Academic Journal
Urease-coupled systems and materials: design strategies, scope and applications.
| Τίτλος: | Urease-coupled systems and materials: design strategies, scope and applications. |
|---|---|
| Συγγραφείς: | Haranal S; Centre for Nano and Material Sciences, Jain (Deemed-to-be University), Jain Global Campus, Bangalore-562112, Karnataka, India. maityindrajitchem@gmail.com., Ranganath VA; Centre for Nano and Material Sciences, Jain (Deemed-to-be University), Jain Global Campus, Bangalore-562112, Karnataka, India. maityindrajitchem@gmail.com., Maity I; Centre for Nano and Material Sciences, Jain (Deemed-to-be University), Jain Global Campus, Bangalore-562112, Karnataka, India. maityindrajitchem@gmail.com. |
| Πηγή: | Journal of materials chemistry. B [J Mater Chem B] 2025 Apr 02; Vol. 13 (14), pp. 4252-4278. Date of Electronic Publication: 2025 Apr 02. |
| Τύπος έκδοσης: | Journal Article; Review |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: Royal Society of Chemistry Country of Publication: England NLM ID: 101598493 Publication Model: Electronic Cited Medium: Internet ISSN: 2050-7518 (Electronic) Linking ISSN: 2050750X NLM ISO Abbreviation: J Mater Chem B Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: Cambridge : Royal Society of Chemistry |
| Ιατρικοί όροι (MeSH): | Urease*/metabolism , Urease*/chemistry , Enzymes, Immobilized*/chemistry , Enzymes, Immobilized*/metabolism, Urea/metabolism ; Urea/chemistry ; Humans |
| Περίληψη: | Synthetic systems have co-opted urease, a crucial enzyme serving many biological functions, to recapitulate complex biological features. Therefore, the urease-urea feedback reaction network (FCRN) is reciprocated with soft materials to induce various animate-like features, including self-regulation, error correction, and decision-making capabilities, that are processed through a variety of non-linear functions. Although free-urease-based homogeneous systems are capable of adhering to many non-linear characteristics, they lack the ability to showcase the diffusion-controlled spatiotemporal phenomena. Therefore, it demands urease immobilization, whereby a compartmentalized reaction hub can facilitate the interplay of FCRN with reaction diffusion to regulate the system's operation, allowing various non-linear responses and spatiotemporal self-organization. Indeed, the beneficial framework of urease-based commercial systems in modern technology necessitates the accessibility, reusability, and long-term stability of urease. Consequently, several techniques for urease immobilization merit attention. This review highlights the diverse covalent and non-covalent approaches for urease immobilization on different substrates and illustrates several chemical reactions and non-covalent interactions as tools for creating targeted systems and soft materials to realize many on-demand functions. We also emphasize how the advancement of systems chemistry has propelled research in soft materials to comprehend system-level applications by demonstrating several emerging non-linear functions with potent applications in many directions, including sensing, soft robotics, regulation of material properties and many more. |
| Substance Nomenclature: | EC 3.5.1.5 (Urease) 0 (Enzymes, Immobilized) 8W8T17847W (Urea) |
| Entry Date(s): | Date Created: 20250311 Date Completed: 20250512 Latest Revision: 20250512 |
| Update Code: | 20260130 |
| DOI: | 10.1039/d4tb02853h |
| PMID: | 40066476 |
| Βάση Δεδομένων: | MEDLINE |
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