Academic Journal
Childhood trauma affects speech and language measures in patients with major depressive disorder during clinical interviews.
| Τίτλος: | Childhood trauma affects speech and language measures in patients with major depressive disorder during clinical interviews. |
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| Συγγραφείς: | Ettore E; Cobtek (Cognition-Behaviour-Technology), Université Côte d'Azur, Nice, France; Université Côte d'Azur, Centre Hospitalier Universitaire de Nice, Service de Psychiatrie et de Psychologie médicale, Nice, France; Université Côte d'Azur, Centre Hospitalier Universitaire de Nice, Clinique Gériatrique du Cerveau et du Mouvement, Nice, France. Electronic address: ettore.e@chu-nice.fr., Lindsay H; ki:elements GmbH, Saarbrücken, Germany., Tröger J; ki:elements GmbH, Saarbrücken, Germany., Balazia M; INRIA (Institut national de recherche en sciences et technologies du numérique) Sophia Antipolis, France., Benoit M; Cobtek (Cognition-Behaviour-Technology), Université Côte d'Azur, Nice, France; Université Côte d'Azur, Centre Hospitalier Universitaire de Nice, Service de Psychiatrie et de Psychologie médicale, Nice, France., Robert P; Cobtek (Cognition-Behaviour-Technology), Université Côte d'Azur, Nice, France., Postin D; Department of Psychiatry, School of Medicine and Health Sciences, University of Oldenburg, Ammerländer Heerstrasse 114-118, 26129 Oldenburg, Germany., Hurlemann R; Department of Psychiatry, School of Medicine and Health Sciences, University of Oldenburg, Ammerländer Heerstrasse 114-118, 26129 Oldenburg, Germany., König A; Cobtek (Cognition-Behaviour-Technology), Université Côte d'Azur, Nice, France; Université Côte d'Azur, Centre Hospitalier Universitaire de Nice, Clinique Gériatrique du Cerveau et du Mouvement, Nice, France; ki:elements GmbH, Saarbrücken, Germany. |
| Πηγή: | Journal of affective disorders [J Affect Disord] 2025 Nov 01; Vol. 388, pp. 119769. Date of Electronic Publication: 2025 Jun 25. |
| Τύπος έκδοσης: | Journal Article |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: Elsevier/North-Holland Biomedical Press Country of Publication: Netherlands NLM ID: 7906073 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1573-2517 (Electronic) Linking ISSN: 01650327 NLM ISO Abbreviation: J Affect Disord Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: Amsterdam, Elsevier/North-Holland Biomedical Press. |
| Ιατρικοί όροι (MeSH): | Major Depressive Disorder*/psychology , Major Depressive Disorder*/diagnosis , Speech* , Adverse Childhood Experiences*, Humans ; Male ; Female ; Adult ; Middle Aged ; Severity of Illness Index ; Psychiatric Status Rating Scales ; Interview, Psychological |
| Περίληψη: | Background: Speech analysis has shown significant promise as a potential biomarker for depression. However, no studies to date have examined the impact of childhood trauma on speech and language patterns in individuals with depression. This study aims to explore the relationship between vocal characteristics and depressive symptoms, while also assessing how childhood trauma may shape these patterns. Methods: 27 participants with a major depressive episode were included. The severity of depression was assessed using the Montgomery & Asberg Depression Rating Scale (MADRS) and the Beck Depression Inventory II. Childhood trauma was measured using the Childhood Trauma Questionnaire. Speech recordings from the MADRS semi-structured interview and a free clinical interview were analyzed using speaker diarization, automatic speech recognition, and feature extraction. Results: Several acoustics features were significantly associated with depression severity. Correlation analysis revealed that greater depression severity was linked to shorter, less diverse speech, characterized by fewer words, fewer semantic clusters, and reduced articulatory effort. In contrast, childhood trauma was positively associated with distinct speech characteristics. Higher trauma load was associated with richer, longer, and more syntactically complex speech. Additionally, utterances were shorter, with more frequent shifts between semantic clusters, reflecting a more fragmented speech pattern influenced by traumatic load. Conclusion: Our study highlights the influence of childhood trauma on vocal and linguistic characteristics of patients with depression. Automated language analysis offers the possibility to identify biomarkers of traumatic load in patients with depression. This could improve diagnostic accuracy, guide therapeutic management and monitor clinical progress. (Copyright © 2025 The Authors. Published by Elsevier B.V. All rights reserved.) |
| Competing Interests: | Declaration of competing interest The Authors declare no Competing Financial or Non-Financial Interests. |
| Contributed Indexing: | Keywords: Language; Major depressive disorder; Precision psychiatry; Speech; Speech biomarkers; Trauma |
| Entry Date(s): | Date Created: 20250627 Date Completed: 20250719 Latest Revision: 20260127 |
| Update Code: | 20260130 |
| DOI: | 10.1016/j.jad.2025.119769 |
| PMID: | 40578693 |
| Βάση Δεδομένων: | MEDLINE |
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