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Complementarity and integration of animal and in vitro non-animal pre-clinical model systems- an Australian perspective.

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Τίτλος: Complementarity and integration of animal and in vitro non-animal pre-clinical model systems- an Australian perspective.
Συγγραφείς: Arkell RM; John Curtin School of Medical Research, Australian National University, Canberra, ACT, Australia., Wolvetang EJ; Australian Institute for Bioengineering and Nanotechnology, The University of Queensland,, St Lucia, QLD, Australia., Gulati T; Victorian Centre for Functional Genomics, Peter MacCallum Cancer Centre, Melbourne, VIC, Australia.; The Sir Peter MacCallum Department of Oncology, University of Melbourne, Parkville, VIC, Australia., Hennessy JE; Phenomics Australia, John Curtin School of Medical Research, Australian National University, Canberra, ACT, Australia., Hill AP; Victor Chang Cardiac Research Institute, Sydney, NSW, Australia.; School of Clinical Medicine, Faculty of Medicine and Health, University of New South Wales, Sydney, NSW, Australia., Jardé T; Department of Anatomy and Developmental Biology, Monash University, Clayton, VIC, 3800, Australia.; Cancer Program, Monash Biomedicine Discovery Institute, Monash University, Clayton, VIC, 3800, Australia., Kueh AJ; Olivia Newton-John Cancer Research Institute, Heidelberg, Melbourne, VIC, Australia.; School of Cancer Medicine, La Trobe University, Bundoora, Melbourne, VIC, Australia., Thomas PQ; School of Biomedicine, University of Adelaide, Adelaide, South Australia, 5005, Australia.; Genome Editing Program, South Australian Health and Medical Research Institute, Adelaide, South Australia, 5000, Australia., Winteringham LN; Harry Perkins Institute of Medical Research, and Centre for Medical Research, The University of Western Australia, Perth, WA, Australia., Dobbie MS; Phenomics Australia, John Curtin School of Medical Research, Australian National University, Canberra, ACT, Australia. michael.dobbie@anu.edu.au.
Πηγή: Mammalian genome : official journal of the International Mammalian Genome Society [Mamm Genome] 2025 Jun; Vol. 36 (2), pp. 482-487. Date of Electronic Publication: 2025 May 06.
Τύπος έκδοσης: Letter; Research Support, Non-U.S. Gov't
Γλώσσα: English
Στοιχεία περιοδικού: Publisher: Springer-Verlag Country of Publication: United States NLM ID: 9100916 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1432-1777 (Electronic) Linking ISSN: 09388990 NLM ISO Abbreviation: Mamm Genome Subsets: MEDLINE
Imprint Name(s): Publication: New York, NY : Springer-Verlag
Original Publication: New York, NY, USA : Springer International, c1991-
Ιατρικοί όροι (MeSH): Models, Animal*, Animals ; Humans ; Australia ; Disease Models, Animal ; Organoids
Περίληψη: Recent advances in the development of pre-clinical models based on non-animal technologies (NATs) have stimulated expectations that the use of animals in research may soon be phased out. The true value of innovations in NATs and their applications lies, however, in enabling an expanded and integrated portfolio of complementary animal and non-animal model systems to improve the accuracy and efficiency of pre-clinical research and therapeutic development. The term NATs covers a range of techniques spanning in silico, cell free, organ-on-chip as well as in vitro techniques including three-dimensional cell culture models termed organoids. Of these, in vitro systems are currently the most broadly used in biomedicine laboratories and are the first NATs for which Australia has invested in nationwide support. The focus of this commentary is the importance of understanding the strengths and limitations of in vitro and animal models such that an integrated portfolio of complementary genetic models continues to evolve to best support pre-clinical research and therapeutic development pipelines.
(© 2025. The Author(s).)
Competing Interests: Declarations. Competing interests: The authors declare no competing interests.
References: Ann Med. 2022 Dec;54(1):2581-2597. (PMID: 36194178)
Sci Transl Med. 2019 Oct 9;11(513):. (PMID: 31597751)
Nat Rev Mol Cell Biol. 2020 Oct;21(10):571-584. (PMID: 32636524)
Biofabrication. 2024 May 15;16(3):. (PMID: 38697093)
Gastroenterol Rep (Oxf). 2018 Nov;6(4):243-245. (PMID: 30430011)
Nat Commun. 2023 Apr 18;14(1):2214. (PMID: 37072390)
Artif Organs. 2023 Mar;47(3):449-450. (PMID: 36762462)
Contributed Indexing: Keywords: Non-animal technologies; Organoids; Pre-clinical models
Entry Date(s): Date Created: 20250506 Date Completed: 20250603 Latest Revision: 20260507
Update Code: 20260507
PubMed Central ID: PMC12130077
DOI: 10.1007/s00335-025-10132-0
PMID: 40329001
Βάση Δεδομένων: MEDLINE
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  – Url: https://dx.doi.org/doi:10.1007/s00335-025-10132-0
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  Data: Complementarity and integration of animal and in vitro non-animal pre-clinical model systems- an Australian perspective.
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  Data: <searchLink fieldCode="AU" term="%22Arkell+RM%22">Arkell RM</searchLink>; John Curtin School of Medical Research, Australian National University, Canberra, ACT, Australia.<br /><searchLink fieldCode="AU" term="%22Wolvetang+EJ%22">Wolvetang EJ</searchLink>; Australian Institute for Bioengineering and Nanotechnology, The University of Queensland,, St Lucia, QLD, Australia.<br /><searchLink fieldCode="AU" term="%22Gulati+T%22">Gulati T</searchLink>; Victorian Centre for Functional Genomics, Peter MacCallum Cancer Centre, Melbourne, VIC, Australia.; The Sir Peter MacCallum Department of Oncology, University of Melbourne, Parkville, VIC, Australia.<br /><searchLink fieldCode="AU" term="%22Hennessy+JE%22">Hennessy JE</searchLink>; Phenomics Australia, John Curtin School of Medical Research, Australian National University, Canberra, ACT, Australia.<br /><searchLink fieldCode="AU" term="%22Hill+AP%22">Hill AP</searchLink>; Victor Chang Cardiac Research Institute, Sydney, NSW, Australia.; School of Clinical Medicine, Faculty of Medicine and Health, University of New South Wales, Sydney, NSW, Australia.<br /><searchLink fieldCode="AU" term="%22Jardé+T%22">Jardé T</searchLink>; Department of Anatomy and Developmental Biology, Monash University, Clayton, VIC, 3800, Australia.; Cancer Program, Monash Biomedicine Discovery Institute, Monash University, Clayton, VIC, 3800, Australia.<br /><searchLink fieldCode="AU" term="%22Kueh+AJ%22">Kueh AJ</searchLink>; Olivia Newton-John Cancer Research Institute, Heidelberg, Melbourne, VIC, Australia.; School of Cancer Medicine, La Trobe University, Bundoora, Melbourne, VIC, Australia.<br /><searchLink fieldCode="AU" term="%22Thomas+PQ%22">Thomas PQ</searchLink>; School of Biomedicine, University of Adelaide, Adelaide, South Australia, 5005, Australia.; Genome Editing Program, South Australian Health and Medical Research Institute, Adelaide, South Australia, 5000, Australia.<br /><searchLink fieldCode="AU" term="%22Winteringham+LN%22">Winteringham LN</searchLink>; Harry Perkins Institute of Medical Research, and Centre for Medical Research, The University of Western Australia, Perth, WA, Australia.<br /><searchLink fieldCode="AU" term="%22Dobbie+MS%22">Dobbie MS</searchLink>; Phenomics Australia, John Curtin School of Medical Research, Australian National University, Canberra, ACT, Australia. michael.dobbie@anu.edu.au.
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  Data: <searchLink fieldCode="JN" term="%229100916%22">Mammalian genome : official journal of the International Mammalian Genome Society</searchLink> [Mamm Genome] 2025 Jun; Vol. 36 (2), pp. 482-487. <i>Date of Electronic Publication: </i>2025 May 06.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Springer-Verlag%22">Springer-Verlag </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>9100916 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1432-1777 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2209388990%22">09388990 </searchLink><i>NLM ISO Abbreviation: </i>Mamm Genome <i>Subsets: </i>MEDLINE
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  Data: Recent advances in the development of pre-clinical models based on non-animal technologies (NATs) have stimulated expectations that the use of animals in research may soon be phased out. The true value of innovations in NATs and their applications lies, however, in enabling an expanded and integrated portfolio of complementary animal and non-animal model systems to improve the accuracy and efficiency of pre-clinical research and therapeutic development. The term NATs covers a range of techniques spanning in silico, cell free, organ-on-chip as well as in vitro techniques including three-dimensional cell culture models termed organoids. Of these, in vitro systems are currently the most broadly used in biomedicine laboratories and are the first NATs for which Australia has invested in nationwide support. The focus of this commentary is the importance of understanding the strengths and limitations of in vitro and animal models such that an integrated portfolio of complementary genetic models continues to evolve to best support pre-clinical research and therapeutic development pipelines.<br /> (© 2025. The Author(s).)
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  Label: Competing Interests
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  Data: Declarations. Competing interests: The authors declare no competing interests.
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  Data: Ann Med. 2022 Dec;54(1):2581-2597. (PMID: <searchLink fieldCode="PM" term="%2236194178%22">36194178)</searchLink><br />Sci Transl Med. 2019 Oct 9;11(513):. (PMID: <searchLink fieldCode="PM" term="%2231597751%22">31597751)</searchLink><br />Nat Rev Mol Cell Biol. 2020 Oct;21(10):571-584. (PMID: <searchLink fieldCode="PM" term="%2232636524%22">32636524)</searchLink><br />Biofabrication. 2024 May 15;16(3):. (PMID: <searchLink fieldCode="PM" term="%2238697093%22">38697093)</searchLink><br />Gastroenterol Rep (Oxf). 2018 Nov;6(4):243-245. (PMID: <searchLink fieldCode="PM" term="%2230430011%22">30430011)</searchLink><br />Nat Commun. 2023 Apr 18;14(1):2214. (PMID: <searchLink fieldCode="PM" term="%2237072390%22">37072390)</searchLink><br />Artif Organs. 2023 Mar;47(3):449-450. (PMID: <searchLink fieldCode="PM" term="%2236762462%22">36762462)</searchLink>
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