Academic Journal
Sonosensitizer-doped framework theranostic nanoprobe for enhanced spatiotemporal eradication of helicobacter pylori with photoacoustic imaging guidance.
| Τίτλος: | Sonosensitizer-doped framework theranostic nanoprobe for enhanced spatiotemporal eradication of helicobacter pylori with photoacoustic imaging guidance. |
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| Συγγραφείς: | Zhang Z; Key Laboratory of Luminescence and Real-Time Analytical Chemistry, College of Pharmaceutical Sciences, Ministry of Education, Southwest University, Chongqing 400715, China., Lin J; Key Laboratory of Luminescence and Real-Time Analytical Chemistry, College of Pharmaceutical Sciences, Ministry of Education, Southwest University, Chongqing 400715, China., Dai X; Key Laboratory of Luminescence and Real-Time Analytical Chemistry, College of Pharmaceutical Sciences, Ministry of Education, Southwest University, Chongqing 400715, China., Li X; Key Laboratory of Luminescence and Real-Time Analytical Chemistry, College of Pharmaceutical Sciences, Ministry of Education, Southwest University, Chongqing 400715, China., Huang F; Key Laboratory of Luminescence and Real-Time Analytical Chemistry, College of Pharmaceutical Sciences, Ministry of Education, Southwest University, Chongqing 400715, China., Qin S; Key Laboratory of Luminescence and Real-Time Analytical Chemistry, College of Pharmaceutical Sciences, Ministry of Education, Southwest University, Chongqing 400715, China., Song E; Key Laboratory of Luminescence and Real-Time Analytical Chemistry, College of Pharmaceutical Sciences, Ministry of Education, Southwest University, Chongqing 400715, China. Electronic address: eqsong@swu.edu.cn., Tan W; The Key Laboratory of Zhejiang Province for Nucleic Acids, Hangzhou Institute of Medicine, Zhejiang Cancer Hospital, Chinese Academy of Sciences, Hangzhou, Zhejiang 310022, China. |
| Πηγή: | Acta biomaterialia [Acta Biomater] 2025 Jul 01; Vol. 201, pp. 534-544. Date of Electronic Publication: 2025 Jun 11. |
| Τύπος έκδοσης: | Journal Article |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: Elsevier Country of Publication: England NLM ID: 101233144 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1878-7568 (Electronic) Linking ISSN: 17427061 NLM ISO Abbreviation: Acta Biomater Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: Kidlington, Oxford, UK : Elsevier, c2004- |
| Ιατρικοί όροι (MeSH): | Theranostic Nanomedicine*/methods , Helicobacter pylori*/drug effects , Helicobacter Infections*/diagnostic imaging , Helicobacter Infections*/drug therapy , Helicobacter Infections*/microbiology , Helicobacter Infections*/therapy , Helicobacter Infections*/metabolism , Nanoparticles*/chemistry , Nanoparticles*/therapeutic use , Photoacoustic Techniques*, Hematoporphyrins/chemistry ; Hematoporphyrins/pharmacology ; Urease/metabolism ; Animals ; Mice ; Humans |
| Περίληψη: | Helicobacter pylori (H. pylori) infection is the leading cause of gastric cancer. Current antibiotic-based H. pylori suppression therapy suffers from low efficacy, drug resistance, and intestinal flora imbalance, which makes an accurate, controllable, and safe H. pylori inhibition strategy urgent. Here, we present a theranostic nanoprobe, UPE@ZH, which integrates sonodynamic therapy and urease inactivation guided by photoacoustic imaging. The UPE@ZH nanoprobe consists of a sonosensitizer and photoacoustic agent, hematoporphyrin monomethyl ether (HMME), doped into a zeolitic imidazolate framework (ZIF-8) and coated with the pH-responsive polymer Ureido-PEG2000-modified polyacrylic resin (UPE). When administered orally to H. pylori-infected mice, the UPE@ZH nanoprobe collapses gradually in the acidic environment of H. pylori infection, while HMME and zinc ion release occur, resulting in the synergistic eradication of H. pylori through HMME-based sonodynamic therapy and zinc ion-based urease inactivation, under the guidance of photoacoustic imaging. This approach offers a promising, efficient, and safe treatment strategy for H. pylori infection with minimized risk of side effects. STATEMENT OF SIGNIFICANCE: Helicobacter pylori (H. pylori) infection has emerged as a growing public health threat. The current triple antibiotic therapy suffers from limited therapeutic efficacy and carries inherent risks of drug resistance and intestinal microbiota dysbiosis. To address these challenges, we developed a novel strategy for photoacoustic imaging-guided antibiotic-free therapeutic based on a theranostic nanoprobe composed of sonosensitizer-doped zeolitic-imidazolate framework, achieving spatiotemporal and enhanced eradication for H. pylori safely. This study makes not only an important contribution to the treatment of H. pylori-related infections but also has general interest to researchers in a broad range of fields, including bacterial eradication, drug delivery, and in vivo imaging. (Copyright © 2025. Published by Elsevier Inc.) |
| Competing Interests: | Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. |
| Contributed Indexing: | Keywords: Metal-organic framework; Nanoprobe; Pathogen; Photoacoustic imaging; Sonodynamic therapy |
| Substance Nomenclature: | 0 (Hematoporphyrins) 0 (hematoporphyrin monomethyl ether) EC 3.5.1.5 (Urease) |
| Entry Date(s): | Date Created: 20250612 Date Completed: 20250710 Latest Revision: 20260517 |
| Update Code: | 20260517 |
| DOI: | 10.1016/j.actbio.2025.06.008 |
| PMID: | 40506300 |
| Βάση Δεδομένων: | MEDLINE |
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