Academic Journal
Science, faith and belief in pediatric animal models.
| Τίτλος: | Science, faith and belief in pediatric animal models. |
|---|---|
| Συγγραφείς: | Sangild PT; Comparative Pediatrics, Section of Biomedicine, Department of Veterinary and Animal Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark. pts@sund.ku.dk.; Cross-faculty Centre for Science and Faith, Faculty of Theology, University of Copenhagen, Copenhagen, Denmark. pts@sund.ku.dk. |
| Πηγή: | Pediatric research [Pediatr Res] 2025 Aug; Vol. 98 (2), pp. 360-362. Date of Electronic Publication: 2025 Apr 14. |
| Τύπος έκδοσης: | Journal Article |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: Nature Publishing Group Country of Publication: United States NLM ID: 0100714 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1530-0447 (Electronic) Linking ISSN: 00313998 NLM ISO Abbreviation: Pediatr Res Subsets: MEDLINE |
| Imprint Name(s): | Publication: 2012- : New York : Nature Publishing Group Original Publication: Basel ; New York : Karger. |
| Ιατρικοί όροι (MeSH): | Anti-Bacterial Agents*/adverse effects , Gastrointestinal Microbiome*/drug effects , Models, Animal* , Pediatrics*, Animals ; Child ; Humans ; Infant ; Disease Models, Animal ; Translational Research, Biomedical |
| Περίληψη: | Impact Statement: Antibiotic treatment may affect gut microbiota development with adverse effects on immune responses in the gut and other internal organs, like the lung. Animal models help to uncover mechanisms and consequences of antibiotic treatment, but direct translation of animal results to infants and children is often difficult. Objective scientific knowledge from both animal and human studies may need to be combined with more subjective faith convictions, to reach the commonly agreed beliefs that inform clinical practice. (© 2025. The Author(s), under exclusive licence to the International Pediatric Research Foundation, Inc.) |
| Competing Interests: | Competing interests: The author declares no competing interests. |
| References: | Hsueh, M.-Y., Jeng, M.-J., Chou, C.-S., Chang, C.-W. & Zou, C.-T. Prolonged early-life antibiotic exposure alters gut microbiota but does not exacerbate lung injury in a rat pup model. Pediatric Res. (2025). Jota Baptista, C. V., Faustino-Rocha, A. I. & Oliveira, P. A. Animal models in pharmacology: a brief history awarding the nobel prizes for physiology or medicine. Pharmacology 106, 356–368 (2021). (PMID: 10.1159/00051624034023819) Smith, W. C. Faith and Belief: The Difference between Them. (Oneworld Publications, 1998). Tillich, P. Dynamics of Faith. (Harper & Brothers, 1957). Sangild, P. T. Science and Faith to Understand Milk Bioactivity for Infants. Nutrients 16, 1676 (2024). Hoekstra, R. & Vazire, S. Aspiring to greater intellectual humility in science. Nat. Hum. Behav. 5, 1602–1607 (2021). (PMID: 10.1038/s41562-021-01203-834711978) Sangild, P. T. Gut responses to enteral nutrition in preterm infants and animals. Exp. Biol. Med (Maywood) 231, 1695–1711 (2006). (PMID: 10.1177/15353702062310110617138756) Li, Y. et al. Early use of antibiotics is associated with a lower incidence of necrotizing enterocolitis in preterm, very low birth weight infants: The NEOMUNE-NeoNutriNet Cohort Study. J. Pediatr. 227, 128–134.e122 (2020). (PMID: 10.1016/j.jpeds.2020.06.032325538657686259) Shi, W. et al. Early antibiotic exposure and bronchopulmonary dysplasia in very preterm infants at low risk of early-onset sepsis. JAMA Netw. Open 7, e2418831 (2024). (PMID: 10.1001/jamanetworkopen.2024.188313893537611211957) Vatne, A. et al. Early empirical antibiotics and adverse clinical outcomes in infants born very preterm: a population-based cohort. J. Pediatr. 253, 107–114.e105 (2023). (PMID: 10.1016/j.jpeds.2022.09.02936179887) Birck, M. M. et al. Enteral but not parenteral antibiotics enhance gut function and prevent necrotizing enterocolitis in formula-fed newborn preterm pigs. Am. J. Physiol. Gastrointest. Liver Physiol. 310, G323–G333 (2016). (PMID: 10.1152/ajpgi.00392.201526680737) Brunse, A. et al. Enteral broad-spectrum antibiotics antagonize the effect of fecal microbiota transplantation in preterm pigs. Gut Microbes 13, 1–16 (2021). (PMID: 10.1080/19490976.2020.184999733382952) Muk, T. et al. Neonatal prophylactic antibiotics after preterm birth affect plasma proteome and immune development in pigs. Pediatr. Res. 94, 530–538 (2023). (PMID: 10.1038/s41390-023-02492-736804504) Yun, J., Olkkola, S., Hanninen, M. L., Oliviero, C. & Heinonen, M. The effects of amoxicillin treatment of newborn piglets on the prevalence of hernias and abscesses, growth and ampicillin resistance of intestinal coliform bacteria in weaned pigs. PLoS One 12, e0172150 (2017). (PMID: 10.1371/journal.pone.0172150281993795310895) Heo, J. M. et al. Gastrointestinal health and function in weaned pigs: a review of feeding strategies to control post-weaning diarrhoea without using in-feed antimicrobial compounds. J. Anim. Physiol. Anim. Nutr. (Berl.) 97, 207–237 (2013). (PMID: 10.1111/j.1439-0396.2012.01284.x22416941) |
| Substance Nomenclature: | 0 (Anti-Bacterial Agents) |
| Entry Date(s): | Date Created: 20250414 Date Completed: 20250922 Latest Revision: 20250923 |
| Update Code: | 20260130 |
| DOI: | 10.1038/s41390-025-04036-7 |
| PMID: | 40229420 |
| Βάση Δεδομένων: | MEDLINE |
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