Academic Journal
Mitochondrial oxidative stress related LncRNA predict cervical cancer prognosis and immunotherapy response: Molecular structure and protein interaction of ribosomal protein L34.
| Τίτλος: | Mitochondrial oxidative stress related LncRNA predict cervical cancer prognosis and immunotherapy response: Molecular structure and protein interaction of ribosomal protein L34. |
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| Συγγραφείς: | Wu N; Department of gynecology, Affiliated Hospital of Youjiang Medical University for Nationalities, Baise 533000, Guangxi Zhuang Autonomous Region, China; Baise Key Laboratory for Research and Development on Clinical Molecular Diagnosis for High-Incidence Diseases, Baise 533000, Guangxi Zhuang Autonomous Region, China., Lin F; Baise Key Laboratory for Research and Development on Clinical Molecular Diagnosis for High-Incidence Diseases, Baise 533000, Guangxi Zhuang Autonomous Region, China; Department of Obstetrics, Affiliated Hospital of Youjiang Medical University for Nationalities, Baise 533000, Guangxi Zhuang Autonomous Region, China., Ji J; Baise Key Laboratory for Research and Development on Clinical Molecular Diagnosis for High-Incidence Diseases, Baise 533000, Guangxi Zhuang Autonomous Region, China; Youjiang Medical University for Nationalities, Baise 533000, Guangxi Zhuang Autonomous Region, China., Pan H; Baise Key Laboratory for Research and Development on Clinical Molecular Diagnosis for High-Incidence Diseases, Baise 533000, Guangxi Zhuang Autonomous Region, China; Youjiang Medical University for Nationalities, Baise 533000, Guangxi Zhuang Autonomous Region, China., Xiang L; Baise Key Laboratory for Research and Development on Clinical Molecular Diagnosis for High-Incidence Diseases, Baise 533000, Guangxi Zhuang Autonomous Region, China; Youjiang Medical University for Nationalities, Baise 533000, Guangxi Zhuang Autonomous Region, China., Xian G; Baise Key Laboratory for Research and Development on Clinical Molecular Diagnosis for High-Incidence Diseases, Baise 533000, Guangxi Zhuang Autonomous Region, China; Youjiang Medical University for Nationalities, Baise 533000, Guangxi Zhuang Autonomous Region, China., Chen S; Department of gynecology, Affiliated Hospital of Youjiang Medical University for Nationalities, Baise 533000, Guangxi Zhuang Autonomous Region, China; Baise Key Laboratory for Research and Development on Clinical Molecular Diagnosis for High-Incidence Diseases, Baise 533000, Guangxi Zhuang Autonomous Region, China. Electronic address: 13877695998@163.com. |
| Πηγή: | International journal of biological macromolecules [Int J Biol Macromol] 2025 Apr; Vol. 299, pp. 140145. Date of Electronic Publication: 2025 Jan 20. |
| Τύπος έκδοσης: | Journal Article; Retracted Publication |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: Elsevier Country of Publication: Netherlands NLM ID: 7909578 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-0003 (Electronic) Linking ISSN: 01418130 NLM ISO Abbreviation: Int J Biol Macromol Subsets: MEDLINE |
| Imprint Name(s): | Publication: Amsterdam : Elsevier Original Publication: Guildford, Eng., IPC Science and Technology Press. |
| Ιατρικοί όροι (MeSH): | Ribosomal Proteins*/chemistry , Ribosomal Proteins*/metabolism , Ribosomal Proteins*/genetics , RNA, Long Noncoding*/genetics , RNA, Long Noncoding*/chemistry , RNA, Long Noncoding*/metabolism , Oxidative Stress*/genetics , Mitochondria*/metabolism , Mitochondria*/genetics , Uterine Cervical Neoplasms*/genetics , Uterine Cervical Neoplasms*/therapy , Uterine Cervical Neoplasms*/metabolism , Uterine Cervical Neoplasms*/diagnosis , Uterine Cervical Neoplasms*/pathology , Immunotherapy*, Humans ; Prognosis ; Female ; Molecular Docking Simulation ; Gene Expression Regulation, Neoplastic ; Protein Binding ; Protein Interaction Maps ; Ribosomal Protein L3 |
| Περίληψη: | The purpose of this study was to investigate the predictive value of mitochondrial oxidative stress-related LncRNA in cancer prognosis and immunotherapy response, and to further analyze the molecular structure of ribosomal protein L34 and its interaction mechanism with the protein. We screened lncrnas associated with mitochondrial oxidative stress, evaluated their expression patterns in different cancer types, and analyzed the three-dimensional structure of ribosomal protein L34 and its interaction network with other proteins. In this study, public databases were used to screen out lncrnas associated with mitochondrial oxidative stress. Bioinformatic analysis, including gene expression profile analysis, survival analysis and functional enrichment analysis, was used to evaluate the expression patterns of these lncrnas in different cancer types and their relationship with prognosis. The interacting proteins of ribosomal protein L34 were identified by proteomic techniques. The three-dimensional structure of ribosomal protein L34 and its binding mode with interacting proteins were studied by molecular docking and dynamic simulation methods. The results showed that the screened lncrnas showed significant expression differences in multiple cancer types and were closely related to the survival rate of patients. The three-dimensional structure of ribosomal protein L34 reveals key amino acid residues and binding sites for its interactions with specific proteins. Functional enrichment analysis showed that these lncrnas may affect the development of cancer through regulating oxidative stress response, cell cycle and apoptosis. The interaction network of ribosomal protein L34 reveals its central role in protein synthesis and cellular stress response. (Copyright © 2025 Elsevier B.V. All rights reserved.) |
| Competing Interests: | Declaration of competing interest The authors declare that there is no conflict of interests regarding the publication of this article. |
| Σχόλια: | Retraction in: Int J Biol Macromol. 2026 Jul 29:153730. doi: 10.1016/j.ijbiomac.2026.153730.. (PMID: 42527171) |
| Contributed Indexing: | Keywords: Cancer prognosis; Immunotherapy response; LncRNA; Mitochondria; Molecular structure; Oxidative stress; Proteinization; Ribosomal protein L34 |
| Substance Nomenclature: | 0 (Ribosomal Proteins) 0 (RNA, Long Noncoding) 0 (RPL3 protein, human) 0 (Ribosomal Protein L3) |
| Entry Date(s): | Date Created: 20250122 Date Completed: 20250502 Latest Revision: 20260730 |
| Update Code: | 20260731 |
| DOI: | 10.1016/j.ijbiomac.2025.140145 |
| PMID: | 39842564 |
| Βάση Δεδομένων: | MEDLINE |
| ISSN: | 1879-0003 |
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| DOI: | 10.1016/j.ijbiomac.2025.140145 |