Academic Journal
View in EDS

Translational Biomedical Research: Challenges and Solutions of Using Animal Models.

Bibliographic Details
Title: Translational Biomedical Research: Challenges and Solutions of Using Animal Models.
Authors: Akhund SA; Department of Medical Education and Anatomy and Genetics, College of Medicine Alfaisal University, Riyadh, Kingdom of Saudi Arabia.
Source: Journal of the College of Physicians and Surgeons--Pakistan : JCPSP [J Coll Physicians Surg Pak] 2025 May; Vol. 35 (5), pp. 661-664.
Publication Type: Journal Article
Language: English
Journal Info: Publisher: College of Physicians and Surgeons Pakistan Country of Publication: Pakistan NLM ID: 9606447 Publication Model: Print Cited Medium: Internet ISSN: 1681-7168 (Electronic) Linking ISSN: 1022386X NLM ISO Abbreviation: J Coll Physicians Surg Pak Subsets: MEDLINE
Imprint Name(s): Original Publication: Karachi : College of Physicians and Surgeons Pakistan
MeSH Terms: Animal Experimentation*/ethics , Translational Research, Biomedical*/ethics , Translational Research, Biomedical*/methods , Models, Animal*, Animals ; Humans ; Disease Models, Animal ; Reproducibility of Results
Abstract: In translational research, utilisation of laboratory animal models contributes significantly to the understanding of human diseases, diagnostics, and therapeutics. Due to their genetic, anatomical, and physiological similarities to humans, their use allows for in vivo studies to assess the safety, efficacy, and side effects of potential treatments before human trials. However, the relevance is often challenged by significant physiological and genetic differences between species. Additionally, ethical concerns regarding the use of animals' research and variability and reproducibility issues also arise due to differences in strains, breeding practices, and housing conditions, complicating the consistency and reliability of experimental outcomes. To address these challenges, researchers are exploring alternative approaches such as in vitro models, organoids, and computational simulations, which offer promising and ethical substitutes for animal models. Despite these developments, animal models remain indispensable for certain investigations due to their ability to replicate complex biological processes and disease mechanisms. Collaborative efforts to standardise protocols and promote data sharing are essential to improve the reproducibility and translational value of animal research. Key Words: Animal models, Translational research, Challenges in translational research, Alternative to animal models.
Entry Date(s): Date Created: 20250506 Date Completed: 20250506 Latest Revision: 20250509
Update Code: 20260130
DOI: 10.29271/jcpsp.2025.05.661
PMID: 40325588
Database: MEDLINE
FullText Text:
  Availability: 0
Header DbId: cmedm
DbLabel: MEDLINE
An: 40325588
AccessLevel: 3
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: Translational Biomedical Research: Challenges and Solutions of Using Animal Models.
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AU" term="%22Akhund+SA%22">Akhund SA</searchLink>; Department of Medical Education and Anatomy and Genetics, College of Medicine Alfaisal University, Riyadh, Kingdom of Saudi Arabia.
– Name: TitleSource
  Label: Source
  Group: Src
  Data: <searchLink fieldCode="JN" term="%229606447%22">Journal of the College of Physicians and Surgeons--Pakistan : JCPSP</searchLink> [J Coll Physicians Surg Pak] 2025 May; Vol. 35 (5), pp. 661-664.
– Name: TypePub
  Label: Publication Type
  Group: TypPub
  Data: Journal Article
– Name: Language
  Label: Language
  Group: Lang
  Data: English
– Name: TitleSource
  Label: Journal Info
  Group: Src
  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22College+of+Physicians+and+Surgeons+Pakistan%22">College of Physicians and Surgeons Pakistan </searchLink><i>Country of Publication: </i>Pakistan <i>NLM ID: </i>9606447 <i>Publication Model: </i>Print <i>Cited Medium: </i>Internet <i>ISSN: </i>1681-7168 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%221022386X%22">1022386X </searchLink><i>NLM ISO Abbreviation: </i>J Coll Physicians Surg Pak <i>Subsets: </i>MEDLINE
– Name: PublisherInfo
  Label: Imprint Name(s)
  Group: PubInfo
  Data: <i>Original Publication</i>: Karachi : College of Physicians and Surgeons Pakistan
– Name: SubjectMESH
  Label: MeSH Terms
  Group: Su
  Data: <searchLink fieldCode="MM" term="%22Animal+Experimentation%22">Animal Experimentation*</searchLink>/<searchLink fieldCode="MM" term="%22Animal+Experimentation+ethics%22">ethics</searchLink> <br /><searchLink fieldCode="MM" term="%22Translational+Research%2C+Biomedical%22">Translational Research, Biomedical*</searchLink>/<searchLink fieldCode="MM" term="%22Translational+Research%2C+Biomedical+ethics%22">ethics</searchLink> <br /><searchLink fieldCode="MM" term="%22Translational+Research%2C+Biomedical%22">Translational Research, Biomedical*</searchLink>/<searchLink fieldCode="MM" term="%22Translational+Research%2C+Biomedical+methods%22">methods</searchLink> <br /><searchLink fieldCode="MM" term="%22Models%2C+Animal%22">Models, Animal*</searchLink><br /><searchLink fieldCode="MH" term="%22Animals%22">Animals</searchLink> ; <searchLink fieldCode="MH" term="%22Humans%22">Humans</searchLink> ; <searchLink fieldCode="MH" term="%22Disease+Models%2C+Animal%22">Disease Models, Animal</searchLink> ; <searchLink fieldCode="MH" term="%22Reproducibility+of+Results%22">Reproducibility of Results</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: In translational research, utilisation of laboratory animal models contributes significantly to the understanding of human diseases, diagnostics, and therapeutics. Due to their genetic, anatomical, and physiological similarities to humans, their use allows for in vivo studies to assess the safety, efficacy, and side effects of potential treatments before human trials. However, the relevance is often challenged by significant physiological and genetic differences between species. Additionally, ethical concerns regarding the use of animals' research and variability and reproducibility issues also arise due to differences in strains, breeding practices, and housing conditions, complicating the consistency and reliability of experimental outcomes. To address these challenges, researchers are exploring alternative approaches such as in vitro models, organoids, and computational simulations, which offer promising and ethical substitutes for animal models. Despite these developments, animal models remain indispensable for certain investigations due to their ability to replicate complex biological processes and disease mechanisms. Collaborative efforts to standardise protocols and promote data sharing are essential to improve the reproducibility and translational value of animal research. Key Words: Animal models, Translational research, Challenges in translational research, Alternative to animal models.
– Name: DateEntry
  Label: Entry Date(s)
  Group: Date
  Data: <i>Date Created: </i>20250506 <i>Date Completed: </i>20250506 <i>Latest Revision: </i>20250509
– Name: DateUpdate
  Label: Update Code
  Group: Date
  Data: 20260130
– Name: DOI
  Label: DOI
  Group: ID
  Data: 10.29271/jcpsp.2025.05.661
– Name: AN
  Label: PMID
  Group: ID
  Data: 40325588
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=cmedm&AN=40325588
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.29271/jcpsp.2025.05.661
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        StartPage: 661
    Subjects:
      – SubjectFull: Animals
        Type: general
      – SubjectFull: Humans
        Type: general
      – SubjectFull: Disease Models, Animal
        Type: general
      – SubjectFull: Reproducibility of Results
        Type: general
      – SubjectFull: Animal Experimentation ethics
        Type: general
      – SubjectFull: Translational Research, Biomedical ethics
        Type: general
      – SubjectFull: Translational Research, Biomedical methods
        Type: general
      – SubjectFull: Models, Animal
        Type: general
    Titles:
      – TitleFull: Translational Biomedical Research: Challenges and Solutions of Using Animal Models.
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: Akhund SA
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 01
              M: 05
              Text: 2025 May
              Type: published
              Y: 2025
          Identifiers:
            – Type: issn-electronic
              Value: 1681-7168
          Numbering:
            – Type: volume
              Value: 35
            – Type: issue
              Value: 5
          Titles:
            – TitleFull: Journal of the College of Physicians and Surgeons--Pakistan : JCPSP
              Type: main
ResultId 1