Academic Journal
Impact of sleeve gastrectomy on the course of metabolic associated fatty liver disease.
| Τίτλος: | Impact of sleeve gastrectomy on the course of metabolic associated fatty liver disease. |
|---|---|
| Συγγραφείς: | Eid RA; Department of Gastroenterology, Hepatology and Infectious Diseases (Tropical Medicine Department), Faculty of Medicine, Beni-Suef University, Beni-Suef, Egypt. ragaeyahmad@med.bsu.edu.eg., Attia D; Department of Gastroenterology, Hepatology and Infectious Diseases (Tropical Medicine Department), Faculty of Medicine, Beni-Suef University, Beni-Suef, Egypt., Soliman AS; Department of Gastroenterology, Hepatology and Infectious Diseases (Tropical Medicine Department), Faculty of Medicine, Beni-Suef University, Beni-Suef, Egypt., Abd Elmaogod EA; Department of Pathology, Faculty of Medicine, Beni-Suef University, Beni-Suef, Egypt., AbdelSalam EM; Department of General Surgery, Faculty of Medicine, University of Beni-Suef, Beni-Suef, Egypt., Rashad AM; Department of General Surgery, Faculty of Medicine, University of Beni-Suef, Beni-Suef, Egypt., Sayed ASA; Department of General Surgery, Faculty of Medicine, University of Beni-Suef, Beni-Suef, Egypt., Nabil TM; Department of General Surgery, Faculty of Medicine, University of Beni-Suef, Beni-Suef, Egypt. |
| Πηγή: | Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology [Indian J Gastroenterol] 2026 Aug; Vol. 45 (4), pp. 745-755. Date of Electronic Publication: 2025 Apr 02. |
| Τύπος έκδοσης: | Journal Article; Observational Study |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: Springer India Country of Publication: India NLM ID: 8409436 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 0975-0711 (Electronic) Linking ISSN: 02548860 NLM ISO Abbreviation: Indian J Gastroenterol Subsets: MEDLINE |
| Imprint Name(s): | Publication: India : Springer India Original Publication: Bombay : Indian Society of Gastroenterology |
| Ιατρικοί όροι (MeSH): | Gastrectomy*/methods , Obesity, Morbid*/surgery , Obesity, Morbid*/complications , Non-alcoholic Fatty Liver Disease*/epidemiology , Non-alcoholic Fatty Liver Disease*/etiology , Bariatric Surgery*/methods , Fatty Liver*/epidemiology , Fatty Liver*/etiology, Liver/pathology ; Humans ; Female ; Prospective Studies ; Male ; Adult ; Middle Aged ; Treatment Outcome ; Elasticity Imaging Techniques ; Cohort Studies |
| Περίληψη: | Background and Aim: Metabolic associated fatty liver disease (MAFLD) is now a leading cause for chronic liver disease worldwide. Bariatric surgery has a beneficial effect on morbid obesity. We aimed at evaluating the impact of sleeve gastrectomy on the course of metabolic associated fatty liver disease. Methods: An observational prospective cohort study from February 2021 to March 2023 included 66 morbidly obese patients diagnosed with MAFLD. Sleeve gastrectomy was done, where intra-operative liver biopsy was obtained. Baseline values of anthropometric measures, full metabolic profile and liver stiffness measurement (LSM) and controlled attenuation parameter (CAP) using the XL probe were compared with three and six-months post-operatively. Results: Prevalence of MAFLD was histologically diagnosed in 75%. There was a significant decrease in body mass index, circumference, systolic and diastolic blood pressures in the low-density lipoprotein (LDL), triglycerides (TG), cholesterol, alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), LSM by transient elastography measurements in kilo Pascals (TE-kPa) and CAP level from baseline to three and six months post-operatively. Also, the AST/platelets ratio (APRI), NAFLD fibrosis score (NFS), fibrosis-4 (FIB-4) and atheroscelerosis cardiovascular risk score (ASCVD) scores decreased significantly from baseline to six months of follow-up. In MAFLD patients, there was a significant positive linear correlation between the CAP score and TE, between the CAP and AST, ALT, ASCVD score, but a negative correlation with high density lipoprotein (HDL). Also, there was a significant positive correlation between the percentage of decline TE and APRI scores and percentage of decline of CAP, glycated hemoglobin (HbA1c) and homeostasis model assessment for insulin resistance (HOMA-IR). Conclusion: There was a very high prevalence of steatosis and steatohepatitis in asymptomatic morbidly obese patients. Sleeve gastrectomy has a beneficial effect on MAFLD and its associated comorbidities. (© 2025. Indian Society of Gastroenterology.) |
| Competing Interests: | Declarations. Ethics approval and consent to participate: Ethical approval was obtained from the ethical committee, Faculty of Medicine, Beni-Suef University. {Approval NO FMBSUREC/07032021}. Written informed consent was taken from the participants. The study was performed following the principles of the Declaration of Helsinki. Consent for publication: Not applicable. Competing interests: RAE, DA, ASS, EAAE, EMAS, AMR, ASAS and TMN declare that they have no competing interests. Permission to reproduce material from other sources: The authors confirm that all materials reproduced from other sources, including tables, figures and images, have obtained the necessary permission or license for publication in this journal. Disclaimer: The authors are solely responsible for the data and the contents of the paper. In no way, the Honorary Editor-in-Chief, Editorial Board Members, the Indian Society of Gastroenterology or the printer/publishers are responsible for the results/findings and content of this article. |
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| Contributed Indexing: | Keywords: Controlled attenuation parameter; Liver stiffness measurement; Metabolic-associated fatty liver disease; Sleeve gastrectomy |
| Entry Date(s): | Date Created: 20250402 Date Completed: 20260616 Latest Revision: 20260620 |
| Update Code: | 20260621 |
| DOI: | 10.1007/s12664-025-01757-9 |
| PMID: | 40172837 |
| Βάση Δεδομένων: | MEDLINE |
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