Academic Journal
Silver diamine fluoride differentially affects dentin and hypomineralized enamel permeabilities.
| Τίτλος: | Silver diamine fluoride differentially affects dentin and hypomineralized enamel permeabilities. |
|---|---|
| Συγγραφείς: | Chou C; Division of Pediatric Dentistry, Department of Orofacial Sciences, School of Dentistry, University of California San Francisco (UCSF), San Francisco, CA 94143, USA., Kang M; Department of Preventive and Restorative Dental Sciences, School of Dentistry, UCSF, San Francisco, CA 94143, USA., Parkinson DY; Advanced Light Source Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA., Sulyanto R; Department of Dentistry, Boston Children's Hospital, Boston, MA 02115, USA., Ho SP; Department of Preventive and Restorative Dental Sciences, School of Dentistry, UCSF, San Francisco, CA 94143, USA; Department of Urology, School of Medicine, UCSF, San Francisco, CA 94143, USA. Electronic address: sunita.ho@ucsf.edu. |
| Πηγή: | Dental materials : official publication of the Academy of Dental Materials [Dent Mater] 2025 Sep; Vol. 41 (9), pp. 1167-1178. Date of Electronic Publication: 2025 Jul 01. |
| Τύπος έκδοσης: | Journal Article |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: Elsevier Science Country of Publication: England NLM ID: 8508040 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-0097 (Electronic) Linking ISSN: 01095641 NLM ISO Abbreviation: Dent Mater Subsets: MEDLINE |
| Imprint Name(s): | Publication: 1998- : Kidlington, Oxford, UK : Elsevier Science Original Publication: Copenhagen : Munksgaard, c1985- |
| Ιατρικοί όροι (MeSH): | Quaternary Ammonium Compounds*/pharmacology , Silver Compounds*/pharmacology , Dentin*/drug effects , Dental Enamel*/drug effects , Dentin Permeability*/drug effects , Cariostatic Agents*/pharmacology , Dental Enamel Permeability*/drug effects, Humans ; X-Ray Microtomography ; Dental Caries ; In Vitro Techniques ; Tooth, Deciduous ; Fluorides, Topical ; Molar |
| Περίληψη: | Objectives: To investigate the physicochemical effect of silver diamine fluoride (SDF) by correlating permeability with mineral density and elemental composition of hypomineralized enamel and carious dentin. Methods: Enamel and dentin from human carious primary teeth with and without SDF treatment in-vivo, and hypomineralized enamel from permanent molars with and without SDF treatment in-vitro were scanned using micro X-ray computed tomography. Spatial maps of biometals (calcium, zinc), phosphorus, and silver were generated using X-ray fluorescence microprobe. Permeabilities were computed using Porous Microstructure Analysis software. Results: The intrinsic permeability of SDF-treated carious dentin was 14.3 % lower than untreated sound dentin (6.39e-15 ± 3.01e-15 m² vs 7.46e-15 ± 1.82e-15 m²; P < 0.0001), while untreated carious dentin was 98.4 % higher (1.48e-14 ± 7.11e-15 m²; P < 0.0001). SDF-treated and untreated transparent dentin showed similar reduced permeabilities (75.6 % and 78.4 % lower than untreated sound dentin, respectively; P = 0.93). Severely hypomineralized enamel showed permeability reaching 108.1 % of adjacent sound dentin (5.71e-15 ± 2.04e-15 m² vs 5.28e-15 ± 1.30e-15 m²; P = 0.1409) and was significantly higher than mildly hypomineralized enamel (1.39e-15 ± 1.04e-15 m²; P < 0.0001). SDF treatment did not significantly impact the permeability of severely hypomineralized enamel (12.4 % reduction; P = 0.07). Principal component regression identified Zn level as a significant effector of tissue permeabilities in carious primary teeth (P < 0.0001). Significance: This study introduces a computational method to measure dental tissue permeability, and demonstrates that SDF significantly reduces permeability in carious dentin but not intact hypomineralized enamel. The study reveals biometal Zn localization can alter dentin and enamel permeabilities, providing new insights into pathobiological mechanisms underlying caries and hypomineralization. (Copyright © 2025 The Authors. Published by Elsevier Inc. All rights reserved.) |
| Competing Interests: | Declaration of Competing Interest None of the authors have conflicts to declare. |
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| Grant Information: | P30 GM124169 United States GM NIGMS NIH HHS; R01 DE022032 United States DE NIDCR NIH HHS |
| Contributed Indexing: | Keywords: Biomineralization; Caries; Hypomineralized enamel; Mineral density; Silver diamine fluoride; Tissue permeability; Zinc |
| Substance Nomenclature: | DDU19UEV1Y (silver diamine fluoride) 0 (Quaternary Ammonium Compounds) 0 (Silver Compounds) 0 (Cariostatic Agents) 0 (Fluorides, Topical) |
| Entry Date(s): | Date Created: 20250702 Date Completed: 20250714 Latest Revision: 20260925 |
| Update Code: | 20260925 |
| PubMed Central ID: | PMC12702468 |
| DOI: | 10.1016/j.dental.2025.06.011 |
| PMID: | 40603236 |
| Βάση Δεδομένων: | MEDLINE |
| FullText | Links: – Type: other Url: https://resolver.ebsco.com:443/public/rma-ftfapi/ejs/direct?AccessToken=4F9F9E848C1CAE2BDB75&Show=Object Text: Availability: 0 CustomLinks: – Url: https://www.doi.org/10.1016/j.dental.2025.06.011? Name: ScienceDirect (all content) (s7799221) Category: fullText Text: View record from ScienceDirect MouseOverText: View record from ScienceDirect |
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| Header | DbId: cmedm DbLabel: MEDLINE An: 40603236 AccessLevel: 3 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
| IllustrationInfo | |
| Items | – Name: Title Label: Title Group: Ti Data: Silver diamine fluoride differentially affects dentin and hypomineralized enamel permeabilities. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AU" term="%22Chou+C%22">Chou C</searchLink>; Division of Pediatric Dentistry, Department of Orofacial Sciences, School of Dentistry, University of California San Francisco (UCSF), San Francisco, CA 94143, USA.<br /><searchLink fieldCode="AU" term="%22Kang+M%22">Kang M</searchLink>; Department of Preventive and Restorative Dental Sciences, School of Dentistry, UCSF, San Francisco, CA 94143, USA.<br /><searchLink fieldCode="AU" term="%22Parkinson+DY%22">Parkinson DY</searchLink>; Advanced Light Source Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA.<br /><searchLink fieldCode="AU" term="%22Sulyanto+R%22">Sulyanto R</searchLink>; Department of Dentistry, Boston Children's Hospital, Boston, MA 02115, USA.<br /><searchLink fieldCode="AU" term="%22Ho+SP%22">Ho SP</searchLink>; Department of Preventive and Restorative Dental Sciences, School of Dentistry, UCSF, San Francisco, CA 94143, USA; Department of Urology, School of Medicine, UCSF, San Francisco, CA 94143, USA. Electronic address: sunita.ho@ucsf.edu. – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%228508040%22">Dental materials : official publication of the Academy of Dental Materials</searchLink> [Dent Mater] 2025 Sep; Vol. 41 (9), pp. 1167-1178. <i>Date of Electronic Publication: </i>2025 Jul 01. – Name: TypePub Label: Publication Type Group: TypPub Data: Journal Article – Name: Language Label: Language Group: Lang Data: English – Name: TitleSource Label: Journal Info Group: Src Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Elsevier+Science%22">Elsevier Science </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>8508040 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1879-0097 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2201095641%22">01095641 </searchLink><i>NLM ISO Abbreviation: </i>Dent Mater <i>Subsets: </i>MEDLINE – Name: PublisherInfo Label: Imprint Name(s) Group: PubInfo Data: <i>Publication</i>: 1998- : Kidlington, Oxford, UK : Elsevier Science<br /><i>Original Publication</i>: Copenhagen : Munksgaard, c1985- – Name: SubjectMESH Label: MeSH Terms Group: Su Data: <searchLink fieldCode="MM" term="%22Quaternary+Ammonium+Compounds%22">Quaternary Ammonium Compounds*</searchLink>/<searchLink fieldCode="MM" term="%22Quaternary+Ammonium+Compounds+pharmacology%22">pharmacology</searchLink> <br /><searchLink fieldCode="MM" term="%22Silver+Compounds%22">Silver Compounds*</searchLink>/<searchLink fieldCode="MM" term="%22Silver+Compounds+pharmacology%22">pharmacology</searchLink> <br /><searchLink fieldCode="MM" term="%22Dentin%22">Dentin*</searchLink>/<searchLink fieldCode="MM" term="%22Dentin+drug+effects%22">drug effects</searchLink> <br /><searchLink fieldCode="MM" term="%22Dental+Enamel%22">Dental Enamel*</searchLink>/<searchLink fieldCode="MM" term="%22Dental+Enamel+drug+effects%22">drug effects</searchLink> <br /><searchLink fieldCode="MM" term="%22Dentin+Permeability%22">Dentin Permeability*</searchLink>/<searchLink fieldCode="MM" term="%22Dentin+Permeability+drug+effects%22">drug effects</searchLink> <br /><searchLink fieldCode="MM" term="%22Cariostatic+Agents%22">Cariostatic Agents*</searchLink>/<searchLink fieldCode="MM" term="%22Cariostatic+Agents+pharmacology%22">pharmacology</searchLink> <br /><searchLink fieldCode="MM" term="%22Dental+Enamel+Permeability%22">Dental Enamel Permeability*</searchLink>/<searchLink fieldCode="MM" term="%22Dental+Enamel+Permeability+drug+effects%22">drug effects</searchLink><br /><searchLink fieldCode="MH" term="%22Humans%22">Humans</searchLink> ; <searchLink fieldCode="MH" term="%22X-Ray+Microtomography%22">X-Ray Microtomography</searchLink> ; <searchLink fieldCode="MH" term="%22Dental+Caries%22">Dental Caries</searchLink> ; <searchLink fieldCode="MH" term="%22In+Vitro+Techniques%22">In Vitro Techniques</searchLink> ; <searchLink fieldCode="MH" term="%22Tooth%2C+Deciduous%22">Tooth, Deciduous</searchLink> ; <searchLink fieldCode="MH" term="%22Fluorides%2C+Topical%22">Fluorides, Topical</searchLink> ; <searchLink fieldCode="MH" term="%22Molar%22">Molar</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: Objectives: To investigate the physicochemical effect of silver diamine fluoride (SDF) by correlating permeability with mineral density and elemental composition of hypomineralized enamel and carious dentin.<br />Methods: Enamel and dentin from human carious primary teeth with and without SDF treatment in-vivo, and hypomineralized enamel from permanent molars with and without SDF treatment in-vitro were scanned using micro X-ray computed tomography. Spatial maps of biometals (calcium, zinc), phosphorus, and silver were generated using X-ray fluorescence microprobe. Permeabilities were computed using Porous Microstructure Analysis software.<br />Results: The intrinsic permeability of SDF-treated carious dentin was 14.3 % lower than untreated sound dentin (6.39e-15 ± 3.01e-15 m² vs 7.46e-15 ± 1.82e-15 m²; P &lt; 0.0001), while untreated carious dentin was 98.4 % higher (1.48e-14 ± 7.11e-15 m²; P &lt; 0.0001). SDF-treated and untreated transparent dentin showed similar reduced permeabilities (75.6 % and 78.4 % lower than untreated sound dentin, respectively; P = 0.93). Severely hypomineralized enamel showed permeability reaching 108.1 % of adjacent sound dentin (5.71e-15 ± 2.04e-15 m² vs 5.28e-15 ± 1.30e-15 m²; P = 0.1409) and was significantly higher than mildly hypomineralized enamel (1.39e-15 ± 1.04e-15 m²; P &lt; 0.0001). SDF treatment did not significantly impact the permeability of severely hypomineralized enamel (12.4 % reduction; P = 0.07). Principal component regression identified Zn level as a significant effector of tissue permeabilities in carious primary teeth (P &lt; 0.0001).<br />Significance: This study introduces a computational method to measure dental tissue permeability, and demonstrates that SDF significantly reduces permeability in carious dentin but not intact hypomineralized enamel. The study reveals biometal Zn localization can alter dentin and enamel permeabilities, providing new insights into pathobiological mechanisms underlying caries and hypomineralization.<br /> (Copyright © 2025 The Authors. Published by Elsevier Inc. All rights reserved.) – Name: Abstract Label: Competing Interests Group: Ab Data: Declaration of Competing Interest None of the authors have conflicts to declare. – Name: Ref Label: References Group: RefInfo Data: Acta Odontol Scand. 2010 Jul;68(4):215-22. (PMID: <searchLink fieldCode="PM" term="%2220392131%22">20392131)</searchLink><br />J Mater Sci Mater Med. 2008 Oct;19(10):3187-92. (PMID: <searchLink fieldCode="PM" term="%2218438701%22">18438701)</searchLink><br />Biomedicines. 2022 Dec 01;10(12):. (PMID: <searchLink fieldCode="PM" term="%2236551842%22">36551842)</searchLink><br />Biol Trace Elem Res. 2019 Jan;187(1):51-58. (PMID: <searchLink fieldCode="PM" term="%2229744817%22">29744817)</searchLink><br />J Biomech. 2013 Jan 18;46(2):253-65. (PMID: <searchLink fieldCode="PM" term="%2223174418%22">23174418)</searchLink><br />J Dent. 2013 Sep;41(9):809-17. (PMID: <searchLink fieldCode="PM" term="%2223810851%22">23810851)</searchLink><br />Materials (Basel). 2022 Jun 27;15(13):. (PMID: <searchLink fieldCode="PM" term="%2235806648%22">35806648)</searchLink><br />Br Dent J. 2018 Oct 05;:. (PMID: <searchLink fieldCode="PM" term="%2230287963%22">30287963)</searchLink><br />BMC Oral Health. 2019 Jul 12;19(1):145. (PMID: <searchLink fieldCode="PM" term="%2231299955%22">31299955)</searchLink><br />Dent Clin North Am. 2002 Apr;46(2):211-45, v-vi. (PMID: <searchLink fieldCode="PM" term="%2212014033%22">12014033)</searchLink><br />Caries Res. 2020;54(3):218-225. (PMID: <searchLink fieldCode="PM" term="%2232920559%22">32920559)</searchLink><br />J Dent. 2024 Jun;145:104981. (PMID: <searchLink fieldCode="PM" term="%2238582436%22">38582436)</searchLink><br />Clin Oral Investig. 2023 Mar;27(3):1123-1131. (PMID: <searchLink fieldCode="PM" term="%2236121494%22">36121494)</searchLink><br />ACS Nanosci Au. 2023 Jul 07;3(4):335-346. (PMID: <searchLink fieldCode="PM" term="%2237601921%22">37601921)</searchLink><br />Community Dent Oral Epidemiol. 1997 Feb;25(1):69-75. (PMID: <searchLink fieldCode="PM" term="%229088694%22">9088694)</searchLink><br />J Dent Res. 2003 Feb;82(2):117-22. (PMID: <searchLink fieldCode="PM" term="%2212562884%22">12562884)</searchLink><br />PLoS One. 2015 Apr 09;10(4):e0121611. (PMID: <searchLink fieldCode="PM" term="%2225856386%22">25856386)</searchLink><br />Arch Oral Biol. 1996 Nov;41(11):1065-72. (PMID: <searchLink fieldCode="PM" term="%229068870%22">9068870)</searchLink><br />Clin Oral Investig. 2022 Feb;26(2):2197-2205. (PMID: <searchLink fieldCode="PM" term="%2234743243%22">34743243)</searchLink><br />Pediatr Dent. 1994 Jan-Feb;16(1):29-35. (PMID: <searchLink fieldCode="PM" term="%228015939%22">8015939)</searchLink><br />Pediatr Dent. 2018 Oct 15;40(6):492-517. (PMID: <searchLink fieldCode="PM" term="%2232074924%22">32074924)</searchLink><br />Dent Mater. 2023 Jan;39(1):41-56. (PMID: <searchLink fieldCode="PM" term="%2236460577%22">36460577)</searchLink><br />J Dent. 2013 Jul;41(7):611-8. (PMID: <searchLink fieldCode="PM" term="%2223685033%22">23685033)</searchLink><br />Caries Res. 1999 Jul-Aug;33(4):252-60. (PMID: <searchLink fieldCode="PM" term="%2210343087%22">10343087)</searchLink><br />JADA Found Sci. 2022 Feb 08;1:100004. (PMID: <searchLink fieldCode="PM" term="%2242238656%22">42238656)</searchLink><br />J Dent Res. 2018 Jul;97(7):751-758. (PMID: <searchLink fieldCode="PM" term="%2229768975%22">29768975)</searchLink><br />Sci Rep. 2018 Sep 21;8(1):14157. (PMID: <searchLink fieldCode="PM" term="%2230242165%22">30242165)</searchLink><br />Acta Biomater. 2007 Nov;3(6):865-72. (PMID: <searchLink fieldCode="PM" term="%2217638598%22">17638598)</searchLink><br />Int Dent J. 2018 Apr;68(2):67-76. (PMID: <searchLink fieldCode="PM" term="%2228542863%22">28542863)</searchLink><br />J Dent. 2024 Feb;141:104827. (PMID: <searchLink fieldCode="PM" term="%2238159901%22">38159901)</searchLink><br />Biol Trace Elem Res. 2017 Jan;175(1):112-121. (PMID: <searchLink fieldCode="PM" term="%2227260533%22">27260533)</searchLink><br />BMC Bioinformatics. 2010 Jul 02;11:367. (PMID: <searchLink fieldCode="PM" term="%2220598126%22">20598126)</searchLink><br />J Dent Res. 1983 Jul;62(7):798-802. 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(PMID: <searchLink fieldCode="PM" term="%2239471896%22">39471896)</searchLink> – Name: GrantInfo Label: Grant Information Group: Grant Data: P30 GM124169 United States GM NIGMS NIH HHS; R01 DE022032 United States DE NIDCR NIH HHS – Name: SubjectMinor Label: Contributed Indexing Group: Data: <i>Keywords: </i>Biomineralization; Caries; Hypomineralized enamel; Mineral density; Silver diamine fluoride; Tissue permeability; Zinc – Name: NumberCAS Label: Substance Nomenclature Group: ID Data: DDU19UEV1Y (silver diamine fluoride)<br />0 (Quaternary Ammonium Compounds)<br />0 (Silver Compounds)<br />0 (Cariostatic Agents)<br />0 (Fluorides, Topical) – Name: DateEntry Label: Entry Date(s) Group: Date Data: <i>Date Created: </i>20250702 <i>Date Completed: </i>20250714 <i>Latest Revision: </i>20260925 – Name: DateUpdate Label: Update Code Group: Date Data: 20260925 – Name: PubmedCentralID Label: PubMed Central ID Group: ID Data: PMC12702468 – Name: DOI Label: DOI Group: ID Data: 10.1016/j.dental.2025.06.011 – Name: AN Label: PMID Group: ID Data: 40603236 |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1016/j.dental.2025.06.011 Languages: – Code: eng Text: English PhysicalDescription: Pagination: StartPage: 1167 Subjects: – SubjectFull: Humans Type: general – SubjectFull: X-Ray Microtomography Type: general – SubjectFull: Dental Caries Type: general – SubjectFull: In Vitro Techniques Type: general – SubjectFull: Tooth, Deciduous Type: general – SubjectFull: Fluorides, Topical Type: general – SubjectFull: Molar Type: general – SubjectFull: Quaternary Ammonium Compounds pharmacology Type: general – SubjectFull: Silver Compounds pharmacology Type: general – SubjectFull: Dentin drug effects Type: general – SubjectFull: Dental Enamel drug effects Type: general – SubjectFull: Dentin Permeability drug effects Type: general – SubjectFull: Cariostatic Agents pharmacology Type: general – SubjectFull: Dental Enamel Permeability drug effects Type: general Titles: – TitleFull: Silver diamine fluoride differentially affects dentin and hypomineralized enamel permeabilities. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Chou C – PersonEntity: Name: NameFull: Kang M – PersonEntity: Name: NameFull: Parkinson DY – PersonEntity: Name: NameFull: Sulyanto R – PersonEntity: Name: NameFull: Ho SP IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 09 Text: 2025 Sep Type: published Y: 2025 Identifiers: – Type: issn-electronic Value: 1879-0097 Numbering: – Type: volume Value: 41 – Type: issue Value: 9 Titles: – TitleFull: Dental materials : official publication of the Academy of Dental Materials Type: main |
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