Academic Journal
Non-human primates as a translational model for the study of male reproductive health.
| Τίτλος: | Non-human primates as a translational model for the study of male reproductive health. |
|---|---|
| Συγγραφείς: | Edenfield RC; Division of Reproductive and Developmental Sciences, Oregon National Primate Research Center, Oregon Health & Science University, Beaverton, OR, USA. edenfiel@ohsu.edu., Bash JC; Department of Urology, Oregon Health & Science University, Portland, OR, USA., Shorey-Kendrick LE; Division of Neuroscience, Oregon National Primate Research Center, Oregon Health & Science University, Beaverton, OR, USA., D'Mello RJ; Division of Reproductive and Developmental Sciences, Oregon National Primate Research Center, Oregon Health & Science University, Beaverton, OR, USA.; Department of Obstetrics and Gynecology, Oregon Health & Science University, Portland, OR, USA., Rice-Stitt TL; Department of Pathology, Oregon Health & Science University, Portland, OR, USA., Hagen OL; Division of Reproductive and Developmental Sciences, Oregon National Primate Research Center, Oregon Health & Science University, Beaverton, OR, USA., Graham JA; Division of Reproductive and Developmental Sciences, Oregon National Primate Research Center, Oregon Health & Science University, Beaverton, OR, USA., Orwig KE; Department of Obstetrics, Gynecology, and Reproductive Services, Magee-Womens Research Institute, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA., Easley CA; Department of Environmental Health Science, University of Georgia College of Public Health, Athens, GA, USA., Hedges JC; Department of Urology, Oregon Health & Science University, Portland, OR, USA., Hanna CB; Division of Reproductive and Developmental Sciences, Oregon National Primate Research Center, Oregon Health & Science University, Beaverton, OR, USA., Lo JO; Division of Reproductive and Developmental Sciences, Oregon National Primate Research Center, Oregon Health & Science University, Beaverton, OR, USA.; Department of Urology, Oregon Health & Science University, Portland, OR, USA.; Department of Obstetrics and Gynecology, Oregon Health & Science University, Portland, OR, USA. |
| Πηγή: | Nature reviews. Urology [Nat Rev Urol] 2025 Nov; Vol. 22 (11), pp. 756-774. Date of Electronic Publication: 2025 Jul 07. |
| Τύπος έκδοσης: | Journal Article; Review; Research Support, N.I.H., Intramural |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101500082 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1759-4820 (Electronic) Linking ISSN: 17594812 NLM ISO Abbreviation: Nat Rev Urol Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: London : Nature Pub. Group |
| Ιατρικοί όροι (MeSH): | Infertility, Male*/therapy , Infertility, Male*/physiopathology , Translational Research, Biomedical*/methods , Reproductive Health* , Models, Animal*, Spermatogenesis/physiology ; Animals ; Male ; Macaca mulatta ; Humans ; Disease Models, Animal |
| Περίληψη: | Male fertility is complex and influenced by genetic, hormonal, environmental and lifestyle factors. However, limitations to human studies necessitate the use of reliable preclinical models to better understand the underlying mechanisms of male fertility. Rhesus macaques (Macaca mulatta), with their close genetic and physiological similarities to humans, offer an invaluable model for male reproductive health studies. The suitability of rhesus macaques for studying male infertility is based on similarities in spermatogenesis, hormonal cycles and the way in which assisted reproductive technologies can be applied, and key differences and similarities between human and rhesus macaque sperm structure, function and cryopreservation techniques highlight the translational potential of findings derived from macaque models. Furthermore, insights into the epigenetic and proteomic characteristics of sperm in both species improve understanding of how these findings can help to advance clinical diagnostics, male contraception and fertility preservation and illuminate the regulatory omics of normal reproduction. Thus, the rhesus macaque model offers critical insights into male fertility and studies in this species could contribute to advances in therapies for male infertility. (© 2025. Springer Nature Limited.) |
| Competing Interests: | Competing interests: The authors declare no competing interests. |
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| Grant Information: | DP1 DA056493 United States DA NIDA NIH HHS; K22 ES025418 United States ES NIEHS NIH HHS; P51 OD011092 United States OD NIH HHS; R01 OD028223 United States OD NIH HHS |
| Entry Date(s): | Date Created: 20250707 Date Completed: 20251101 Latest Revision: 20260726 |
| Update Code: | 20260726 |
| PubMed Central ID: | PMC12343197 |
| DOI: | 10.1038/s41585-025-01062-2 |
| PMID: | 40624316 |
| Βάση Δεδομένων: | MEDLINE |
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