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A new seco-iridoid glycoside from fruits of Cornus officinalis Sieb. et Zucc and their neuroprotective activities.

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Τίτλος: A new seco-iridoid glycoside from fruits of Cornus officinalis Sieb. et Zucc and their neuroprotective activities.
Συγγραφείς: Yang M; School of Pharmacy, Henan University of Chinese Medicine, Zhengzhou, Henan, China.; The Engineering and Technology Center for Chinese Medicine Development of Henan Province China, Zhengzhou, Henan, China., Hao ZY; School of Pharmacy, Henan University of Chinese Medicine, Zhengzhou, Henan, China.; The Engineering and Technology Center for Chinese Medicine Development of Henan Province China, Zhengzhou, Henan, China., Wang XL; The Engineering and Technology Center for Chinese Medicine Development of Henan Province China, Zhengzhou, Henan, China.; Academy of Chinese Medical Sciences, Henan University of Chinese Medicine, Zhengzhou, Henan, China., Zhou SQ; School of Pharmacy, Henan University of Chinese Medicine, Zhengzhou, Henan, China.; The Engineering and Technology Center for Chinese Medicine Development of Henan Province China, Zhengzhou, Henan, China., Xiao CY; School of Pharmacy, Henan University of Chinese Medicine, Zhengzhou, Henan, China.; The Engineering and Technology Center for Chinese Medicine Development of Henan Province China, Zhengzhou, Henan, China., Zheng XK; School of Pharmacy, Henan University of Chinese Medicine, Zhengzhou, Henan, China.; The Engineering and Technology Center for Chinese Medicine Development of Henan Province China, Zhengzhou, Henan, China., Feng WS; School of Pharmacy, Henan University of Chinese Medicine, Zhengzhou, Henan, China.; The Engineering and Technology Center for Chinese Medicine Development of Henan Province China, Zhengzhou, Henan, China.
Πηγή: Natural product research [Nat Prod Res] 2026 Jul; Vol. 40 (13), pp. 3772-3782. Date of Electronic Publication: 2025 Apr 15.
Τύπος έκδοσης: Journal Article
Γλώσσα: English
Στοιχεία περιοδικού: Publisher: Taylor & Francis Health Sciences Country of Publication: England NLM ID: 101167924 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1478-6427 (Electronic) Linking ISSN: 14786419 NLM ISO Abbreviation: Nat Prod Res Subsets: MEDLINE
Imprint Name(s): Original Publication: Milton Park, UK : Taylor & Francis Health Sciences, c2003-
Ιατρικοί όροι (MeSH): Cornus*/chemistry , Neuroprotective Agents*/chemistry , Neuroprotective Agents*/pharmacology , Neuroprotective Agents*/isolation & purification , Iridoid Glycosides*/chemistry , Iridoid Glycosides*/isolation & purification , Iridoid Glycosides*/pharmacology, Fruit/chemistry ; Apoptosis/drug effects ; Molecular Structure ; Animals
Περίληψη: A new seco-iridoid glycoside, named neocornuside I (1), together with seven previously reported compounds (2-8) were isolated from fruits of Cornus officinalis Sieb. et Zucc. Their structures were determined by extensive analysis of HRESIMS, IR, UV, 1D and 2D NMR spectral data. The isolated compounds (1-8) were evaluated for their in vitro neuroprotective activities. Based on flow cytometry results, compound 1 was found to alleviate apoptosis and G2/M phase arrest, indicating its considerable neuroprotective effects.
Contributed Indexing: Keywords: Cornus officinalis; iridoid glycosides; neuroprotective activity
Substance Nomenclature: 0 (Neuroprotective Agents)
0 (Iridoid Glycosides)
Entry Date(s): Date Created: 20250415 Date Completed: 20260630 Latest Revision: 20260630
Update Code: 20260630
DOI: 10.1080/14786419.2025.2479254
PMID: 40233249
Βάση Δεδομένων: MEDLINE
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  Data: A new seco-iridoid glycoside from fruits of Cornus officinalis Sieb. et Zucc and their neuroprotective activities.
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  Data: <searchLink fieldCode="AU" term="%22Yang+M%22">Yang M</searchLink>; School of Pharmacy, Henan University of Chinese Medicine, Zhengzhou, Henan, China.; The Engineering and Technology Center for Chinese Medicine Development of Henan Province China, Zhengzhou, Henan, China.<br /><searchLink fieldCode="AU" term="%22Hao+ZY%22">Hao ZY</searchLink>; School of Pharmacy, Henan University of Chinese Medicine, Zhengzhou, Henan, China.; The Engineering and Technology Center for Chinese Medicine Development of Henan Province China, Zhengzhou, Henan, China.<br /><searchLink fieldCode="AU" term="%22Wang+XL%22">Wang XL</searchLink>; The Engineering and Technology Center for Chinese Medicine Development of Henan Province China, Zhengzhou, Henan, China.; Academy of Chinese Medical Sciences, Henan University of Chinese Medicine, Zhengzhou, Henan, China.<br /><searchLink fieldCode="AU" term="%22Zhou+SQ%22">Zhou SQ</searchLink>; School of Pharmacy, Henan University of Chinese Medicine, Zhengzhou, Henan, China.; The Engineering and Technology Center for Chinese Medicine Development of Henan Province China, Zhengzhou, Henan, China.<br /><searchLink fieldCode="AU" term="%22Xiao+CY%22">Xiao CY</searchLink>; School of Pharmacy, Henan University of Chinese Medicine, Zhengzhou, Henan, China.; The Engineering and Technology Center for Chinese Medicine Development of Henan Province China, Zhengzhou, Henan, China.<br /><searchLink fieldCode="AU" term="%22Zheng+XK%22">Zheng XK</searchLink>; School of Pharmacy, Henan University of Chinese Medicine, Zhengzhou, Henan, China.; The Engineering and Technology Center for Chinese Medicine Development of Henan Province China, Zhengzhou, Henan, China.<br /><searchLink fieldCode="AU" term="%22Feng+WS%22">Feng WS</searchLink>; School of Pharmacy, Henan University of Chinese Medicine, Zhengzhou, Henan, China.; The Engineering and Technology Center for Chinese Medicine Development of Henan Province China, Zhengzhou, Henan, China.
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  Data: <searchLink fieldCode="JN" term="%22101167924%22">Natural product research</searchLink> [Nat Prod Res] 2026 Jul; Vol. 40 (13), pp. 3772-3782. <i>Date of Electronic Publication: </i>2025 Apr 15.
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  Data: <searchLink fieldCode="MM" term="%22Cornus%22">Cornus*</searchLink>/<searchLink fieldCode="MM" term="%22Cornus+chemistry%22">chemistry</searchLink> <br /><searchLink fieldCode="MM" term="%22Neuroprotective+Agents%22">Neuroprotective Agents*</searchLink>/<searchLink fieldCode="MM" term="%22Neuroprotective+Agents+chemistry%22">chemistry</searchLink> <br /><searchLink fieldCode="MM" term="%22Neuroprotective+Agents%22">Neuroprotective Agents*</searchLink>/<searchLink fieldCode="MM" term="%22Neuroprotective+Agents+pharmacology%22">pharmacology</searchLink> <br /><searchLink fieldCode="MM" term="%22Neuroprotective+Agents%22">Neuroprotective Agents*</searchLink>/<searchLink fieldCode="MM" term="%22Neuroprotective+Agents+isolation+%26+purification%22">isolation & purification</searchLink> <br /><searchLink fieldCode="MM" term="%22Iridoid+Glycosides%22">Iridoid Glycosides*</searchLink>/<searchLink fieldCode="MM" term="%22Iridoid+Glycosides+chemistry%22">chemistry</searchLink> <br /><searchLink fieldCode="MM" term="%22Iridoid+Glycosides%22">Iridoid Glycosides*</searchLink>/<searchLink fieldCode="MM" term="%22Iridoid+Glycosides+isolation+%26+purification%22">isolation & purification</searchLink> <br /><searchLink fieldCode="MM" term="%22Iridoid+Glycosides%22">Iridoid Glycosides*</searchLink>/<searchLink fieldCode="MM" term="%22Iridoid+Glycosides+pharmacology%22">pharmacology</searchLink><br /><searchLink fieldCode="MH" term="%22Fruit%22">Fruit</searchLink>/<searchLink fieldCode="MH" term="%22Fruit+chemistry%22">chemistry</searchLink> ; <searchLink fieldCode="MH" term="%22Apoptosis%22">Apoptosis</searchLink>/<searchLink fieldCode="MH" term="%22Apoptosis+drug+effects%22">drug effects</searchLink> ; <searchLink fieldCode="MH" term="%22Molecular+Structure%22">Molecular Structure</searchLink> ; <searchLink fieldCode="MH" term="%22Animals%22">Animals</searchLink>
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  Data: A new seco-iridoid glycoside, named neocornuside I (1), together with seven previously reported compounds (2-8) were isolated from fruits of Cornus officinalis Sieb. et Zucc. Their structures were determined by extensive analysis of HRESIMS, IR, UV, 1D and 2D NMR spectral data. The isolated compounds (1-8) were evaluated for their in vitro neuroprotective activities. Based on flow cytometry results, compound 1 was found to alleviate apoptosis and G2/M phase arrest, indicating its considerable neuroprotective effects.
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  Data: <i>Keywords: </i>Cornus officinalis; iridoid glycosides; neuroprotective activity
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        Value: 10.1080/14786419.2025.2479254
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      – Code: eng
        Text: English
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      Pagination:
        StartPage: 3772
    Subjects:
      – SubjectFull: Fruit chemistry
        Type: general
      – SubjectFull: Apoptosis drug effects
        Type: general
      – SubjectFull: Molecular Structure
        Type: general
      – SubjectFull: Animals
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      – SubjectFull: Cornus chemistry
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              Text: 2026 Jul
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