Academic Journal
Effectiveness of cellulite treatment with combined enzymatic therapy.
| Τίτλος: | Effectiveness of cellulite treatment with combined enzymatic therapy. |
|---|---|
| Συγγραφείς: | Santaella-Sosa E; ERSA Medical Aesthetics, Monterrey, Mexico., Bageorgou F; Andreas Sygros Hospital of Dermal and Venereal Diseases, Athens, Greece., Castelanich DG; Private Practice, Buenos Aires, Argentina., López Berroa J; Proteos Biotech, Madrid, Spain. |
| Πηγή: | Acta dermatovenerologica Alpina, Pannonica, et Adriatica [Acta Dermatovenerol Alp Pannonica Adriat] 2024 Sep; Vol. 33 (3), pp. 141-143. |
| Τύπος έκδοσης: | Journal Article; Case Reports |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: Združenje Slovenskih Dermatovenerologov Country of Publication: Slovenia NLM ID: 9422563 Publication Model: Print Cited Medium: Internet ISSN: 1581-2979 (Electronic) Linking ISSN: 13184458 NLM ISO Abbreviation: Acta Dermatovenerol Alp Pannonica Adriat Subsets: MEDLINE |
| Imprint Name(s): | Publication: Ljubljana : Združenje Slovenskih Dermatovenerologov Original Publication: Ljubljana : Slovene Welding Society, 1992- |
| Ιατρικοί όροι (MeSH): | Cellulite*/therapy , Cellulite*/drug therapy, Collagenases/therapeutic use ; Lipase/therapeutic use ; Lipase/blood ; Humans ; Female ; Adult ; Middle Aged ; Treatment Outcome ; Enzyme Therapy |
| Περίληψη: | Introduction: Cellulite, also known as edematous fibrosclerotic panniculopathy (EFP), affects up to 90% of women and has a significant aesthetic impact. EFP is a multifactorial condition characterized by local circulatory changes, increased adipose tissue thickness, and a fibrotic response involving thick collagen bundles and septa, driven by local hypoxia. Although numerous treatments exist, their effects are typically temporary. This study evaluates the outcomes of four patients with EFP treated using a combined recombinant enzymatic therapy consisting of a lyase, lipase, and collagenase. Methods: A standardized protocol involving injections of a combined enzyme solution (pbserum Medium™) was administered to the lower limbs in three separate sessions. Pre- and post-treatment photographs were collected for comparative analysis. Results: All four patients showed improvements in skin appearance and fibrosis, with no systemic or local adverse events reported. Conclusions: We propose that a treatment strategy targeting the edematous, adipose, and fibrotic components of EFP may offer an economical and pathogenic-based approach for managing this condition in affected women. |
| Substance Nomenclature: | EC 3.4.24.- (Collagenases) EC 3.1.1.3 (Lipase) |
| Entry Date(s): | Date Created: 20240926 Date Completed: 20240926 Latest Revision: 20241023 |
| Update Code: | 20260130 |
| PMID: | 39324352 |
| Βάση Δεδομένων: | MEDLINE |
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