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Effect of intracanal medicaments on dentinal tubule penetration of root canal sealers: a confocal laser scanning microscopy study.

Λεπτομέρειες βιβλιογραφικής εγγραφής
Τίτλος: Effect of intracanal medicaments on dentinal tubule penetration of root canal sealers: a confocal laser scanning microscopy study.
Συγγραφείς: Bayram E; Faculty of Dentistry, Tokat Gaziosmanpasa University, Tokat, Türkiye., Bayram HM; Faculty of Dentistry, Tokat Gaziosmanpasa University, Tokat, Türkiye. melikealaca@yahoo.com.
Πηγή: BMC oral health [BMC Oral Health] 2025 Jul 26; Vol. 25 (1), pp. 1253. Date of Electronic Publication: 2025 Jul 26.
Τύπος έκδοσης: Journal Article; Comparative Study
Γλώσσα: English
Στοιχεία περιοδικού: Publisher: BioMed Central Country of Publication: England NLM ID: 101088684 Publication Model: Electronic Cited Medium: Internet ISSN: 1472-6831 (Electronic) Linking ISSN: 14726831 NLM ISO Abbreviation: BMC Oral Health Subsets: MEDLINE
Imprint Name(s): Original Publication: London : BioMed Central, [2001-
Ιατρικοί όροι (MeSH): Root Canal Irrigants*/pharmacology , Dentin*/drug effects , Dentin*/ultrastructure , Dental Pulp Cavity*/ultrastructure , Dental Pulp Cavity*/drug effects , Dentin Permeability*/drug effects , Root Canal Filling Materials*, Calcium Hydroxide/pharmacology ; Silicates/pharmacology ; Aluminum Compounds/pharmacology ; Calcium Compounds/pharmacology ; Anti-Bacterial Agents/pharmacology ; Oxides/pharmacology ; Metronidazole/pharmacology ; Ciprofloxacin/pharmacology ; Minocycline/pharmacology ; Humans ; Microscopy, Confocal ; Rhodamines ; Drug Combinations ; Epoxy Resins ; Fluorescent Dyes ; Fluorescein ; Materials Testing
Περίληψη: Background: This study investigated the effect of three intracanal medicaments on the penetration ability of three different root canal sealers using confocal laser scanning microscopy (CLSM).
Materials and Methods: 120 extracted single-rooted human teeth were used. The crowns were removed, and each canal was prepared. The teeth were divided into four groups (n = 30): three medicament groups (calcium hydroxide (CH), triple antibiotic paste (TAP), and double antibiotic paste [DAP]) and one control group. 0.1% Rhodamine B was incorporated. After three weeks, the medicaments were removed, and then canals were filled with one of the following sealers: AH Plus, MTA Fillapex, and TotalFill (n = 10). Fluorescein dye was added to the sealers. Horizontal sections (1 mm thick) were taken from each canal's coronal, middle, and apical portions. Samples were then viewed under CLSM. Statistical analysis was performed using Kruskal-Wallis and Mann-Whitney U tests.
Results: TotalFill exhibited the highest dentinal tubule penetration values across all root levels and medicament groups, followed by AH Plus and MTA Fillapex. However, these differences were not statistically significant (p > 0.05). All sealers showed greater penetration in the coronal third compared to the apical third.
Conclusions: Although intracanal medicaments did not significantly affect sealer penetration, TotalFill demonstrated more consistent penetration patterns regardless of the medicament used.
(© 2025. The Author(s).)
Competing Interests: Declarations. Ethics approval and consent to participate: All procedures performed in studies involving human biological material were by the ethical standards of the institutional and national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards. This study was approved by the ethics committee of Tokat Gaziosmanpaşa University’s Faculty of Medicine project number 15- KAEK-071. The informed consent form was obtained. Consent for publication: Not applicable to this study. Competing interests: The authors declare no competing interests.
References: J Endod. 2014 Sep;40(9):1439-42. (PMID: 25146028)
J Endod. 2013 Mar;39(3 Suppl):S30-43. (PMID: 23439043)
J Endod. 2007 Aug;33(8):957-61. (PMID: 17878082)
Clin Oral Investig. 2023 Dec 22;28(1):11. (PMID: 38129367)
J Endod. 2005 Jun;31(6):439-43. (PMID: 15917683)
Microsc Res Tech. 2019 Jun;82(6):903-908. (PMID: 30811819)
J Endod. 2012 Oct;38(10):1372-5. (PMID: 22980180)
Aust Endod J. 2021 Dec;47(3):480-486. (PMID: 33769648)
Clin Oral Investig. 2017 May;21(4):1277-1282. (PMID: 27287499)
J Endod. 2016 Apr;42(4):637-40. (PMID: 26906243)
J Clin Diagn Res. 2017 Jan;11(1):ZC06-ZC09. (PMID: 28274034)
Odontology. 2019 Jan;107(1):64-71. (PMID: 29651668)
Aust Endod J. 2014 Apr;40(1):21-5. (PMID: 24330380)
Clin Oral Investig. 2024 Aug 19;28(9):491. (PMID: 39155361)
J Endod. 2005 May;31(5):359-63. (PMID: 15851929)
Int Endod J. 2007 Nov;40(11):873-81. (PMID: 17764458)
J Mech Behav Biomed Mater. 2024 Mar;151:106400. (PMID: 38262184)
Dent Traumatol. 2014 Dec;30(6):429-34. (PMID: 24645753)
Aust Endod J. 2018 Dec;44(3):225-234. (PMID: 29034531)
Pediatr Dent. 2012 Jan-Feb;34(1):66-9. (PMID: 22353461)
Braz Oral Res. 2014;28:. (PMID: 25006626)
J Endod. 2014 Jun;40(6):845-8. (PMID: 24862714)
Microsc Res Tech. 2013 May;76(5):496-502. (PMID: 23456772)
J Endod. 2014 Aug;40(8):1172-7. (PMID: 25069927)
J Endod. 2018 Jun;44(6):1018-1023. (PMID: 29680722)
J Endod. 2007 Dec;33(12):1473-6. (PMID: 18037062)
J Adhes Dent. 2009 Feb;11(1):7-14. (PMID: 19343922)
J Endod. 2012 Jan;38(1):91-4. (PMID: 22152628)
Microsc Res Tech. 2014 Jun;77(6):467-71. (PMID: 24753317)
Int Endod J. 2014 Jun;47(6):594-9. (PMID: 24138387)
J Endod. 2024 Aug;50(8):1044-1058.e5. (PMID: 38729300)
Int Endod J. 2006 Jan;39(1):10-7. (PMID: 16409323)
J Endod. 2017 Mar;43(3):452-455. (PMID: 28131413)
Int Endod J. 2001 Jul;34(5):346-53. (PMID: 11482717)
Contributed Indexing: Keywords: AH plus; Confocal microscopy; Dentin penetration; Intracanal medicament; Root Canal sealer
Substance Nomenclature: 0 (Root Canal Filling Materials)
PF5DZW74VN (Calcium Hydroxide)
0 (Silicates)
0 (Root Canal Irrigants)
0 (Rhodamines)
K7G5SCF8IL (rhodamine B)
0 (Drug Combinations)
0 (Aluminum Compounds)
0 (mineral trioxide aggregate)
0 (Calcium Compounds)
0 (Anti-Bacterial Agents)
0 (epoxy resin-based root canal sealer)
0 (Oxides)
0 (Epoxy Resins)
140QMO216E (Metronidazole)
0 (Fluorescent Dyes)
5E8K9I0O4U (Ciprofloxacin)
TPY09G7XIR (Fluorescein)
FYY3R43WGO (Minocycline)
Entry Date(s): Date Created: 20250727 Date Completed: 20250727 Latest Revision: 20250731
Update Code: 20260130
PubMed Central ID: PMC12297755
DOI: 10.1186/s12903-025-06657-0
PMID: 40713572
Βάση Δεδομένων: MEDLINE
FullText Text:
  Availability: 0
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  Data: Effect of intracanal medicaments on dentinal tubule penetration of root canal sealers: a confocal laser scanning microscopy study.
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  Data: <searchLink fieldCode="AU" term="%22Bayram+E%22">Bayram E</searchLink>; Faculty of Dentistry, Tokat Gaziosmanpasa University, Tokat, Türkiye.<br /><searchLink fieldCode="AU" term="%22Bayram+HM%22">Bayram HM</searchLink>; Faculty of Dentistry, Tokat Gaziosmanpasa University, Tokat, Türkiye. melikealaca@yahoo.com.
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  Data: <searchLink fieldCode="JN" term="%22101088684%22">BMC oral health</searchLink> [BMC Oral Health] 2025 Jul 26; Vol. 25 (1), pp. 1253. <i>Date of Electronic Publication: </i>2025 Jul 26.
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  Data: Journal Article; Comparative Study
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22BioMed+Central%22">BioMed Central </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>101088684 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1472-6831 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2214726831%22">14726831 </searchLink><i>NLM ISO Abbreviation: </i>BMC Oral Health <i>Subsets: </i>MEDLINE
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  Data: <i>Original Publication</i>: London : BioMed Central, [2001-
– Name: SubjectMESH
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  Data: <searchLink fieldCode="MM" term="%22Root+Canal+Irrigants%22">Root Canal Irrigants*</searchLink>/<searchLink fieldCode="MM" term="%22Root+Canal+Irrigants+pharmacology%22">pharmacology</searchLink> <br /><searchLink fieldCode="MM" term="%22Dentin%22">Dentin*</searchLink>/<searchLink fieldCode="MM" term="%22Dentin+drug+effects%22">drug effects</searchLink> <br /><searchLink fieldCode="MM" term="%22Dentin%22">Dentin*</searchLink>/<searchLink fieldCode="MM" term="%22Dentin+ultrastructure%22">ultrastructure</searchLink> <br /><searchLink fieldCode="MM" term="%22Dental+Pulp+Cavity%22">Dental Pulp Cavity*</searchLink>/<searchLink fieldCode="MM" term="%22Dental+Pulp+Cavity+ultrastructure%22">ultrastructure</searchLink> <br /><searchLink fieldCode="MM" term="%22Dental+Pulp+Cavity%22">Dental Pulp Cavity*</searchLink>/<searchLink fieldCode="MM" term="%22Dental+Pulp+Cavity+drug+effects%22">drug effects</searchLink> <br /><searchLink fieldCode="MM" term="%22Dentin+Permeability%22">Dentin Permeability*</searchLink>/<searchLink fieldCode="MM" term="%22Dentin+Permeability+drug+effects%22">drug effects</searchLink> <br /><searchLink fieldCode="MM" term="%22Root+Canal+Filling+Materials%22">Root Canal Filling Materials*</searchLink><br /><searchLink fieldCode="MH" term="%22Calcium+Hydroxide%22">Calcium Hydroxide</searchLink>/<searchLink fieldCode="MH" term="%22Calcium+Hydroxide+pharmacology%22">pharmacology</searchLink> ; <searchLink fieldCode="MH" term="%22Silicates%22">Silicates</searchLink>/<searchLink fieldCode="MH" term="%22Silicates+pharmacology%22">pharmacology</searchLink> ; <searchLink fieldCode="MH" term="%22Aluminum+Compounds%22">Aluminum Compounds</searchLink>/<searchLink fieldCode="MH" term="%22Aluminum+Compounds+pharmacology%22">pharmacology</searchLink> ; <searchLink fieldCode="MH" term="%22Calcium+Compounds%22">Calcium Compounds</searchLink>/<searchLink fieldCode="MH" term="%22Calcium+Compounds+pharmacology%22">pharmacology</searchLink> ; <searchLink fieldCode="MH" term="%22Anti-Bacterial+Agents%22">Anti-Bacterial Agents</searchLink>/<searchLink fieldCode="MH" term="%22Anti-Bacterial+Agents+pharmacology%22">pharmacology</searchLink> ; <searchLink fieldCode="MH" term="%22Oxides%22">Oxides</searchLink>/<searchLink fieldCode="MH" term="%22Oxides+pharmacology%22">pharmacology</searchLink> ; <searchLink fieldCode="MH" term="%22Metronidazole%22">Metronidazole</searchLink>/<searchLink fieldCode="MH" term="%22Metronidazole+pharmacology%22">pharmacology</searchLink> ; <searchLink fieldCode="MH" term="%22Ciprofloxacin%22">Ciprofloxacin</searchLink>/<searchLink fieldCode="MH" term="%22Ciprofloxacin+pharmacology%22">pharmacology</searchLink> ; <searchLink fieldCode="MH" term="%22Minocycline%22">Minocycline</searchLink>/<searchLink fieldCode="MH" term="%22Minocycline+pharmacology%22">pharmacology</searchLink> ; <searchLink fieldCode="MH" term="%22Humans%22">Humans</searchLink> ; <searchLink fieldCode="MH" term="%22Microscopy%2C+Confocal%22">Microscopy, Confocal</searchLink> ; <searchLink fieldCode="MH" term="%22Rhodamines%22">Rhodamines</searchLink> ; <searchLink fieldCode="MH" term="%22Drug+Combinations%22">Drug Combinations</searchLink> ; <searchLink fieldCode="MH" term="%22Epoxy+Resins%22">Epoxy Resins</searchLink> ; <searchLink fieldCode="MH" term="%22Fluorescent+Dyes%22">Fluorescent Dyes</searchLink> ; <searchLink fieldCode="MH" term="%22Fluorescein%22">Fluorescein</searchLink> ; <searchLink fieldCode="MH" term="%22Materials+Testing%22">Materials Testing</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Background: This study investigated the effect of three intracanal medicaments on the penetration ability of three different root canal sealers using confocal laser scanning microscopy (CLSM).<br />Materials and Methods: 120 extracted single-rooted human teeth were used. The crowns were removed, and each canal was prepared. The teeth were divided into four groups (n = 30): three medicament groups (calcium hydroxide (CH), triple antibiotic paste (TAP), and double antibiotic paste [DAP]) and one control group. 0.1% Rhodamine B was incorporated. After three weeks, the medicaments were removed, and then canals were filled with one of the following sealers: AH Plus, MTA Fillapex, and TotalFill (n = 10). Fluorescein dye was added to the sealers. Horizontal sections (1 mm thick) were taken from each canal's coronal, middle, and apical portions. Samples were then viewed under CLSM. Statistical analysis was performed using Kruskal-Wallis and Mann-Whitney U tests.<br />Results: TotalFill exhibited the highest dentinal tubule penetration values across all root levels and medicament groups, followed by AH Plus and MTA Fillapex. However, these differences were not statistically significant (p > 0.05). All sealers showed greater penetration in the coronal third compared to the apical third.<br />Conclusions: Although intracanal medicaments did not significantly affect sealer penetration, TotalFill demonstrated more consistent penetration patterns regardless of the medicament used.<br /> (© 2025. The Author(s).)
– Name: Abstract
  Label: Competing Interests
  Group: Ab
  Data: Declarations. Ethics approval and consent to participate: All procedures performed in studies involving human biological material were by the ethical standards of the institutional and national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards. This study was approved by the ethics committee of Tokat Gaziosmanpaşa University’s Faculty of Medicine project number 15- KAEK-071. The informed consent form was obtained. Consent for publication: Not applicable to this study. Competing interests: The authors declare no competing interests.
– Name: Ref
  Label: References
  Group: RefInfo
  Data: J Endod. 2014 Sep;40(9):1439-42. (PMID: <searchLink fieldCode="PM" term="%2225146028%22">25146028)</searchLink><br />J Endod. 2013 Mar;39(3 Suppl):S30-43. (PMID: <searchLink fieldCode="PM" term="%2223439043%22">23439043)</searchLink><br />J Endod. 2007 Aug;33(8):957-61. (PMID: <searchLink fieldCode="PM" term="%2217878082%22">17878082)</searchLink><br />Clin Oral Investig. 2023 Dec 22;28(1):11. (PMID: <searchLink fieldCode="PM" term="%2238129367%22">38129367)</searchLink><br />J Endod. 2005 Jun;31(6):439-43. (PMID: <searchLink fieldCode="PM" term="%2215917683%22">15917683)</searchLink><br />Microsc Res Tech. 2019 Jun;82(6):903-908. (PMID: <searchLink fieldCode="PM" term="%2230811819%22">30811819)</searchLink><br />J Endod. 2012 Oct;38(10):1372-5. (PMID: <searchLink fieldCode="PM" term="%2222980180%22">22980180)</searchLink><br />Aust Endod J. 2021 Dec;47(3):480-486. (PMID: <searchLink fieldCode="PM" term="%2233769648%22">33769648)</searchLink><br />Clin Oral Investig. 2017 May;21(4):1277-1282. (PMID: <searchLink fieldCode="PM" term="%2227287499%22">27287499)</searchLink><br />J Endod. 2016 Apr;42(4):637-40. (PMID: <searchLink fieldCode="PM" term="%2226906243%22">26906243)</searchLink><br />J Clin Diagn Res. 2017 Jan;11(1):ZC06-ZC09. (PMID: <searchLink fieldCode="PM" term="%2228274034%22">28274034)</searchLink><br />Odontology. 2019 Jan;107(1):64-71. (PMID: <searchLink fieldCode="PM" term="%2229651668%22">29651668)</searchLink><br />Aust Endod J. 2014 Apr;40(1):21-5. (PMID: <searchLink fieldCode="PM" term="%2224330380%22">24330380)</searchLink><br />Clin Oral Investig. 2024 Aug 19;28(9):491. (PMID: <searchLink fieldCode="PM" term="%2239155361%22">39155361)</searchLink><br />J Endod. 2005 May;31(5):359-63. (PMID: <searchLink fieldCode="PM" term="%2215851929%22">15851929)</searchLink><br />Int Endod J. 2007 Nov;40(11):873-81. (PMID: <searchLink fieldCode="PM" term="%2217764458%22">17764458)</searchLink><br />J Mech Behav Biomed Mater. 2024 Mar;151:106400. (PMID: <searchLink fieldCode="PM" term="%2238262184%22">38262184)</searchLink><br />Dent Traumatol. 2014 Dec;30(6):429-34. (PMID: <searchLink fieldCode="PM" term="%2224645753%22">24645753)</searchLink><br />Aust Endod J. 2018 Dec;44(3):225-234. (PMID: <searchLink fieldCode="PM" term="%2229034531%22">29034531)</searchLink><br />Pediatr Dent. 2012 Jan-Feb;34(1):66-9. (PMID: <searchLink fieldCode="PM" term="%2222353461%22">22353461)</searchLink><br />Braz Oral Res. 2014;28:. (PMID: <searchLink fieldCode="PM" term="%2225006626%22">25006626)</searchLink><br />J Endod. 2014 Jun;40(6):845-8. (PMID: <searchLink fieldCode="PM" term="%2224862714%22">24862714)</searchLink><br />Microsc Res Tech. 2013 May;76(5):496-502. (PMID: <searchLink fieldCode="PM" term="%2223456772%22">23456772)</searchLink><br />J Endod. 2014 Aug;40(8):1172-7. (PMID: <searchLink fieldCode="PM" term="%2225069927%22">25069927)</searchLink><br />J Endod. 2018 Jun;44(6):1018-1023. (PMID: <searchLink fieldCode="PM" term="%2229680722%22">29680722)</searchLink><br />J Endod. 2007 Dec;33(12):1473-6. (PMID: <searchLink fieldCode="PM" term="%2218037062%22">18037062)</searchLink><br />J Adhes Dent. 2009 Feb;11(1):7-14. (PMID: <searchLink fieldCode="PM" term="%2219343922%22">19343922)</searchLink><br />J Endod. 2012 Jan;38(1):91-4. (PMID: <searchLink fieldCode="PM" term="%2222152628%22">22152628)</searchLink><br />Microsc Res Tech. 2014 Jun;77(6):467-71. (PMID: <searchLink fieldCode="PM" term="%2224753317%22">24753317)</searchLink><br />Int Endod J. 2014 Jun;47(6):594-9. (PMID: <searchLink fieldCode="PM" term="%2224138387%22">24138387)</searchLink><br />J Endod. 2024 Aug;50(8):1044-1058.e5. (PMID: <searchLink fieldCode="PM" term="%2238729300%22">38729300)</searchLink><br />Int Endod J. 2006 Jan;39(1):10-7. (PMID: <searchLink fieldCode="PM" term="%2216409323%22">16409323)</searchLink><br />J Endod. 2017 Mar;43(3):452-455. (PMID: <searchLink fieldCode="PM" term="%2228131413%22">28131413)</searchLink><br />Int Endod J. 2001 Jul;34(5):346-53. (PMID: <searchLink fieldCode="PM" term="%2211482717%22">11482717)</searchLink>
– Name: SubjectMinor
  Label: Contributed Indexing
  Group:
  Data: <i>Keywords: </i>AH plus; Confocal microscopy; Dentin penetration; Intracanal medicament; Root Canal sealer
– Name: NumberCAS
  Label: Substance Nomenclature
  Group: ID
  Data: 0 (Root Canal Filling Materials)<br />PF5DZW74VN (Calcium Hydroxide)<br />0 (Silicates)<br />0 (Root Canal Irrigants)<br />0 (Rhodamines)<br />K7G5SCF8IL (rhodamine B)<br />0 (Drug Combinations)<br />0 (Aluminum Compounds)<br />0 (mineral trioxide aggregate)<br />0 (Calcium Compounds)<br />0 (Anti-Bacterial Agents)<br />0 (epoxy resin-based root canal sealer)<br />0 (Oxides)<br />0 (Epoxy Resins)<br />140QMO216E (Metronidazole)<br />0 (Fluorescent Dyes)<br />5E8K9I0O4U (Ciprofloxacin)<br />TPY09G7XIR (Fluorescein)<br />FYY3R43WGO (Minocycline)
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  Data: <i>Date Created: </i>20250727 <i>Date Completed: </i>20250727 <i>Latest Revision: </i>20250731
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        Text: English
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        StartPage: 1253
    Subjects:
      – SubjectFull: Calcium Hydroxide pharmacology
        Type: general
      – SubjectFull: Silicates pharmacology
        Type: general
      – SubjectFull: Aluminum Compounds pharmacology
        Type: general
      – SubjectFull: Calcium Compounds pharmacology
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      – SubjectFull: Oxides pharmacology
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      – SubjectFull: Metronidazole pharmacology
        Type: general
      – SubjectFull: Ciprofloxacin pharmacology
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      – SubjectFull: Minocycline pharmacology
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      – SubjectFull: Microscopy, Confocal
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      – SubjectFull: Drug Combinations
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        Type: general
      – SubjectFull: Fluorescein
        Type: general
      – SubjectFull: Materials Testing
        Type: general
      – SubjectFull: Root Canal Irrigants pharmacology
        Type: general
      – SubjectFull: Dentin drug effects
        Type: general
      – SubjectFull: Dentin ultrastructure
        Type: general
      – SubjectFull: Dental Pulp Cavity ultrastructure
        Type: general
      – SubjectFull: Dental Pulp Cavity drug effects
        Type: general
      – SubjectFull: Dentin Permeability drug effects
        Type: general
      – SubjectFull: Root Canal Filling Materials
        Type: general
    Titles:
      – TitleFull: Effect of intracanal medicaments on dentinal tubule penetration of root canal sealers: a confocal laser scanning microscopy study.
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          Dates:
            – D: 26
              M: 07
              Text: 2025 Jul 26
              Type: published
              Y: 2025
          Identifiers:
            – Type: issn-electronic
              Value: 1472-6831
          Numbering:
            – Type: volume
              Value: 25
            – Type: issue
              Value: 1
          Titles:
            – TitleFull: BMC oral health
              Type: main
ResultId 1