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Dentinal Tubule Occlusion and Dentin Permeability Efficacy of Silver Diamine Fluoride Solutions.

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Title: Dentinal Tubule Occlusion and Dentin Permeability Efficacy of Silver Diamine Fluoride Solutions.
Authors: El-Damanhoury HM; Department of Preventive and Restorative Dentistry, College of Dental Medicine, University of Sharjah, Sharjah, UAE.; Research Institute for Medical and Health Sciences, University of Sharjah, Sharjah, UAE., Rahman B; Department of Preventive and Restorative Dentistry, College of Dental Medicine, University of Sharjah, Sharjah, UAE.; Research Institute for Medical and Health Sciences, University of Sharjah, Sharjah, UAE., Sheela S; Research Institute for Medical and Health Sciences, University of Sharjah, Sharjah, UAE., Ngo HC; The University of Western Australia, Nedlands, Western Australia, Australia.
Source: International journal of dental hygiene [Int J Dent Hyg] 2025 May; Vol. 23 (2), pp. 286-293. Date of Electronic Publication: 2024 Oct 31.
Publication Type: Journal Article
Language: English
Journal Info: Publisher: Blackwell Pub Country of Publication: England NLM ID: 101168070 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1601-5037 (Electronic) Linking ISSN: 16015029 NLM ISO Abbreviation: Int J Dent Hyg Subsets: MEDLINE
Imprint Name(s): Original Publication: Oxford [Eng.] : Blackwell Pub., c2003-
MeSH Terms: Quaternary Ammonium Compounds*/pharmacology , Dentin Permeability*/drug effects , Dentin*/drug effects , Dentin*/ultrastructure , Silver Compounds*/pharmacology , Dentin Desensitizing Agents*/pharmacology, Fluorides, Topical/pharmacology ; Acid Etching, Dental/methods ; Dentin Sensitivity/prevention & control ; Humans ; In Vitro Techniques ; Microscopy, Electron, Scanning ; Materials Testing
Abstract: Aim: This in vitro study compared the effect of two commercially available silver diamine fluoride (SDF) products on dentinal tubule (DT) occlusion and dentin permeability.
Methods: Sixty-six dentin discs (1.0 mm thick) were divided equally into six groups: acid-etched with no treatment (negative control-NC), etched and sealed with nail varnish (positive control-PC), non-etched and treated with Advantage Arrest (AA), non-etched and treated with Topamine (TP), etched and treated with AA, and etched and treated with TP. Eight specimens from each group were tested for permeability using the dye percolation method. The remaining three samples from each group were assessed for dentinal tubule occlusion, depth of SDF penetration, and elemental analysis using a scanning electron microscope coupled with an energy-dispersive X-ray (SEM/EDX) system. One-way ANOVA and Tukey's post hoc test were used to analyze the results.
Results: TP exhibited lower (p < 0.05) dye percolation compared to AA. While both SDF materials showed a statistically similar (p > 0.05) penetration depth in the DT, none of them had the ability to completely occlude all the DTs. AA exhibited more silver and fluoride ion deposition on etched dentin than TP, and both materials showed a similar increase in the deposition of Ca and P compared to NC.
Conclusions: Whereas the effectiveness of dentin tubule (DT) occlusion varies based on the material used, both tested SDF products exhibit the capability to seal dentinal tubules, decrease dentin permeability, and promote dentin remineralization. These findings suggest their potential advantage in managing dentin hypersensitivity.
(© 2024 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.)
References: O. V. Boiko, S. R. Baker, B. J. Gibson, et al., “Construction and Validation of the Quality of Life Measure for Dentine Hypersensitivity (DHEQ),” Journal of Clinical Periodontology 37, no. 11 (2010): 973–980.
R. Biagi, G. Cossellu, M. Sarcina, I. Pizzamiglio, and G. Farronato, “Laser‐Assisted Treatment of Dentin Hypersensitivity: A Literature Review,” Annali di Stomatologia 6 (2015): 75–80.
M. Addy and M. L. Hunter, “Can Tooth Brushing Damage Your Health? Effects on Oral and Dental Tissues,” International Dental Journal 53, no. Suppl 3 (2003): 177–186.
C. Susin, A. N. Haas, R. V. Oppermann, O. Haugejorden, and J. M. Albandar, “Gingival Recession: Epidemiology and Risk Indicators in a Representative Urban Brazilian Population,” Journal of Periodontology 75, no. 10 (2004): 1377–1386.
M. Brännström, G. Johnson, and K. J. Nordenvall, “Transmission and Control of Dentinal Pain: Resin Impregnation for the Desensitization of Dentin,” Journal of the American Dental Association (1939) 99, no. 4 (1979): 612–618.
M. Brännström, L. A. Lindén, and A. Aström, “The Hydrodynamics of the Dental Tubule and of Pulp Fluid. A Discussion of Its Significance in Relation to Dentinal Sensitivity,” Caries Research 1, no. 4 (1967): 310–317.
E. G. Absi, M. Addy, and D. Adams, “Dentine Hypersensitivity. The Development and Evaluation of a Replica Technique to Study Sensitive and Non‐sensitive Cervical Dentine,” Journal of Clinical Periodontology 16, no. 3 (1989): 190–195.
S. Poulsen, M. Errboe, Y. Lescay Mevil, and A. M. Glenny, “Potassium Containing Toothpastes for Dentine Hypersensitivity,” Cochrane Database of Systematic Reviews 2006, no. 3 (2006): CD001476.
A. P. Forsback, S. Areva, and J. I. Salonen, “Mineralization of Dentin Induced by Treatment With Bioactive Glass S53P4 In Vitro,” Acta Odontologica Scandinavica 62, no. 1 (2004): 14–20.
R. Docimo, L. Montesani, P. Maturo, et al., “Comparing the Efficacy in Reducing Dentin Hypersensitivity of a New Toothpaste Containing 8.0% Arginine, Calcium Carbonate, and 1450 ppm Fluoride to a Benchmark Commercial Desensitizing Toothpaste Containing 2% Potassium Ion: An Eight‐Week Clinical Study in Rome, Italy,” Journal of Clinical Dentistry 20, no. 4 (2009): 137–143.
K. Que, Y. Fu, L. Lin, et al., “Dentin Hypersensitivity Reduction of a New Toothpaste Containing 8.0% Arginine and 1450 ppm Fluoride: An 8‐Week Clinical Study on Chinese Adults,” American Journal of Dentistry 23 (2010): 28A–35A.
S. H. João‐Souza, T. Scaramucci, A. Bühler Borges, A. Lussi, T. Saads Carvalho, and A. C. Corrêa Aranha, “Influence of Desensitizing and Anti‐Erosive Toothpastes on Dentine Permeability: An In Vitro Study,” Journal of Dentistry 89 (2019): 103176.
A. Diniz, S. Lima, R. Tavarez, et al., “Preventive Use of a Resin‐Based Desensitizer Containing Glutaraldehyde on Tooth Sensitivity Caused by in‐Office Bleaching: A Randomized, Single‐Blind Clinical Trial,” Operative Dentistry 43, no. 5 (2018): 472–481.
M. Firouzmandi, F. Valipour, M. Roshanzamir, and T. Mobaleghi, “The Effect of Oxalate‐Based Desensitizers on the Microleakage and Shear Bond Strength of Resin Modified Glass Ionomer,” Journal of Clinical and Experimental Dentistry 9, no. 10 (2017): e1183–e1188.
D. G. Kerns, M. J. Scheidt, D. H. Pashley, J. A. Horner, S. L. Strong, and T. E. Van Dyke, “Dentinal Tubule Occlusion and Root Hypersensitivity,” Journal of Periodontology 62, no. 7 (1991): 421–428.
M. Nishino, S. Yoshida, S. Sobue, J. Kato, and M. Nishida, “Effect of Topically Applied Ammoniacal Silver Fluoride on Dental Caries in Children,” Journal of Osaka University Dental School 9 (1969): 149–155.
M. L. Mei, C. H. Chu, E. C. Lo, and L. P. Samaranayake, “Fluoride and Silver Concentrations of Silver Diammine Fluoride Solutions for Dental Use,” International Journal of Paediatric Dentistry 23, no. 4 (2013): 279–285.
R. Yamaga, M. Nishino, S. Yoshida, and I. Yokomizo, “Diammine Silver Fluoride and Its Clinical Application,” Journal of Osaka University Dental School 12 (1972): 1–20.
J. L. Castillo, S. Rivera, T. Aparicio, et al., “The Short‐Term Effects of Diamine Silver Fluoride on Tooth Sensitivity: A Randomized Controlled Trial,” Journal of Dental Research 90, no. 2 (2011): 203–208.
G. C. Craig, G. M. Knight, and J. M. McIntyre, “Clinical Evaluation of Diamine Silver Fluoride/Potassium Iodide as a Dentine Desensitizing Agent: A Pilot Study,” Australian Dental Journal 57 (2012): 308–311.
É. T. de Almeida Piovesan, J. B. Alves, C. D. Ribeiro, C. Massignan, A. C. Bezerra, and S. C. Leal, “Is Silver Diamine Fluoride Effective in Reducing Dentin Hypersensitivity? A Systematic Review,” Journal of Dental Research 17, no. 2 (2023): 64.
A. K. Chan, Y. C. Tsang, C. M. Jiang, K. C. Leung, E. C. Lo, and C. H. Chu, “Treating Hypersensitivity in Older Adults With Silver Diamine Fluoride: A Randomised Clinical Trial,” Journal of Dentistry 136 (2023): 104616.
T. Suge, A. Kawasaki, K. Ishikawa, T. Matsuo, and S. Ebisu, “Effect of Ammonium Hexafluorosilicate on Dentin Tubule Occlusion for the Treatment of Dentin Hypersensitivity,” American Journal of Dentistry 19, no. 4 (2006): 248–252.
G. M. Knight, J. M. McIntyre, G. G. Craig, Z. P. S. Mulyani, and N. J. Gully, “Inability to Form a Biofilm of Streptococcus mutans on Silver Fluoride‐ and Potassium Iodide‐Treated Demineralized Dentin,” Quintessence International 40, no. 2 (2009): 155–161.
B. Rahman, H. M. El‐Damanhoury, S. Sheela, and H. C. Ngo, “Effect of Calcium Silicate, Sodium Phosphate, and Fluoride on Dentinal Tubule Occlusion and Permeability in Comparison to Desensitizing Toothpaste: An In Vitro Study,” Operative Dentistry 46, no. 6 (2021): 641–649.
M. L. Mei, E. C. Lo, and C. H. Chu, “Clinical Use of Silver Diamine Fluoride in Dental Treatment,” Compendium of Continuing Education in Dentistry 37, no. 2 (2016): 93–98.
H. Hamama, C. Yiu, and M. Burrow, “Effect of Silver Diamine Fluoride and Potassium Iodide on Residual Bacteria in Dentinal Tubules,” Australian Dental Journal 60 (2015): 80–87.
J. O. Burgess and P. M. Vaghela, “Silver Diamine Fluoride: A Successful Anticarious Solution With Limits,” Advances in Dental Research 29 (2018): 131–134.
M. Jain, R. Thakkar, S. Jadeja, L. Mohanty, S. Sahu, and F. Khan, “Assessment of Various Application Times of Diamine Silver Fluoride Desensitizing Solution on Dentin Hydraulic Conductance,” Journal of Advanced Medical and Dental Sciences Research 9, no. 7 (2021): 137–141.
N. Hiraishi, M. Sayed, R. Hill, and Y. Shimada, “Solid‐State NMR Spectroscopy Measurement of Fluoride Reaction by Bovine Enamel and Dentin Treated With Silver Diammine Fluoride,” Dental Materials 38, no. 5 (2022): 769–777.
I. Willershausen, D. Schulte, A. Azaripour, V. Weyer, B. Briseño, and B. Willershausen, “Penetration Potential of a Silver Diamine Fluoride Solution on Dentin Surfaces. An Ex Vivo Study,” Clinical Laboratory 61 (2015): 1695–1701.
K. Savitha, P. S. Manoharan, J. Balaji, G. Ezhumalai, B. T. Pradeep Raja, and S. Roy, “Effect of Silver Diamine Fluoride, Potassium Nitrate, and Glutaraldehyde in Reducing the Post Vital Tooth Preparation Hypersensitivity: A Randomized Controlled Trial,” Journal of Indian Prosthodontic Society 22, no. 2 (2022): 143–151.
A. C. Chibinski, The Use of Silver Diamine Fluoride in Pediatric Dentistry. Dental Caries (London, United Kingdom: IntechOpen, 2020), 100.
S. Hu, B. Meyer, and M. Duggal, “A Silver Renaissance in Dentistry,” European Archives of Paediatric Dentistry 19 (2018): 221–227.
M. Mei, E. Lo, and C. Chu, “Arresting Dentine Caries With Silver Diamine Fluoride: What's Behind It?,” Journal of Dental Research 97 (2018): 751–758.
Contributed Indexing: Keywords: dentin permeability; hypersensitivity; silver diamine fluoride; tubule occlusion
Substance Nomenclature: DDU19UEV1Y (silver diamine fluoride)
0 (Quaternary Ammonium Compounds)
0 (Silver Compounds)
0 (Dentin Desensitizing Agents)
0 (Fluorides, Topical)
Entry Date(s): Date Created: 20241031 Date Completed: 20250410 Latest Revision: 20250410
Update Code: 20260130
DOI: 10.1111/idh.12854
PMID: 39480698
Database: MEDLINE
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  Data: Dentinal Tubule Occlusion and Dentin Permeability Efficacy of Silver Diamine Fluoride Solutions.
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  Data: &lt;searchLink fieldCode=&quot;AU&quot; term=&quot;%22El-Damanhoury+HM%22&quot;&gt;El-Damanhoury HM&lt;/searchLink&gt;; Department of Preventive and Restorative Dentistry, College of Dental Medicine, University of Sharjah, Sharjah, UAE.; Research Institute for Medical and Health Sciences, University of Sharjah, Sharjah, UAE.&lt;br /&gt;&lt;searchLink fieldCode=&quot;AU&quot; term=&quot;%22Rahman+B%22&quot;&gt;Rahman B&lt;/searchLink&gt;; Department of Preventive and Restorative Dentistry, College of Dental Medicine, University of Sharjah, Sharjah, UAE.; Research Institute for Medical and Health Sciences, University of Sharjah, Sharjah, UAE.&lt;br /&gt;&lt;searchLink fieldCode=&quot;AU&quot; term=&quot;%22Sheela+S%22&quot;&gt;Sheela S&lt;/searchLink&gt;; Research Institute for Medical and Health Sciences, University of Sharjah, Sharjah, UAE.&lt;br /&gt;&lt;searchLink fieldCode=&quot;AU&quot; term=&quot;%22Ngo+HC%22&quot;&gt;Ngo HC&lt;/searchLink&gt;; The University of Western Australia, Nedlands, Western Australia, Australia.
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  Data: &lt;searchLink fieldCode=&quot;JN&quot; term=&quot;%22101168070%22&quot;&gt;International journal of dental hygiene&lt;/searchLink&gt; [Int J Dent Hyg] 2025 May; Vol. 23 (2), pp. 286-293. &lt;i&gt;Date of Electronic Publication: &lt;/i&gt;2024 Oct 31.
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  Data: &lt;searchLink fieldCode=&quot;MM&quot; term=&quot;%22Quaternary+Ammonium+Compounds%22&quot;&gt;Quaternary Ammonium Compounds*&lt;/searchLink&gt;/&lt;searchLink fieldCode=&quot;MM&quot; term=&quot;%22Quaternary+Ammonium+Compounds+pharmacology%22&quot;&gt;pharmacology&lt;/searchLink&gt; &lt;br /&gt;&lt;searchLink fieldCode=&quot;MM&quot; term=&quot;%22Dentin+Permeability%22&quot;&gt;Dentin Permeability*&lt;/searchLink&gt;/&lt;searchLink fieldCode=&quot;MM&quot; term=&quot;%22Dentin+Permeability+drug+effects%22&quot;&gt;drug effects&lt;/searchLink&gt; &lt;br /&gt;&lt;searchLink fieldCode=&quot;MM&quot; term=&quot;%22Dentin%22&quot;&gt;Dentin*&lt;/searchLink&gt;/&lt;searchLink fieldCode=&quot;MM&quot; term=&quot;%22Dentin+drug+effects%22&quot;&gt;drug effects&lt;/searchLink&gt; &lt;br /&gt;&lt;searchLink fieldCode=&quot;MM&quot; term=&quot;%22Dentin%22&quot;&gt;Dentin*&lt;/searchLink&gt;/&lt;searchLink fieldCode=&quot;MM&quot; term=&quot;%22Dentin+ultrastructure%22&quot;&gt;ultrastructure&lt;/searchLink&gt; &lt;br /&gt;&lt;searchLink fieldCode=&quot;MM&quot; term=&quot;%22Silver+Compounds%22&quot;&gt;Silver Compounds*&lt;/searchLink&gt;/&lt;searchLink fieldCode=&quot;MM&quot; term=&quot;%22Silver+Compounds+pharmacology%22&quot;&gt;pharmacology&lt;/searchLink&gt; &lt;br /&gt;&lt;searchLink fieldCode=&quot;MM&quot; term=&quot;%22Dentin+Desensitizing+Agents%22&quot;&gt;Dentin Desensitizing Agents*&lt;/searchLink&gt;/&lt;searchLink fieldCode=&quot;MM&quot; term=&quot;%22Dentin+Desensitizing+Agents+pharmacology%22&quot;&gt;pharmacology&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;MH&quot; term=&quot;%22Fluorides%2C+Topical%22&quot;&gt;Fluorides, Topical&lt;/searchLink&gt;/&lt;searchLink fieldCode=&quot;MH&quot; term=&quot;%22Fluorides%2C+Topical+pharmacology%22&quot;&gt;pharmacology&lt;/searchLink&gt; ; &lt;searchLink fieldCode=&quot;MH&quot; term=&quot;%22Acid+Etching%2C+Dental%22&quot;&gt;Acid Etching, Dental&lt;/searchLink&gt;/&lt;searchLink fieldCode=&quot;MH&quot; term=&quot;%22Acid+Etching%2C+Dental+methods%22&quot;&gt;methods&lt;/searchLink&gt; ; &lt;searchLink fieldCode=&quot;MH&quot; term=&quot;%22Dentin+Sensitivity%22&quot;&gt;Dentin Sensitivity&lt;/searchLink&gt;/&lt;searchLink fieldCode=&quot;MH&quot; term=&quot;%22Dentin+Sensitivity+prevention+%26+control%22&quot;&gt;prevention &amp; control&lt;/searchLink&gt; ; &lt;searchLink fieldCode=&quot;MH&quot; term=&quot;%22Humans%22&quot;&gt;Humans&lt;/searchLink&gt; ; &lt;searchLink fieldCode=&quot;MH&quot; term=&quot;%22In+Vitro+Techniques%22&quot;&gt;In Vitro Techniques&lt;/searchLink&gt; ; &lt;searchLink fieldCode=&quot;MH&quot; term=&quot;%22Microscopy%2C+Electron%2C+Scanning%22&quot;&gt;Microscopy, Electron, Scanning&lt;/searchLink&gt; ; &lt;searchLink fieldCode=&quot;MH&quot; term=&quot;%22Materials+Testing%22&quot;&gt;Materials Testing&lt;/searchLink&gt;
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Aim: This in&#160;vitro study compared the effect of two commercially available silver diamine fluoride (SDF) products on dentinal tubule (DT) occlusion and dentin permeability.&lt;br /&gt;Methods: Sixty-six dentin discs (1.0 mm thick) were divided equally into six groups: acid-etched with no treatment (negative control-NC), etched and sealed with nail varnish (positive control-PC), non-etched and treated with Advantage Arrest (AA), non-etched and treated with Topamine (TP), etched and treated with AA, and etched and treated with TP. Eight specimens from each group were tested for permeability using the dye percolation method. The remaining three samples from each group were assessed for dentinal tubule occlusion, depth of SDF penetration, and elemental analysis using a scanning electron microscope coupled with an energy-dispersive X-ray (SEM/EDX) system. One-way ANOVA and Tukey&#39;s post hoc test were used to analyze the results.&lt;br /&gt;Results: TP exhibited lower (p &amp;lt; 0.05) dye percolation compared to AA. While both SDF materials showed a statistically similar (p &amp;gt; 0.05) penetration depth in the DT, none of them had the ability to completely occlude all the DTs. AA exhibited more silver and fluoride ion deposition on etched dentin than TP, and both materials showed a similar increase in the deposition of Ca and P compared to NC.&lt;br /&gt;Conclusions: Whereas the effectiveness of dentin tubule (DT) occlusion varies based on the material used, both tested SDF products exhibit the capability to seal dentinal tubules, decrease dentin permeability, and promote dentin remineralization. These findings suggest their potential advantage in managing dentin hypersensitivity.&lt;br /&gt; (&#169; 2024 John Wiley &amp; Sons A/S. Published by John Wiley &amp; Sons Ltd.)
– Name: Ref
  Label: References
  Group: RefInfo
  Data: O. V. Boiko, S. R. Baker, B. J. Gibson, et&#160;al., “Construction and Validation of the Quality of Life Measure for Dentine Hypersensitivity (DHEQ),” Journal of Clinical Periodontology 37, no. 11 (2010): 973–980.&lt;br /&gt;R. Biagi, G. Cossellu, M. Sarcina, I. Pizzamiglio, and G. Farronato, “Laser‐Assisted Treatment of Dentin Hypersensitivity: A Literature Review,” Annali di Stomatologia 6 (2015): 75–80.&lt;br /&gt;M. Addy and M. L. Hunter, “Can Tooth Brushing Damage Your Health? Effects on Oral and Dental Tissues,” International Dental Journal 53, no. Suppl 3 (2003): 177–186.&lt;br /&gt;C. Susin, A. N. Haas, R. V. Oppermann, O. Haugejorden, and J. M. Albandar, “Gingival Recession: Epidemiology and Risk Indicators in a Representative Urban Brazilian Population,” Journal of Periodontology 75, no. 10 (2004): 1377–1386.&lt;br /&gt;M. Br&#228;nnstr&#246;m, G. Johnson, and K. J. Nordenvall, “Transmission and Control of Dentinal Pain: Resin Impregnation for the Desensitization of Dentin,” Journal of the American Dental Association (1939) 99, no. 4 (1979): 612–618.&lt;br /&gt;M. Br&#228;nnstr&#246;m, L. A. Lind&#233;n, and A. Astr&#246;m, “The Hydrodynamics of the Dental Tubule and of Pulp Fluid. A Discussion of Its Significance in Relation to Dentinal Sensitivity,” Caries Research 1, no. 4 (1967): 310–317.&lt;br /&gt;E. G. Absi, M. Addy, and D. Adams, “Dentine Hypersensitivity. The Development and Evaluation of a Replica Technique to Study Sensitive and Non‐sensitive Cervical Dentine,” Journal of Clinical Periodontology 16, no. 3 (1989): 190–195.&lt;br /&gt;S. Poulsen, M. Errboe, Y. Lescay Mevil, and A. M. Glenny, “Potassium Containing Toothpastes for Dentine Hypersensitivity,” Cochrane Database of Systematic Reviews 2006, no. 3 (2006): CD001476.&lt;br /&gt;A. P. Forsback, S. Areva, and J. I. Salonen, “Mineralization of Dentin Induced by Treatment With Bioactive Glass S53P4 In&#160;Vitro,” Acta Odontologica Scandinavica 62, no. 1 (2004): 14–20.&lt;br /&gt;R. Docimo, L. Montesani, P. Maturo, et&#160;al., “Comparing the Efficacy in Reducing Dentin Hypersensitivity of a New Toothpaste Containing 8.0% Arginine, Calcium Carbonate, and 1450 ppm Fluoride to a Benchmark Commercial Desensitizing Toothpaste Containing 2% Potassium Ion: An Eight‐Week Clinical Study in Rome, Italy,” Journal of Clinical Dentistry 20, no. 4 (2009): 137–143.&lt;br /&gt;K. Que, Y. Fu, L. Lin, et&#160;al., “Dentin Hypersensitivity Reduction of a New Toothpaste Containing 8.0% Arginine and 1450 ppm Fluoride: An 8‐Week Clinical Study on Chinese Adults,” American Journal of Dentistry 23 (2010): 28A–35A.&lt;br /&gt;S. H. Jo&#227;o‐Souza, T. Scaramucci, A. B&#252;hler Borges, A. Lussi, T. Saads Carvalho, and A. C. Corr&#234;a Aranha, “Influence of Desensitizing and Anti‐Erosive Toothpastes on Dentine Permeability: An In&#160;Vitro Study,” Journal of Dentistry 89 (2019): 103176.&lt;br /&gt;A. Diniz, S. Lima, R. Tavarez, et&#160;al., “Preventive Use of a Resin‐Based Desensitizer Containing Glutaraldehyde on Tooth Sensitivity Caused by in‐Office Bleaching: A Randomized, Single‐Blind Clinical Trial,” Operative Dentistry 43, no. 5 (2018): 472–481.&lt;br /&gt;M. Firouzmandi, F. Valipour, M. Roshanzamir, and T. Mobaleghi, “The Effect of Oxalate‐Based Desensitizers on the Microleakage and Shear Bond Strength of Resin Modified Glass Ionomer,” Journal of Clinical and Experimental Dentistry 9, no. 10 (2017): e1183–e1188.&lt;br /&gt;D. G. Kerns, M. J. Scheidt, D. H. Pashley, J. A. Horner, S. L. Strong, and T. E. Van Dyke, “Dentinal Tubule Occlusion and Root Hypersensitivity,” Journal of Periodontology 62, no. 7 (1991): 421–428.&lt;br /&gt;M. Nishino, S. Yoshida, S. Sobue, J. Kato, and M. Nishida, “Effect of Topically Applied Ammoniacal Silver Fluoride on Dental Caries in Children,” Journal of Osaka University Dental School 9 (1969): 149–155.&lt;br /&gt;M. L. Mei, C. H. Chu, E. C. Lo, and L. P. Samaranayake, “Fluoride and Silver Concentrations of Silver Diammine Fluoride Solutions for Dental Use,” International Journal of Paediatric Dentistry 23, no. 4 (2013): 279–285.&lt;br /&gt;R. Yamaga, M. Nishino, S. Yoshida, and I. Yokomizo, “Diammine Silver Fluoride and Its Clinical Application,” Journal of Osaka University Dental School 12 (1972): 1–20.&lt;br /&gt;J. L. Castillo, S. Rivera, T. Aparicio, et&#160;al., “The Short‐Term Effects of Diamine Silver Fluoride on Tooth Sensitivity: A Randomized Controlled Trial,” Journal of Dental Research 90, no. 2 (2011): 203–208.&lt;br /&gt;G. C. Craig, G. M. Knight, and J. M. McIntyre, “Clinical Evaluation of Diamine Silver Fluoride/Potassium Iodide as a Dentine Desensitizing Agent: A Pilot Study,” Australian Dental Journal 57 (2012): 308–311.&lt;br /&gt;&#201;. T. de Almeida Piovesan, J. B. Alves, C. D. Ribeiro, C. Massignan, A. C. Bezerra, and S. C. Leal, “Is Silver Diamine Fluoride Effective in Reducing Dentin Hypersensitivity? A Systematic Review,” Journal of Dental Research 17, no. 2 (2023): 64.&lt;br /&gt;A. K. Chan, Y. C. Tsang, C. M. Jiang, K. C. Leung, E. C. Lo, and C. H. Chu, “Treating Hypersensitivity in Older Adults With Silver Diamine Fluoride: A Randomised Clinical Trial,” Journal of Dentistry 136 (2023): 104616.&lt;br /&gt;T. Suge, A. Kawasaki, K. Ishikawa, T. Matsuo, and S. Ebisu, “Effect of Ammonium Hexafluorosilicate on Dentin Tubule Occlusion for the Treatment of Dentin Hypersensitivity,” American Journal of Dentistry 19, no. 4 (2006): 248–252.&lt;br /&gt;G. M. Knight, J. M. McIntyre, G. G. Craig, Z. P. S. Mulyani, and N. J. 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  Label: Contributed Indexing
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  Data: &lt;i&gt;Keywords: &lt;/i&gt;dentin permeability; hypersensitivity; silver diamine fluoride; tubule occlusion
– Name: NumberCAS
  Label: Substance Nomenclature
  Group: ID
  Data: DDU19UEV1Y (silver diamine fluoride)&lt;br /&gt;0 (Quaternary Ammonium Compounds)&lt;br /&gt;0 (Silver Compounds)&lt;br /&gt;0 (Dentin Desensitizing Agents)&lt;br /&gt;0 (Fluorides, Topical)
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  Data: &lt;i&gt;Date Created: &lt;/i&gt;20241031 &lt;i&gt;Date Completed: &lt;/i&gt;20250410 &lt;i&gt;Latest Revision: &lt;/i&gt;20250410
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  Data: 20260130
– Name: DOI
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  Data: 10.1111/idh.12854
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  Data: 39480698
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=cmedm&AN=39480698
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1111/idh.12854
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        StartPage: 286
    Subjects:
      – SubjectFull: Fluorides, Topical pharmacology
        Type: general
      – SubjectFull: Acid Etching, Dental methods
        Type: general
      – SubjectFull: Dentin Sensitivity prevention & control
        Type: general
      – SubjectFull: Humans
        Type: general
      – SubjectFull: In Vitro Techniques
        Type: general
      – SubjectFull: Microscopy, Electron, Scanning
        Type: general
      – SubjectFull: Materials Testing
        Type: general
      – SubjectFull: Quaternary Ammonium Compounds pharmacology
        Type: general
      – SubjectFull: Dentin Permeability drug effects
        Type: general
      – SubjectFull: Dentin drug effects
        Type: general
      – SubjectFull: Dentin ultrastructure
        Type: general
      – SubjectFull: Silver Compounds pharmacology
        Type: general
      – SubjectFull: Dentin Desensitizing Agents pharmacology
        Type: general
    Titles:
      – TitleFull: Dentinal Tubule Occlusion and Dentin Permeability Efficacy of Silver Diamine Fluoride Solutions.
        Type: main
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            NameFull: El-Damanhoury HM
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            NameFull: Rahman B
      – PersonEntity:
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            NameFull: Sheela S
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          Dates:
            – D: 01
              M: 05
              Text: 2025 May
              Type: published
              Y: 2025
          Identifiers:
            – Type: issn-electronic
              Value: 1601-5037
          Numbering:
            – Type: volume
              Value: 23
            – Type: issue
              Value: 2
          Titles:
            – TitleFull: International journal of dental hygiene
              Type: main
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