Academic Journal
Προβολή σε EDS
Συνδεδεμένο Πλήρες Κείμενο

Translating medication effects for alcohol use disorder across preclinical, human laboratory, and clinical trial outcomes using meta-analysis.

Λεπτομέρειες βιβλιογραφικής εγγραφής
Τίτλος: Translating medication effects for alcohol use disorder across preclinical, human laboratory, and clinical trial outcomes using meta-analysis.
Συγγραφείς: Nieto SJ; Department of Psychology, University of California at Los Angeles, Los Angeles, CA, USA. snieto@psych.ucla.edu.; Department of Psychiatry and Behavioral Neurosciences, Wayne State University School of Medicine, Detroit, MI, USA. snieto@psych.ucla.edu., Donato S; Department of Psychology, University of California at Los Angeles, Los Angeles, CA, USA., Du H; Department of Psychology, University of California at Los Angeles, Los Angeles, CA, USA., Meredith LR; Department of Psychology, University of California at Los Angeles, Los Angeles, CA, USA., Baskerville WA; Department of Psychology, University of California at Los Angeles, Los Angeles, CA, USA., McManus KR; Department of Psychology, University of California at Los Angeles, Los Angeles, CA, USA., Magill M; Center for Alcohol and Addiction Studies, Brown University School of Public Health, Providence, RI, USA., Lopez MF; Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina, Charleston, SC, USA., Becker HC; Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina, Charleston, SC, USA., Ray LA; Department of Psychology, University of California at Los Angeles, Los Angeles, CA, USA.; Department of Psychiatry and Biobehavioral Sciences, University of California at Los Angeles, Los Angeles, CA, USA.
Πηγή: Translational psychiatry [Transl Psychiatry] 2025 Jul 21; Vol. 15 (1), pp. 250. Date of Electronic Publication: 2025 Jul 21.
Τύπος έκδοσης: Journal Article; Meta-Analysis; Systematic Review
Γλώσσα: English
Στοιχεία περιοδικού: Publisher: Nature Pub. Group Country of Publication: United States NLM ID: 101562664 Publication Model: Electronic Cited Medium: Internet ISSN: 2158-3188 (Electronic) Linking ISSN: 21583188 NLM ISO Abbreviation: Transl Psychiatry Subsets: MEDLINE
Imprint Name(s): Original Publication: New York, NY : Nature Pub. Group
Ιατρικοί όροι (MeSH): Alcoholism*/drug therapy , Alcohol Deterrents*/therapeutic use , Alcohol Deterrents*/pharmacology, Craving/drug effects ; Humans ; Animals ; Disease Models, Animal ; Randomized Controlled Trials as Topic ; Drug Evaluation, Preclinical ; Cues ; Translational Research, Biomedical
Περίληψη: Animal models are used for preliminary testing of novel compounds for alcohol use disorder (AUD). However, it is unclear whether early efficacy in preclinical models reliably predicts efficacy in human laboratory and clinical trials. We searched the literature for medications tested for AUD in preclinical models (i.e., two-bottle choice [2-BC] and operant reinstatement), human laboratory cue-reactivity, and randomized clinical trials (RCTs). For preclinical models, we computed medication effects on 2-BC alcohol preference and consumption (k = 77 studies, 14 medications) as well as operant reinstatement (k = 18 studies, 8 medications). For human laboratory studies, we computed medication effects on alcohol cue-induced craving (k = 36 studies, 15 medications). For RCTs, we computed medication effects on RCT endpoints including return to any drinking and return to heavy drinking (k = 139 studies, 19 medications). We used medication as the unit of analysis and applied the Williamson-York bivariate weighted least squares estimation to preserve the errors in both the independent and dependent variables. Medication effects on 2-BC alcohol preference ( INLINEMATH  = 0.04, p = 0.004) and reinstatement ( INLINEMATH  = 0.20, p = 0.05) were positively associated with medication effects on return to any drinking in human clinical trials but no associations were found on other RCT outcomes tested. Preclinical medications findings were not associated with medication effects on cue-induced craving in the human laboratory. Medication findings on 2-BC alcohol preference and operant reinstatement track medication effects on select clinical trial outcomes, specifically return to any drinking. This study provides empirical support for the association between medication effects across species and experimental models, a critical, yet untested, premise of preclinical studies in medications development.
(© 2025. The Author(s).)
References: Alcohol. 2024 Nov;120:194-203. (PMID: 38972367)
Psychopharmacology (Berl). 2003 Jul;168(1-2):3-20. (PMID: 12402102)
Alcohol. 2014 May;48(3):243-52. (PMID: 24721195)
Behav Res Ther. 2016 Nov;86:11-22. (PMID: 27266992)
Transl Psychiatry. 2021 Sep 29;11(1):496. (PMID: 34588417)
Addict Biol. 2010 Apr;15(2):109-24. (PMID: 20148775)
Neuropharmacology. 2017 Aug 1;122:201-243. (PMID: 28215999)
Psychopharmacology (Berl). 2023 Sep;240(9):1921-1930. (PMID: 37452887)
Dialogues Clin Neurosci. 2017 Sep;19(3):247-258. (PMID: 29302222)
Psychopharmacology (Berl). 2024 Aug;241(8):1679-1689. (PMID: 38613685)
Control Clin Trials. 1986 Sep;7(3):177-88. (PMID: 3802833)
Neuropsychopharmacology. 2021 Feb;46(3):519-527. (PMID: 33235284)
Pharmacol Rev. 2002 Mar;54(1):1-42. (PMID: 11870259)
Cerebrum. 2013 Apr 02;2013:5. (PMID: 23720708)
Int J Evid Based Healthc. 2019 Mar;17(1):36-43. (PMID: 30239357)
Alcohol Clin Exp Res. 2018 Sep;42(9):1612-1622. (PMID: 29969156)
Addict Biol. 2017 May;22(3):581-615. (PMID: 26833803)
Handb Clin Neurol. 2014;125:71-86. (PMID: 25307569)
Neuropsychopharmacology. 2000 Jun;22(6):581-94. (PMID: 10788758)
J Stud Alcohol. 1993 Mar;54(2):235-45. (PMID: 8384678)
Science. 1940 May 24;91(2369):507-8. (PMID: 17847448)
J Abnorm Psychol. 1997 May;106(2):243-50. (PMID: 9131844)
Alcohol Clin Exp Res (Hoboken). 2023 Sep;47(9):1629-1645. (PMID: 37423771)
Ann N Y Acad Sci. 2011 Jan;1216:24-40. (PMID: 21272009)
Grant Information: K24AA025704 U.S. Department of Health & Human Services | NIH | National Institute on Alcohol Abuse and Alcoholism (NIAAA); U24 AA029968 United States AA NIAAA NIH HHS; R21 AA029771 United States AA NIAAA NIH HHS; F31AA029295 U.S. Department of Health & Human Services | NIH | National Institute on Alcohol Abuse and Alcoholism (NIAAA); R01 AA029701 United States AA NIAAA NIH HHS; K24 AA025704 United States AA NIAAA NIH HHS; U01 AA014095 United States AA NIAAA NIH HHS; F32AA029288 U.S. Department of Health & Human Services | NIH | National Institute on Alcohol Abuse and Alcoholism (NIAAA); R01AA029701-01S1 U.S. Department of Health & Human Services | NIH | National Institute on Alcohol Abuse and Alcoholism (NIAAA); R21AA029771 U.S. Department of Health & Human Services | NIH | National Institute on Alcohol Abuse and Alcoholism (NIAAA); F32 AA029288 United States AA NIAAA NIH HHS; P50 AA010761 United States AA NIAAA NIH HHS; F31 AA029295 United States AA NIAAA NIH HHS
Substance Nomenclature: 0 (Alcohol Deterrents)
Entry Date(s): Date Created: 20250721 Date Completed: 20250721 Latest Revision: 20260307
Update Code: 20260307
PubMed Central ID: PMC12279940
DOI: 10.1038/s41398-025-03473-6
PMID: 40691154
Βάση Δεδομένων: MEDLINE
FullText Links:
  – Type: other
    Url: https://resolver.ebsco.com:443/public/rma-ftfapi/ejs/direct?AccessToken=44AA816F261E9AF1081C&Show=Object
Text:
  Availability: 0
CustomLinks:
  – Url: https://dx.doi.org/doi:10.1038/s41398-025-03473-6
    Name: EDS - Springer Nature Journals (s7799221)
    Category: fullText
    Text: View record at Springer
Header DbId: cmedm
DbLabel: MEDLINE
An: 40691154
AccessLevel: 3
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: Translating medication effects for alcohol use disorder across preclinical, human laboratory, and clinical trial outcomes using meta-analysis.
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AU" term="%22Nieto+SJ%22">Nieto SJ</searchLink>; Department of Psychology, University of California at Los Angeles, Los Angeles, CA, USA. snieto@psych.ucla.edu.; Department of Psychiatry and Behavioral Neurosciences, Wayne State University School of Medicine, Detroit, MI, USA. snieto@psych.ucla.edu.<br /><searchLink fieldCode="AU" term="%22Donato+S%22">Donato S</searchLink>; Department of Psychology, University of California at Los Angeles, Los Angeles, CA, USA.<br /><searchLink fieldCode="AU" term="%22Du+H%22">Du H</searchLink>; Department of Psychology, University of California at Los Angeles, Los Angeles, CA, USA.<br /><searchLink fieldCode="AU" term="%22Meredith+LR%22">Meredith LR</searchLink>; Department of Psychology, University of California at Los Angeles, Los Angeles, CA, USA.<br /><searchLink fieldCode="AU" term="%22Baskerville+WA%22">Baskerville WA</searchLink>; Department of Psychology, University of California at Los Angeles, Los Angeles, CA, USA.<br /><searchLink fieldCode="AU" term="%22McManus+KR%22">McManus KR</searchLink>; Department of Psychology, University of California at Los Angeles, Los Angeles, CA, USA.<br /><searchLink fieldCode="AU" term="%22Magill+M%22">Magill M</searchLink>; Center for Alcohol and Addiction Studies, Brown University School of Public Health, Providence, RI, USA.<br /><searchLink fieldCode="AU" term="%22Lopez+MF%22">Lopez MF</searchLink>; Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina, Charleston, SC, USA.<br /><searchLink fieldCode="AU" term="%22Becker+HC%22">Becker HC</searchLink>; Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina, Charleston, SC, USA.<br /><searchLink fieldCode="AU" term="%22Ray+LA%22">Ray LA</searchLink>; Department of Psychology, University of California at Los Angeles, Los Angeles, CA, USA.; Department of Psychiatry and Biobehavioral Sciences, University of California at Los Angeles, Los Angeles, CA, USA.
– Name: TitleSource
  Label: Source
  Group: Src
  Data: <searchLink fieldCode="JN" term="%22101562664%22">Translational psychiatry</searchLink> [Transl Psychiatry] 2025 Jul 21; Vol. 15 (1), pp. 250. <i>Date of Electronic Publication: </i>2025 Jul 21.
– Name: TypePub
  Label: Publication Type
  Group: TypPub
  Data: Journal Article; Meta-Analysis; Systematic Review
– Name: Language
  Label: Language
  Group: Lang
  Data: English
– Name: TitleSource
  Label: Journal Info
  Group: Src
  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Nature+Pub%2E+Group%22">Nature Pub. Group </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>101562664 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>2158-3188 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2221583188%22">21583188 </searchLink><i>NLM ISO Abbreviation: </i>Transl Psychiatry <i>Subsets: </i>MEDLINE
– Name: PublisherInfo
  Label: Imprint Name(s)
  Group: PubInfo
  Data: <i>Original Publication</i>: New York, NY : Nature Pub. Group
– Name: SubjectMESH
  Label: MeSH Terms
  Group: Su
  Data: <searchLink fieldCode="MM" term="%22Alcoholism%22">Alcoholism*</searchLink>/<searchLink fieldCode="MM" term="%22Alcoholism+drug+therapy%22">drug therapy</searchLink> <br /><searchLink fieldCode="MM" term="%22Alcohol+Deterrents%22">Alcohol Deterrents*</searchLink>/<searchLink fieldCode="MM" term="%22Alcohol+Deterrents+therapeutic+use%22">therapeutic use</searchLink> <br /><searchLink fieldCode="MM" term="%22Alcohol+Deterrents%22">Alcohol Deterrents*</searchLink>/<searchLink fieldCode="MM" term="%22Alcohol+Deterrents+pharmacology%22">pharmacology</searchLink><br /><searchLink fieldCode="MH" term="%22Craving%22">Craving</searchLink>/<searchLink fieldCode="MH" term="%22Craving+drug+effects%22">drug effects</searchLink> ; <searchLink fieldCode="MH" term="%22Humans%22">Humans</searchLink> ; <searchLink fieldCode="MH" term="%22Animals%22">Animals</searchLink> ; <searchLink fieldCode="MH" term="%22Disease+Models%2C+Animal%22">Disease Models, Animal</searchLink> ; <searchLink fieldCode="MH" term="%22Randomized+Controlled+Trials+as+Topic%22">Randomized Controlled Trials as Topic</searchLink> ; <searchLink fieldCode="MH" term="%22Drug+Evaluation%2C+Preclinical%22">Drug Evaluation, Preclinical</searchLink> ; <searchLink fieldCode="MH" term="%22Cues%22">Cues</searchLink> ; <searchLink fieldCode="MH" term="%22Translational+Research%2C+Biomedical%22">Translational Research, Biomedical</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Animal models are used for preliminary testing of novel compounds for alcohol use disorder (AUD). However, it is unclear whether early efficacy in preclinical models reliably predicts efficacy in human laboratory and clinical trials. We searched the literature for medications tested for AUD in preclinical models (i.e., two-bottle choice [2-BC] and operant reinstatement), human laboratory cue-reactivity, and randomized clinical trials (RCTs). For preclinical models, we computed medication effects on 2-BC alcohol preference and consumption (k = 77 studies, 14 medications) as well as operant reinstatement (k = 18 studies, 8 medications). For human laboratory studies, we computed medication effects on alcohol cue-induced craving (k = 36 studies, 15 medications). For RCTs, we computed medication effects on RCT endpoints including return to any drinking and return to heavy drinking (k = 139 studies, 19 medications). We used medication as the unit of analysis and applied the Williamson-York bivariate weighted least squares estimation to preserve the errors in both the independent and dependent variables. Medication effects on 2-BC alcohol preference ( INLINEMATH  = 0.04, p = 0.004) and reinstatement ( INLINEMATH  = 0.20, p = 0.05) were positively associated with medication effects on return to any drinking in human clinical trials but no associations were found on other RCT outcomes tested. Preclinical medications findings were not associated with medication effects on cue-induced craving in the human laboratory. Medication findings on 2-BC alcohol preference and operant reinstatement track medication effects on select clinical trial outcomes, specifically return to any drinking. This study provides empirical support for the association between medication effects across species and experimental models, a critical, yet untested, premise of preclinical studies in medications development.<br /> (© 2025. The Author(s).)
– Name: Ref
  Label: References
  Group: RefInfo
  Data: Alcohol. 2024 Nov;120:194-203. (PMID: <searchLink fieldCode="PM" term="%2238972367%22">38972367)</searchLink><br />Psychopharmacology (Berl). 2003 Jul;168(1-2):3-20. (PMID: <searchLink fieldCode="PM" term="%2212402102%22">12402102)</searchLink><br />Alcohol. 2014 May;48(3):243-52. (PMID: <searchLink fieldCode="PM" term="%2224721195%22">24721195)</searchLink><br />Behav Res Ther. 2016 Nov;86:11-22. (PMID: <searchLink fieldCode="PM" term="%2227266992%22">27266992)</searchLink><br />Transl Psychiatry. 2021 Sep 29;11(1):496. (PMID: <searchLink fieldCode="PM" term="%2234588417%22">34588417)</searchLink><br />Addict Biol. 2010 Apr;15(2):109-24. (PMID: <searchLink fieldCode="PM" term="%2220148775%22">20148775)</searchLink><br />Neuropharmacology. 2017 Aug 1;122:201-243. (PMID: <searchLink fieldCode="PM" term="%2228215999%22">28215999)</searchLink><br />Psychopharmacology (Berl). 2023 Sep;240(9):1921-1930. (PMID: <searchLink fieldCode="PM" term="%2237452887%22">37452887)</searchLink><br />Dialogues Clin Neurosci. 2017 Sep;19(3):247-258. (PMID: <searchLink fieldCode="PM" term="%2229302222%22">29302222)</searchLink><br />Psychopharmacology (Berl). 2024 Aug;241(8):1679-1689. (PMID: <searchLink fieldCode="PM" term="%2238613685%22">38613685)</searchLink><br />Control Clin Trials. 1986 Sep;7(3):177-88. (PMID: <searchLink fieldCode="PM" term="%223802833%22">3802833)</searchLink><br />Neuropsychopharmacology. 2021 Feb;46(3):519-527. (PMID: <searchLink fieldCode="PM" term="%2233235284%22">33235284)</searchLink><br />Pharmacol Rev. 2002 Mar;54(1):1-42. (PMID: <searchLink fieldCode="PM" term="%2211870259%22">11870259)</searchLink><br />Cerebrum. 2013 Apr 02;2013:5. (PMID: <searchLink fieldCode="PM" term="%2223720708%22">23720708)</searchLink><br />Int J Evid Based Healthc. 2019 Mar;17(1):36-43. (PMID: <searchLink fieldCode="PM" term="%2230239357%22">30239357)</searchLink><br />Alcohol Clin Exp Res. 2018 Sep;42(9):1612-1622. (PMID: <searchLink fieldCode="PM" term="%2229969156%22">29969156)</searchLink><br />Addict Biol. 2017 May;22(3):581-615. (PMID: <searchLink fieldCode="PM" term="%2226833803%22">26833803)</searchLink><br />Handb Clin Neurol. 2014;125:71-86. (PMID: <searchLink fieldCode="PM" term="%2225307569%22">25307569)</searchLink><br />Neuropsychopharmacology. 2000 Jun;22(6):581-94. (PMID: <searchLink fieldCode="PM" term="%2210788758%22">10788758)</searchLink><br />J Stud Alcohol. 1993 Mar;54(2):235-45. (PMID: <searchLink fieldCode="PM" term="%228384678%22">8384678)</searchLink><br />Science. 1940 May 24;91(2369):507-8. (PMID: <searchLink fieldCode="PM" term="%2217847448%22">17847448)</searchLink><br />J Abnorm Psychol. 1997 May;106(2):243-50. (PMID: <searchLink fieldCode="PM" term="%229131844%22">9131844)</searchLink><br />Alcohol Clin Exp Res (Hoboken). 2023 Sep;47(9):1629-1645. (PMID: <searchLink fieldCode="PM" term="%2237423771%22">37423771)</searchLink><br />Ann N Y Acad Sci. 2011 Jan;1216:24-40. (PMID: <searchLink fieldCode="PM" term="%2221272009%22">21272009)</searchLink>
– Name: GrantInfo
  Label: Grant Information
  Group: Grant
  Data: K24AA025704 U.S. Department of Health & Human Services | NIH | National Institute on Alcohol Abuse and Alcoholism (NIAAA); U24 AA029968 United States AA NIAAA NIH HHS; R21 AA029771 United States AA NIAAA NIH HHS; F31AA029295 U.S. Department of Health & Human Services | NIH | National Institute on Alcohol Abuse and Alcoholism (NIAAA); R01 AA029701 United States AA NIAAA NIH HHS; K24 AA025704 United States AA NIAAA NIH HHS; U01 AA014095 United States AA NIAAA NIH HHS; F32AA029288 U.S. Department of Health & Human Services | NIH | National Institute on Alcohol Abuse and Alcoholism (NIAAA); R01AA029701-01S1 U.S. Department of Health & Human Services | NIH | National Institute on Alcohol Abuse and Alcoholism (NIAAA); R21AA029771 U.S. Department of Health & Human Services | NIH | National Institute on Alcohol Abuse and Alcoholism (NIAAA); F32 AA029288 United States AA NIAAA NIH HHS; P50 AA010761 United States AA NIAAA NIH HHS; F31 AA029295 United States AA NIAAA NIH HHS
– Name: NumberCAS
  Label: Substance Nomenclature
  Group: ID
  Data: 0 (Alcohol Deterrents)
– Name: DateEntry
  Label: Entry Date(s)
  Group: Date
  Data: <i>Date Created: </i>20250721 <i>Date Completed: </i>20250721 <i>Latest Revision: </i>20260307
– Name: DateUpdate
  Label: Update Code
  Group: Date
  Data: 20260307
– Name: PubmedCentralID
  Label: PubMed Central ID
  Group: ID
  Data: PMC12279940
– Name: DOI
  Label: DOI
  Group: ID
  Data: 10.1038/s41398-025-03473-6
– Name: AN
  Label: PMID
  Group: ID
  Data: 40691154
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=cmedm&AN=40691154
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1038/s41398-025-03473-6
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        StartPage: 250
    Subjects:
      – SubjectFull: Craving drug effects
        Type: general
      – SubjectFull: Humans
        Type: general
      – SubjectFull: Animals
        Type: general
      – SubjectFull: Disease Models, Animal
        Type: general
      – SubjectFull: Randomized Controlled Trials as Topic
        Type: general
      – SubjectFull: Drug Evaluation, Preclinical
        Type: general
      – SubjectFull: Cues
        Type: general
      – SubjectFull: Translational Research, Biomedical
        Type: general
      – SubjectFull: Alcoholism drug therapy
        Type: general
      – SubjectFull: Alcohol Deterrents therapeutic use
        Type: general
      – SubjectFull: Alcohol Deterrents pharmacology
        Type: general
    Titles:
      – TitleFull: Translating medication effects for alcohol use disorder across preclinical, human laboratory, and clinical trial outcomes using meta-analysis.
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: Nieto SJ
      – PersonEntity:
          Name:
            NameFull: Donato S
      – PersonEntity:
          Name:
            NameFull: Du H
      – PersonEntity:
          Name:
            NameFull: Meredith LR
      – PersonEntity:
          Name:
            NameFull: Baskerville WA
      – PersonEntity:
          Name:
            NameFull: McManus KR
      – PersonEntity:
          Name:
            NameFull: Magill M
      – PersonEntity:
          Name:
            NameFull: Lopez MF
      – PersonEntity:
          Name:
            NameFull: Becker HC
      – PersonEntity:
          Name:
            NameFull: Ray LA
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 21
              M: 07
              Text: 2025 Jul 21
              Type: published
              Y: 2025
          Identifiers:
            – Type: issn-electronic
              Value: 2158-3188
          Numbering:
            – Type: volume
              Value: 15
            – Type: issue
              Value: 1
          Titles:
            – TitleFull: Translational psychiatry
              Type: main
ResultId 1