Academic Journal
A prospective self-controlled study on the alterations of the ocular surface and conjunctival transcriptomic profile associated with prolonged exposure to video display terminals.
| Τίτλος: | A prospective self-controlled study on the alterations of the ocular surface and conjunctival transcriptomic profile associated with prolonged exposure to video display terminals. |
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| Συγγραφείς: | Li L; Ningbo Eye Hospital, Wenzhou Medical University, Ningbo, 315042, China; National Clinical Research Center for Ocular Diseases, Eye Hospital, Wenzhou Medical University, Wenzhou, 325027, China., Zhu X; National Clinical Research Center for Ocular Diseases, Eye Hospital, Wenzhou Medical University, Wenzhou, 325027, China., Xu W; National Clinical Research Center for Ocular Diseases, Eye Hospital, Wenzhou Medical University, Wenzhou, 325027, China., Dai M; National Clinical Research Center for Ocular Diseases, Eye Hospital, Wenzhou Medical University, Wenzhou, 325027, China., Liu Z; National Clinical Research Center for Ocular Diseases, Eye Hospital, Wenzhou Medical University, Wenzhou, 325027, China., Li Y; National Clinical Research Center for Ocular Diseases, Eye Hospital, Wenzhou Medical University, Wenzhou, 325027, China., Fang Y; Hangzhou Lin'an Traditional Chinese Medicine Hospital, Hangzhou, 311300, China., Li J; National Clinical Research Center for Ocular Diseases, Eye Hospital, Wenzhou Medical University, Wenzhou, 325027, China; Department of Ophthalmology, The Quzhou Affiliated Hospital of Wenzhou Medical University, Quzhou People's Hospital, Quzhou, 32400, Zhejiang Province, China. Electronic address: lijinyang@eye.ac.cn., Chen W; National Clinical Research Center for Ocular Diseases, Eye Hospital, Wenzhou Medical University, Wenzhou, 325027, China; Ningbo Eye Institute, Ningbo Eye Hospital, Wenzhou Medical University, Ningbo, 315040, China. Electronic address: chenweimd@wmu.edu.cn. |
| Πηγή: | The ocular surface [Ocul Surf] 2025 Apr; Vol. 36, pp. 94-105. Date of Electronic Publication: 2025 Jan 17. |
| Τύπος έκδοσης: | Journal Article; Research Support, Non-U.S. Gov't |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: Elsevier Inc Country of Publication: United States NLM ID: 101156063 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1937-5913 (Electronic) Linking ISSN: 15420124 NLM ISO Abbreviation: Ocul Surf Subsets: MEDLINE |
| Imprint Name(s): | Publication: 2012- : [Philadelphia, PA] : Elsevier Inc. Original Publication: New York, N.Y. : Ethis Communications, [c2003]- |
| Ιατρικοί όροι (MeSH): | Conjunctiva*/metabolism , Conjunctiva*/pathology , Dry Eye Syndromes*/metabolism , Dry Eye Syndromes*/etiology , Dry Eye Syndromes*/diagnosis , Dry Eye Syndromes*/genetics , Cornea*/metabolism , Transcriptome* , Computer Terminals*, Meibomian Glands/metabolism ; Meibomian Glands/pathology ; Tears/metabolism ; Humans ; Male ; Female ; Prospective Studies ; Adult ; Middle Aged ; Surveys and Questionnaires ; Aged |
| Περίληψη: | Purpose: To assess the impact of prolonged and intense exposure to video display terminals (VDTs) on ocular surface homeostasis. Methods: 30 subjects limited daily VDT usage to less than 3 h for one week, then extended usage to more than 8 h/day for the next three weeks. Ocular symptoms and signs were evaluated weekly using the Ocular Surface Disease Index (OSDI) questionnaire and clinical examinations. Eyelid margins and meibomian glands were examined, and ocular surface samples were collected for transcriptomic analysis. Results: Average daily VDT time increased from 2.55 ± 0.46 h initially to 11.17 ± 2.45, 11.75 ± 2.63, and 10.89 ± 2.41 h over three weeks. The dry eye diagnosis rate rose from 6.67 % to 51.67 %. Total OSDI score (P = 0.008), symptoms score (P = 0.014), and visual function score (P = 0.002) significantly increased. Mean fluorescein break-up time (FBUT) decreased from 6.46s to 3.08s. Corneal fluorescein staining (CFS) score (P < 0.001) and lissamine green conjunctival staining (LCjs) score (P = 0.036) worsened. Ocular redness index (RI) increased at 1 week and 3 weeks (P = 0.007, P = 0.001). Telangiectasia scores of both upper and lower eyelid margins increased at 3 weeks (P = 0.002, P < 0.001). Meibomian gland orifice blockage worsened (P = 0.014, P = 0.002). Transcriptomic analysis revealed dynamic alterations in ocular surface gene expression, including inflammatory and hormonal responses. MUC5AC and TFF1 genes showed negative correlations with OSDI and conjunctival staining score, respectively. Conclusion: Prolonged VDT exposure deteriorates ocular surface symptoms and signs, with significant inflammatory responses and hormonal activity indicating an imbalance in ocular surface homeostasis. (Copyright © 2025. Published by Elsevier Inc.) |
| Competing Interests: | Declaration of competing interest None for any of the authors. |
| Contributed Indexing: | Keywords: Computer vision syndrome; Dry eye disease; Transcriptome; Visual display terminal |
| Entry Date(s): | Date Created: 20250119 Date Completed: 20250501 Latest Revision: 20260604 |
| Update Code: | 20260604 |
| DOI: | 10.1016/j.jtos.2025.01.007 |
| PMID: | 39828134 |
| Βάση Δεδομένων: | MEDLINE |
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