Academic Journal
Enhanced antimycotic activity of biomodified copper oxide nanoparticles from indigenous state flowers of Jharkhand: an in vitro and in silico approach.
| Τίτλος: | Enhanced antimycotic activity of biomodified copper oxide nanoparticles from indigenous state flowers of Jharkhand: an in vitro and in silico approach. |
|---|---|
| Συγγραφείς: | Kumari M; Department of Bioengineering and Biotechnology, Birla Institute of Technology, Ranchi, Jharkhand, India., Sarkar B; ICAR-Indian Institute of Agricultural Biotechnology (IIAB), Ranchi, Jharkhand, India., Mukherjee K; Department of Bioengineering and Biotechnology, Birla Institute of Technology, Ranchi, Jharkhand, India. |
| Πηγή: | Natural product research [Nat Prod Res] 2026 Jun; Vol. 40 (11), pp. 3162-3168. Date of Electronic Publication: 2025 Jan 25. |
| Τύπος έκδοσης: | Journal Article |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: Taylor & Francis Health Sciences Country of Publication: England NLM ID: 101167924 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1478-6427 (Electronic) Linking ISSN: 14786419 NLM ISO Abbreviation: Nat Prod Res Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: Milton Park, UK : Taylor & Francis Health Sciences, c2003- |
| Ιατρικοί όροι (MeSH): | Antifungal Agents*/pharmacology , Antifungal Agents*/chemistry , Copper*/chemistry , Copper*/pharmacology , Flowers*/chemistry , Butea*/chemistry , Metal Nanoparticles*/chemistry, Fusarium/drug effects ; Flavonoids/chemistry ; Flavonoids/analysis ; Plant Extracts/chemistry ; Plant Extracts/pharmacology ; Nanoparticles/chemistry ; India ; Molecular Docking Simulation ; Microbial Sensitivity Tests |
| Περίληψη: | Current study investigates the medicinal applications of Butea monosperma (Palash), the state flower of Jharkhand, India, focusing on synthesising biomodified copper oxide nanoparticles (CuO-NPs) and its antifungal properties. Flavonoid content in the flower extract was quantified by aluminium chloride colorimetric analysis. CuO-NPs were synthesised via co-precipitation method and then modified with methanolic flower extract. Characterization confirmed the properties of these NPs including their high crystallinity, spherical structure and nanoscale size (9-90 nm size). Anti-fungal activity revealed significant inhibition of hyphal growth at concentrations of 100-1000 ppm (76.6% for F. oxysporum and 75.05% for S. rolfsii). Statistical and computational analysis confirmed the effectiveness of these NPs by showing strong interactions between the CuO-NPs and fungal proteins. |
| Contributed Indexing: | Keywords: Biomodified CuO-NPs; Butea monosperma; flavonoid; fungal hyphae; molecular docking |
| Substance Nomenclature: | 0 (Antifungal Agents) 789U1901C5 (Copper) 0 (Flavonoids) 0 (Plant Extracts) T8BEA5064F (cuprous oxide) |
| SCR Organism: | Fusarium oxysporum |
| Entry Date(s): | Date Created: 20250125 Date Completed: 20260528 Latest Revision: 20260528 |
| Update Code: | 20260528 |
| DOI: | 10.1080/14786419.2025.2456671 |
| PMID: | 39862148 |
| Βάση Δεδομένων: | MEDLINE |
καταχωρήστε σχόλιο πρώτοι!