatic islets during prenatal development. These cells probably represent maturing β cells that accumulate the enzyme prior to the insulin biosynthesis. In some of these cells, co-localization of PC1/3 and glucagon was revealed, which indicates a possible temporary expression of glucagon in differentiating and maturing β cells. (© 2025. Springer Science+Business Media, LLC, part of Springer Nature.) |
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| Contributed Indexing: | Keywords: glucagon; human development; insulin; pancreas; prohormone convertase 1/3 (PC1/3) |
| Substance Nomenclature: | EC 3.4.21.93 (Proprotein Convertase 1) 9007-92-5 (Glucagon) 0 (Insulin) |
| Entry Date(s): | Date Created: 20250830 Date Completed: 20250911 Latest Revision: 20250911 |
| Update Code: | 20260130 |
| DOI: | 10.1007/s10517-025-06470-3 |
| PMID: | 40884625 |
| Βάση Δεδομένων: | MEDLINE |
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