Academic Journal
A new seco-iridoid glycoside from fruits of Cornus officinalis Sieb. et Zucc and their neuroprotective activities.
| Title: | A new seco-iridoid glycoside from fruits of Cornus officinalis Sieb. et Zucc and their neuroprotective activities. |
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| Authors: | Yang M; School of Pharmacy, Henan University of Chinese Medicine, Zhengzhou, Henan, China.; The Engineering and Technology Center for Chinese Medicine Development of Henan Province China, Zhengzhou, Henan, China., Hao ZY; School of Pharmacy, Henan University of Chinese Medicine, Zhengzhou, Henan, China.; The Engineering and Technology Center for Chinese Medicine Development of Henan Province China, Zhengzhou, Henan, China., Wang XL; The Engineering and Technology Center for Chinese Medicine Development of Henan Province China, Zhengzhou, Henan, China.; Academy of Chinese Medical Sciences, Henan University of Chinese Medicine, Zhengzhou, Henan, China., Zhou SQ; School of Pharmacy, Henan University of Chinese Medicine, Zhengzhou, Henan, China.; The Engineering and Technology Center for Chinese Medicine Development of Henan Province China, Zhengzhou, Henan, China., Xiao CY; School of Pharmacy, Henan University of Chinese Medicine, Zhengzhou, Henan, China.; The Engineering and Technology Center for Chinese Medicine Development of Henan Province China, Zhengzhou, Henan, China., Zheng XK; School of Pharmacy, Henan University of Chinese Medicine, Zhengzhou, Henan, China.; The Engineering and Technology Center for Chinese Medicine Development of Henan Province China, Zhengzhou, Henan, China., Feng WS; School of Pharmacy, Henan University of Chinese Medicine, Zhengzhou, Henan, China.; The Engineering and Technology Center for Chinese Medicine Development of Henan Province China, Zhengzhou, Henan, China. |
| Source: | Natural product research [Nat Prod Res] 2026 Jul; Vol. 40 (13), pp. 3772-3782. Date of Electronic Publication: 2025 Apr 15. |
| Publication Type: | Journal Article |
| Language: | English |
| Journal Info: | Publisher: Taylor & Francis Health Sciences Country of Publication: England NLM ID: 101167924 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1478-6427 (Electronic) Linking ISSN: 14786419 NLM ISO Abbreviation: Nat Prod Res Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: Milton Park, UK : Taylor & Francis Health Sciences, c2003- |
| MeSH Terms: | Cornus*/chemistry , Neuroprotective Agents*/chemistry , Neuroprotective Agents*/pharmacology , Neuroprotective Agents*/isolation & purification , Iridoid Glycosides*/chemistry , Iridoid Glycosides*/isolation & purification , Iridoid Glycosides*/pharmacology, Fruit/chemistry ; Apoptosis/drug effects ; Molecular Structure ; Animals |
| Abstract: | A new seco-iridoid glycoside, named neocornuside I (1), together with seven previously reported compounds (2-8) were isolated from fruits of Cornus officinalis Sieb. et Zucc. Their structures were determined by extensive analysis of HRESIMS, IR, UV, 1D and 2D NMR spectral data. The isolated compounds (1-8) were evaluated for their in vitro neuroprotective activities. Based on flow cytometry results, compound 1 was found to alleviate apoptosis and G2/M phase arrest, indicating its considerable neuroprotective effects. |
| Contributed Indexing: | Keywords: Cornus officinalis; iridoid glycosides; neuroprotective activity |
| Substance Nomenclature: | 0 (Neuroprotective Agents) 0 (Iridoid Glycosides) |
| Entry Date(s): | Date Created: 20250415 Date Completed: 20260630 Latest Revision: 20260630 |
| Update Code: | 20260630 |
| DOI: | 10.1080/14786419.2025.2479254 |
| PMID: | 40233249 |
| Database: | MEDLINE |
| ISSN: | 1478-6427 |
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| DOI: | 10.1080/14786419.2025.2479254 |