Academic Journal
Translating medication effects for alcohol use disorder across preclinical, human laboratory, and clinical trial outcomes using meta-analysis.
| Τίτλος: | Translating medication effects for alcohol use disorder across preclinical, human laboratory, and clinical trial outcomes using meta-analysis. |
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| Συγγραφείς: | Nieto SJ; Department of Psychology, University of California at Los Angeles, Los Angeles, CA, USA. snieto@psych.ucla.edu.; Department of Psychiatry and Behavioral Neurosciences, Wayne State University School of Medicine, Detroit, MI, USA. snieto@psych.ucla.edu., Donato S; Department of Psychology, University of California at Los Angeles, Los Angeles, CA, USA., Du H; Department of Psychology, University of California at Los Angeles, Los Angeles, CA, USA., Meredith LR; Department of Psychology, University of California at Los Angeles, Los Angeles, CA, USA., Baskerville WA; Department of Psychology, University of California at Los Angeles, Los Angeles, CA, USA., McManus KR; Department of Psychology, University of California at Los Angeles, Los Angeles, CA, USA., Magill M; Center for Alcohol and Addiction Studies, Brown University School of Public Health, Providence, RI, USA., Lopez MF; Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina, Charleston, SC, USA., Becker HC; Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina, Charleston, SC, USA., Ray LA; Department of Psychology, University of California at Los Angeles, Los Angeles, CA, USA.; Department of Psychiatry and Biobehavioral Sciences, University of California at Los Angeles, Los Angeles, CA, USA. |
| Πηγή: | Translational psychiatry [Transl Psychiatry] 2025 Jul 21; Vol. 15 (1), pp. 250. Date of Electronic Publication: 2025 Jul 21. |
| Τύπος έκδοσης: | Journal Article; Meta-Analysis; Systematic Review |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: Nature Pub. Group Country of Publication: United States NLM ID: 101562664 Publication Model: Electronic Cited Medium: Internet ISSN: 2158-3188 (Electronic) Linking ISSN: 21583188 NLM ISO Abbreviation: Transl Psychiatry Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: New York, NY : Nature Pub. Group |
| Ιατρικοί όροι (MeSH): | Alcoholism*/drug therapy , Alcohol Deterrents*/therapeutic use , Alcohol Deterrents*/pharmacology, Craving/drug effects ; Humans ; Animals ; Disease Models, Animal ; Randomized Controlled Trials as Topic ; Drug Evaluation, Preclinical ; Cues ; Translational Research, Biomedical |
| Περίληψη: | Animal models are used for preliminary testing of novel compounds for alcohol use disorder (AUD). However, it is unclear whether early efficacy in preclinical models reliably predicts efficacy in human laboratory and clinical trials. We searched the literature for medications tested for AUD in preclinical models (i.e., two-bottle choice [2-BC] and operant reinstatement), human laboratory cue-reactivity, and randomized clinical trials (RCTs). For preclinical models, we computed medication effects on 2-BC alcohol preference and consumption (k = 77 studies, 14 medications) as well as operant reinstatement (k = 18 studies, 8 medications). For human laboratory studies, we computed medication effects on alcohol cue-induced craving (k = 36 studies, 15 medications). For RCTs, we computed medication effects on RCT endpoints including return to any drinking and return to heavy drinking (k = 139 studies, 19 medications). We used medication as the unit of analysis and applied the Williamson-York bivariate weighted least squares estimation to preserve the errors in both the independent and dependent variables. Medication effects on 2-BC alcohol preference ( INLINEMATH = 0.04, p = 0.004) and reinstatement ( INLINEMATH = 0.20, p = 0.05) were positively associated with medication effects on return to any drinking in human clinical trials but no associations were found on other RCT outcomes tested. Preclinical medications findings were not associated with medication effects on cue-induced craving in the human laboratory. Medication findings on 2-BC alcohol preference and operant reinstatement track medication effects on select clinical trial outcomes, specifically return to any drinking. This study provides empirical support for the association between medication effects across species and experimental models, a critical, yet untested, premise of preclinical studies in medications development. (© 2025. The Author(s).) |
| References: | Alcohol. 2024 Nov;120:194-203. (PMID: 38972367) Psychopharmacology (Berl). 2003 Jul;168(1-2):3-20. (PMID: 12402102) Alcohol. 2014 May;48(3):243-52. (PMID: 24721195) Behav Res Ther. 2016 Nov;86:11-22. (PMID: 27266992) Transl Psychiatry. 2021 Sep 29;11(1):496. (PMID: 34588417) Addict Biol. 2010 Apr;15(2):109-24. (PMID: 20148775) Neuropharmacology. 2017 Aug 1;122:201-243. (PMID: 28215999) Psychopharmacology (Berl). 2023 Sep;240(9):1921-1930. (PMID: 37452887) Dialogues Clin Neurosci. 2017 Sep;19(3):247-258. (PMID: 29302222) Psychopharmacology (Berl). 2024 Aug;241(8):1679-1689. (PMID: 38613685) Control Clin Trials. 1986 Sep;7(3):177-88. (PMID: 3802833) Neuropsychopharmacology. 2021 Feb;46(3):519-527. (PMID: 33235284) Pharmacol Rev. 2002 Mar;54(1):1-42. (PMID: 11870259) Cerebrum. 2013 Apr 02;2013:5. (PMID: 23720708) Int J Evid Based Healthc. 2019 Mar;17(1):36-43. (PMID: 30239357) Alcohol Clin Exp Res. 2018 Sep;42(9):1612-1622. (PMID: 29969156) Addict Biol. 2017 May;22(3):581-615. (PMID: 26833803) Handb Clin Neurol. 2014;125:71-86. (PMID: 25307569) Neuropsychopharmacology. 2000 Jun;22(6):581-94. (PMID: 10788758) J Stud Alcohol. 1993 Mar;54(2):235-45. (PMID: 8384678) Science. 1940 May 24;91(2369):507-8. (PMID: 17847448) J Abnorm Psychol. 1997 May;106(2):243-50. (PMID: 9131844) Alcohol Clin Exp Res (Hoboken). 2023 Sep;47(9):1629-1645. (PMID: 37423771) Ann N Y Acad Sci. 2011 Jan;1216:24-40. (PMID: 21272009) |
| Grant Information: | K24AA025704 U.S. Department of Health & Human Services | NIH | National Institute on Alcohol Abuse and Alcoholism (NIAAA); U24 AA029968 United States AA NIAAA NIH HHS; R21 AA029771 United States AA NIAAA NIH HHS; F31AA029295 U.S. Department of Health & Human Services | NIH | National Institute on Alcohol Abuse and Alcoholism (NIAAA); R01 AA029701 United States AA NIAAA NIH HHS; K24 AA025704 United States AA NIAAA NIH HHS; U01 AA014095 United States AA NIAAA NIH HHS; F32AA029288 U.S. Department of Health & Human Services | NIH | National Institute on Alcohol Abuse and Alcoholism (NIAAA); R01AA029701-01S1 U.S. Department of Health & Human Services | NIH | National Institute on Alcohol Abuse and Alcoholism (NIAAA); R21AA029771 U.S. Department of Health & Human Services | NIH | National Institute on Alcohol Abuse and Alcoholism (NIAAA); F32 AA029288 United States AA NIAAA NIH HHS; P50 AA010761 United States AA NIAAA NIH HHS; F31 AA029295 United States AA NIAAA NIH HHS |
| Substance Nomenclature: | 0 (Alcohol Deterrents) |
| Entry Date(s): | Date Created: 20250721 Date Completed: 20250721 Latest Revision: 20260307 |
| Update Code: | 20260307 |
| PubMed Central ID: | PMC12279940 |
| DOI: | 10.1038/s41398-025-03473-6 |
| PMID: | 40691154 |
| Βάση Δεδομένων: | MEDLINE |
| ISSN: | 2158-3188 |
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| DOI: | 10.1038/s41398-025-03473-6 |