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Microalgae-Based Disinfectant Formulation for Aseptic Processing of Ethiopian Ingredient-Sourced Functional Bread and Its Molecular Docking Analysis to Reduce Hypernatremia.

Λεπτομέρειες βιβλιογραφικής εγγραφής
Τίτλος: Microalgae-Based Disinfectant Formulation for Aseptic Processing of Ethiopian Ingredient-Sourced Functional Bread and Its Molecular Docking Analysis to Reduce Hypernatremia.
Συγγραφείς: Mishra T; Department of Biotechnology, School of Bio Science and Technology, Vellore Institute of Technology, Vellore, Tamil Nadu, 632014, India., Kidie E; Department of Biotechnology, School of Bio Science and Technology, Vellore Institute of Technology, Vellore, Tamil Nadu, 632014, India., Vuppu S; Department of Biotechnology, School of Bio Science and Technology, Vellore Institute of Technology, Vellore, Tamil Nadu, 632014, India. vsuneetha@vit.ac.in.
Πηγή: Molecular biotechnology [Mol Biotechnol] 2026 Sep; Vol. 68 (9), pp. 3782-3798. Date of Electronic Publication: 2023 Nov 22.
Τύπος έκδοσης: Journal Article
Γλώσσα: English
Στοιχεία περιοδικού: Publisher: Springer Country of Publication: Switzerland NLM ID: 9423533 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1559-0305 (Electronic) Linking ISSN: 10736085 NLM ISO Abbreviation: Mol Biotechnol Subsets: MEDLINE
Imprint Name(s): Publication: [Cham] : Springer
Original Publication: Totowa, NJ : Humana Press, c1994-
Ιατρικοί όροι (MeSH): Disinfectants*/chemistry , Disinfectants*/pharmacology , Bread*/analysis , Bread*/microbiology , Hypernatremia*/prevention & control , Chlorella*/chemistry, Food Handling/methods ; Molecular Docking Simulation ; Humans
Περίληψη: The global prevalence of food-borne infections has become a major concern. Food-borne pathogens like Campylobacter jejuni, Salmonella enterica, and Clostridium botulinum cause food poisoning and even mortality, necessitating the maintenance of aseptic conditions during food processing. The sterilization of food processing facilities often requires chemical and heat treatment. The formulation of many chemical-based disinfectants includes chemicals generating toxic and carcinogenic by-products. The microalgae like Chlorella spp. reportedly exhibit antimicrobial activity and therefore, can be used for formulating safer and eco-friendly natural sanitizers. This study aims to aseptically prepare functional bread using Ethiopian ingredients, highlighting the application of microalgae-based disinfectant formulation and various disinfection techniques. The functional bread was designed to be potentially effective in reducing hypernatremia condition which is indicative of high levels of sodium in serum that can cause an array of symptoms including deaths in serious cases. The physico-chemical and sensory properties of the designed functional bread were analyzed. The interaction of phytochemicals in the ingredients with the target receptor (Vasopressin V2 receptor) and their drug-likeness were determined using molecular docking and Lipinski's rule of five analyses. The results suggest that the designed functional bread incorporating Ethiopian ingredients may serve as an effective dietary strategy to prevent hypernatremia. Aseptic processing of the bread ensures longer shelf life and prevention of spoilage by food pathogens.
(© 2023. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.)
Competing Interests: Declarations. Conflict of interest: The authors declare that they have no competing interests.
References: Pflugers Arch. 2008 Sep;456(6):1005-24. (PMID: 18431594)
Nutrients. 2020 Mar 24;12(3):. (PMID: 32213941)
J Pediatr. 1983 May;102(5):703-8. (PMID: 6188820)
Foods. 2023 Sep 15;12(18):. (PMID: 37761143)
Int J Environ Res Public Health. 2021 May 17;18(10):. (PMID: 34067768)
ScientificWorldJournal. 2015;2015:816364. (PMID: 26106644)
Saudi J Biol Sci. 2022 Feb;29(2):1043-1052. (PMID: 35197773)
Clin J Am Soc Nephrol. 2019 Mar 7;14(3):432-434. (PMID: 30728169)
Br J Nutr. 2007 Mar;97(3):458-63. (PMID: 17313706)
Microb Pathog. 2018 Jul;120:198-203. (PMID: 29702210)
Food Bioproc Tech. 2022;15(9):2102-2113. (PMID: 35855202)
J Comput Chem. 2010 Jan 30;31(2):455-61. (PMID: 19499576)
Korean J Intern Med. 2023 May;38(3):290-302. (PMID: 36578134)
Heliyon. 2023 Jul 04;9(7):e17795. (PMID: 37483828)
Microorganisms. 2020 Jul 28;8(8):. (PMID: 32731589)
Sci Total Environ. 2019 Nov 20;692:209-218. (PMID: 31344572)
Front Oncol. 2019 Jun 21;9:541. (PMID: 31293975)
Saudi J Biol Sci. 2021 Jul;28(7):3855-3863. (PMID: 34220240)
Mar Drugs. 2015 Oct 20;13(10):6440-52. (PMID: 26492256)
Front Genet. 2020 Nov 11;11:584718. (PMID: 33262788)
FASEB J. 2011 Oct;25(10):3279-89. (PMID: 21737616)
Nat Prod Commun. 2014 Jul;9(7):1027-30. (PMID: 25230520)
Mar Drugs. 2016 Apr 22;14(4):. (PMID: 27110798)
Int J Emerg Med. 2019 Sep 18;12(1):29. (PMID: 31533619)
Molecules. 2022 May 30;27(11):. (PMID: 35684447)
Food Chem Toxicol. 2021 Jul;153:112259. (PMID: 33984423)
Front Microbiol. 2016 May 17;7:681. (PMID: 27242708)
Am Fam Physician. 2015 Mar 1;91(5):299-307. (PMID: 25822386)
Contributed Indexing: Keywords: Aseptic processing; Bioactives; Disinfectant; Functional bread; Hypernatremia; Microalgae; Molecular docking
Substance Nomenclature: 0 (Disinfectants)
Entry Date(s): Date Created: 20231122 Date Completed: 20260909 Latest Revision: 20261008
Update Code: 20261008
DOI: 10.1007/s12033-023-00970-1
PMID: 37991627
Βάση Δεδομένων: MEDLINE
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  – Url: https://dx.doi.org/doi:10.1007/s12033-023-00970-1
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  Data: Microalgae-Based Disinfectant Formulation for Aseptic Processing of Ethiopian Ingredient-Sourced Functional Bread and Its Molecular Docking Analysis to Reduce Hypernatremia.
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  Data: <searchLink fieldCode="AU" term="%22Mishra+T%22">Mishra T</searchLink>; Department of Biotechnology, School of Bio Science and Technology, Vellore Institute of Technology, Vellore, Tamil Nadu, 632014, India.<br /><searchLink fieldCode="AU" term="%22Kidie+E%22">Kidie E</searchLink>; Department of Biotechnology, School of Bio Science and Technology, Vellore Institute of Technology, Vellore, Tamil Nadu, 632014, India.<br /><searchLink fieldCode="AU" term="%22Vuppu+S%22">Vuppu S</searchLink>; Department of Biotechnology, School of Bio Science and Technology, Vellore Institute of Technology, Vellore, Tamil Nadu, 632014, India. vsuneetha@vit.ac.in.
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  Data: <searchLink fieldCode="JN" term="%229423533%22">Molecular biotechnology</searchLink> [Mol Biotechnol] 2026 Sep; Vol. 68 (9), pp. 3782-3798. <i>Date of Electronic Publication: </i>2023 Nov 22.
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  Data: <searchLink fieldCode="MM" term="%22Disinfectants%22">Disinfectants*</searchLink>/<searchLink fieldCode="MM" term="%22Disinfectants+chemistry%22">chemistry</searchLink> <br /><searchLink fieldCode="MM" term="%22Disinfectants%22">Disinfectants*</searchLink>/<searchLink fieldCode="MM" term="%22Disinfectants+pharmacology%22">pharmacology</searchLink> <br /><searchLink fieldCode="MM" term="%22Bread%22">Bread*</searchLink>/<searchLink fieldCode="MM" term="%22Bread+analysis%22">analysis</searchLink> <br /><searchLink fieldCode="MM" term="%22Bread%22">Bread*</searchLink>/<searchLink fieldCode="MM" term="%22Bread+microbiology%22">microbiology</searchLink> <br /><searchLink fieldCode="MM" term="%22Hypernatremia%22">Hypernatremia*</searchLink>/<searchLink fieldCode="MM" term="%22Hypernatremia+prevention+%26+control%22">prevention & control</searchLink> <br /><searchLink fieldCode="MM" term="%22Chlorella%22">Chlorella*</searchLink>/<searchLink fieldCode="MM" term="%22Chlorella+chemistry%22">chemistry</searchLink><br /><searchLink fieldCode="MH" term="%22Food+Handling%22">Food Handling</searchLink>/<searchLink fieldCode="MH" term="%22Food+Handling+methods%22">methods</searchLink> ; <searchLink fieldCode="MH" term="%22Molecular+Docking+Simulation%22">Molecular Docking Simulation</searchLink> ; <searchLink fieldCode="MH" term="%22Humans%22">Humans</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: The global prevalence of food-borne infections has become a major concern. Food-borne pathogens like Campylobacter jejuni, Salmonella enterica, and Clostridium botulinum cause food poisoning and even mortality, necessitating the maintenance of aseptic conditions during food processing. The sterilization of food processing facilities often requires chemical and heat treatment. The formulation of many chemical-based disinfectants includes chemicals generating toxic and carcinogenic by-products. The microalgae like Chlorella spp. reportedly exhibit antimicrobial activity and therefore, can be used for formulating safer and eco-friendly natural sanitizers. This study aims to aseptically prepare functional bread using Ethiopian ingredients, highlighting the application of microalgae-based disinfectant formulation and various disinfection techniques. The functional bread was designed to be potentially effective in reducing hypernatremia condition which is indicative of high levels of sodium in serum that can cause an array of symptoms including deaths in serious cases. The physico-chemical and sensory properties of the designed functional bread were analyzed. The interaction of phytochemicals in the ingredients with the target receptor (Vasopressin V2 receptor) and their drug-likeness were determined using molecular docking and Lipinski's rule of five analyses. The results suggest that the designed functional bread incorporating Ethiopian ingredients may serve as an effective dietary strategy to prevent hypernatremia. Aseptic processing of the bread ensures longer shelf life and prevention of spoilage by food pathogens.<br /> (© 2023. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.)
– Name: Abstract
  Label: Competing Interests
  Group: Ab
  Data: Declarations. Conflict of interest: The authors declare that they have no competing interests.
– Name: Ref
  Label: References
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  Data: Pflugers Arch. 2008 Sep;456(6):1005-24. (PMID: <searchLink fieldCode="PM" term="%2218431594%22">18431594)</searchLink><br />Nutrients. 2020 Mar 24;12(3):. (PMID: <searchLink fieldCode="PM" term="%2232213941%22">32213941)</searchLink><br />J Pediatr. 1983 May;102(5):703-8. (PMID: <searchLink fieldCode="PM" term="%226188820%22">6188820)</searchLink><br />Foods. 2023 Sep 15;12(18):. (PMID: <searchLink fieldCode="PM" term="%2237761143%22">37761143)</searchLink><br />Int J Environ Res Public Health. 2021 May 17;18(10):. (PMID: <searchLink fieldCode="PM" term="%2234067768%22">34067768)</searchLink><br />ScientificWorldJournal. 2015;2015:816364. (PMID: <searchLink fieldCode="PM" term="%2226106644%22">26106644)</searchLink><br />Saudi J Biol Sci. 2022 Feb;29(2):1043-1052. (PMID: <searchLink fieldCode="PM" term="%2235197773%22">35197773)</searchLink><br />Clin J Am Soc Nephrol. 2019 Mar 7;14(3):432-434. (PMID: <searchLink fieldCode="PM" term="%2230728169%22">30728169)</searchLink><br />Br J Nutr. 2007 Mar;97(3):458-63. (PMID: <searchLink fieldCode="PM" term="%2217313706%22">17313706)</searchLink><br />Microb Pathog. 2018 Jul;120:198-203. (PMID: <searchLink fieldCode="PM" term="%2229702210%22">29702210)</searchLink><br />Food Bioproc Tech. 2022;15(9):2102-2113. (PMID: <searchLink fieldCode="PM" term="%2235855202%22">35855202)</searchLink><br />J Comput Chem. 2010 Jan 30;31(2):455-61. (PMID: <searchLink fieldCode="PM" term="%2219499576%22">19499576)</searchLink><br />Korean J Intern Med. 2023 May;38(3):290-302. (PMID: <searchLink fieldCode="PM" term="%2236578134%22">36578134)</searchLink><br />Heliyon. 2023 Jul 04;9(7):e17795. (PMID: <searchLink fieldCode="PM" term="%2237483828%22">37483828)</searchLink><br />Microorganisms. 2020 Jul 28;8(8):. (PMID: <searchLink fieldCode="PM" term="%2232731589%22">32731589)</searchLink><br />Sci Total Environ. 2019 Nov 20;692:209-218. (PMID: <searchLink fieldCode="PM" term="%2231344572%22">31344572)</searchLink><br />Front Oncol. 2019 Jun 21;9:541. (PMID: <searchLink fieldCode="PM" term="%2231293975%22">31293975)</searchLink><br />Saudi J Biol Sci. 2021 Jul;28(7):3855-3863. (PMID: <searchLink fieldCode="PM" term="%2234220240%22">34220240)</searchLink><br />Mar Drugs. 2015 Oct 20;13(10):6440-52. (PMID: <searchLink fieldCode="PM" term="%2226492256%22">26492256)</searchLink><br />Front Genet. 2020 Nov 11;11:584718. (PMID: <searchLink fieldCode="PM" term="%2233262788%22">33262788)</searchLink><br />FASEB J. 2011 Oct;25(10):3279-89. (PMID: <searchLink fieldCode="PM" term="%2221737616%22">21737616)</searchLink><br />Nat Prod Commun. 2014 Jul;9(7):1027-30. (PMID: <searchLink fieldCode="PM" term="%2225230520%22">25230520)</searchLink><br />Mar Drugs. 2016 Apr 22;14(4):. (PMID: <searchLink fieldCode="PM" term="%2227110798%22">27110798)</searchLink><br />Int J Emerg Med. 2019 Sep 18;12(1):29. (PMID: <searchLink fieldCode="PM" term="%2231533619%22">31533619)</searchLink><br />Molecules. 2022 May 30;27(11):. (PMID: <searchLink fieldCode="PM" term="%2235684447%22">35684447)</searchLink><br />Food Chem Toxicol. 2021 Jul;153:112259. (PMID: <searchLink fieldCode="PM" term="%2233984423%22">33984423)</searchLink><br />Front Microbiol. 2016 May 17;7:681. (PMID: <searchLink fieldCode="PM" term="%2227242708%22">27242708)</searchLink><br />Am Fam Physician. 2015 Mar 1;91(5):299-307. (PMID: <searchLink fieldCode="PM" term="%2225822386%22">25822386)</searchLink>
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        StartPage: 3782
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      – SubjectFull: Food Handling methods
        Type: general
      – SubjectFull: Molecular Docking Simulation
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      – TitleFull: Microalgae-Based Disinfectant Formulation for Aseptic Processing of Ethiopian Ingredient-Sourced Functional Bread and Its Molecular Docking Analysis to Reduce Hypernatremia.
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