Academic Journal
Microalgae-Based Disinfectant Formulation for Aseptic Processing of Ethiopian Ingredient-Sourced Functional Bread and Its Molecular Docking Analysis to Reduce Hypernatremia.
| Τίτλος: | Microalgae-Based Disinfectant Formulation for Aseptic Processing of Ethiopian Ingredient-Sourced Functional Bread and Its Molecular Docking Analysis to Reduce Hypernatremia. |
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| Συγγραφείς: | Mishra T; Department of Biotechnology, School of Bio Science and Technology, Vellore Institute of Technology, Vellore, Tamil Nadu, 632014, India., Kidie E; Department of Biotechnology, School of Bio Science and Technology, Vellore Institute of Technology, Vellore, Tamil Nadu, 632014, India., Vuppu S; Department of Biotechnology, School of Bio Science and Technology, Vellore Institute of Technology, Vellore, Tamil Nadu, 632014, India. vsuneetha@vit.ac.in. |
| Πηγή: | Molecular biotechnology [Mol Biotechnol] 2026 Sep; Vol. 68 (9), pp. 3782-3798. Date of Electronic Publication: 2023 Nov 22. |
| Τύπος έκδοσης: | Journal Article |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: Springer Country of Publication: Switzerland NLM ID: 9423533 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1559-0305 (Electronic) Linking ISSN: 10736085 NLM ISO Abbreviation: Mol Biotechnol Subsets: MEDLINE |
| Imprint Name(s): | Publication: [Cham] : Springer Original Publication: Totowa, NJ : Humana Press, c1994- |
| Ιατρικοί όροι (MeSH): | Disinfectants*/chemistry , Disinfectants*/pharmacology , Bread*/analysis , Bread*/microbiology , Hypernatremia*/prevention & control , Chlorella*/chemistry, Food Handling/methods ; Molecular Docking Simulation ; Humans |
| Περίληψη: | The global prevalence of food-borne infections has become a major concern. Food-borne pathogens like Campylobacter jejuni, Salmonella enterica, and Clostridium botulinum cause food poisoning and even mortality, necessitating the maintenance of aseptic conditions during food processing. The sterilization of food processing facilities often requires chemical and heat treatment. The formulation of many chemical-based disinfectants includes chemicals generating toxic and carcinogenic by-products. The microalgae like Chlorella spp. reportedly exhibit antimicrobial activity and therefore, can be used for formulating safer and eco-friendly natural sanitizers. This study aims to aseptically prepare functional bread using Ethiopian ingredients, highlighting the application of microalgae-based disinfectant formulation and various disinfection techniques. The functional bread was designed to be potentially effective in reducing hypernatremia condition which is indicative of high levels of sodium in serum that can cause an array of symptoms including deaths in serious cases. The physico-chemical and sensory properties of the designed functional bread were analyzed. The interaction of phytochemicals in the ingredients with the target receptor (Vasopressin V2 receptor) and their drug-likeness were determined using molecular docking and Lipinski's rule of five analyses. The results suggest that the designed functional bread incorporating Ethiopian ingredients may serve as an effective dietary strategy to prevent hypernatremia. Aseptic processing of the bread ensures longer shelf life and prevention of spoilage by food pathogens. (© 2023. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.) |
| Competing Interests: | Declarations. Conflict of interest: The authors declare that they have no competing interests. |
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| Contributed Indexing: | Keywords: Aseptic processing; Bioactives; Disinfectant; Functional bread; Hypernatremia; Microalgae; Molecular docking |
| Substance Nomenclature: | 0 (Disinfectants) |
| Entry Date(s): | Date Created: 20231122 Date Completed: 20260909 Latest Revision: 20261008 |
| Update Code: | 20261008 |
| DOI: | 10.1007/s12033-023-00970-1 |
| PMID: | 37991627 |
| Βάση Δεδομένων: | MEDLINE |
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