Academic Journal
Rapid dissemination of host metabolism-manipulating genes via integrative and conjugative elements.
| Τίτλος: | Rapid dissemination of host metabolism-manipulating genes via integrative and conjugative elements. |
|---|---|
| Συγγραφείς: | Colombi E; School of Agriculture, Food and Ecosystem Sciences, Faculty of Science, The University of Melbourne, Parkville, VIC 3010, Australia., Bertels F; Department of Microbial Population Biology, Max Planck Institute for Evolutionary Biology, Plön 24306, Germany., Doulcier G; Laboratoire Biophysique et Évolution, Institut Chemie Biologie Innovation, École Supérieure de Physique et de Chemie Industrielles de la Ville de Paris, Université Paris Science et Lettres, Centre National de al Reserche Scientifique, Paris 75005, France., McConnell E; Department of Microbial Population Biology, Max Planck Institute for Evolutionary Biology, Plön 24306, Germany., Pichugina T; Department of Microbial Population Biology, Max Planck Institute for Evolutionary Biology, Plön 24306, Germany., Sohn KH; Plant Immunity Research Center, Seoul National University, Seoul 08826, Republic of Korea.; Department of Agricultural Biotechnology, Seoul National University, Seoul 08826, Republic of Korea.; Research Institute of Agriculture and Life Sciences, Seoul National University, Seoul 08826, Republic of Korea.; Plant Genomics and Breeding Institute, Seoul National University, Seoul 08826, Republic of Korea., Straub C; Health and Environment, Institute of Environmental Science and Research, Auckland 1025, New Zealand.; Division of Microbial Ecology, Center for Microbiology and Environmental Systems Science, University of Vienna, Vienna 1030, Austria., McCann HC; Plant Pathogen Evolution Research Group, Max Planck Institute for Biology, Tübingen 72076, Germany., Rainey PB; Department of Microbial Population Biology, Max Planck Institute for Evolutionary Biology, Plön 24306, Germany.; Laboratoire Biophysique et Évolution, Institut Chemie Biologie Innovation, École Supérieure de Physique et de Chemie Industrielles de la Ville de Paris, Université Paris Science et Lettres, Centre National de al Reserche Scientifique, Paris 75005, France. |
| Πηγή: | Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2024 Mar 12; Vol. 121 (11), pp. e2309263121. Date of Electronic Publication: 2024 Mar 08. |
| Τύπος έκδοσης: | Journal Article; Research Support, Non-U.S. Gov't |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: National Academy of Sciences Country of Publication: United States NLM ID: 7505876 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1091-6490 (Electronic) Linking ISSN: 00278424 NLM ISO Abbreviation: Proc Natl Acad Sci U S A Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: Washington, DC : National Academy of Sciences |
| Ιατρικοί όροι (MeSH): | Gene Transfer, Horizontal*/genetics , Conjugation, Genetic*, DNA Transposable Elements/genetics ; Phylogeny ; Biological Evolution |
| Περίληψη: | Integrative and conjugative elements (ICEs) are self-transmissible mobile elements that transfer functional genetic units across broad phylogenetic distances. Accessory genes shuttled by ICEs can make significant contributions to bacterial fitness. Most ICEs characterized to date encode readily observable phenotypes contributing to symbiosis, pathogenicity, and antimicrobial resistance, yet the majority of ICEs carry genes of unknown function. Recent observations of rapid acquisition of ICEs in a pandemic lineage of Pseudomonas syringae pv. actinidae led to investigation of the structural and functional diversity of these elements. Fifty-three unique ICE types were identified across the P. syringae species complex. Together they form a distinct family of ICEs (PsICEs) that share a distant relationship to ICEs found in Pseudomonas aeruginosa. PsICEs are defined by conserved backbone genes punctuated by an array of accessory cargo genes, are highly recombinogenic, and display distinct evolutionary histories compared to their bacterial hosts. The most common cargo is a recently disseminated 16-kb mobile genetic element designated Tn6212. Deletion of Tn6212 did not alter pathogen growth in planta, but mutants displayed fitness defects when grown on tricarboxylic acid (TCA) cycle intermediates. RNA-seq analysis of a set of nested deletion mutants showed that a Tn6212-encoded LysR regulator has global effects on chromosomal gene expression. We show that Tn6212 responds to preferred carbon sources and manipulates bacterial metabolism to maximize growth. |
| Competing Interests: | Competing interests statement:The authors declare no competing interest. |
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| Grant Information: | MAU1709 Royal Society of New Zealand | Marsden Fund (Royal Society of New Zealand Marsden Fund); SFB1182 Project C4 Deutsche Forschungsgemeinschaft (DFG) |
| Contributed Indexing: | Keywords: horizontal gene transfer; microbial evolution; mobile elements; plant–microbe interactions |
| Substance Nomenclature: | 0 (DNA Transposable Elements) |
| Entry Date(s): | Date Created: 20240308 Date Completed: 20240311 Latest Revision: 20260917 |
| Update Code: | 20260917 |
| PubMed Central ID: | PMC10945833 |
| DOI: | 10.1073/pnas.2309263121 |
| PMID: | 38457521 |
| Βάση Δεδομένων: | MEDLINE |
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