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Harnessing Simple Animal Models to Decode Sleep Mysteries.

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Title: Harnessing Simple Animal Models to Decode Sleep Mysteries.
Authors: Pandi-Perumal SR; Department of Pharmacology, JSS College of Pharmacy, JSS Academy of Higher Education & Research, Mysuru, 570015, Karnataka, India.; Centre for Research and Development, Chandigarh University, Mohali, 140413, Punjab, India.; Division of Research and Development, Lovely Professional University, Phagwara, 144411, Punjab, India., Saravanan KM; B Aatral Biosciences Private Limited, Bangalore, 560091, Karnataka, India., Paul S; Department of Biochemistry & Molecular Biology, The University of Texas Medical Branch at Galveston, Galveston, TX, 77555, USA., Chidambaram SB; Department of Pharmacology, JSS College of Pharmacy, JSS Academy of Higher Education & Research, Mysuru, 570015, Karnataka, India. babupublications@gmail.com.; Centre for Experimental Pharmacology and Toxicology, Central Animal Facility, JSS Academy of Higher Education & Research, Mysuru, 570015, Karnataka, India. babupublications@gmail.com.
Source: Molecular biotechnology [Mol Biotechnol] 2025 Nov; Vol. 67 (11), pp. 4078-4094. Date of Electronic Publication: 2024 Nov 23.
Publication Type: Journal Article; Review
Language: English
Journal Info: Publisher: Springer Country of Publication: Switzerland NLM ID: 9423533 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1559-0305 (Electronic) Linking ISSN: 10736085 NLM ISO Abbreviation: Mol Biotechnol Subsets: MEDLINE
Imprint Name(s): Publication: [Cham] : Springer
Original Publication: Totowa, NJ : Humana Press, c1994-
MeSH Terms: Sleep*/physiology , Sleep*/genetics , Models, Animal*, Caenorhabditis elegans/physiology ; Circadian Rhythm/physiology ; Zebrafish/physiology ; Drosophila melanogaster/physiology ; Drosophila melanogaster/genetics ; Animals ; Humans ; Disease Models, Animal
Abstract: Whether it involves human subjects or non-human animals, basic, translational, or clinical sleep research poses significant ethical challenges for researchers and ethical committees alike. Sleep research greatly benefits from using diverse animal models, each offering unique insights into sleep control mechanisms. The fruit fly (Drosophila melanogaster) is a superior genetic model due to its quick generation period, large progenies, and rich genetic tools. Its well-characterized genome and ability to respond to hypnotics and stimulants make it an effective tool for studying sleep genetics and physiological foundations. The nematode (Caenorhabditis elegans) has a simpler neural organization and transparent body, allowing researchers to explore molecular underpinnings of sleep control. Vertebrate models, like zebrafish (Danio rerio), provide insights into circadian rhythm regulation, memory consolidation, and drug effects on sleep. Invertebrate models, like California sea hare (Aplysia californica) and Upside-down jellyfish (Cassiopea xamachana), have simpler nervous systems and behave similarly to humans, allowing for the examination of sleep principles without logistical and ethical challenges. Combining vertebrate and invertebrate animal models offers a comprehensive approach to studying sleep, improving our understanding of sleep regulation and potentially leading to new drug discovery processes for sleep disorders and related illnesses.
(© 2024. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.)
Competing Interests: Declarations. Conflict of interests: The authors declare that they have no known conflict or competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. Ethical Approval: This study does not contain any work involving animals or human participants performed by any of the authors. Hence, no IRB approval was necessary for this work.
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Contributed Indexing: Keywords: Animal models; Aplysia; C. elegans; Drosophila; Sleep research; Zebrafish
Entry Date(s): Date Created: 20241123 Date Completed: 20251029 Latest Revision: 20261010
Update Code: 20261010
DOI: 10.1007/s12033-024-01318-z
PMID: 39579174
Database: MEDLINE
Description
ISSN:1559-0305
DOI:10.1007/s12033-024-01318-z