Academic Journal
Silver diamine fluoride differentially affects dentin and hypomineralized enamel permeabilities.
| Τίτλος: | Silver diamine fluoride differentially affects dentin and hypomineralized enamel permeabilities. |
|---|---|
| Συγγραφείς: | Chou C; Division of Pediatric Dentistry, Department of Orofacial Sciences, School of Dentistry, University of California San Francisco (UCSF), San Francisco, CA 94143, USA., Kang M; Department of Preventive and Restorative Dental Sciences, School of Dentistry, UCSF, San Francisco, CA 94143, USA., Parkinson DY; Advanced Light Source Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA., Sulyanto R; Department of Dentistry, Boston Children's Hospital, Boston, MA 02115, USA., Ho SP; Department of Preventive and Restorative Dental Sciences, School of Dentistry, UCSF, San Francisco, CA 94143, USA; Department of Urology, School of Medicine, UCSF, San Francisco, CA 94143, USA. Electronic address: sunita.ho@ucsf.edu. |
| Πηγή: | Dental materials : official publication of the Academy of Dental Materials [Dent Mater] 2025 Sep; Vol. 41 (9), pp. 1167-1178. Date of Electronic Publication: 2025 Jul 01. |
| Τύπος έκδοσης: | Journal Article |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: Elsevier Science Country of Publication: England NLM ID: 8508040 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-0097 (Electronic) Linking ISSN: 01095641 NLM ISO Abbreviation: Dent Mater Subsets: MEDLINE |
| Imprint Name(s): | Publication: 1998- : Kidlington, Oxford, UK : Elsevier Science Original Publication: Copenhagen : Munksgaard, c1985- |
| Ιατρικοί όροι (MeSH): | Quaternary Ammonium Compounds*/pharmacology , Silver Compounds*/pharmacology , Dentin*/drug effects , Dental Enamel*/drug effects , Dentin Permeability*/drug effects , Cariostatic Agents*/pharmacology , Dental Enamel Permeability*/drug effects, Humans ; X-Ray Microtomography ; Dental Caries ; In Vitro Techniques ; Tooth, Deciduous ; Fluorides, Topical ; Molar |
| Περίληψη: | Objectives: To investigate the physicochemical effect of silver diamine fluoride (SDF) by correlating permeability with mineral density and elemental composition of hypomineralized enamel and carious dentin. Methods: Enamel and dentin from human carious primary teeth with and without SDF treatment in-vivo, and hypomineralized enamel from permanent molars with and without SDF treatment in-vitro were scanned using micro X-ray computed tomography. Spatial maps of biometals (calcium, zinc), phosphorus, and silver were generated using X-ray fluorescence microprobe. Permeabilities were computed using Porous Microstructure Analysis software. Results: The intrinsic permeability of SDF-treated carious dentin was 14.3 % lower than untreated sound dentin (6.39e-15 ± 3.01e-15 m² vs 7.46e-15 ± 1.82e-15 m²; P < 0.0001), while untreated carious dentin was 98.4 % higher (1.48e-14 ± 7.11e-15 m²; P < 0.0001). SDF-treated and untreated transparent dentin showed similar reduced permeabilities (75.6 % and 78.4 % lower than untreated sound dentin, respectively; P = 0.93). Severely hypomineralized enamel showed permeability reaching 108.1 % of adjacent sound dentin (5.71e-15 ± 2.04e-15 m² vs 5.28e-15 ± 1.30e-15 m²; P = 0.1409) and was significantly higher than mildly hypomineralized enamel (1.39e-15 ± 1.04e-15 m²; P < 0.0001). SDF treatment did not significantly impact the permeability of severely hypomineralized enamel (12.4 % reduction; P = 0.07). Principal component regression identified Zn level as a significant effector of tissue permeabilities in carious primary teeth (P < 0.0001). Significance: This study introduces a computational method to measure dental tissue permeability, and demonstrates that SDF significantly reduces permeability in carious dentin but not intact hypomineralized enamel. The study reveals biometal Zn localization can alter dentin and enamel permeabilities, providing new insights into pathobiological mechanisms underlying caries and hypomineralization. (Copyright © 2025 The Authors. Published by Elsevier Inc. All rights reserved.) |
| Competing Interests: | Declaration of Competing Interest None of the authors have conflicts to declare. |
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| Grant Information: | P30 GM124169 United States GM NIGMS NIH HHS; R01 DE022032 United States DE NIDCR NIH HHS |
| Contributed Indexing: | Keywords: Biomineralization; Caries; Hypomineralized enamel; Mineral density; Silver diamine fluoride; Tissue permeability; Zinc |
| Substance Nomenclature: | DDU19UEV1Y (silver diamine fluoride) 0 (Quaternary Ammonium Compounds) 0 (Silver Compounds) 0 (Cariostatic Agents) 0 (Fluorides, Topical) |
| Entry Date(s): | Date Created: 20250702 Date Completed: 20250714 Latest Revision: 20260925 |
| Update Code: | 20260925 |
| PubMed Central ID: | PMC12702468 |
| DOI: | 10.1016/j.dental.2025.06.011 |
| PMID: | 40603236 |
| Βάση Δεδομένων: | MEDLINE |
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