Academic Journal
Brief Report: Relationships Between Caregiver-Reported Externalizing and Internalizing Behaviors and the Modified Checklist for Autism in Toddlers.
| Τίτλος: | Brief Report: Relationships Between Caregiver-Reported Externalizing and Internalizing Behaviors and the Modified Checklist for Autism in Toddlers. |
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| Συγγραφείς: | Marryat J; Department of Psychiatry and Behavioral Sciences, Duke Center for Autism and Brain Development, Duke University School of Medicine, 2608 Erwin Road, Suite 300, Durham, NC, 27705, USA., Davis NO; Department of Psychiatry and Behavioral Sciences, Duke Center for Autism and Brain Development, Duke University School of Medicine, 2608 Erwin Road, Suite 300, Durham, NC, 27705, USA. naomi.davis@duke.edu., Lerebours R; Department of Biostatistics and Bioinformatics, Duke University, 415 Chapel Drive, Durham, NC, 27705, USA., Carpenter KLH; Department of Psychiatry and Behavioral Sciences, Duke Center for Autism and Brain Development, Duke University School of Medicine, 2608 Erwin Road, Suite 300, Durham, NC, 27705, USA., Compton S; Department of Psychiatry and Behavioral Sciences, Duke Center for Autism and Brain Development, Duke University School of Medicine, 2608 Erwin Road, Suite 300, Durham, NC, 27705, USA., Eichner B; Duke University School of Medicine, 8 Searle Center Drive, Durham, NC, 27705, USA., Franz L; Department of Psychiatry and Behavioral Sciences, Duke Center for Autism and Brain Development, Duke University School of Medicine, 2608 Erwin Road, Suite 300, Durham, NC, 27705, USA., Kollins SH; Duke University School of Medicine, 8 Searle Center Drive, Durham, NC, 27705, USA.; Akili Interactive Labs, 125 Broad Street, Boston, MA, 02110, USA., Spanos M; Department of Psychiatry and Behavioral Sciences, Duke Center for Autism and Brain Development, Duke University School of Medicine, 2608 Erwin Road, Suite 300, Durham, NC, 27705, USA., Dawson G; Department of Psychiatry and Behavioral Sciences, Duke Center for Autism and Brain Development, Duke University School of Medicine, 2608 Erwin Road, Suite 300, Durham, NC, 27705, USA. |
| Πηγή: | Journal of autism and developmental disorders [J Autism Dev Disord] 2026 Sep; Vol. 56 (9), pp. 3744-3751. Date of Electronic Publication: 2024 Jul 12. |
| Τύπος έκδοσης: | Journal Article |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: Springer Country of Publication: United States NLM ID: 7904301 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1573-3432 (Electronic) Linking ISSN: 01623257 NLM ISO Abbreviation: J Autism Dev Disord Subsets: MEDLINE |
| Imprint Name(s): | Publication: <2006- >: New York, NY : Springer Original Publication: New York, Plenum Press. |
| Ιατρικοί όροι (MeSH): | Caregivers*/psychology , Child Behavior*/psychology , Autistic Disorder*/diagnosis , Autistic Disorder*/psychology , Autism Spectrum Disorder*/diagnosis , Autism Spectrum Disorder*/psychology, Attention Deficit Disorder with Hyperactivity/diagnosis ; Attention Deficit Disorder with Hyperactivity/psychology ; Anxiety/psychology ; Anxiety/diagnosis ; Humans ; Male ; Child, Preschool ; Female ; Checklist ; Infant ; Surveys and Questionnaires |
| Περίληψη: | Purpose: Early detection and intervention are associated with improved outcomes for autistic children. Thus, it is important to understand factors influencing early screening tools designed to detect autism. This study examined the relationship between caregiver-reported emotional and behavioral symptoms and children's scores on a commonly used autism screening questionnaire, the Modified Checklist for Autism in Toddlers-Revised with Follow-Up (M-CHAT-R/F). Methods: Toddlers were recruited from four primary care clinics between 2018 and 2021. Their caregivers completed the M-CHAT-R/F as well as the Child Behavior Checklist (CBCL), a well-validated, normed measure of emotional and behavioral functioning. Correlational and group analyses were evaluated to examine relationships between CBCL scales and M-CHAT-R/F scores. Results: 1765 toddlers were recruited for the study. CBCL scores for the internalizing, externalizing, autism, ADHD, and anxiety scales were all modestly positively correlated with M-CHAT-R/F scores. Compared to toddlers with elevated autism scale scores only, toddlers with elevations in both autism and ADHD/externalizing scales had higher M-CHAT-R/F scores. In contrast, no significant difference in scores were found between toddlers with elevated autism scale scores only compared to those with elevated scores on both autism and internalizing scales. Conclusion: Findings suggest that, for children with elevated autism behaviors, the presence of externalizing symptoms, including ADHD-related concerns, is associated with elevated scores on the M-CHAT-R/F. In contrast, internalizing symptoms did not show an association with elevated M-CHAT-R/F scores among toddlers with elevated autism-related behaviors. Interpretation of the M-CHAT-R/F should include consideration of co-occurring psychiatric conditions, especially externalizing conditions such as ADHD. (© 2024. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.) |
| Competing Interests: | Declarations. Competing interests: Dr. Dawson is on the Scientific Advisory Boards of Akili, Inc, Zynerba Pharmaceutical, Inc., Nonverbal Learning Disability Project, and Tris Pharma, Inc., is a consultant to Apple, Inc., Gerson Lehrman Group, and Guidepoint Global, LLC, received speaker fees from WebMD and book royalties from Guilford Press, Oxford University Press, Springer Nature Press. Dr. Dawson has stock interests in Neuvana, Inc. Dr. Dawson and Dr. Carpenter have developed technology, data, and/or products that have been licensed to Apple, Inc. and Cryocell, Inc. and Dawson, Carpenter and Duke University have benefited financially. Dr. Kollins is a full-time employee and equity shareholder in Akili Interactive Labs. Dr. Davis has received research support from Akili Interactive. Drs. Davis, Carpenter, Compton, Eichner, Kollins, Franz, Spanos and Dawson received research support from NICHD P50HD093074 (Dawson, PI). Ms. Marryat and Mr. Lerebours have no competing interests to declare that are relevant to the content of this article. Ethical Approval: All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards. This study was approved by the Duke University Health System Institutional Review Board (protocol #00085434). Consent to Participate: Informed consent was obtained from legal guardians of all participants included in the study. |
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| Grant Information: | P50 HD093074 United States HD NICHD NIH HHS; 2P50HD093074 National Institute of Child Health and Human Development |
| Contributed Indexing: | Keywords: ADHD; Anxiety; Autism; Pediatrics; Screening |
| Entry Date(s): | Date Created: 20240712 Date Completed: 20260731 Latest Revision: 20260731 |
| Update Code: | 20260731 |
| PubMed Central ID: | PMC11913061 |
| DOI: | 10.1007/s10803-024-06453-9 |
| PMID: | 38995481 |
| Βάση Δεδομένων: | MEDLINE |
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