Academic Journal
Antibacterial efficacy, mode of action, and safety of a novel nano-antibiotic against antibiotic-resistant Escherichia coli strains.
| Τίτλος: | Antibacterial efficacy, mode of action, and safety of a novel nano-antibiotic against antibiotic-resistant Escherichia coli strains. |
|---|---|
| Συγγραφείς: | Ubah CS; Department of Public Health, Brody School of Medicine, East Carolina University, Greenville, NC, USA., Pokhrel LR; Department of Public Health, Brody School of Medicine, East Carolina University, Greenville, NC, USA. Electronic address: POKHRELL18@ecu.edu., Williams JE; Environmental Health Science Program, Department of Health Education and Promotion, College of Health and Human Performance, East Carolina University, Greenville, NC, USA., Akula SM; Department of Microbiology and Immunology, Brody School of Medicine, East Carolina University, Greenville, NC, USA., Richards SL; Environmental Health Science Program, Department of Health Education and Promotion, College of Health and Human Performance, East Carolina University, Greenville, NC, USA., Kearney GD; Department of Public Health, Brody School of Medicine, East Carolina University, Greenville, NC, USA., Williams A; Woebot Health, San Francisco, CA, USA. |
| Πηγή: | The Science of the total environment [Sci Total Environ] 2024 May 15; Vol. 925, pp. 171675. Date of Electronic Publication: 2024 Mar 12. |
| Τύπος έκδοσης: | Journal Article |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: Elsevier Country of Publication: Netherlands NLM ID: 0330500 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-1026 (Electronic) Linking ISSN: 00489697 NLM ISO Abbreviation: Sci Total Environ Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: Amsterdam, Elsevier. |
| Ιατρικοί όροι (MeSH): | Metal Nanoparticles*/toxicity , Bacterial Infections*, Anti-Bacterial Agents/toxicity ; Silver/toxicity ; Ampicillin/pharmacology ; Kanamycin/pharmacology ; Humans ; Escherichia coli ; Bacteria ; Microbial Sensitivity Tests |
| Περίληψη: | Globally rising antibiotic-resistant (AR) and multi-drug resistant (MDR) bacterial infections are of public health concern due to treatment failure with current antibiotics. Enterobacteria, particularly Escherichia coli, cause infections of surgical wound, bloodstream, and urinary tract, including pneumonia and sepsis. Herein, we tested in vitro antibacterial efficacy, mode of action (MoA), and safety of novel amino-functionalized silver nanoparticles (NH (Copyright © 2024 Elsevier B.V. All rights reserved.) |
| Competing Interests: | Declaration of competing interest There is no conflict of interest to disclose. |
| Contributed Indexing: | Keywords: Antibiotic resistant bacteria; Hospital acquired infections; Nano-antibiotics; Nanomedicine; Nosocomial infections; Superbugs |
| Substance Nomenclature: | 0 (Anti-Bacterial Agents) 3M4G523W1G (Silver) 7C782967RD (Ampicillin) 59-01-8 (Kanamycin) |
| Entry Date(s): | Date Created: 20240314 Date Completed: 20240401 Latest Revision: 20240401 |
| Update Code: | 20260130 |
| DOI: | 10.1016/j.scitotenv.2024.171675 |
| PMID: | 38485022 |
| Βάση Δεδομένων: | MEDLINE |
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