Academic Journal
Sea Cucumber Fucoidan Inhibits Helicobacter pylori Gastritis via MAPK/NF-κB Signaling and Gut Microbiota Modulation.
| Τίτλος: | Sea Cucumber Fucoidan Inhibits Helicobacter pylori Gastritis via MAPK/NF-κB Signaling and Gut Microbiota Modulation. |
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| Συγγραφείς: | Cao J; College of Food Science and Engineering, Ocean University of China, Qingdao 266003, China.; Qingdao Key Laboratory of Marine Natural Products Research and Development Laboratory, First Institute of Oceanography, Ministry of Natural Resources, Qingdao 266061, China., Yao M; College of Food Science and Engineering, Ocean University of China, Qingdao 266003, China.; Qingdao Key Laboratory of Marine Natural Products Research and Development Laboratory, First Institute of Oceanography, Ministry of Natural Resources, Qingdao 266061, China., Wang K; Qingdao Key Laboratory of Marine Natural Products Research and Development Laboratory, First Institute of Oceanography, Ministry of Natural Resources, Qingdao 266061, China.; Key Laboratory of Marine Drugs, Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, China., Qin L; Qingdao Key Laboratory of Marine Natural Products Research and Development Laboratory, First Institute of Oceanography, Ministry of Natural Resources, Qingdao 266061, China., Zhang Q; Qingdao Key Laboratory of Marine Natural Products Research and Development Laboratory, First Institute of Oceanography, Ministry of Natural Resources, Qingdao 266061, China., Zhang H; Qingdao Key Laboratory of Marine Natural Products Research and Development Laboratory, First Institute of Oceanography, Ministry of Natural Resources, Qingdao 266061, China., Wei J; Qingdao Key Laboratory of Marine Natural Products Research and Development Laboratory, First Institute of Oceanography, Ministry of Natural Resources, Qingdao 266061, China., Qu C; Qingdao Key Laboratory of Marine Natural Products Research and Development Laboratory, First Institute of Oceanography, Ministry of Natural Resources, Qingdao 266061, China.; Laboratory for Marine Drugs and Bioproducts, Qingdao Marine Science and Technology Center, Qingdao 266237, China., Xue C; College of Food Science and Engineering, Ocean University of China, Qingdao 266003, China., Miao J; College of Food Science and Engineering, Ocean University of China, Qingdao 266003, China.; Qingdao Key Laboratory of Marine Natural Products Research and Development Laboratory, First Institute of Oceanography, Ministry of Natural Resources, Qingdao 266061, China.; Laboratory for Marine Drugs and Bioproducts, Qingdao Marine Science and Technology Center, Qingdao 266237, China. |
| Πηγή: | Journal of agricultural and food chemistry [J Agric Food Chem] 2025 Jun 11; Vol. 73 (23), pp. 14333-14352. Date of Electronic Publication: 2025 May 30. |
| Τύπος έκδοσης: | Journal Article |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: American Chemical Society Country of Publication: United States NLM ID: 0374755 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-5118 (Electronic) Linking ISSN: 00218561 NLM ISO Abbreviation: J Agric Food Chem Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: Washington, American Chemical Society. |
| Ιατρικοί όροι (MeSH): | Sea Cucumbers*/chemistry , Anti-Ulcer Agents*/chemistry , Anti-Ulcer Agents*/isolation & purification , Anti-Ulcer Agents*/pharmacology , Anti-Ulcer Agents*/therapeutic use , Gastritis*/blood , Gastritis*/drug therapy , Gastritis*/microbiology , Helicobacter Infections*/drug therapy , Gastric Mucosa*/drug effects , Gastric Mucosa*/microbiology , Biological Products*/chemistry , Biological Products*/isolation & purification , Biological Products*/pharmacology , Biological Products*/therapeutic use, Helicobacter pylori/drug effects ; Helicobacter pylori/enzymology ; Bacterial Adhesion/drug effects ; Urease/analysis ; Oxidative Stress/drug effects ; MAP Kinase Signaling System/drug effects ; Gastrointestinal Microbiome/drug effects ; Fatty Acids, Volatile/metabolism ; Metabolome/drug effects ; Humans ; Animals ; Male ; Mice ; Mice, Inbred C57BL ; Drug Evaluation, Preclinical ; Polysaccharides |
| Περίληψη: | Antibiotic-based eradication therapy forHelicobacter pylori faces challenges such as the increasing number of antibiotic-resistant strains and gut microbiota dysbiosis. The study evaluated the effects of fucoidan from sea cucumber cooking liquid (Fuc-SC) on Helicobacter pylori Sydney strain SS1 (Hp SS1)-associated gastritis. The backbone structure of Fuc-SC was composed of alternating → 3)-α-L-Fucp-(1 → 4)-α-L-Fucp-(1 → linked fucose residues. The mouse experiments demonstrated that Fuc-SC reduced the colonization of Hp SS1 in the gastric mucosa through decreasing the level of urease, Hp-IgG, and CagA-IgG. In addition, Fuc-SC regulated oxidative stress levels by reducing NO, MDA, and ROS levels, while increasing the activity of SOD and GSH-Px. Compared to antibiotic treatment alone, the combination of Fuc-SC with antibiotics further enhanced the antioxidant effects. Molecular mechanisms indicated that Fuc-SC regulated the MAPK/NF-κB signaling pathway, downregulating the expression of inflammatory factors such as IL-1β and TNF-α and further modulating the expression of S100A8 and E-cadherin. Gut microbiota analysis indicated that Fuc-SC reversed the depletion of Lactobacillus caused by antibiotic treatment. Additionally, Fuc-SC significantly promoted the biosynthesis of microbial metabolites such as butyric acid, isobutyric acid, hexanoic acid, and phospholipids, thereby alleviating inflammation. These findings highlight its potential as a sustainable, nonantibiotic therapy for Helicobacter pylori-associated gastritis. |
| Contributed Indexing: | Keywords: Helicobacter pylori; cooking liquid; fucoidan; gastritis; sea cucumber |
| Substance Nomenclature: | 9072-19-9 (fucoidan) 0 (Anti-Ulcer Agents) EC 3.5.1.5 (Urease) 0 (Fatty Acids, Volatile) 0 (Biological Products) 0 (Polysaccharides) |
| Entry Date(s): | Date Created: 20250530 Date Completed: 20250709 Latest Revision: 20260127 |
| Update Code: | 20260130 |
| DOI: | 10.1021/acs.jafc.5c02190 |
| PMID: | 40444701 |
| Βάση Δεδομένων: | MEDLINE |
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