Academic Journal
Mussel-inspired remineralizing agent: effects on morphology and permeability of dentin after erosion and abrasion cycling protocol.
| Τίτλος: | Mussel-inspired remineralizing agent: effects on morphology and permeability of dentin after erosion and abrasion cycling protocol. |
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| Συγγραφείς: | de Lima Marques JF; Department of Restorative Dentistry, Piracicaba School of Dentistry, University of Campinas, Av. Limeira, 901, Piracicaba, SP, CEP: 13414-903, Brazil. jcinhafml@hotmail.com., Aguilar MF; Department of Restorative Dentistry, Piracicaba School of Dentistry, University of Campinas, Av. Limeira, 901, Piracicaba, SP, CEP: 13414-903, Brazil., Vieira-Junior WF; Department of Restorative Dentistry, Piracicaba School of Dentistry, University of Campinas, Av. Limeira, 901, Piracicaba, SP, CEP: 13414-903, Brazil., Pecorari VGA; Department of Children's Health Sciences and Dentistry, - Area of Biostatistics, Piracicaba School of Dentistry, University of Campinas, Av. Limeira, 901, Piracicaba, SP, CEP: 13414-903, Brazil., Rischka K; Adhesive Bonding Technology and Surfaces, Fraunhofer Institute for Manufacturing Technology and Advanced Materials IFAM, Wiener Straße 12, 28359, Bremen, Germany., Aguiar FHB; Department of Restorative Dentistry, Piracicaba School of Dentistry, University of Campinas, Av. Limeira, 901, Piracicaba, SP, CEP: 13414-903, Brazil. |
| Πηγή: | Clinical oral investigations [Clin Oral Investig] 2025 Mar 19; Vol. 29 (4), pp. 193. Date of Electronic Publication: 2025 Mar 19. |
| Τύπος έκδοσης: | Journal Article |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: Springer-Verlag Country of Publication: Germany NLM ID: 9707115 Publication Model: Electronic Cited Medium: Internet ISSN: 1436-3771 (Electronic) Linking ISSN: 14326981 NLM ISO Abbreviation: Clin Oral Investig Subsets: MEDLINE |
| Imprint Name(s): | Publication: Berlin : Springer-Verlag Original Publication: Berlin : Springer, c1997- |
| Ιατρικοί όροι (MeSH): | Dentin*/drug effects , Dentin Permeability*/drug effects , Tooth Remineralization*/methods , Dopamine*/pharmacology , Dentin Sensitivity*/drug therapy , Tooth Erosion* , Tooth Abrasion*, Sodium Fluoride/pharmacology ; Humans ; Microscopy, Electron, Scanning ; In Vitro Techniques ; Surface Properties ; Animals ; Citric Acid |
| Περίληψη: | Objective: This study aimed to evaluate the effects on morphology and permeability of dentin after an erosive and abrasive cycling protocol followed by treatment with an experimental solution containing dopamine. Materials and Methods: Dentin hypersensitivity was simulated in human dentin discs by applying EDTA for 5 min. After assessing maximum dentin permeability (initial), specimens were randomly allocated into four groups: distilled water (control), NaF 0.05% solution, a commercial solution (Colgate® Sensitive Pró-AlívioTM), or an experimental solution containing dopamine and laccase (n = 15). An erosive/abrasive cycling protocol was applied, including 0.3% citric acid for 2 min 4x/day, brushing for 5 s 2x/day, treatments for 5 min 2x/day. Dentin permeability was reassessed (final). Percentage permeability for each time point was calculated relative to maximum permeability (%Lp) and analyzed by generalized linear mixed models (α = 0.05). Surface effects were analyzed by scanning electron microscopy. Results: A significant reduction in permeability occurred in all groups post-cycling and treatment (p < 0.05), with no significant differences between groups (p = 0.6082). All groups exhibited sparse surface deposits, with few occluded tubules. Tubules appeared smaller in diameter in the Colgate® and experimental solution groups, while distilled water and NaF groups showed more open tubules. Conclusion: In this model, dopamine demonstrated a limited effect, showing no significant protection of the dentin surface or reduction in permeability, similar to the other tested solutions. Clinical Relevance: Changes in the habits of modern society have increased the prevalence of tooth wear and dentin hypersensitivity. In this context, it is essential to develop not only new active ingredients to prevent or minimize mineral loss but also new treatment methods. (© 2025. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.) |
| Competing Interests: | Declarations. Ethical approval: The study was performed in line with the Declaration of Helsinki and approved by the local Research Ethics Committee (04-17-2023 / No. 67959823.0.0000.5418). Competing interests: The authors declare no competing interests. |
| References: | Dent Mater. 2021 Apr;37(4):655-671. (PMID: 33579531) J Mech Behav Biomed Mater. 2024 Apr;152:106420. (PMID: 38310812) Quintessence Int. 2013 Jul;44(7):535-46. (PMID: 23616976) Ther Adv Drug Saf. 2019 Sep 23;10:2042098619854881. (PMID: 31579502) Arch Oral Biol. 2018 Dec;96:130-136. (PMID: 30237094) Eur J Oral Sci. 2011 Dec;119(6):497-503. (PMID: 22112037) Int Dent J. 2005;55(4 Suppl 1):261-7. (PMID: 16167604) Caries Res. 1998;32(5):344-50. (PMID: 9701659) J Dent. 2019 Oct;89:103176. (PMID: 31351084) Angew Chem Int Ed Engl. 2019 Jan 21;58(4):1077-1082. (PMID: 30485624) J Dent. 2020 Oct;101:103450. (PMID: 32798588) Int J Dent Hyg. 2017 May;15(2):84-94. (PMID: 27762076) Braz Dent J. 2017 Mar-Apr;28(2):216-224. (PMID: 28492753) Oper Dent. 2022 Sep 1;47(5):549-561. (PMID: 36026699) J Clin Dent. 2009;20(1):23-31. (PMID: 19489189) J Oral Rehabil. 1999 Feb;26(2):97-102. (PMID: 10080305) Caries Res. 1992;26(5):345-50. (PMID: 1468098) J Periodontol. 2003 Apr;74(4):428-36. (PMID: 12747446) Caries Res. 1967;1(4):310-7. (PMID: 5241870) J Oral Rehabil. 2019 Oct;46(10):952-990. (PMID: 31216069) ACS Appl Mater Interfaces. 2012 Dec;4(12):6901-10. (PMID: 23176019) Pesqui Odontol Bras. 2003 Jul-Sep;17(3):241-6. (PMID: 14762502) Clin Oral Investig. 2013 Jan;17(1):195-203. (PMID: 22315153) J Appl Biomater Funct Mater. 2021 Jan-Dec;19:22808000211005384. (PMID: 33784188) Acta Odontol Latinoam. 2022 Dec 31;35(3):229-237. (PMID: 36748742) Caries Res. 2011;45 Suppl 1:53-9. (PMID: 21625133) J Oral Rehabil. 2008 Apr;35(4):300-15. (PMID: 18321266) Eur J Oral Sci. 2010 Aug;118(4):376-84. (PMID: 20662911) J Dent. 2013 Mar;41 Suppl 1:S1-11. (PMID: 23000522) Bioresour Technol. 2008 Nov;99(16):7825-34. (PMID: 18406607) Caries Res. 2016;50(3):337-45. (PMID: 27246229) J Endod. 2021 Nov;47(11):1696-1702. (PMID: 34302871) ACS Biomater Sci Eng. 2023 Mar 13;9(3):1486-1495. (PMID: 36854046) BMC Oral Health. 2020 Aug 6;20(1):220. (PMID: 32762733) Sci Rep. 2025 Jan 17;15(1):2243. (PMID: 39825001) J Dent. 2015 Dec;43(12):1442-7. (PMID: 26497231) Br Dent J. 2012 Jul 27;213(2):55-7. (PMID: 22836413) Dent Med Probl. 2022 Jul-Sep;59(3):451-460. (PMID: 36206495) |
| Grant Information: | 140857/2019-2 National Council for Scientific and Technological Development (CNPq) |
| Contributed Indexing: | Keywords: Catechols; Dentin hypersensitivity; Mouthwashes; Mussel; Tooth wear |
| Substance Nomenclature: | VTD58H1Z2X (Dopamine) 8ZYQ1474W7 (Sodium Fluoride) 2968PHW8QP (Citric Acid) |
| Entry Date(s): | Date Created: 20250319 Date Completed: 20250514 Latest Revision: 20261010 |
| Update Code: | 20261010 |
| DOI: | 10.1007/s00784-025-06276-7 |
| PMID: | 40106040 |
| Βάση Δεδομένων: | MEDLINE |
| ISSN: | 1436-3771 |
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| DOI: | 10.1007/s00784-025-06276-7 |