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Gardnerella subgroup dominant microbiomes are associated with divergent cervicovaginal immune responses in a longitudinal cohort of Kenyan women.

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Title: Gardnerella subgroup dominant microbiomes are associated with divergent cervicovaginal immune responses in a longitudinal cohort of Kenyan women.
Authors: Shvartsman E; Department of Medical Microbiology and Infectious Disease, University of Manitoba, Winnipeg, MB, Canada.; JC Wilt Infectious Diseases Research Centre, Winnipeg, MB, Canada.; Department of Internal Medicine, University of Manitoba, Winnipeg, MB, Canada., Perciani CT; Department of Immunology, University of Toronto, Toronto, ON, Canada., Richmond MEI; Department of Medical Microbiology and Infectious Disease, University of Manitoba, Winnipeg, MB, Canada.; JC Wilt Infectious Diseases Research Centre, Winnipeg, MB, Canada., Russell JNH; JC Wilt Infectious Diseases Research Centre, Winnipeg, MB, Canada.; Department of Immunology, University of Toronto, Toronto, ON, Canada., Tough RH; Department of Medical Microbiology and Infectious Disease, University of Manitoba, Winnipeg, MB, Canada.; JC Wilt Infectious Diseases Research Centre, Winnipeg, MB, Canada., Vancuren SJ; Department of Veterinary Microbiology, University of Saskatchewan, Saskatoon, SK, Canada., Hill JE; Department of Veterinary Microbiology, University of Saskatchewan, Saskatoon, SK, Canada., Kavi-Icr; Kenyan AIDS Vaccine Initiative-Institute of Clinical Research (KAVI-ICR), University of Nairobi, Nairobi, Kenya., Jaoko W; Kenyan AIDS Vaccine Initiative-Institute of Clinical Research (KAVI-ICR), University of Nairobi, Nairobi, Kenya., McKinnon LR; Department of Medical Microbiology and Infectious Disease, University of Manitoba, Winnipeg, MB, Canada.; JC Wilt Infectious Diseases Research Centre, Winnipeg, MB, Canada.; Centre for the AIDS Program of Research in South Africa (CAPRISA), Durban, South Africa., Sandstrom PA; Department of Medical Microbiology and Infectious Disease, University of Manitoba, Winnipeg, MB, Canada.; JC Wilt Infectious Diseases Research Centre, Winnipeg, MB, Canada., MacDonald KS; Department of Medical Microbiology and Infectious Disease, University of Manitoba, Winnipeg, MB, Canada.; JC Wilt Infectious Diseases Research Centre, Winnipeg, MB, Canada.; Department of Internal Medicine, University of Manitoba, Winnipeg, MB, Canada.; Department of Immunology, University of Toronto, Toronto, ON, Canada.
Source: Frontiers in immunology [Front Immunol] 2023 Jan 16; Vol. 13, pp. 974195. Date of Electronic Publication: 2023 Jan 16 (Print Publication: 2022).
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Language: English
Journal Info: Publisher: Frontiers Research Foundation] Country of Publication: Switzerland NLM ID: 101560960 Publication Model: eCollection Cited Medium: Internet ISSN: 1664-3224 (Electronic) Linking ISSN: 16643224 NLM ISO Abbreviation: Front Immunol Subsets: MEDLINE
Imprint Name(s): Original Publication: [Lausanne : Frontiers Research Foundation]
MeSH Terms: Gardnerella* , Microbiota* , Vaginosis, Bacterial*, Kenya/epidemiology ; Lactobacillus/genetics ; Vagina/immunology ; Vagina/microbiology ; Female ; Humans ; Chemokine CXCL10 ; HIV Infections ; Immunity
Abstract: Most cervicovaginal microbiome-immunology studies to date have relied on 16S rDNA microbial profiling which does not resolve the molecular subgroups of Gardnerella, believed to be central to the pathogenesis of bacterial vaginosis (BV) and subsequent risk of HIV acquisition. Here we used the cpn60 universal target which in addition to other microbial taxa, resolves four Gardnerella subgroups, for cervicovaginal microbial profiling in a longitudinal cohort of Kenyan women to examine associations with cellular and soluble markers of inflammation and HIV susceptibility. Participants (N = 41) were sampled, contributing 362 samples for microbiome analysis. All non-Lactobacillus dominant microbial communities were associated with high pro-inflammatory cytokine levels. Divergent associations were observed among different Gardnerella subgroup dominated communities with respect to the chemokine IP-10. Specifically, Gardnerella subgroup A dominant and polymicrobial communities were associated with reduced concentrations of IP-10 in adjusted linear mixed models (p<0.0001), compared to microbial communities dominated by Lactobacillus (non-iners) species. However, these associations did not translate to significant differences in the proportion or absolute number of CCR5, HLA-DR and CD38 expressed on cervical CD4+ T- cells. These findings suggest that some associations between Gardnerella subgroup dominant microbiomes and mucosal immunity differ and are relevant for the study of BV-pathogenesis and understanding the mechanisms of BV-associated HIV risk.
(Copyright © 2023 Shvartsman, Perciani, Richmond, Russell, Tough, Vancuren, Hill, KAVI-ICR, Jaoko, McKinnon, Sandstrom and MacDonald.)
Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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Grant Information: THA-11960 Canada CIHR
Contributed Indexing: Keywords: HIV susceptibility; IP-10 (CXCL-10); bacterial vaginosis (BV); cpn60; cytokines; gardnerella species; mucosal immunity; vaginal microbiome
Substance Nomenclature: 0 (Chemokine CXCL10)
Entry Date(s): Date Created: 20230202 Date Completed: 20230206 Latest Revision: 20230217
Update Code: 20260130
PubMed Central ID: PMC9886495
DOI: 10.3389/fimmu.2022.974195
PMID: 36726972
Database: MEDLINE
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  Data: Gardnerella subgroup dominant microbiomes are associated with divergent cervicovaginal immune responses in a longitudinal cohort of Kenyan women.
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  Data: &lt;searchLink fieldCode=&quot;AU&quot; term=&quot;%22Shvartsman+E%22&quot;&gt;Shvartsman E&lt;/searchLink&gt;; Department of Medical Microbiology and Infectious Disease, University of Manitoba, Winnipeg, MB, Canada.; JC Wilt Infectious Diseases Research Centre, Winnipeg, MB, Canada.; Department of Internal Medicine, University of Manitoba, Winnipeg, MB, Canada.&lt;br /&gt;&lt;searchLink fieldCode=&quot;AU&quot; term=&quot;%22Perciani+CT%22&quot;&gt;Perciani CT&lt;/searchLink&gt;; Department of Immunology, University of Toronto, Toronto, ON, Canada.&lt;br /&gt;&lt;searchLink fieldCode=&quot;AU&quot; term=&quot;%22Richmond+MEI%22&quot;&gt;Richmond MEI&lt;/searchLink&gt;; Department of Medical Microbiology and Infectious Disease, University of Manitoba, Winnipeg, MB, Canada.; JC Wilt Infectious Diseases Research Centre, Winnipeg, MB, Canada.&lt;br /&gt;&lt;searchLink fieldCode=&quot;AU&quot; term=&quot;%22Russell+JNH%22&quot;&gt;Russell JNH&lt;/searchLink&gt;; JC Wilt Infectious Diseases Research Centre, Winnipeg, MB, Canada.; Department of Immunology, University of Toronto, Toronto, ON, Canada.&lt;br /&gt;&lt;searchLink fieldCode=&quot;AU&quot; term=&quot;%22Tough+RH%22&quot;&gt;Tough RH&lt;/searchLink&gt;; Department of Medical Microbiology and Infectious Disease, University of Manitoba, Winnipeg, MB, Canada.; JC Wilt Infectious Diseases Research Centre, Winnipeg, MB, Canada.&lt;br /&gt;&lt;searchLink fieldCode=&quot;AU&quot; term=&quot;%22Vancuren+SJ%22&quot;&gt;Vancuren SJ&lt;/searchLink&gt;; Department of Veterinary Microbiology, University of Saskatchewan, Saskatoon, SK, Canada.&lt;br /&gt;&lt;searchLink fieldCode=&quot;AU&quot; term=&quot;%22Hill+JE%22&quot;&gt;Hill JE&lt;/searchLink&gt;; Department of Veterinary Microbiology, University of Saskatchewan, Saskatoon, SK, Canada.&lt;br /&gt;&lt;searchLink fieldCode=&quot;AU&quot; term=&quot;%22Kavi-Icr%22&quot;&gt;Kavi-Icr&lt;/searchLink&gt;; Kenyan AIDS Vaccine Initiative-Institute of Clinical Research (KAVI-ICR), University of Nairobi, Nairobi, Kenya.&lt;br /&gt;&lt;searchLink fieldCode=&quot;AU&quot; term=&quot;%22Jaoko+W%22&quot;&gt;Jaoko W&lt;/searchLink&gt;; Kenyan AIDS Vaccine Initiative-Institute of Clinical Research (KAVI-ICR), University of Nairobi, Nairobi, Kenya.&lt;br /&gt;&lt;searchLink fieldCode=&quot;AU&quot; term=&quot;%22McKinnon+LR%22&quot;&gt;McKinnon LR&lt;/searchLink&gt;; Department of Medical Microbiology and Infectious Disease, University of Manitoba, Winnipeg, MB, Canada.; JC Wilt Infectious Diseases Research Centre, Winnipeg, MB, Canada.; Centre for the AIDS Program of Research in South Africa (CAPRISA), Durban, South Africa.&lt;br /&gt;&lt;searchLink fieldCode=&quot;AU&quot; term=&quot;%22Sandstrom+PA%22&quot;&gt;Sandstrom PA&lt;/searchLink&gt;; Department of Medical Microbiology and Infectious Disease, University of Manitoba, Winnipeg, MB, Canada.; JC Wilt Infectious Diseases Research Centre, Winnipeg, MB, Canada.&lt;br /&gt;&lt;searchLink fieldCode=&quot;AU&quot; term=&quot;%22MacDonald+KS%22&quot;&gt;MacDonald KS&lt;/searchLink&gt;; Department of Medical Microbiology and Infectious Disease, University of Manitoba, Winnipeg, MB, Canada.; JC Wilt Infectious Diseases Research Centre, Winnipeg, MB, Canada.; Department of Internal Medicine, University of Manitoba, Winnipeg, MB, Canada.; Department of Immunology, University of Toronto, Toronto, ON, Canada.
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  Data: &lt;searchLink fieldCode=&quot;JN&quot; term=&quot;%22101560960%22&quot;&gt;Frontiers in immunology&lt;/searchLink&gt; [Front Immunol] 2023 Jan 16; Vol. 13, pp. 974195. &lt;i&gt;Date of Electronic Publication: &lt;/i&gt;2023 Jan 16 (&lt;i&gt;Print Publication: &lt;/i&gt;2022).
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  Data: &lt;searchLink fieldCode=&quot;MM&quot; term=&quot;%22Gardnerella%22&quot;&gt;Gardnerella*&lt;/searchLink&gt; &lt;br /&gt;&lt;searchLink fieldCode=&quot;MM&quot; term=&quot;%22Microbiota%22&quot;&gt;Microbiota*&lt;/searchLink&gt; &lt;br /&gt;&lt;searchLink fieldCode=&quot;MM&quot; term=&quot;%22Vaginosis%2C+Bacterial%22&quot;&gt;Vaginosis, Bacterial*&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;MH&quot; term=&quot;%22Kenya%22&quot;&gt;Kenya&lt;/searchLink&gt;/&lt;searchLink fieldCode=&quot;MH&quot; term=&quot;%22Kenya+epidemiology%22&quot;&gt;epidemiology&lt;/searchLink&gt; ; &lt;searchLink fieldCode=&quot;MH&quot; term=&quot;%22Lactobacillus%22&quot;&gt;Lactobacillus&lt;/searchLink&gt;/&lt;searchLink fieldCode=&quot;MH&quot; term=&quot;%22Lactobacillus+genetics%22&quot;&gt;genetics&lt;/searchLink&gt; ; &lt;searchLink fieldCode=&quot;MH&quot; term=&quot;%22Vagina%22&quot;&gt;Vagina&lt;/searchLink&gt;/&lt;searchLink fieldCode=&quot;MH&quot; term=&quot;%22Vagina+immunology%22&quot;&gt;immunology&lt;/searchLink&gt; ; &lt;searchLink fieldCode=&quot;MH&quot; term=&quot;%22Vagina%22&quot;&gt;Vagina&lt;/searchLink&gt;/&lt;searchLink fieldCode=&quot;MH&quot; term=&quot;%22Vagina+microbiology%22&quot;&gt;microbiology&lt;/searchLink&gt; ; &lt;searchLink fieldCode=&quot;MH&quot; term=&quot;%22Female%22&quot;&gt;Female&lt;/searchLink&gt; ; &lt;searchLink fieldCode=&quot;MH&quot; term=&quot;%22Humans%22&quot;&gt;Humans&lt;/searchLink&gt; ; &lt;searchLink fieldCode=&quot;MH&quot; term=&quot;%22Chemokine+CXCL10%22&quot;&gt;Chemokine CXCL10&lt;/searchLink&gt; ; &lt;searchLink fieldCode=&quot;MH&quot; term=&quot;%22HIV+Infections%22&quot;&gt;HIV Infections&lt;/searchLink&gt; ; &lt;searchLink fieldCode=&quot;MH&quot; term=&quot;%22Immunity%22&quot;&gt;Immunity&lt;/searchLink&gt;
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Most cervicovaginal microbiome-immunology studies to date have relied on 16S rDNA microbial profiling which does not resolve the molecular subgroups of Gardnerella, believed to be central to the pathogenesis of bacterial vaginosis (BV) and subsequent risk of HIV acquisition. Here we used the cpn60 universal target which in addition to other microbial taxa, resolves four Gardnerella subgroups, for cervicovaginal microbial profiling in a longitudinal cohort of Kenyan women to examine associations with cellular and soluble markers of inflammation and HIV susceptibility. Participants (N = 41) were sampled, contributing 362 samples for microbiome analysis. All non-Lactobacillus dominant microbial communities were associated with high pro-inflammatory cytokine levels. Divergent associations were observed among different Gardnerella subgroup dominated communities with respect to the chemokine IP-10. Specifically, Gardnerella subgroup A dominant and polymicrobial communities were associated with reduced concentrations of IP-10 in adjusted linear mixed models (p&amp;lt;0.0001), compared to microbial communities dominated by Lactobacillus (non-iners) species. However, these associations did not translate to significant differences in the proportion or absolute number of CCR5, HLA-DR and CD38 expressed on cervical CD4&lt;superscript&gt;+&lt;/superscript&gt; T- cells. These findings suggest that some associations between Gardnerella subgroup dominant microbiomes and mucosal immunity differ and are relevant for the study of BV-pathogenesis and understanding the mechanisms of BV-associated HIV risk.&lt;br /&gt; (Copyright &#169; 2023 Shvartsman, Perciani, Richmond, Russell, Tough, Vancuren, Hill, KAVI-ICR, Jaoko, McKinnon, Sandstrom and MacDonald.)
– Name: Abstract
  Label: Competing Interests
  Group: Ab
  Data: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
– Name: Ref
  Label: References
  Group: RefInfo
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  Data: &lt;i&gt;Keywords: &lt;/i&gt;HIV susceptibility; IP-10 (CXCL-10); bacterial vaginosis (BV); cpn60; cytokines; gardnerella species; mucosal immunity; vaginal microbiome
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        Value: 10.3389/fimmu.2022.974195
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        Text: English
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        StartPage: 974195
    Subjects:
      – SubjectFull: Kenya epidemiology
        Type: general
      – SubjectFull: Lactobacillus genetics
        Type: general
      – SubjectFull: Vagina immunology
        Type: general
      – SubjectFull: Vagina microbiology
        Type: general
      – SubjectFull: Female
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      – SubjectFull: Humans
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      – SubjectFull: Chemokine CXCL10
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      – SubjectFull: HIV Infections
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      – SubjectFull: Immunity
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      – SubjectFull: Gardnerella
        Type: general
      – SubjectFull: Microbiota
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      – SubjectFull: Vaginosis, Bacterial
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      – TitleFull: Gardnerella subgroup dominant microbiomes are associated with divergent cervicovaginal immune responses in a longitudinal cohort of Kenyan women.
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            – D: 16
              M: 01
              Text: 2023 Jan 16
              Type: published
              Y: 2023
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              Value: 1664-3224
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            – TitleFull: Frontiers in immunology
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