Academic Journal
Deciphering the significance of p53 mutant proteins.
| Τίτλος: | Deciphering the significance of p53 mutant proteins. |
|---|---|
| Συγγραφείς: | Butera A; Chair of Systems Toxicology, University of Konstanz, Konstanz, Germany., Amelio I; Chair of Systems Toxicology, University of Konstanz, Konstanz, Germany. Electronic address: ivano.amelio@uni-konstanz.de. |
| Πηγή: | Trends in cell biology [Trends Cell Biol] 2025 Mar; Vol. 35 (3), pp. 258-268. Date of Electronic Publication: 2024 Jul 02. |
| Τύπος έκδοσης: | Journal Article; Review |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: Elsevier Science Publishers Country of Publication: England NLM ID: 9200566 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-3088 (Electronic) Linking ISSN: 09628924 NLM ISO Abbreviation: Trends Cell Biol Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: Cambridge, UK : Elsevier Science Publishers, c1991- |
| Ιατρικοί όροι (MeSH): | Tumor Suppressor Protein p53*/genetics , Tumor Suppressor Protein p53*/metabolism , Mutation*/genetics , Neoplasms*/genetics , Neoplasms*/metabolism , Neoplasms*/pathology , Mutant Proteins*/genetics , Mutant Proteins*/metabolism, Humans ; Animals |
| Περίληψη: | Mutations in the p53 gene compromise its role as guardian of genomic integrity, yielding predominantly missense p53 mutant proteins. The gain-of-function hypothesis has long suggested that these mutant proteins acquire new oncogenic properties; however, recent studies challenge this notion, indicating that targeting these mutants may not impact the fitness of cancer cells. Mounting evidence indicates that tumorigenesis involves a cooperative interplay between driver mutations and cellular state, influenced by developmental stage, external insults, and tissue damage. Consistently, the behavior and properties of p53 mutants are altered by the context. This article aims to provide a balanced summary of the evolving evidence regarding the contribution of p53 mutants in the biology of cancer while contemplating alternative frameworks to decipher the complexity of p53 mutants within their physiological contexts. (Copyright © 2024 The Author(s). Published by Elsevier Ltd.. All rights reserved.) |
| Competing Interests: | Declaration of interests The authors declare that they have no competing interests. |
| Σχόλια: | Erratum in: Trends Cell Biol. 2026 Apr 1:S0962-8924(26)00002-4. doi: 10.1016/j.tcb.2026.01.002.. (PMID: 41927354) |
| Contributed Indexing: | Keywords: cancer; context-dependent; dominant-negative; gain-of-function; microenvironment |
| Substance Nomenclature: | 0 (Tumor Suppressor Protein p53) 0 (Mutant Proteins) |
| Entry Date(s): | Date Created: 20240703 Date Completed: 20250422 Latest Revision: 20260402 |
| Update Code: | 20260403 |
| DOI: | 10.1016/j.tcb.2024.06.003 |
| PMID: | 38960851 |
| Βάση Δεδομένων: | MEDLINE |
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