Academic Journal
Pulse wave Doppler ultrasound of umbilical cord in experimentally induced pregnancy toxemia in sheep.
| Τίτλος: | Pulse wave Doppler ultrasound of umbilical cord in experimentally induced pregnancy toxemia in sheep. |
|---|---|
| Συγγραφείς: | Kivrak MB; Department of Obstetrics and Gynecology, Faculty of Veterinary Medicine, Sivas Cumhuriyet University, Sivas, Türkiye. Electronic address: mbkivrak@cumhuriyet.edu.tr., Turk S; Department of Internal Medicine, Faculty of Veterinary Medicine, Sivas Cumhuriyet University, Sivas, Türkiye., Takci A; Department of Obstetrics and Gynecology, Faculty of Veterinary Medicine, Sivas Cumhuriyet University, Sivas, Türkiye., Bolukbas B; Department of Animal Nutrition and Nutritional Diseases, Faculty of Veterinary Medicine, Ondokuz Mayıs University, Samsun, Türkiye., Agaoglu RT; Perinatology Department, University of Health Sciences, Ankara City Hospital, Ankara, Türkiye., Coskun A; Department of Internal Medicine, Faculty of Veterinary Medicine, Sivas Cumhuriyet University, Sivas, Türkiye. |
| Πηγή: | Research in veterinary science [Res Vet Sci] 2023 Jul; Vol. 160, pp. 18-25. Date of Electronic Publication: 2023 May 15. |
| Τύπος έκδοσης: | Journal Article; Randomized Controlled Trial, Veterinary |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: British Veterinary Association Country of Publication: England NLM ID: 0401300 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1532-2661 (Electronic) Linking ISSN: 00345288 NLM ISO Abbreviation: Res Vet Sci Subsets: MEDLINE |
| Imprint Name(s): | Publication: London : British Veterinary Association Original Publication: Oxford. |
| Ιατρικοί όροι (MeSH): | Pre-Eclampsia*/veterinary , Sheep Diseases*, Blood Flow Velocity/physiology ; Blood Flow Velocity/veterinary ; Ultrasonography, Doppler/veterinary ; Umbilical Cord/diagnostic imaging ; Animals ; Female ; Pregnancy ; Sheep ; Ultrasonography |
| Περίληψη: | Contrary to its widespread use in human cases, the use of Doppler ultrasonography is only recently becoming prevalent in farm animals. This study aimed to determine the effects of maternal metabolic and clinical changes on fetal hemodynamics during pregnancy toxemia with the doppler examination of umbilical cord. In the study twenty ewes with a single healthy fetus were included in the study. At the end of the 120th day of pregnancy, 20 single-bearing pregnant ewes were randomly categorized into two groups. Ewes in the control group were fed to meet all nutritional requirements. On the other contrary, the experimental ewes were fed to meet equivalent to 50 % of the daily needs and then fasted for 96 h. Doppler ultrasonographic examinations of umbilical cord were performed once every two days and once a day during fasting. Beta hydroxybutyric acid (BHBA) concentration was measured by taking blood from sheep on examination days. Pulse systolic velocity (PSV), end diastolic velocity (EDV), PSV/EDV, pulsatility index (PI), resistance index (RI), and fetal heart rate (FHR) as well as BHBA values and how those parameters has changed over time (time by treatment effect) due to energy deprivation during pregnancy were evaluated using repeated measure analysis of variance. No clinical signs were observed in both toxemia and control groups during restricted feeding. BHBA concentration increased and there was a significant time, time by treatment and main effect of treatment effect between groups. No significant main effect of treatment and time by treatment interaction was observed in the changes of PI, RI, FHR, and systolic/diastolic velocity values over time in both groups. FHR was reduced over time, and there was a significant time effect in FHR in both groups. Although doppler indices didn't increase, both PSV and EDV values increased significantly in the pregnancy toxemia group compared with the controls (Time P = 0.03, time by treatment interaction P < 0.05) and the main effect of treatment P < 0.05). The marked increase in blood velocities (PSV and EDV) in the umbilical cord is probably due to the compensatory functioning for excessive energy deprivation of the fetus. Therefore, PSV and EDV might be a valuable indicator for evaluating the fetus's health status during the management of the PT. (Copyright © 2023 Elsevier Ltd. All rights reserved.) |
| Competing Interests: | Declaration of Competing Interest None. |
| Contributed Indexing: | Keywords: Doppler; End diastolic velocity; Peak systolic velocity; Pregnancy toxemia; Umbilical cord |
| Entry Date(s): | Date Created: 20230526 Date Completed: 20230925 Latest Revision: 20230925 |
| Update Code: | 20260130 |
| DOI: | 10.1016/j.rvsc.2023.05.004 |
| PMID: | 37235922 |
| Βάση Δεδομένων: | MEDLINE |
καταχωρήστε σχόλιο πρώτοι!