Academic Journal
Translational Biomedical Research: Challenges and Solutions of Using Animal Models.
| Τίτλος: | Translational Biomedical Research: Challenges and Solutions of Using Animal Models. |
|---|---|
| Συγγραφείς: | Akhund SA; Department of Medical Education and Anatomy and Genetics, College of Medicine Alfaisal University, Riyadh, Kingdom of Saudi Arabia. |
| Πηγή: | Journal of the College of Physicians and Surgeons--Pakistan : JCPSP [J Coll Physicians Surg Pak] 2025 May; Vol. 35 (5), pp. 661-664. |
| Τύπος έκδοσης: | Journal Article |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: College of Physicians and Surgeons Pakistan Country of Publication: Pakistan NLM ID: 9606447 Publication Model: Print Cited Medium: Internet ISSN: 1681-7168 (Electronic) Linking ISSN: 1022386X NLM ISO Abbreviation: J Coll Physicians Surg Pak Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: Karachi : College of Physicians and Surgeons Pakistan |
| Ιατρικοί όροι (MeSH): | Animal Experimentation*/ethics , Translational Research, Biomedical*/ethics , Translational Research, Biomedical*/methods , Models, Animal*, Animals ; Humans ; Disease Models, Animal ; Reproducibility of Results |
| Περίληψη: | In translational research, utilisation of laboratory animal models contributes significantly to the understanding of human diseases, diagnostics, and therapeutics. Due to their genetic, anatomical, and physiological similarities to humans, their use allows for in vivo studies to assess the safety, efficacy, and side effects of potential treatments before human trials. However, the relevance is often challenged by significant physiological and genetic differences between species. Additionally, ethical concerns regarding the use of animals' research and variability and reproducibility issues also arise due to differences in strains, breeding practices, and housing conditions, complicating the consistency and reliability of experimental outcomes. To address these challenges, researchers are exploring alternative approaches such as in vitro models, organoids, and computational simulations, which offer promising and ethical substitutes for animal models. Despite these developments, animal models remain indispensable for certain investigations due to their ability to replicate complex biological processes and disease mechanisms. Collaborative efforts to standardise protocols and promote data sharing are essential to improve the reproducibility and translational value of animal research. Key Words: Animal models, Translational research, Challenges in translational research, Alternative to animal models. |
| Entry Date(s): | Date Created: 20250506 Date Completed: 20250506 Latest Revision: 20250509 |
| Update Code: | 20260130 |
| DOI: | 10.29271/jcpsp.2025.05.661 |
| PMID: | 40325588 |
| Βάση Δεδομένων: | MEDLINE |
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