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Science, faith and belief in pediatric animal models.

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Title: Science, faith and belief in pediatric animal models.
Authors: Sangild PT; Comparative Pediatrics, Section of Biomedicine, Department of Veterinary and Animal Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark. pts@sund.ku.dk.; Cross-faculty Centre for Science and Faith, Faculty of Theology, University of Copenhagen, Copenhagen, Denmark. pts@sund.ku.dk.
Source: Pediatric research [Pediatr Res] 2025 Aug; Vol. 98 (2), pp. 360-362. Date of Electronic Publication: 2025 Apr 14.
Publication Type: Journal Article
Language: English
Journal Info: Publisher: Nature Publishing Group Country of Publication: United States NLM ID: 0100714 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1530-0447 (Electronic) Linking ISSN: 00313998 NLM ISO Abbreviation: Pediatr Res Subsets: MEDLINE
Imprint Name(s): Publication: 2012- : New York : Nature Publishing Group
Original Publication: Basel ; New York : Karger.
MeSH Terms: Anti-Bacterial Agents*/adverse effects , Gastrointestinal Microbiome*/drug effects , Models, Animal* , Pediatrics*, Animals ; Child ; Humans ; Infant ; Disease Models, Animal ; Translational Research, Biomedical
Abstract: Impact Statement: Antibiotic treatment may affect gut microbiota development with adverse effects on immune responses in the gut and other internal organs, like the lung. Animal models help to uncover mechanisms and consequences of antibiotic treatment, but direct translation of animal results to infants and children is often difficult. Objective scientific knowledge from both animal and human studies may need to be combined with more subjective faith convictions, to reach the commonly agreed beliefs that inform clinical practice.
(© 2025. The Author(s), under exclusive licence to the International Pediatric Research Foundation, Inc.)
Competing Interests: Competing interests: The author declares no competing interests.
References: Pediatr Res. 2023 Aug;94(2):530-538. (PMID: 36804504)
J Pediatr. 2020 Dec;227:128-134.e2. (PMID: 32553865)
PLoS One. 2017 Feb 15;12(2):e0172150. (PMID: 28199379)
J Pediatr. 2023 Feb;253:107-114.e5. (PMID: 36179887)
J Anim Physiol Anim Nutr (Berl). 2013 Apr;97(2):207-37. (PMID: 22416941)
Nat Hum Behav. 2021 Dec;5(12):1602-1607. (PMID: 34711978)
Exp Biol Med (Maywood). 2006 Dec;231(11):1695-711. (PMID: 17138756)
JAMA Netw Open. 2024 Jun 3;7(6):e2418831. (PMID: 38935376)
Am J Physiol Gastrointest Liver Physiol. 2016 Mar 1;310(5):G323-33. (PMID: 26680737)
Gut Microbes. 2021 Jan-Dec;13(1):1-16. (PMID: 33382952)
Pharmacology. 2021;106(7-8):356-368. (PMID: 34023819)
Substance Nomenclature: 0 (Anti-Bacterial Agents)
Entry Date(s): Date Created: 20250414 Date Completed: 20250922 Latest Revision: 20261010
Update Code: 20261010
DOI: 10.1038/s41390-025-04036-7
PMID: 40229420
Database: MEDLINE
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  Data: Science, faith and belief in pediatric animal models.
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  Data: <searchLink fieldCode="AU" term="%22Sangild+PT%22">Sangild PT</searchLink>; Comparative Pediatrics, Section of Biomedicine, Department of Veterinary and Animal Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark. pts@sund.ku.dk.; Cross-faculty Centre for Science and Faith, Faculty of Theology, University of Copenhagen, Copenhagen, Denmark. pts@sund.ku.dk.
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  Data: Impact Statement: Antibiotic treatment may affect gut microbiota development with adverse effects on immune responses in the gut and other internal organs, like the lung. Animal models help to uncover mechanisms and consequences of antibiotic treatment, but direct translation of animal results to infants and children is often difficult. Objective scientific knowledge from both animal and human studies may need to be combined with more subjective faith convictions, to reach the commonly agreed beliefs that inform clinical practice.<br /> (© 2025. The Author(s), under exclusive licence to the International Pediatric Research Foundation, Inc.)
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  Data: Competing interests: The author declares no competing interests.
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  Data: Pediatr Res. 2023 Aug;94(2):530-538. (PMID: <searchLink fieldCode="PM" term="%2236804504%22">36804504)</searchLink><br />J Pediatr. 2020 Dec;227:128-134.e2. (PMID: <searchLink fieldCode="PM" term="%2232553865%22">32553865)</searchLink><br />PLoS One. 2017 Feb 15;12(2):e0172150. (PMID: <searchLink fieldCode="PM" term="%2228199379%22">28199379)</searchLink><br />J Pediatr. 2023 Feb;253:107-114.e5. (PMID: <searchLink fieldCode="PM" term="%2236179887%22">36179887)</searchLink><br />J Anim Physiol Anim Nutr (Berl). 2013 Apr;97(2):207-37. (PMID: <searchLink fieldCode="PM" term="%2222416941%22">22416941)</searchLink><br />Nat Hum Behav. 2021 Dec;5(12):1602-1607. (PMID: <searchLink fieldCode="PM" term="%2234711978%22">34711978)</searchLink><br />Exp Biol Med (Maywood). 2006 Dec;231(11):1695-711. (PMID: <searchLink fieldCode="PM" term="%2217138756%22">17138756)</searchLink><br />JAMA Netw Open. 2024 Jun 3;7(6):e2418831. (PMID: <searchLink fieldCode="PM" term="%2238935376%22">38935376)</searchLink><br />Am J Physiol Gastrointest Liver Physiol. 2016 Mar 1;310(5):G323-33. (PMID: <searchLink fieldCode="PM" term="%2226680737%22">26680737)</searchLink><br />Gut Microbes. 2021 Jan-Dec;13(1):1-16. (PMID: <searchLink fieldCode="PM" term="%2233382952%22">33382952)</searchLink><br />Pharmacology. 2021;106(7-8):356-368. (PMID: <searchLink fieldCode="PM" term="%2234023819%22">34023819)</searchLink>
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        Type: general
      – SubjectFull: Child
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