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The role of blood-based biomarkers in Parkinsonian disorders, Alzheimer's disease and frontotemporal dementia.

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Τίτλος: The role of blood-based biomarkers in Parkinsonian disorders, Alzheimer's disease and frontotemporal dementia.
Συγγραφείς: Campagnolo M; Neurodegenerative Disease Unit, Centre for Rare Neurological Diseases (ERN-RND), Department of Neuroscience, Padua Neuroscience Center (PNC), University of Padua, Via Giustiniani, 5 - 35128 Padua, Italy. Electronic address: marta.campagnolo@unipd.it., Fiorenzato E; Neurodegenerative Disease Unit, Centre for Rare Neurological Diseases (ERN-RND), Department of Neuroscience, Padua Neuroscience Center (PNC), University of Padua, Via Giustiniani, 5 - 35128 Padua, Italy. Electronic address: eleonora.fiorenzato@unipd.it., Musso G; Department of Medicine - DIMED, University of Padua, Via Giustiniani, 2 - 35128 Padua, Italy; Laboratory Medicine, University-Hospital of Padua, via Giustiniani, 2 - 35128, Padua, Italy. Electronic address: giulia.musso@unipd.it., Misenti V; Neurodegenerative Disease Unit, Centre for Rare Neurological Diseases (ERN-RND), Department of Neuroscience, Padua Neuroscience Center (PNC), University of Padua, Via Giustiniani, 5 - 35128 Padua, Italy. Electronic address: valentina.misenti@unipd.it., Cauzzo S; Neurodegenerative Disease Unit, Centre for Rare Neurological Diseases (ERN-RND), Department of Neuroscience, Padua Neuroscience Center (PNC), University of Padua, Via Giustiniani, 5 - 35128 Padua, Italy. Electronic address: simone.cauzzo@unipd.it., Cagnin A; Department of Neuroscience, University of Padua, Via Giustiniani, 5 - 35128 Padua, Italy; Padova Neuroscience Center (PNC), University of Padua, Via Giuseppe Orus, 2/b - 35131 Padua, Italy. Electronic address: annachiara.cagnin@unipd.it., Biundo R; Department of General Psychology, University of Padua, Via Venezia, 8 - 35131 Padua, Italy; IRCCS, San Camillo Hospital, Via Alberoni, 70 - 30126, Venice, Lido, Italy. Electronic address: roberta.biundo@unipd.it., Bussè C; Department of Neuroscience, University of Padua, Via Giustiniani, 5 - 35128 Padua, Italy; Padova Neuroscience Center (PNC), University of Padua, Via Giuseppe Orus, 2/b - 35131 Padua, Italy. Electronic address: cinzia.busse@unipd.it., Fogliano CA; Neurodegenerative Disease Unit, Centre for Rare Neurological Diseases (ERN-RND), Department of Neuroscience, Padua Neuroscience Center (PNC), University of Padua, Via Giustiniani, 5 - 35128 Padua, Italy. Electronic address: carmelo.fogliano1@gmail.com., Mozzetta S; Department of Neuroscience, University of Padua, Via Giustiniani, 5 - 35128 Padua, Italy; Padova Neuroscience Center (PNC), University of Padua, Via Giuseppe Orus, 2/b - 35131 Padua, Italy. Electronic address: stefano.mozzetta@aopd.veneto.it., Codemo A; Regional Brain Aging Center, University Hospital of Padua, Piazza de Claricini, 12 - 35030 Selvazzano Dentro, Padua, Italy. Electronic address: alessandra.codemo@aopd.veneto.it., Gasparoli E; Regional Brain Aging Center, University Hospital of Padua, Piazza de Claricini, 12 - 35030 Selvazzano Dentro, Padua, Italy. Electronic address: elisabetta.gasparoli@aopd.veneto.it., Moz S; Laboratory Medicine, University-Hospital of Padua, via Giustiniani, 2 - 35128, Padua, Italy. Electronic address: stefania.moz@aopd.veneto.it., Narici M; Department of Biomedical Sciences, University of Padua, Via Ugo Bassi, 58/b - 35131 Padua, Italy. Electronic address: marco.narici@unipd.it., Pizzo P; Department of Biomedical Sciences, University of Padua, Via Ugo Bassi, 58/b - 35131 Padua, Italy; Institute of Neuroscience, National Research Council (CNR), University of Padua, Via Ugo Bassi, 58/b - 35131 Padua, Italy. Electronic address: paola.pizzo@unipd.it., Corbetta M; Department of Neuroscience, University of Padua, Via Giustiniani, 5 - 35128 Padua, Italy; Padova Neuroscience Center (PNC), University of Padua, Via Giuseppe Orus, 2/b - 35131 Padua, Italy. Electronic address: maurizio.corbetta@unipd.it., Montagnana M; Department of Medicine - DIMED, University of Padua, Via Giustiniani, 2 - 35128 Padua, Italy; Laboratory Medicine, University-Hospital of Padua, via Giustiniani, 2 - 35128, Padua, Italy. Electronic address: martina.montagnana@unipd.it., Antonini A; Neurodegenerative Disease Unit, Centre for Rare Neurological Diseases (ERN-RND), Department of Neuroscience, Padua Neuroscience Center (PNC), University of Padua, Via Giustiniani, 5 - 35128 Padua, Italy; IRCCS, San Camillo Hospital, Via Alberoni, 70 - 30126, Venice, Lido, Italy. Electronic address: angelo.antonini@unipd.it.
Πηγή: Journal of the neurological sciences [J Neurol Sci] 2025 Sep 15; Vol. 476, pp. 123617. Date of Electronic Publication: 2025 Jul 11.
Τύπος έκδοσης: Journal Article
Γλώσσα: English
Στοιχεία περιοδικού: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 0375403 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1878-5883 (Electronic) Linking ISSN: 0022510X NLM ISO Abbreviation: J Neurol Sci Subsets: MEDLINE
Imprint Name(s): Original Publication: Amsterdam : Elsevier, <19 ->
Ιατρικοί όροι (MeSH): Alzheimer Disease*/blood , Alzheimer Disease*/diagnosis , Frontotemporal Dementia*/blood , Frontotemporal Dementia*/diagnosis , Neurofilament Proteins*/blood , Parkinsonian Disorders*/blood , Parkinsonian Disorders*/diagnosis , Parkinson Disease*/blood , Parkinson Disease*/diagnosis, Biomarkers/blood ; tau Proteins/blood ; Glial Fibrillary Acidic Protein/blood ; Supranuclear Palsy, Progressive/blood ; Supranuclear Palsy, Progressive/diagnosis ; Multiple System Atrophy/blood ; Multiple System Atrophy/diagnosis ; Humans ; Male ; Female ; Aged ; Middle Aged ; Cohort Studies ; Aged, 80 and over
Περίληψη: The complexity of neurodegenerative disorders necessitates an integrative approach that incorporates morphological, functional, and molecular biomarkers. The advent of highly sensitive single-molecule array (Simoa®) assays has significantly enhanced the accuracy of blood-based biomarker quantification, including glial fibrillary acidic protein (GFAP), neurofilament light chain (NfL), and phosphorylated tau181 (p-tau181). This study evaluates the diagnostic utility of these biomarkers in neurodegenerative diseases. We analyzed data from 279 individuals from the PADUA-CESNE cohort: 120 with Parkinson's disease (PD), 88 with Alzheimer's disease (AD), 16 with frontotemporal dementia (FTD), 11 with multiple system atrophy (MSA), 14 with progressive supranuclear palsy (PSP), and 30 cognitively unimpaired controls. NfL levels were significantly lower in PD and AD compared to atypical parkinsonisms and FTD, effectively distinguishing MSA and PSP from controls. NfL also negatively correlated with Montreal Cognitive Assessment (MoCA) scores in AD and PD, indicating its association with cognitive decline. Elevated GFAP levels were observed in both PD and AD and inversely correlated with global cognition. Combining GFAP and p-tau181 improved AD differentiation from PD and other parkinsonian disorders, while the integration of all three biomarkers facilitated the distinction between AD and FTD. Notably, lower NfL levels (<20 ng/L) in conjunction with elevated p-tau181 were indicative of AD, whereas NfL levels below 40 ng/L were suggestive of PD. In conclusion, NfL serves as a sensitive indicator of neurodegeneration, albeit with limited specificity. However, by establishing biomarker concentration thresholds and integrating complementary biomarkers, blood-based assays may enhance the differential diagnosis of neurodegenerative diseases, providing valuable clinical insights.
(Copyright © 2025. Published by Elsevier B.V.)
Contributed Indexing: Keywords: Blood-based biomarkers; Glial fibrillary acidic protein (GFAP); Neurodegenerative diseases; Neurofilament light chain (NfL); Parkinson's disease; Phosphorylated tau181 (p-tau181)
Substance Nomenclature: 0 (Biomarkers)
0 (Neurofilament Proteins)
0 (tau Proteins)
0 (neurofilament protein L)
0 (Glial Fibrillary Acidic Protein)
0 (GFAP protein, human)
Entry Date(s): Date Created: 20250719 Date Completed: 20250828 Latest Revision: 20260506
Update Code: 20260507
DOI: 10.1016/j.jns.2025.123617
PMID: 40682931
Βάση Δεδομένων: MEDLINE
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  – Url: https://www.doi.org/10.1016/j.jns.2025.123617?
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Items – Name: Title
  Label: Title
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  Data: The role of blood-based biomarkers in Parkinsonian disorders, Alzheimer&#39;s disease and frontotemporal dementia.
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  Data: &lt;searchLink fieldCode=&quot;AU&quot; term=&quot;%22Campagnolo+M%22&quot;&gt;Campagnolo M&lt;/searchLink&gt;; Neurodegenerative Disease Unit, Centre for Rare Neurological Diseases (ERN-RND), Department of Neuroscience, Padua Neuroscience Center (PNC), University of Padua, Via Giustiniani, 5 - 35128 Padua, Italy. Electronic address: marta.campagnolo@unipd.it.&lt;br /&gt;&lt;searchLink fieldCode=&quot;AU&quot; term=&quot;%22Fiorenzato+E%22&quot;&gt;Fiorenzato E&lt;/searchLink&gt;; Neurodegenerative Disease Unit, Centre for Rare Neurological Diseases (ERN-RND), Department of Neuroscience, Padua Neuroscience Center (PNC), University of Padua, Via Giustiniani, 5 - 35128 Padua, Italy. Electronic address: eleonora.fiorenzato@unipd.it.&lt;br /&gt;&lt;searchLink fieldCode=&quot;AU&quot; term=&quot;%22Musso+G%22&quot;&gt;Musso G&lt;/searchLink&gt;; Department of Medicine - DIMED, University of Padua, Via Giustiniani, 2 - 35128 Padua, Italy; Laboratory Medicine, University-Hospital of Padua, via Giustiniani, 2 - 35128, Padua, Italy. Electronic address: giulia.musso@unipd.it.&lt;br /&gt;&lt;searchLink fieldCode=&quot;AU&quot; term=&quot;%22Misenti+V%22&quot;&gt;Misenti V&lt;/searchLink&gt;; Neurodegenerative Disease Unit, Centre for Rare Neurological Diseases (ERN-RND), Department of Neuroscience, Padua Neuroscience Center (PNC), University of Padua, Via Giustiniani, 5 - 35128 Padua, Italy. Electronic address: valentina.misenti@unipd.it.&lt;br /&gt;&lt;searchLink fieldCode=&quot;AU&quot; term=&quot;%22Cauzzo+S%22&quot;&gt;Cauzzo S&lt;/searchLink&gt;; Neurodegenerative Disease Unit, Centre for Rare Neurological Diseases (ERN-RND), Department of Neuroscience, Padua Neuroscience Center (PNC), University of Padua, Via Giustiniani, 5 - 35128 Padua, Italy. Electronic address: simone.cauzzo@unipd.it.&lt;br /&gt;&lt;searchLink fieldCode=&quot;AU&quot; term=&quot;%22Cagnin+A%22&quot;&gt;Cagnin A&lt;/searchLink&gt;; Department of Neuroscience, University of Padua, Via Giustiniani, 5 - 35128 Padua, Italy; Padova Neuroscience Center (PNC), University of Padua, Via Giuseppe Orus, 2/b - 35131 Padua, Italy. Electronic address: annachiara.cagnin@unipd.it.&lt;br /&gt;&lt;searchLink fieldCode=&quot;AU&quot; term=&quot;%22Biundo+R%22&quot;&gt;Biundo R&lt;/searchLink&gt;; Department of General Psychology, University of Padua, Via Venezia, 8 - 35131 Padua, Italy; IRCCS, San Camillo Hospital, Via Alberoni, 70 - 30126, Venice, Lido, Italy. Electronic address: roberta.biundo@unipd.it.&lt;br /&gt;&lt;searchLink fieldCode=&quot;AU&quot; term=&quot;%22Buss&#232;+C%22&quot;&gt;Buss&#232; C&lt;/searchLink&gt;; Department of Neuroscience, University of Padua, Via Giustiniani, 5 - 35128 Padua, Italy; Padova Neuroscience Center (PNC), University of Padua, Via Giuseppe Orus, 2/b - 35131 Padua, Italy. Electronic address: cinzia.busse@unipd.it.&lt;br /&gt;&lt;searchLink fieldCode=&quot;AU&quot; term=&quot;%22Fogliano+CA%22&quot;&gt;Fogliano CA&lt;/searchLink&gt;; Neurodegenerative Disease Unit, Centre for Rare Neurological Diseases (ERN-RND), Department of Neuroscience, Padua Neuroscience Center (PNC), University of Padua, Via Giustiniani, 5 - 35128 Padua, Italy. Electronic address: carmelo.fogliano1@gmail.com.&lt;br /&gt;&lt;searchLink fieldCode=&quot;AU&quot; term=&quot;%22Mozzetta+S%22&quot;&gt;Mozzetta S&lt;/searchLink&gt;; Department of Neuroscience, University of Padua, Via Giustiniani, 5 - 35128 Padua, Italy; Padova Neuroscience Center (PNC), University of Padua, Via Giuseppe Orus, 2/b - 35131 Padua, Italy. Electronic address: stefano.mozzetta@aopd.veneto.it.&lt;br /&gt;&lt;searchLink fieldCode=&quot;AU&quot; term=&quot;%22Codemo+A%22&quot;&gt;Codemo A&lt;/searchLink&gt;; Regional Brain Aging Center, University Hospital of Padua, Piazza de Claricini, 12 - 35030 Selvazzano Dentro, Padua, Italy. Electronic address: alessandra.codemo@aopd.veneto.it.&lt;br /&gt;&lt;searchLink fieldCode=&quot;AU&quot; term=&quot;%22Gasparoli+E%22&quot;&gt;Gasparoli E&lt;/searchLink&gt;; Regional Brain Aging Center, University Hospital of Padua, Piazza de Claricini, 12 - 35030 Selvazzano Dentro, Padua, Italy. Electronic address: elisabetta.gasparoli@aopd.veneto.it.&lt;br /&gt;&lt;searchLink fieldCode=&quot;AU&quot; term=&quot;%22Moz+S%22&quot;&gt;Moz S&lt;/searchLink&gt;; Laboratory Medicine, University-Hospital of Padua, via Giustiniani, 2 - 35128, Padua, Italy. Electronic address: stefania.moz@aopd.veneto.it.&lt;br /&gt;&lt;searchLink fieldCode=&quot;AU&quot; term=&quot;%22Narici+M%22&quot;&gt;Narici M&lt;/searchLink&gt;; Department of Biomedical Sciences, University of Padua, Via Ugo Bassi, 58/b - 35131 Padua, Italy. Electronic address: marco.narici@unipd.it.&lt;br /&gt;&lt;searchLink fieldCode=&quot;AU&quot; term=&quot;%22Pizzo+P%22&quot;&gt;Pizzo P&lt;/searchLink&gt;; Department of Biomedical Sciences, University of Padua, Via Ugo Bassi, 58/b - 35131 Padua, Italy; Institute of Neuroscience, National Research Council (CNR), University of Padua, Via Ugo Bassi, 58/b - 35131 Padua, Italy. Electronic address: paola.pizzo@unipd.it.&lt;br /&gt;&lt;searchLink fieldCode=&quot;AU&quot; term=&quot;%22Corbetta+M%22&quot;&gt;Corbetta M&lt;/searchLink&gt;; Department of Neuroscience, University of Padua, Via Giustiniani, 5 - 35128 Padua, Italy; Padova Neuroscience Center (PNC), University of Padua, Via Giuseppe Orus, 2/b - 35131 Padua, Italy. Electronic address: maurizio.corbetta@unipd.it.&lt;br /&gt;&lt;searchLink fieldCode=&quot;AU&quot; term=&quot;%22Montagnana+M%22&quot;&gt;Montagnana M&lt;/searchLink&gt;; Department of Medicine - DIMED, University of Padua, Via Giustiniani, 2 - 35128 Padua, Italy; Laboratory Medicine, University-Hospital of Padua, via Giustiniani, 2 - 35128, Padua, Italy. Electronic address: martina.montagnana@unipd.it.&lt;br /&gt;&lt;searchLink fieldCode=&quot;AU&quot; term=&quot;%22Antonini+A%22&quot;&gt;Antonini A&lt;/searchLink&gt;; Neurodegenerative Disease Unit, Centre for Rare Neurological Diseases (ERN-RND), Department of Neuroscience, Padua Neuroscience Center (PNC), University of Padua, Via Giustiniani, 5 - 35128 Padua, Italy; IRCCS, San Camillo Hospital, Via Alberoni, 70 - 30126, Venice, Lido, Italy. Electronic address: angelo.antonini@unipd.it.
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  Data: &lt;searchLink fieldCode=&quot;JN&quot; term=&quot;%220375403%22&quot;&gt;Journal of the neurological sciences&lt;/searchLink&gt; [J Neurol Sci] 2025 Sep 15; Vol. 476, pp. 123617. &lt;i&gt;Date of Electronic Publication: &lt;/i&gt;2025 Jul 11.
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  Data: &lt;i&gt;Original Publication&lt;/i&gt;: Amsterdam : Elsevier, &lt;19 -&gt;
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  Data: &lt;searchLink fieldCode=&quot;MM&quot; term=&quot;%22Alzheimer+Disease%22&quot;&gt;Alzheimer Disease*&lt;/searchLink&gt;/&lt;searchLink fieldCode=&quot;MM&quot; term=&quot;%22Alzheimer+Disease+blood%22&quot;&gt;blood&lt;/searchLink&gt; &lt;br /&gt;&lt;searchLink fieldCode=&quot;MM&quot; term=&quot;%22Alzheimer+Disease%22&quot;&gt;Alzheimer Disease*&lt;/searchLink&gt;/&lt;searchLink fieldCode=&quot;MM&quot; term=&quot;%22Alzheimer+Disease+diagnosis%22&quot;&gt;diagnosis&lt;/searchLink&gt; &lt;br /&gt;&lt;searchLink fieldCode=&quot;MM&quot; term=&quot;%22Frontotemporal+Dementia%22&quot;&gt;Frontotemporal Dementia*&lt;/searchLink&gt;/&lt;searchLink fieldCode=&quot;MM&quot; term=&quot;%22Frontotemporal+Dementia+blood%22&quot;&gt;blood&lt;/searchLink&gt; &lt;br /&gt;&lt;searchLink fieldCode=&quot;MM&quot; term=&quot;%22Frontotemporal+Dementia%22&quot;&gt;Frontotemporal Dementia*&lt;/searchLink&gt;/&lt;searchLink fieldCode=&quot;MM&quot; term=&quot;%22Frontotemporal+Dementia+diagnosis%22&quot;&gt;diagnosis&lt;/searchLink&gt; &lt;br /&gt;&lt;searchLink fieldCode=&quot;MM&quot; term=&quot;%22Neurofilament+Proteins%22&quot;&gt;Neurofilament Proteins*&lt;/searchLink&gt;/&lt;searchLink fieldCode=&quot;MM&quot; term=&quot;%22Neurofilament+Proteins+blood%22&quot;&gt;blood&lt;/searchLink&gt; &lt;br /&gt;&lt;searchLink fieldCode=&quot;MM&quot; term=&quot;%22Parkinsonian+Disorders%22&quot;&gt;Parkinsonian Disorders*&lt;/searchLink&gt;/&lt;searchLink fieldCode=&quot;MM&quot; term=&quot;%22Parkinsonian+Disorders+blood%22&quot;&gt;blood&lt;/searchLink&gt; &lt;br /&gt;&lt;searchLink fieldCode=&quot;MM&quot; term=&quot;%22Parkinsonian+Disorders%22&quot;&gt;Parkinsonian Disorders*&lt;/searchLink&gt;/&lt;searchLink fieldCode=&quot;MM&quot; term=&quot;%22Parkinsonian+Disorders+diagnosis%22&quot;&gt;diagnosis&lt;/searchLink&gt; &lt;br /&gt;&lt;searchLink fieldCode=&quot;MM&quot; term=&quot;%22Parkinson+Disease%22&quot;&gt;Parkinson Disease*&lt;/searchLink&gt;/&lt;searchLink fieldCode=&quot;MM&quot; term=&quot;%22Parkinson+Disease+blood%22&quot;&gt;blood&lt;/searchLink&gt; &lt;br /&gt;&lt;searchLink fieldCode=&quot;MM&quot; term=&quot;%22Parkinson+Disease%22&quot;&gt;Parkinson Disease*&lt;/searchLink&gt;/&lt;searchLink fieldCode=&quot;MM&quot; term=&quot;%22Parkinson+Disease+diagnosis%22&quot;&gt;diagnosis&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;MH&quot; term=&quot;%22Biomarkers%22&quot;&gt;Biomarkers&lt;/searchLink&gt;/&lt;searchLink fieldCode=&quot;MH&quot; term=&quot;%22Biomarkers+blood%22&quot;&gt;blood&lt;/searchLink&gt; ; &lt;searchLink fieldCode=&quot;MH&quot; term=&quot;%22tau+Proteins%22&quot;&gt;tau Proteins&lt;/searchLink&gt;/&lt;searchLink fieldCode=&quot;MH&quot; term=&quot;%22tau+Proteins+blood%22&quot;&gt;blood&lt;/searchLink&gt; ; &lt;searchLink fieldCode=&quot;MH&quot; term=&quot;%22Glial+Fibrillary+Acidic+Protein%22&quot;&gt;Glial Fibrillary Acidic Protein&lt;/searchLink&gt;/&lt;searchLink fieldCode=&quot;MH&quot; term=&quot;%22Glial+Fibrillary+Acidic+Protein+blood%22&quot;&gt;blood&lt;/searchLink&gt; ; &lt;searchLink fieldCode=&quot;MH&quot; term=&quot;%22Supranuclear+Palsy%2C+Progressive%22&quot;&gt;Supranuclear Palsy, Progressive&lt;/searchLink&gt;/&lt;searchLink fieldCode=&quot;MH&quot; term=&quot;%22Supranuclear+Palsy%2C+Progressive+blood%22&quot;&gt;blood&lt;/searchLink&gt; ; &lt;searchLink fieldCode=&quot;MH&quot; term=&quot;%22Supranuclear+Palsy%2C+Progressive%22&quot;&gt;Supranuclear Palsy, Progressive&lt;/searchLink&gt;/&lt;searchLink fieldCode=&quot;MH&quot; term=&quot;%22Supranuclear+Palsy%2C+Progressive+diagnosis%22&quot;&gt;diagnosis&lt;/searchLink&gt; ; &lt;searchLink fieldCode=&quot;MH&quot; term=&quot;%22Multiple+System+Atrophy%22&quot;&gt;Multiple System Atrophy&lt;/searchLink&gt;/&lt;searchLink fieldCode=&quot;MH&quot; term=&quot;%22Multiple+System+Atrophy+blood%22&quot;&gt;blood&lt;/searchLink&gt; ; &lt;searchLink fieldCode=&quot;MH&quot; term=&quot;%22Multiple+System+Atrophy%22&quot;&gt;Multiple System Atrophy&lt;/searchLink&gt;/&lt;searchLink fieldCode=&quot;MH&quot; term=&quot;%22Multiple+System+Atrophy+diagnosis%22&quot;&gt;diagnosis&lt;/searchLink&gt; ; &lt;searchLink fieldCode=&quot;MH&quot; term=&quot;%22Humans%22&quot;&gt;Humans&lt;/searchLink&gt; ; &lt;searchLink fieldCode=&quot;MH&quot; term=&quot;%22Male%22&quot;&gt;Male&lt;/searchLink&gt; ; &lt;searchLink fieldCode=&quot;MH&quot; term=&quot;%22Female%22&quot;&gt;Female&lt;/searchLink&gt; ; &lt;searchLink fieldCode=&quot;MH&quot; term=&quot;%22Aged%22&quot;&gt;Aged&lt;/searchLink&gt; ; &lt;searchLink fieldCode=&quot;MH&quot; term=&quot;%22Middle+Aged%22&quot;&gt;Middle Aged&lt;/searchLink&gt; ; &lt;searchLink fieldCode=&quot;MH&quot; term=&quot;%22Cohort+Studies%22&quot;&gt;Cohort Studies&lt;/searchLink&gt; ; &lt;searchLink fieldCode=&quot;MH&quot; term=&quot;%22Aged%2C+80+and+over%22&quot;&gt;Aged, 80 and over&lt;/searchLink&gt;
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: The complexity of neurodegenerative disorders necessitates an integrative approach that incorporates morphological, functional, and molecular biomarkers. The advent of highly sensitive single-molecule array (Simoa&#174;) assays has significantly enhanced the accuracy of blood-based biomarker quantification, including glial fibrillary acidic protein (GFAP), neurofilament light chain (NfL), and phosphorylated tau181 (p-tau181). This study evaluates the diagnostic utility of these biomarkers in neurodegenerative diseases. We analyzed data from 279 individuals from the PADUA-CESNE cohort: 120 with Parkinson&#39;s disease (PD), 88 with Alzheimer&#39;s disease (AD), 16 with frontotemporal dementia (FTD), 11 with multiple system atrophy (MSA), 14 with progressive supranuclear palsy (PSP), and 30 cognitively unimpaired controls. NfL levels were significantly lower in PD and AD compared to atypical parkinsonisms and FTD, effectively distinguishing MSA and PSP from controls. NfL also negatively correlated with Montreal Cognitive Assessment (MoCA) scores in AD and PD, indicating its association with cognitive decline. Elevated GFAP levels were observed in both PD and AD and inversely correlated with global cognition. Combining GFAP and p-tau181 improved AD differentiation from PD and other parkinsonian disorders, while the integration of all three biomarkers facilitated the distinction between AD and FTD. Notably, lower NfL levels (&amp;lt;20&#160;ng/L) in conjunction with elevated p-tau181 were indicative of AD, whereas NfL levels below 40&#160;ng/L were suggestive of PD. In conclusion, NfL serves as a sensitive indicator of neurodegeneration, albeit with limited specificity. However, by establishing biomarker concentration thresholds and integrating complementary biomarkers, blood-based assays may enhance the differential diagnosis of neurodegenerative diseases, providing valuable clinical insights.&lt;br /&gt; (Copyright &#169; 2025. Published by Elsevier B.V.)
– Name: SubjectMinor
  Label: Contributed Indexing
  Group:
  Data: &lt;i&gt;Keywords: &lt;/i&gt;Blood-based biomarkers; Glial fibrillary acidic protein (GFAP); Neurodegenerative diseases; Neurofilament light chain (NfL); Parkinson&#39;s disease; Phosphorylated tau181 (p-tau181)
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    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        StartPage: 123617
    Subjects:
      – SubjectFull: Biomarkers blood
        Type: general
      – SubjectFull: tau Proteins blood
        Type: general
      – SubjectFull: Glial Fibrillary Acidic Protein blood
        Type: general
      – SubjectFull: Supranuclear Palsy, Progressive blood
        Type: general
      – SubjectFull: Supranuclear Palsy, Progressive diagnosis
        Type: general
      – SubjectFull: Multiple System Atrophy blood
        Type: general
      – SubjectFull: Multiple System Atrophy diagnosis
        Type: general
      – SubjectFull: Humans
        Type: general
      – SubjectFull: Male
        Type: general
      – SubjectFull: Female
        Type: general
      – SubjectFull: Aged
        Type: general
      – SubjectFull: Middle Aged
        Type: general
      – SubjectFull: Cohort Studies
        Type: general
      – SubjectFull: Aged, 80 and over
        Type: general
      – SubjectFull: Alzheimer Disease blood
        Type: general
      – SubjectFull: Alzheimer Disease diagnosis
        Type: general
      – SubjectFull: Frontotemporal Dementia blood
        Type: general
      – SubjectFull: Frontotemporal Dementia diagnosis
        Type: general
      – SubjectFull: Neurofilament Proteins blood
        Type: general
      – SubjectFull: Parkinsonian Disorders blood
        Type: general
      – SubjectFull: Parkinsonian Disorders diagnosis
        Type: general
      – SubjectFull: Parkinson Disease blood
        Type: general
      – SubjectFull: Parkinson Disease diagnosis
        Type: general
    Titles:
      – TitleFull: The role of blood-based biomarkers in Parkinsonian disorders, Alzheimer's disease and frontotemporal dementia.
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: Campagnolo M
      – PersonEntity:
          Name:
            NameFull: Fiorenzato E
      – PersonEntity:
          Name:
            NameFull: Musso G
      – PersonEntity:
          Name:
            NameFull: Misenti V
      – PersonEntity:
          Name:
            NameFull: Cauzzo S
      – PersonEntity:
          Name:
            NameFull: Cagnin A
      – PersonEntity:
          Name:
            NameFull: Biundo R
      – PersonEntity:
          Name:
            NameFull: Bussè C
      – PersonEntity:
          Name:
            NameFull: Fogliano CA
      – PersonEntity:
          Name:
            NameFull: Mozzetta S
      – PersonEntity:
          Name:
            NameFull: Codemo A
      – PersonEntity:
          Name:
            NameFull: Gasparoli E
      – PersonEntity:
          Name:
            NameFull: Moz S
      – PersonEntity:
          Name:
            NameFull: Narici M
      – PersonEntity:
          Name:
            NameFull: Pizzo P
      – PersonEntity:
          Name:
            NameFull: Corbetta M
      – PersonEntity:
          Name:
            NameFull: Montagnana M
      – PersonEntity:
          Name:
            NameFull: Antonini A
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 15
              M: 09
              Text: 2025 Sep 15
              Type: published
              Y: 2025
          Identifiers:
            – Type: issn-electronic
              Value: 1878-5883
          Numbering:
            – Type: volume
              Value: 476
          Titles:
            – TitleFull: Journal of the neurological sciences
              Type: main
ResultId 1