Academic Journal
Combination of omics, bioinformatics, molecular docking, and experimental validation to elucidate the hepatoprotective effects, mechanisms, and active compounds of Shandougen.
| Τίτλος: | Combination of omics, bioinformatics, molecular docking, and experimental validation to elucidate the hepatoprotective effects, mechanisms, and active compounds of Shandougen. |
|---|---|
| Συγγραφείς: | Zhang SN; College of Pharmacy, Guizhou University of Traditional Chinese Medicine, Guian New Area, China., Liu Q; The Research Institute of Medicine and Pharmacy, Qiqihar Medical University, Qiqihar, China., Li XZ; College of Pharmacy, Guizhou University of Traditional Chinese Medicine, Guian New Area, China. |
| Πηγή: | Biomedical chromatography : BMC [Biomed Chromatogr] 2024 Jul; Vol. 38 (7), pp. e5887. Date of Electronic Publication: 2024 May 15. |
| Τύπος έκδοσης: | Journal Article |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: Wiley Country of Publication: England NLM ID: 8610241 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1099-0801 (Electronic) Linking ISSN: 02693879 NLM ISO Abbreviation: Biomed Chromatogr Subsets: MEDLINE |
| Imprint Name(s): | Publication: 1990- : Chichester : Wiley Original Publication: London : Heyden & Son, c1986-1990 |
| Ιατρικοί όροι (MeSH): | Molecular Docking Simulation* , Computational Biology*, Liver/drug effects ; Liver/metabolism ; Protective Agents/pharmacology ; Protective Agents/chemistry ; Liver Cirrhosis/drug therapy ; Liver Cirrhosis/metabolism ; Gallic Acid/chemistry ; Gallic Acid/pharmacology ; Triterpenes/chemistry ; Triterpenes/pharmacology ; Proteomics/methods ; Drugs, Chinese Herbal/pharmacology ; Drugs, Chinese Herbal/chemistry ; Animals ; Male ; Rats ; Carbon Tetrachloride |
| Περίληψη: | Omics, bioinformatics, molecular docking, and experimental validation were used to elucidate the hepatoprotective effects, mechanisms, and active compounds of Shandougen (SDG) based on the biolabel-led research pattern. Integrated omics were used to explore the biolabels of SDG intervention in liver tissue. Subsequently, bioinformatics and molecular docking were applied to topologically analyze its therapeutic effects, mechanisms, and active compounds based on biolabels. Finally, an animal model was used to verify the biolabel analysis results. Omics, bioinformatics, and molecular docking revealed that SDG may exert therapeutic effects on liver diseases in the multicompound and multitarget synergistic modes, especially liver cirrhosis. In the validation experiment, SDG and its active compounds (betulinic acid and gallic acid) significantly improved the liver histopathological damage in the CCl (© 2024 John Wiley & Sons, Ltd.) |
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| Grant Information: | 81960749 National Natural Science Foundation of China |
| Contributed Indexing: | Keywords: Sophora tonkinensis Gagnep; biolabel; carcinogenesis; focal adhesion pathway; inflammation; liver cirrhosis |
| Substance Nomenclature: | 0 (Protective Agents) CL2T97X0V0 (Carbon Tetrachloride) 632XD903SP (Gallic Acid) 0 (Triterpenes) 0 (Drugs, Chinese Herbal) |
| Entry Date(s): | Date Created: 20240516 Date Completed: 20240618 Latest Revision: 20240618 |
| Update Code: | 20260130 |
| DOI: | 10.1002/bmc.5887 |
| PMID: | 38751131 |
| Βάση Δεδομένων: | MEDLINE |
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