Academic Journal
Inhaled salbutamol delivery in small children with disposable and reusable spacers: an in vitro study.
| Τίτλος: | Inhaled salbutamol delivery in small children with disposable and reusable spacers: an in vitro study. |
|---|---|
| Συγγραφείς: | Ojanperä L; Tampere Universities, Tampere, Pirkanmaa, Finland., Lehtimäki L; Tampere Universities, Tampere, Pirkanmaa, Finland.; Tampere University Hospital, Tampere, Finland., Kelemen B; Tampere Universities, Tampere, Pirkanmaa, Finland., Csonka P; Tampere Universities, Tampere, Pirkanmaa, Finland peter.csonka@tuni.fi. |
| Πηγή: | Archives of disease in childhood [Arch Dis Child] 2025 Dec 15; Vol. 111 (1), pp. 35-42. Date of Electronic Publication: 2025 Dec 15. |
| Τύπος έκδοσης: | Journal Article |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: BMJ Pub. Group [etc.] Country of Publication: England NLM ID: 0372434 Publication Model: Electronic Cited Medium: Internet ISSN: 1468-2044 (Electronic) Linking ISSN: 00039888 NLM ISO Abbreviation: Arch Dis Child Subsets: MEDLINE |
| Imprint Name(s): | Publication: London :, BMJ Pub. Group [etc.] Original Publication: London : British Medical Association |
| Ιατρικοί όροι (MeSH): | Albuterol*/administration & dosage , Bronchodilator Agents*/administration & dosage , Metered Dose Inhalers* , Inhalation Spacers*, Humans ; Administration, Inhalation ; Child, Preschool ; Child ; Disposable Equipment ; Equipment Design ; Equipment Reuse ; Particle Size |
| Περίληψη: | Background: Research on spacers for paediatric breathing patterns is limited, especially for disposable types, which may be a practical alternative to reusable valved holding chambers (VHC) in certain clinical settings. Methods: In vitro, the fine particle dose (FPD) of salbutamol from a pressurised metered-dose inhaler (pMDI) was tested using two paperboard spacers-DispozABLE (Diz) and LiteAire (LA)-and three reusable VHCs: AeroChamber Plus Flow-Vu (AC), EasyChamber (EC) and OptiChamber Diamond (OC). The pMDI+VHC setup was connected to a child throat model without a facemask. Salbutamol availability for inhalation was measured using a Next Generation Impactor under three paediatric breathing patterns: calm breathing (6 and 4 year olds) and obstructive breathing. Results: Median FPD in the respirable range (1-5 µm) was significantly higher for EC compared with LA, Diz and AC. Obstructive breathing increased throat deposition for all spacers, with Diz showing the highest. LA had the lowest throat deposition in calm breathing, and EC in obstructive breathing. Conclusion: Traditional VHCs, especially EC and OC, outperformed disposable spacers. Among disposables, the valved LA performed better than the valveless Diz and may offer a cost-effective, practical alternative to reusable spacers in specific scenarios. (© Author(s) (or their employer(s)) 2026. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ Group.) |
| Competing Interests: | Competing interests: None declared. |
| References: | Eur J Clin Pharmacol. 2000 Nov;56(8):591-6. (PMID: 11151750) Eur Respir J. 2008 Jan;31(1):143-78. (PMID: 18166595) J Allergy Clin Immunol Pract. 2024 Feb;12(2):509-511.e3. (PMID: 37979688) Lancet. 2011 Mar 19;377(9770):1011-8. (PMID: 21411136) Pulm Pharmacol Ther. 2019 Dec;59:101857. (PMID: 31678460) Pediatr Pulmonol. 2017 Oct;52(10):1250-1259. (PMID: 28815996) Respir Care. 2000 Jun;45(6):646-51. (PMID: 10894457) Int J Pharm. 2024 Dec 5;666:124774. (PMID: 39343331) J Allergy Clin Immunol Pract. 2018 Jan - Feb;6(1):307-309. (PMID: 28970085) Ann Allergy Asthma Immunol. 2016 Sep;117(3):246-50. (PMID: 27613457) Br J Clin Pharmacol. 1995 Jul;40(1):76-8. (PMID: 8527272) Lancet. 2001 Jun 9;357(9271):1821-5. (PMID: 11410189) Eur J Pediatr. 2021 Oct;180(10):3101-3109. (PMID: 33877400) J Allergy Clin Immunol. 2010 Jun;125(6):1206-11. (PMID: 20338620) Pediatr Pulmonol. 2025 Jan;60(1):e27300. (PMID: 39347594) J Allergy Clin Immunol Pract. 2020 May;8(5):1569-1573. (PMID: 31927099) ERJ Open Res. 2019 Feb 04;5(1):. (PMID: 30740461) J Emerg Med. 2011 Mar;40(3):247-55. (PMID: 19081697) Pharm Res. 2007 Nov;24(11):2008-17. (PMID: 17510755) Eur Respir J. 2012 Jan;39(1):97-103. (PMID: 21933835) ERJ Open Res. 2021 Jun 07;7(2):. (PMID: 34109249) Respir Care. 2005 Sep;50(9):1191-200. (PMID: 16122402) Pulm Med. 2015;2015:176194. (PMID: 26491563) Respir Care. 2020 Mar;65(3):320-325. (PMID: 31455686) Pediatrics. 2010 Dec;126(6):e1493-8. (PMID: 21078734) Ann Med. 2011 May;43(3):235-48. (PMID: 20854213) |
| Contributed Indexing: | Keywords: Paediatric Emergency Medicine; Paediatrics; Pharmacology; Respiratory Medicine |
| Substance Nomenclature: | QF8SVZ843E (Albuterol) 0 (Bronchodilator Agents) |
| Entry Date(s): | Date Created: 20250820 Date Completed: 20251215 Latest Revision: 20260702 |
| Update Code: | 20260703 |
| PubMed Central ID: | PMC12772549 |
| DOI: | 10.1136/archdischild-2025-328830 |
| PMID: | 40835412 |
| Βάση Δεδομένων: | MEDLINE |
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