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Unveiling anomalies in visual processing regions in obsessive-compulsive disorder: evidence from gray matter volume and functional connectivity analyses.

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Title: Unveiling anomalies in visual processing regions in obsessive-compulsive disorder: evidence from gray matter volume and functional connectivity analyses.
Authors: Liu R; Beijing Key Laboratory of Mental Disorders, Beijing Anding Hospital, National Clinical Research Center for Mental Disorders & National Center for Mental Disorders, Capital Medical University, Beijing, China.; Advanced Innovation Center for Human Brain Protection, Capital Medical University, Beijing, China., Zhang F; Beijing Key Laboratory of Mental Disorders, Beijing Anding Hospital, National Clinical Research Center for Mental Disorders & National Center for Mental Disorders, Capital Medical University, Beijing, China.; Advanced Innovation Center for Human Brain Protection, Capital Medical University, Beijing, China., Wang P; Beijing Key Laboratory of Mental Disorders, Beijing Anding Hospital, National Clinical Research Center for Mental Disorders & National Center for Mental Disorders, Capital Medical University, Beijing, China.; Advanced Innovation Center for Human Brain Protection, Capital Medical University, Beijing, China., Luo J; Beijing Key Laboratory of Mental Disorders, Beijing Anding Hospital, National Clinical Research Center for Mental Disorders & National Center for Mental Disorders, Capital Medical University, Beijing, China.; Advanced Innovation Center for Human Brain Protection, Capital Medical University, Beijing, China., Liu Y; Beijing Key Laboratory of Mental Disorders, Beijing Anding Hospital, National Clinical Research Center for Mental Disorders & National Center for Mental Disorders, Capital Medical University, Beijing, China.; Advanced Innovation Center for Human Brain Protection, Capital Medical University, Beijing, China., Huang K; Beijing Key Laboratory of Mental Disorders, Beijing Anding Hospital, National Clinical Research Center for Mental Disorders & National Center for Mental Disorders, Capital Medical University, Beijing, China.; Advanced Innovation Center for Human Brain Protection, Capital Medical University, Beijing, China., Yang X; Beijing Key Laboratory of Mental Disorders, Beijing Anding Hospital, National Clinical Research Center for Mental Disorders & National Center for Mental Disorders, Capital Medical University, Beijing, China. xyyang@ccmu.edu.cn.; Advanced Innovation Center for Human Brain Protection, Capital Medical University, Beijing, China. xyyang@ccmu.edu.cn., Yu A; Beijing Key Laboratory of Mental Disorders, Beijing Anding Hospital, National Clinical Research Center for Mental Disorders & National Center for Mental Disorders, Capital Medical University, Beijing, China. yuaihong@mail.ccmu.edu.cn.; Advanced Innovation Center for Human Brain Protection, Capital Medical University, Beijing, China. yuaihong@mail.ccmu.edu.cn., Li Z; Beijing Key Laboratory of Mental Disorders, Beijing Anding Hospital, National Clinical Research Center for Mental Disorders & National Center for Mental Disorders, Capital Medical University, Beijing, China. lizhj8@ccmu.edu.cn.; Advanced Innovation Center for Human Brain Protection, Capital Medical University, Beijing, China. lizhj8@ccmu.edu.cn.
Source: Brain imaging and behavior [Brain Imaging Behav] 2025 Dec; Vol. 19 (6), pp. 1168-1177. Date of Electronic Publication: 2025 Jul 10.
Publication Type: Journal Article
Language: English
Journal Info: Publisher: Springer Country of Publication: United States NLM ID: 101300405 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1931-7565 (Electronic) Linking ISSN: 19317557 NLM ISO Abbreviation: Brain Imaging Behav Subsets: MEDLINE
Imprint Name(s): Original Publication: Secaucus, NJ : Springer
MeSH Terms: Obsessive-Compulsive Disorder*/physiopathology , Obsessive-Compulsive Disorder*/diagnostic imaging , Obsessive-Compulsive Disorder*/pathology , Gray Matter*/diagnostic imaging , Gray Matter*/physiopathology , Gray Matter*/pathology , Brain*/physiopathology , Brain*/diagnostic imaging , Brain*/pathology , Visual Perception*/physiology, Magnetic Resonance Imaging/methods ; Brain Mapping/methods ; Neural Pathways/physiopathology ; Neural Pathways/diagnostic imaging ; Humans ; Male ; Female ; Adult ; Young Adult ; Organ Size
Abstract: Obsessive-compulsive disorder (OCD) is a prevalent neurological condition characterized by recurring obsessive thoughts and compulsive behaviors. The underlying mechanisms of the disorder remain poorly understood due to its considerable heterogeneity. Given the extensive brain impairments observed in OCD, this study aimed to investigate gray matter volume and functional connectivity in individuals with OCD using a multimodal neuroimaging approach, while also exploring the relationship between these neural changes and clinical symptom severity. Structural and resting-state functional magnetic resonance imaging data were collected from 56 OCD patients and 41 healthy controls. Voxel-based morphometry analysis was employed to identify gray matter volume differences between the patient and control groups. Compared to healthy controls, patients exhibited reduced gray matter volume in visual processing regions, including the cuneus, left calcarine, and middle occipital gyrus. Furthermore, whole-brain functional connectivity analysis was conducted on these regions with abnormal gray matter volume, showing increased connectivity between the visual processing areas and subcortical and prefrontal regions. Additionally, gray matter volume reductions in the left calcarine and middle temporal gyrus were significantly correlated with higher scores on the Yale-Brown Obsessive Compulsive Scale, suggesting a link between visual processing abnormalities and the severity of clinical symptoms. These findings highlight structural and functional alterations in visual-related brain regions as key contributors to the pathophysiology of OCD, providing valuable insights into its neural basis and potential avenues for therapeutic intervention.
(© 2025. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.)
Competing Interests: Declarations. Ethical approval: The study received approval from the Research Ethics Committee at Beijing Anding Hospital, Capital Medical University, under approval code (2013) Keyan (7). Consent to participate: Informed consent was obtained from all subjects involved in the study. Consent for publication: All authors approved the final manuscript. Competing interests: The authors declare no competing interests.
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Grant Information: 81271493 National Natural Science Foundation of China; 7122082 Natural Science Foundation of Beijing Municipality
Contributed Indexing: Keywords: Functional connectivity; Functional magnetic resonance imaging; Gray matter volume; Obsessive-compulsive disorder
Entry Date(s): Date Created: 20250710 Date Completed: 20260124 Latest Revision: 20260124
Update Code: 20260130
DOI: 10.1007/s11682-025-01039-0
PMID: 40638012
Database: MEDLINE
Description
ISSN:1931-7565
DOI:10.1007/s11682-025-01039-0