Academic Journal
Gastrointestinal neuroprosthesis for motility and metabolic neuromodulation.
| Τίτλος: | Gastrointestinal neuroprosthesis for motility and metabolic neuromodulation. |
|---|---|
| Συγγραφείς: | Srinivasan S; Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.; Division of Gastroenterology, Hepatology and Endoscopy, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.; David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA.; Society of Fellows, Harvard University, Cambridge, MA, USA., Antonini MJ; Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA, USA.; McGovern Institute for Brain Research, Massachusetts Institute of Technology, Cambridge, MA, USA.; Research Laboratory of Electronics, Massachusetts Institute of Technology, Cambridge, MA, USA., Alshareef A; Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.; Division of Gastroenterology, Hepatology and Endoscopy, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.; David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA., Sahasrabudhe A; McGovern Institute for Brain Research, Massachusetts Institute of Technology, Cambridge, MA, USA.; Research Laboratory of Electronics, Massachusetts Institute of Technology, Cambridge, MA, USA.; Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA, USA., Jenkins J; Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA., Ishida K; Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.; Division of Gastroenterology, Hepatology and Endoscopy, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.; David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA., Kuosmanen J; Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.; David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA., Hayward A; Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.; Division of Gastroenterology, Hepatology and Endoscopy, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.; Division of Comparative Medicine, Massachusetts Institute of Technology, Cambridge, MA, USA., Min S; Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.; David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA., Langer R; Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.; David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA., Anikeeva P; McGovern Institute for Brain Research, Massachusetts Institute of Technology, Cambridge, MA, USA. anikeeva@mit.edu.; Research Laboratory of Electronics, Massachusetts Institute of Technology, Cambridge, MA, USA. anikeeva@mit.edu.; Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA, USA. anikeeva@mit.edu.; Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA, USA. anikeeva@mit.edu.; Department of Materials Science and Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA. anikeeva@mit.edu., Traverso G; Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA. cgt20@mit.edu.; Division of Gastroenterology, Hepatology and Endoscopy, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA. cgt20@mit.edu. |
| Πηγή: | Nature communications [Nat Commun] 2025 Aug 10; Vol. 16 (1), pp. 7374. Date of Electronic Publication: 2025 Aug 10. |
| Τύπος έκδοσης: | Journal Article |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: [London] : Nature Pub. Group |
| Ιατρικοί όροι (MeSH): | Gastrointestinal Motility*/physiology , Gastrointestinal Tract*/innervation , Electric Stimulation Therapy*/methods , Electric Stimulation Therapy*/instrumentation , Neural Prostheses*, Peristalsis/physiology ; Enteric Nervous System/physiology ; Myenteric Plexus/physiology ; Animals ; Swine ; Electric Stimulation ; Esophagus ; Female |
| Περίληψη: | Gastrointestinal (GI) dysmotility and associated conditions affect over 20% of population, yet pharmacological, behavioural, and surgical interventions offer limited therapeutic efficacy. Targeted electrical stimulation addressing underlying neuromuscular pathology stands to transform our ability to treat dysmotility. Here, we developed a closed-loop GI neuroprosthesis which activates or relaxes GI tract musculature through electrochemical stimulation in response to sensed food stimuli. We additionally describe a tool supporting minimally invasive endoscopically guided implantation that can penetrate the mucosa, accurately localize the submucosa, and safely deploy this device to directly interface with the enteric nervous system. The neuroprosthesis enables generation of coordinated peristaltic waves, significantly increasing the motility rate in a swine model of oesophageal and stomach dysmotility (p < 0.05, student's t-test). Further, by directly modulating the myenteric plexus and thus mimicking meal ingestion, we induce peristalsis in a fasted state and achieve a metabolic response commensurate with a fed or satiated state. This neuroprosthesis and implantation platform expand opportunities in fundamental studies and treatments of metabolic and neuromuscular pathologies affecting the GI tract. (© 2025. The Author(s).) |
| Competing Interests: | Competing interests: Shriya Srinivasan, Marc-Joseph Antonini, Polina Anikeeva, Robert Langer, and Giovanni Traverso are co-inventors on provisional patent applications describing the developments presented here. R.L. and G.T. Report receiving consulting fees from Novo Nordisk. Complete details of all relationships for profit and not for profit for G.T. and R.L can be found at as supplemental attachments. All authors have submitted an invention disclosure to MIT. M.-J.A. and P.A. are cofounders of NeuroBionics Inc. that seeks to translate fibre-based technology to treatment of neurological conditions. |
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| Entry Date(s): | Date Created: 20250809 Date Completed: 20250809 Latest Revision: 20250813 |
| Update Code: | 20260130 |
| PubMed Central ID: | PMC12335536 |
| DOI: | 10.1038/s41467-025-62413-6 |
| PMID: | 40783382 |
| Βάση Δεδομένων: | MEDLINE |
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