Academic Journal
Non-human primates as a translational model for the study of male reproductive health.
| Title: | Non-human primates as a translational model for the study of male reproductive health. |
|---|---|
| Authors: | Edenfield RC; Division of Reproductive and Developmental Sciences, Oregon National Primate Research Center, Oregon Health & Science University, Beaverton, OR, USA. edenfiel@ohsu.edu., Bash JC; Department of Urology, Oregon Health & Science University, Portland, OR, USA., Shorey-Kendrick LE; Division of Neuroscience, Oregon National Primate Research Center, Oregon Health & Science University, Beaverton, OR, USA., D'Mello RJ; Division of Reproductive and Developmental Sciences, Oregon National Primate Research Center, Oregon Health & Science University, Beaverton, OR, USA.; Department of Obstetrics and Gynecology, Oregon Health & Science University, Portland, OR, USA., Rice-Stitt TL; Department of Pathology, Oregon Health & Science University, Portland, OR, USA., Hagen OL; Division of Reproductive and Developmental Sciences, Oregon National Primate Research Center, Oregon Health & Science University, Beaverton, OR, USA., Graham JA; Division of Reproductive and Developmental Sciences, Oregon National Primate Research Center, Oregon Health & Science University, Beaverton, OR, USA., Orwig KE; Department of Obstetrics, Gynecology, and Reproductive Services, Magee-Womens Research Institute, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA., Easley CA; Department of Environmental Health Science, University of Georgia College of Public Health, Athens, GA, USA., Hedges JC; Department of Urology, Oregon Health & Science University, Portland, OR, USA., Hanna CB; Division of Reproductive and Developmental Sciences, Oregon National Primate Research Center, Oregon Health & Science University, Beaverton, OR, USA., Lo JO; Division of Reproductive and Developmental Sciences, Oregon National Primate Research Center, Oregon Health & Science University, Beaverton, OR, USA.; Department of Urology, Oregon Health & Science University, Portland, OR, USA.; Department of Obstetrics and Gynecology, Oregon Health & Science University, Portland, OR, USA. |
| Source: | Nature reviews. Urology [Nat Rev Urol] 2025 Nov; Vol. 22 (11), pp. 756-774. Date of Electronic Publication: 2025 Jul 07. |
| Publication Type: | Journal Article; Review; Research Support, N.I.H., Intramural |
| Language: | English |
| Journal Info: | Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101500082 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1759-4820 (Electronic) Linking ISSN: 17594812 NLM ISO Abbreviation: Nat Rev Urol Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: London : Nature Pub. Group |
| MeSH Terms: | Infertility, Male*/therapy , Infertility, Male*/physiopathology , Translational Research, Biomedical*/methods , Reproductive Health* , Models, Animal*, Spermatogenesis/physiology ; Animals ; Male ; Macaca mulatta ; Humans ; Disease Models, Animal |
| Abstract: | Male fertility is complex and influenced by genetic, hormonal, environmental and lifestyle factors. However, limitations to human studies necessitate the use of reliable preclinical models to better understand the underlying mechanisms of male fertility. Rhesus macaques (Macaca mulatta), with their close genetic and physiological similarities to humans, offer an invaluable model for male reproductive health studies. The suitability of rhesus macaques for studying male infertility is based on similarities in spermatogenesis, hormonal cycles and the way in which assisted reproductive technologies can be applied, and key differences and similarities between human and rhesus macaque sperm structure, function and cryopreservation techniques highlight the translational potential of findings derived from macaque models. Furthermore, insights into the epigenetic and proteomic characteristics of sperm in both species improve understanding of how these findings can help to advance clinical diagnostics, male contraception and fertility preservation and illuminate the regulatory omics of normal reproduction. Thus, the rhesus macaque model offers critical insights into male fertility and studies in this species could contribute to advances in therapies for male infertility. (© 2025. Springer Nature Limited.) |
| Competing Interests: | Competing interests: The authors declare no competing interests. |
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| Grant Information: | DP1 DA056493 United States DA NIDA NIH HHS; K22 ES025418 United States ES NIEHS NIH HHS; P51 OD011092 United States OD NIH HHS; R01 OD028223 United States OD NIH HHS |
| Entry Date(s): | Date Created: 20250707 Date Completed: 20251101 Latest Revision: 20260726 |
| Update Code: | 20260726 |
| PubMed Central ID: | PMC12343197 |
| DOI: | 10.1038/s41585-025-01062-2 |
| PMID: | 40624316 |
| Database: | MEDLINE |
| FullText | Text: Availability: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Non-human primates as a translational model for the study of male reproductive health. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AU" term="%22Edenfield+RC%22">Edenfield RC</searchLink>; Division of Reproductive and Developmental Sciences, Oregon National Primate Research Center, Oregon Health & Science University, Beaverton, OR, USA. edenfiel@ohsu.edu.<br /><searchLink fieldCode="AU" term="%22Bash+JC%22">Bash JC</searchLink>; Department of Urology, Oregon Health & Science University, Portland, OR, USA.<br /><searchLink fieldCode="AU" term="%22Shorey-Kendrick+LE%22">Shorey-Kendrick LE</searchLink>; Division of Neuroscience, Oregon National Primate Research Center, Oregon Health & Science University, Beaverton, OR, USA.<br /><searchLink fieldCode="AU" term="%22D'Mello+RJ%22">D'Mello RJ</searchLink>; Division of Reproductive and Developmental Sciences, Oregon National Primate Research Center, Oregon Health & Science University, Beaverton, OR, USA.; Department of Obstetrics and Gynecology, Oregon Health & Science University, Portland, OR, USA.<br /><searchLink fieldCode="AU" term="%22Rice-Stitt+TL%22">Rice-Stitt TL</searchLink>; Department of Pathology, Oregon Health & Science University, Portland, OR, USA.<br /><searchLink fieldCode="AU" term="%22Hagen+OL%22">Hagen OL</searchLink>; Division of Reproductive and Developmental Sciences, Oregon National Primate Research Center, Oregon Health & Science University, Beaverton, OR, USA.<br /><searchLink fieldCode="AU" term="%22Graham+JA%22">Graham JA</searchLink>; Division of Reproductive and Developmental Sciences, Oregon National Primate Research Center, Oregon Health & Science University, Beaverton, OR, USA.<br /><searchLink fieldCode="AU" term="%22Orwig+KE%22">Orwig KE</searchLink>; Department of Obstetrics, Gynecology, and Reproductive Services, Magee-Womens Research Institute, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.<br /><searchLink fieldCode="AU" term="%22Easley+CA%22">Easley CA</searchLink>; Department of Environmental Health Science, University of Georgia College of Public Health, Athens, GA, USA.<br /><searchLink fieldCode="AU" term="%22Hedges+JC%22">Hedges JC</searchLink>; Department of Urology, Oregon Health & Science University, Portland, OR, USA.<br /><searchLink fieldCode="AU" term="%22Hanna+CB%22">Hanna CB</searchLink>; Division of Reproductive and Developmental Sciences, Oregon National Primate Research Center, Oregon Health & Science University, Beaverton, OR, USA.<br /><searchLink fieldCode="AU" term="%22Lo+JO%22">Lo JO</searchLink>; Division of Reproductive and Developmental Sciences, Oregon National Primate Research Center, Oregon Health & Science University, Beaverton, OR, USA.; Department of Urology, Oregon Health & Science University, Portland, OR, USA.; Department of Obstetrics and Gynecology, Oregon Health & Science University, Portland, OR, USA. – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22101500082%22">Nature reviews. Urology</searchLink> [Nat Rev Urol] 2025 Nov; Vol. 22 (11), pp. 756-774. <i>Date of Electronic Publication: </i>2025 Jul 07. – Name: TypePub Label: Publication Type Group: TypPub Data: Journal Article; Review; Research Support, N.I.H., Intramural – Name: Language Label: Language Group: Lang Data: English – Name: TitleSource Label: Journal Info Group: Src Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Nature+Pub%2E+Group%22">Nature Pub. Group </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>101500082 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1759-4820 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2217594812%22">17594812 </searchLink><i>NLM ISO Abbreviation: </i>Nat Rev Urol <i>Subsets: </i>MEDLINE – Name: PublisherInfo Label: Imprint Name(s) Group: PubInfo Data: <i>Original Publication</i>: London : Nature Pub. Group – Name: SubjectMESH Label: MeSH Terms Group: Su Data: <searchLink fieldCode="MM" term="%22Infertility%2C+Male%22">Infertility, Male*</searchLink>/<searchLink fieldCode="MM" term="%22Infertility%2C+Male+therapy%22">therapy</searchLink> <br /><searchLink fieldCode="MM" term="%22Infertility%2C+Male%22">Infertility, Male*</searchLink>/<searchLink fieldCode="MM" term="%22Infertility%2C+Male+physiopathology%22">physiopathology</searchLink> <br /><searchLink fieldCode="MM" term="%22Translational+Research%2C+Biomedical%22">Translational Research, Biomedical*</searchLink>/<searchLink fieldCode="MM" term="%22Translational+Research%2C+Biomedical+methods%22">methods</searchLink> <br /><searchLink fieldCode="MM" term="%22Reproductive+Health%22">Reproductive Health*</searchLink> <br /><searchLink fieldCode="MM" term="%22Models%2C+Animal%22">Models, Animal*</searchLink><br /><searchLink fieldCode="MH" term="%22Spermatogenesis%22">Spermatogenesis</searchLink>/<searchLink fieldCode="MH" term="%22Spermatogenesis+physiology%22">physiology</searchLink> ; <searchLink fieldCode="MH" term="%22Animals%22">Animals</searchLink> ; <searchLink fieldCode="MH" term="%22Male%22">Male</searchLink> ; <searchLink fieldCode="MH" term="%22Macaca+mulatta%22">Macaca mulatta</searchLink> ; <searchLink fieldCode="MH" term="%22Humans%22">Humans</searchLink> ; <searchLink fieldCode="MH" term="%22Disease+Models%2C+Animal%22">Disease Models, Animal</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: Male fertility is complex and influenced by genetic, hormonal, environmental and lifestyle factors. However, limitations to human studies necessitate the use of reliable preclinical models to better understand the underlying mechanisms of male fertility. Rhesus macaques (Macaca mulatta), with their close genetic and physiological similarities to humans, offer an invaluable model for male reproductive health studies. The suitability of rhesus macaques for studying male infertility is based on similarities in spermatogenesis, hormonal cycles and the way in which assisted reproductive technologies can be applied, and key differences and similarities between human and rhesus macaque sperm structure, function and cryopreservation techniques highlight the translational potential of findings derived from macaque models. Furthermore, insights into the epigenetic and proteomic characteristics of sperm in both species improve understanding of how these findings can help to advance clinical diagnostics, male contraception and fertility preservation and illuminate the regulatory omics of normal reproduction. Thus, the rhesus macaque model offers critical insights into male fertility and studies in this species could contribute to advances in therapies for male infertility.<br /> (© 2025. Springer Nature Limited.) – Name: Abstract Label: Competing Interests Group: Ab Data: Competing interests: The authors declare no competing interests. – Name: Ref Label: References Group: RefInfo Data: Andrologia. 2021 Mar;53(2):e13614. (PMID: <searchLink fieldCode="PM" term="%2232400107%22">32400107)</searchLink><br />Front Endocrinol (Lausanne). 2022 May 18;13:889959. (PMID: <searchLink fieldCode="PM" term="%2235663331%22">35663331)</searchLink><br />Am J Hum Biol. 1991;3(6):671-676. 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(PMID: <searchLink fieldCode="PM" term="%2226801756%22">26801756)</searchLink> – Name: GrantInfo Label: Grant Information Group: Grant Data: DP1 DA056493 United States DA NIDA NIH HHS; K22 ES025418 United States ES NIEHS NIH HHS; P51 OD011092 United States OD NIH HHS; R01 OD028223 United States OD NIH HHS – Name: DateEntry Label: Entry Date(s) Group: Date Data: <i>Date Created: </i>20250707 <i>Date Completed: </i>20251101 <i>Latest Revision: </i>20260726 – Name: DateUpdate Label: Update Code Group: Date Data: 20260726 – Name: PubmedCentralID Label: PubMed Central ID Group: ID Data: PMC12343197 – Name: DOI Label: DOI Group: ID Data: 10.1038/s41585-025-01062-2 – Name: AN Label: PMID Group: ID Data: 40624316 |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1038/s41585-025-01062-2 Languages: – Code: eng Text: English PhysicalDescription: Pagination: StartPage: 756 Subjects: – SubjectFull: Spermatogenesis physiology Type: general – SubjectFull: Animals Type: general – SubjectFull: Male Type: general – SubjectFull: Macaca mulatta Type: general – SubjectFull: Humans Type: general – SubjectFull: Disease Models, Animal Type: general – SubjectFull: Infertility, Male therapy Type: general – SubjectFull: Infertility, Male physiopathology Type: general – SubjectFull: Translational Research, Biomedical methods Type: general – SubjectFull: Reproductive Health Type: general – SubjectFull: Models, Animal Type: general Titles: – TitleFull: Non-human primates as a translational model for the study of male reproductive health. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Edenfield RC – PersonEntity: Name: NameFull: Bash JC – PersonEntity: Name: NameFull: Shorey-Kendrick LE – PersonEntity: Name: NameFull: D'Mello RJ – PersonEntity: Name: NameFull: Rice-Stitt TL – PersonEntity: Name: NameFull: Hagen OL – PersonEntity: Name: NameFull: Graham JA – PersonEntity: Name: NameFull: Orwig KE – PersonEntity: Name: NameFull: Easley CA – PersonEntity: Name: NameFull: Hedges JC – PersonEntity: Name: NameFull: Hanna CB – PersonEntity: Name: NameFull: Lo JO IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 11 Text: 2025 Nov Type: published Y: 2025 Identifiers: – Type: issn-electronic Value: 1759-4820 Numbering: – Type: volume Value: 22 – Type: issue Value: 11 Titles: – TitleFull: Nature reviews. Urology Type: main |
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