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Mussel-inspired remineralizing agent: effects on morphology and permeability of dentin after erosion and abrasion cycling protocol.

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Title: Mussel-inspired remineralizing agent: effects on morphology and permeability of dentin after erosion and abrasion cycling protocol.
Authors: de Lima Marques JF; Department of Restorative Dentistry, Piracicaba School of Dentistry, University of Campinas, Av. Limeira, 901, Piracicaba, SP, CEP: 13414-903, Brazil. jcinhafml@hotmail.com., Aguilar MF; Department of Restorative Dentistry, Piracicaba School of Dentistry, University of Campinas, Av. Limeira, 901, Piracicaba, SP, CEP: 13414-903, Brazil., Vieira-Junior WF; Department of Restorative Dentistry, Piracicaba School of Dentistry, University of Campinas, Av. Limeira, 901, Piracicaba, SP, CEP: 13414-903, Brazil., Pecorari VGA; Department of Children's Health Sciences and Dentistry, - Area of Biostatistics, Piracicaba School of Dentistry, University of Campinas, Av. Limeira, 901, Piracicaba, SP, CEP: 13414-903, Brazil., Rischka K; Adhesive Bonding Technology and Surfaces, Fraunhofer Institute for Manufacturing Technology and Advanced Materials IFAM, Wiener Straße 12, 28359, Bremen, Germany., Aguiar FHB; Department of Restorative Dentistry, Piracicaba School of Dentistry, University of Campinas, Av. Limeira, 901, Piracicaba, SP, CEP: 13414-903, Brazil.
Source: Clinical oral investigations [Clin Oral Investig] 2025 Mar 19; Vol. 29 (4), pp. 193. Date of Electronic Publication: 2025 Mar 19.
Publication Type: Journal Article
Language: English
Journal Info: Publisher: Springer-Verlag Country of Publication: Germany NLM ID: 9707115 Publication Model: Electronic Cited Medium: Internet ISSN: 1436-3771 (Electronic) Linking ISSN: 14326981 NLM ISO Abbreviation: Clin Oral Investig Subsets: MEDLINE
Imprint Name(s): Publication: Berlin : Springer-Verlag
Original Publication: Berlin : Springer, c1997-
MeSH Terms: Dentin*/drug effects , Dentin Permeability*/drug effects , Tooth Remineralization*/methods , Dopamine*/pharmacology , Dentin Sensitivity*/drug therapy , Tooth Erosion* , Tooth Abrasion*, Sodium Fluoride/pharmacology ; Humans ; Microscopy, Electron, Scanning ; In Vitro Techniques ; Surface Properties ; Animals ; Citric Acid
Abstract: Objective: This study aimed to evaluate the effects on morphology and permeability of dentin after an erosive and abrasive cycling protocol followed by treatment with an experimental solution containing dopamine.
Materials and Methods: Dentin hypersensitivity was simulated in human dentin discs by applying EDTA for 5 min. After assessing maximum dentin permeability (initial), specimens were randomly allocated into four groups: distilled water (control), NaF 0.05% solution, a commercial solution (Colgate® Sensitive Pró-AlívioTM), or an experimental solution containing dopamine and laccase (n = 15). An erosive/abrasive cycling protocol was applied, including 0.3% citric acid for 2 min 4x/day, brushing for 5 s 2x/day, treatments for 5 min 2x/day. Dentin permeability was reassessed (final). Percentage permeability for each time point was calculated relative to maximum permeability (%Lp) and analyzed by generalized linear mixed models (α = 0.05). Surface effects were analyzed by scanning electron microscopy.
Results: A significant reduction in permeability occurred in all groups post-cycling and treatment (p < 0.05), with no significant differences between groups (p = 0.6082). All groups exhibited sparse surface deposits, with few occluded tubules. Tubules appeared smaller in diameter in the Colgate® and experimental solution groups, while distilled water and NaF groups showed more open tubules.
Conclusion: In this model, dopamine demonstrated a limited effect, showing no significant protection of the dentin surface or reduction in permeability, similar to the other tested solutions.
Clinical Relevance: Changes in the habits of modern society have increased the prevalence of tooth wear and dentin hypersensitivity. In this context, it is essential to develop not only new active ingredients to prevent or minimize mineral loss but also new treatment methods.
(© 2025. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.)
Competing Interests: Declarations. Ethical approval: The study was performed in line with the Declaration of Helsinki and approved by the local Research Ethics Committee (04-17-2023 / No. 67959823.0.0000.5418). Competing interests: The authors declare no competing interests.
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Grant Information: 140857/2019-2 National Council for Scientific and Technological Development (CNPq)
Contributed Indexing: Keywords: Catechols; Dentin hypersensitivity; Mouthwashes; Mussel; Tooth wear
Substance Nomenclature: VTD58H1Z2X (Dopamine)
8ZYQ1474W7 (Sodium Fluoride)
2968PHW8QP (Citric Acid)
Entry Date(s): Date Created: 20250319 Date Completed: 20250514 Latest Revision: 20250514
Update Code: 20260130
DOI: 10.1007/s00784-025-06276-7
PMID: 40106040
Database: MEDLINE
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  Label: Abstract
  Group: Ab
  Data: Objective: This study aimed to evaluate the effects on morphology and permeability of dentin after an erosive and abrasive cycling protocol followed by treatment with an experimental solution containing dopamine.&lt;br /&gt;Materials and Methods: Dentin hypersensitivity was simulated in human dentin discs by applying EDTA for 5&#160;min. After assessing maximum dentin permeability (initial), specimens were randomly allocated into four groups: distilled water (control), NaF 0.05% solution, a commercial solution (Colgate&lt;superscript&gt;&#174;&lt;/superscript&gt; Sensitive Pr&#243;-Al&#237;vioTM), or an experimental solution containing dopamine and laccase (n = 15). An erosive/abrasive cycling protocol was applied, including 0.3% citric acid for 2&#160;min 4x/day, brushing for 5&#160;s 2x/day, treatments for 5&#160;min 2x/day. Dentin permeability was reassessed (final). Percentage permeability for each time point was calculated relative to maximum permeability (%Lp) and analyzed by generalized linear mixed models (α = 0.05). Surface effects were analyzed by scanning electron microscopy.&lt;br /&gt;Results: A significant reduction in permeability occurred in all groups post-cycling and treatment (p &amp;lt; 0.05), with no significant differences between groups (p = 0.6082). All groups exhibited sparse surface deposits, with few occluded tubules. Tubules appeared smaller in diameter in the Colgate&lt;superscript&gt;&#174;&lt;/superscript&gt; and experimental solution groups, while distilled water and NaF groups showed more open tubules.&lt;br /&gt;Conclusion: In this model, dopamine demonstrated a limited effect, showing no significant protection of the dentin surface or reduction in permeability, similar to the other tested solutions.&lt;br /&gt;Clinical Relevance: Changes in the habits of modern society have increased the prevalence of tooth wear and dentin hypersensitivity. In this context, it is essential to develop not only new active ingredients to prevent or minimize mineral loss but also new treatment methods.&lt;br /&gt; (&#169; 2025. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.)
– Name: Abstract
  Label: Competing Interests
  Group: Ab
  Data: Declarations. Ethical approval: The study was performed in line with the Declaration of Helsinki and approved by the local Research Ethics Committee (04-17-2023 / No. 67959823.0.0000.5418). Competing interests: The authors declare no competing interests.
– Name: Ref
  Label: References
  Group: RefInfo
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  Data: &lt;i&gt;Keywords: &lt;/i&gt;Catechols; Dentin hypersensitivity; Mouthwashes; Mussel; Tooth wear
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  Data: &lt;i&gt;Date Created: &lt;/i&gt;20250319 &lt;i&gt;Date Completed: &lt;/i&gt;20250514 &lt;i&gt;Latest Revision: &lt;/i&gt;20250514
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        Text: English
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        StartPage: 193
    Subjects:
      – SubjectFull: Sodium Fluoride pharmacology
        Type: general
      – SubjectFull: Humans
        Type: general
      – SubjectFull: Microscopy, Electron, Scanning
        Type: general
      – SubjectFull: In Vitro Techniques
        Type: general
      – SubjectFull: Surface Properties
        Type: general
      – SubjectFull: Animals
        Type: general
      – SubjectFull: Citric Acid
        Type: general
      – SubjectFull: Dentin drug effects
        Type: general
      – SubjectFull: Dentin Permeability drug effects
        Type: general
      – SubjectFull: Tooth Remineralization methods
        Type: general
      – SubjectFull: Dopamine pharmacology
        Type: general
      – SubjectFull: Dentin Sensitivity drug therapy
        Type: general
      – SubjectFull: Tooth Erosion
        Type: general
      – SubjectFull: Tooth Abrasion
        Type: general
    Titles:
      – TitleFull: Mussel-inspired remineralizing agent: effects on morphology and permeability of dentin after erosion and abrasion cycling protocol.
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: de Lima Marques JF
      – PersonEntity:
          Name:
            NameFull: Aguilar MF
      – PersonEntity:
          Name:
            NameFull: Vieira-Junior WF
      – PersonEntity:
          Name:
            NameFull: Pecorari VGA
      – PersonEntity:
          Name:
            NameFull: Rischka K
      – PersonEntity:
          Name:
            NameFull: Aguiar FHB
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 19
              M: 03
              Text: 2025 Mar 19
              Type: published
              Y: 2025
          Identifiers:
            – Type: issn-electronic
              Value: 1436-3771
          Numbering:
            – Type: volume
              Value: 29
            – Type: issue
              Value: 4
          Titles:
            – TitleFull: Clinical oral investigations
              Type: main
ResultId 1