Academic Journal
Προβολή σε EDS

Clinical and morphopathological assay in vulvovaginal candidiasis.

Λεπτομέρειες βιβλιογραφικής εγγραφής
Τίτλος: Clinical and morphopathological assay in vulvovaginal candidiasis.
Συγγραφείς: Manolea MM; Department of Histology, Department of Obstetrics and Gynecology, University of Medicine and Pharmacy of Craiova, Romania; ancaofiteru92@yahoo.com; ssidoniam@yahoo.com., Istrate-Ofiţeru AM, Săndulescu MS, Camen IV, Piciu IA, Dijmărescu AL, Vrabie SC, Neamţu SD, Obleagă CV, Siminel MA
Πηγή: Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie [Rom J Morphol Embryol] 2022 Jul-Sep; Vol. 63 (3), pp. 511-520.
Τύπος έκδοσης: Journal Article
Γλώσσα: English
Στοιχεία περιοδικού: Publisher: Editura Academiei Române Country of Publication: Romania NLM ID: 9112454 Publication Model: Print Cited Medium: Internet ISSN: 2066-8279 (Electronic) Linking ISSN: 12200522 NLM ISO Abbreviation: Rom J Morphol Embryol Subsets: MEDLINE
Imprint Name(s): Original Publication: Bucuresti, România : Editura Academiei Române, [1990-
Ιατρικοί όροι (MeSH): Candidiasis, Vulvovaginal*/drug therapy , Candidiasis, Vulvovaginal*/diagnosis , Candidiasis, Vulvovaginal*/microbiology, Nystatin/pharmacology ; Nystatin/therapeutic use ; Female ; Humans ; Retrospective Studies ; Neoplasm Recurrence, Local ; Vagina
Περίληψη: Candida vulvovaginitis is characterized by the appearance of inflammatory changes in the vaginal and vulvar epithelium secondary to infection with Candida species. The purpose of this study was to analyze and compare the clinical, microbiological, and histopathological aspects of pregnant and non-pregnant patients, symptomatic or asymptomatic in the case of candida vaginitis and to correlate the microscopic aspects with the symptoms before applying the local treatment with Nystatin. The study presents a retrospective analysis of the management of vaginitis in 166 pregnant or non-pregnant patients during 2021-2022. We observed the structure of the Malpighian squamous epithelium without keratinization present on the vaginal mucosa and the structure of the subepithelial connective tissue, which shows increased numerical values of inflammatory and vascular cellularity in the case of candida vaginitis symptomatic compared to asymptomatic ones. We noticed also in the microscopic study that in cases of asymptomatic patients before treatment, the number of inflammatory cells and blood vessels situated immediately under the epithelium was significantly lower compared to their number in symptomatic patients before treatment. Analyzing the results obtained after the administration of the treatment proposed by us, we can say that local Nystatin treatment is beneficial and safe for pregnant and non-pregnant patients and is a good alternative for patients with recurrent vulvovaginal candidiasis.
References: Oncol Lett. 2017 Sep;14(3):3869-3877. (PMID: 28927159)
Am Surg. 2015 Jan;81(1):41-7. (PMID: 25569064)
Expert Rev Mol Med. 2011 Jul 11;13:e23. (PMID: 21740602)
Nat Rev Cancer. 2017 Oct;17(10):577-593. (PMID: 28912578)
J Clin Med. 2022 Aug 30;11(17):. (PMID: 36079025)
Rom J Morphol Embryol. 2020;61(1):81-93. (PMID: 32747898)
Open Access Maced J Med Sci. 2019 Apr 10;7(7):1067-1070. (PMID: 31049082)
Clin Cancer Res. 2015 Feb 15;21(4):882-8. (PMID: 25473000)
Prz Gastroenterol. 2019;14(2):89-103. (PMID: 31616522)
Ann Surg. 2004 Aug;240(2):205-13. (PMID: 15273542)
Ann Surg Oncol. 2010 Jun;17(6):1471-4. (PMID: 20180029)
J Thromb Haemost. 2013 Feb;11(2):223-33. (PMID: 23279708)
J Adolesc Young Adult Oncol. 2022 Mar 18;:. (PMID: 35319280)
Medicine (Baltimore). 2021 Jan 8;100(1):e24062. (PMID: 33429770)
Adv Cancer Res. 2015;128:173-96. (PMID: 26216633)
Surgery. 2010 Mar;147(3):339-51. (PMID: 20004450)
Rom J Morphol Embryol. 2020 Jul-Sep;61(3):673-680. (PMID: 33817708)
Cancer Metastasis Rev. 2019 Jun;38(1-2):205-222. (PMID: 30911978)
Thromb Res. 2016 Mar;139:56-64. (PMID: 26916297)
Eur J Cancer. 2009 Aug;45(12):2138-45. (PMID: 19409772)
Minerva Chir. 2017 Dec;72(6):491-498. (PMID: 28621509)
Semin Colon Rectal Surg. 2022 Jun;33(2):. (PMID: 35937614)
Eur J Cancer. 2005 Nov;41(17):2645-54. (PMID: 16239109)
Rom J Morphol Embryol. 2021 Jan-Mar;62(1):117-124. (PMID: 34609414)
Br J Cancer. 2012 Aug 21;107(5):864-73. (PMID: 22878371)
World J Surg Oncol. 2019 Jun 29;17(1):112. (PMID: 31255181)
Rom J Morphol Embryol. 2021 Oct-Dec;62(4):971-979. (PMID: 35673816)
J Immunol Res. 2018 Feb 18;2018:6827237. (PMID: 29670921)
Genes (Basel). 2022 Jul 22;13(8):. (PMID: 35893034)
Ann Afr Med. 2019 Jul-Sep;18(3):121-126. (PMID: 31417011)
Substance Nomenclature: 1400-61-9 (Nystatin)
Entry Date(s): Date Created: 20230102 Date Completed: 20230103 Latest Revision: 20230217
Update Code: 20260130
PubMed Central ID: PMC9926141
DOI: 10.47162/RJME.63.3.05
PMID: 36588489
Βάση Δεδομένων: MEDLINE
FullText Text:
  Availability: 0
CustomLinks:
  – Url: https://resolver.ebsco.com/c/fiv2js/result?sid=EBSCO:cmedm&genre=article&issn=20668279&ISBN=&volume=63&issue=3&date=20220701&spage=511&pages=511-520&title=Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie&atitle=Clinical%20and%20morphopathological%20assay%20in%20vulvovaginal%20candidiasis.&aulast=Manolea%20MM&id=DOI:10.47162/RJME.63.3.05
    Name: Full Text Finder (for New FTF UI) (ns324271)
    Category: fullText
    Text: Full Text Finder
    MouseOverText: Full Text Finder
Header DbId: cmedm
DbLabel: MEDLINE
An: 36588489
AccessLevel: 3
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: Clinical and morphopathological assay in vulvovaginal candidiasis.
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AU" term="%22Manolea+MM%22">Manolea MM</searchLink>; Department of Histology, Department of Obstetrics and Gynecology, University of Medicine and Pharmacy of Craiova, Romania; ancaofiteru92@yahoo.com; ssidoniam@yahoo.com.<br /><searchLink fieldCode="AU" term="%22Istrate-Ofiţeru+AM%22">Istrate-Ofiţeru AM</searchLink><br /><searchLink fieldCode="AU" term="%22Săndulescu+MS%22">Săndulescu MS</searchLink><br /><searchLink fieldCode="AU" term="%22Camen+IV%22">Camen IV</searchLink><br /><searchLink fieldCode="AU" term="%22Piciu+IA%22">Piciu IA</searchLink><br /><searchLink fieldCode="AU" term="%22Dijmărescu+AL%22">Dijmărescu AL</searchLink><br /><searchLink fieldCode="AU" term="%22Vrabie+SC%22">Vrabie SC</searchLink><br /><searchLink fieldCode="AU" term="%22Neamţu+SD%22">Neamţu SD</searchLink><br /><searchLink fieldCode="AU" term="%22Obleagă+CV%22">Obleagă CV</searchLink><br /><searchLink fieldCode="AU" term="%22Siminel+MA%22">Siminel MA</searchLink>
– Name: TitleSource
  Label: Source
  Group: Src
  Data: <searchLink fieldCode="JN" term="%229112454%22">Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie</searchLink> [Rom J Morphol Embryol] 2022 Jul-Sep; Vol. 63 (3), pp. 511-520.
– Name: TypePub
  Label: Publication Type
  Group: TypPub
  Data: Journal Article
– Name: Language
  Label: Language
  Group: Lang
  Data: English
– Name: TitleSource
  Label: Journal Info
  Group: Src
  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Editura+Academiei+Române%22">Editura Academiei Române </searchLink><i>Country of Publication: </i>Romania <i>NLM ID: </i>9112454 <i>Publication Model: </i>Print <i>Cited Medium: </i>Internet <i>ISSN: </i>2066-8279 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2212200522%22">12200522 </searchLink><i>NLM ISO Abbreviation: </i>Rom J Morphol Embryol <i>Subsets: </i>MEDLINE
– Name: PublisherInfo
  Label: Imprint Name(s)
  Group: PubInfo
  Data: <i>Original Publication</i>: Bucuresti, România : Editura Academiei Române, [1990-
– Name: SubjectMESH
  Label: MeSH Terms
  Group: Su
  Data: <searchLink fieldCode="MM" term="%22Candidiasis%2C+Vulvovaginal%22">Candidiasis, Vulvovaginal*</searchLink>/<searchLink fieldCode="MM" term="%22Candidiasis%2C+Vulvovaginal+drug+therapy%22">drug therapy</searchLink> <br /><searchLink fieldCode="MM" term="%22Candidiasis%2C+Vulvovaginal%22">Candidiasis, Vulvovaginal*</searchLink>/<searchLink fieldCode="MM" term="%22Candidiasis%2C+Vulvovaginal+diagnosis%22">diagnosis</searchLink> <br /><searchLink fieldCode="MM" term="%22Candidiasis%2C+Vulvovaginal%22">Candidiasis, Vulvovaginal*</searchLink>/<searchLink fieldCode="MM" term="%22Candidiasis%2C+Vulvovaginal+microbiology%22">microbiology</searchLink><br /><searchLink fieldCode="MH" term="%22Nystatin%22">Nystatin</searchLink>/<searchLink fieldCode="MH" term="%22Nystatin+pharmacology%22">pharmacology</searchLink> ; <searchLink fieldCode="MH" term="%22Nystatin%22">Nystatin</searchLink>/<searchLink fieldCode="MH" term="%22Nystatin+therapeutic+use%22">therapeutic use</searchLink> ; <searchLink fieldCode="MH" term="%22Female%22">Female</searchLink> ; <searchLink fieldCode="MH" term="%22Humans%22">Humans</searchLink> ; <searchLink fieldCode="MH" term="%22Retrospective+Studies%22">Retrospective Studies</searchLink> ; <searchLink fieldCode="MH" term="%22Neoplasm+Recurrence%2C+Local%22">Neoplasm Recurrence, Local</searchLink> ; <searchLink fieldCode="MH" term="%22Vagina%22">Vagina</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Candida vulvovaginitis is characterized by the appearance of inflammatory changes in the vaginal and vulvar epithelium secondary to infection with Candida species. The purpose of this study was to analyze and compare the clinical, microbiological, and histopathological aspects of pregnant and non-pregnant patients, symptomatic or asymptomatic in the case of candida vaginitis and to correlate the microscopic aspects with the symptoms before applying the local treatment with Nystatin. The study presents a retrospective analysis of the management of vaginitis in 166 pregnant or non-pregnant patients during 2021-2022. We observed the structure of the Malpighian squamous epithelium without keratinization present on the vaginal mucosa and the structure of the subepithelial connective tissue, which shows increased numerical values of inflammatory and vascular cellularity in the case of candida vaginitis symptomatic compared to asymptomatic ones. We noticed also in the microscopic study that in cases of asymptomatic patients before treatment, the number of inflammatory cells and blood vessels situated immediately under the epithelium was significantly lower compared to their number in symptomatic patients before treatment. Analyzing the results obtained after the administration of the treatment proposed by us, we can say that local Nystatin treatment is beneficial and safe for pregnant and non-pregnant patients and is a good alternative for patients with recurrent vulvovaginal candidiasis.
– Name: Ref
  Label: References
  Group: RefInfo
  Data: Oncol Lett. 2017 Sep;14(3):3869-3877. (PMID: <searchLink fieldCode="PM" term="%2228927159%22">28927159)</searchLink><br />Am Surg. 2015 Jan;81(1):41-7. (PMID: <searchLink fieldCode="PM" term="%2225569064%22">25569064)</searchLink><br />Expert Rev Mol Med. 2011 Jul 11;13:e23. (PMID: <searchLink fieldCode="PM" term="%2221740602%22">21740602)</searchLink><br />Nat Rev Cancer. 2017 Oct;17(10):577-593. (PMID: <searchLink fieldCode="PM" term="%2228912578%22">28912578)</searchLink><br />J Clin Med. 2022 Aug 30;11(17):. (PMID: <searchLink fieldCode="PM" term="%2236079025%22">36079025)</searchLink><br />Rom J Morphol Embryol. 2020;61(1):81-93. (PMID: <searchLink fieldCode="PM" term="%2232747898%22">32747898)</searchLink><br />Open Access Maced J Med Sci. 2019 Apr 10;7(7):1067-1070. (PMID: <searchLink fieldCode="PM" term="%2231049082%22">31049082)</searchLink><br />Clin Cancer Res. 2015 Feb 15;21(4):882-8. (PMID: <searchLink fieldCode="PM" term="%2225473000%22">25473000)</searchLink><br />Prz Gastroenterol. 2019;14(2):89-103. (PMID: <searchLink fieldCode="PM" term="%2231616522%22">31616522)</searchLink><br />Ann Surg. 2004 Aug;240(2):205-13. (PMID: <searchLink fieldCode="PM" term="%2215273542%22">15273542)</searchLink><br />Ann Surg Oncol. 2010 Jun;17(6):1471-4. (PMID: <searchLink fieldCode="PM" term="%2220180029%22">20180029)</searchLink><br />J Thromb Haemost. 2013 Feb;11(2):223-33. (PMID: <searchLink fieldCode="PM" term="%2223279708%22">23279708)</searchLink><br />J Adolesc Young Adult Oncol. 2022 Mar 18;:. (PMID: <searchLink fieldCode="PM" term="%2235319280%22">35319280)</searchLink><br />Medicine (Baltimore). 2021 Jan 8;100(1):e24062. (PMID: <searchLink fieldCode="PM" term="%2233429770%22">33429770)</searchLink><br />Adv Cancer Res. 2015;128:173-96. (PMID: <searchLink fieldCode="PM" term="%2226216633%22">26216633)</searchLink><br />Surgery. 2010 Mar;147(3):339-51. (PMID: <searchLink fieldCode="PM" term="%2220004450%22">20004450)</searchLink><br />Rom J Morphol Embryol. 2020 Jul-Sep;61(3):673-680. (PMID: <searchLink fieldCode="PM" term="%2233817708%22">33817708)</searchLink><br />Cancer Metastasis Rev. 2019 Jun;38(1-2):205-222. (PMID: <searchLink fieldCode="PM" term="%2230911978%22">30911978)</searchLink><br />Thromb Res. 2016 Mar;139:56-64. (PMID: <searchLink fieldCode="PM" term="%2226916297%22">26916297)</searchLink><br />Eur J Cancer. 2009 Aug;45(12):2138-45. (PMID: <searchLink fieldCode="PM" term="%2219409772%22">19409772)</searchLink><br />Minerva Chir. 2017 Dec;72(6):491-498. (PMID: <searchLink fieldCode="PM" term="%2228621509%22">28621509)</searchLink><br />Semin Colon Rectal Surg. 2022 Jun;33(2):. (PMID: <searchLink fieldCode="PM" term="%2235937614%22">35937614)</searchLink><br />Eur J Cancer. 2005 Nov;41(17):2645-54. (PMID: <searchLink fieldCode="PM" term="%2216239109%22">16239109)</searchLink><br />Rom J Morphol Embryol. 2021 Jan-Mar;62(1):117-124. (PMID: <searchLink fieldCode="PM" term="%2234609414%22">34609414)</searchLink><br />Br J Cancer. 2012 Aug 21;107(5):864-73. (PMID: <searchLink fieldCode="PM" term="%2222878371%22">22878371)</searchLink><br />World J Surg Oncol. 2019 Jun 29;17(1):112. (PMID: <searchLink fieldCode="PM" term="%2231255181%22">31255181)</searchLink><br />Rom J Morphol Embryol. 2021 Oct-Dec;62(4):971-979. (PMID: <searchLink fieldCode="PM" term="%2235673816%22">35673816)</searchLink><br />J Immunol Res. 2018 Feb 18;2018:6827237. (PMID: <searchLink fieldCode="PM" term="%2229670921%22">29670921)</searchLink><br />Genes (Basel). 2022 Jul 22;13(8):. (PMID: <searchLink fieldCode="PM" term="%2235893034%22">35893034)</searchLink><br />Ann Afr Med. 2019 Jul-Sep;18(3):121-126. (PMID: <searchLink fieldCode="PM" term="%2231417011%22">31417011)</searchLink>
– Name: NumberCAS
  Label: Substance Nomenclature
  Group: ID
  Data: 1400-61-9 (Nystatin)
– Name: DateEntry
  Label: Entry Date(s)
  Group: Date
  Data: <i>Date Created: </i>20230102 <i>Date Completed: </i>20230103 <i>Latest Revision: </i>20230217
– Name: DateUpdate
  Label: Update Code
  Group: Date
  Data: 20260130
– Name: PubmedCentralID
  Label: PubMed Central ID
  Group: ID
  Data: PMC9926141
– Name: DOI
  Label: DOI
  Group: ID
  Data: 10.47162/RJME.63.3.05
– Name: AN
  Label: PMID
  Group: ID
  Data: 36588489
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=cmedm&AN=36588489
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.47162/RJME.63.3.05
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        StartPage: 511
    Subjects:
      – SubjectFull: Nystatin pharmacology
        Type: general
      – SubjectFull: Nystatin therapeutic use
        Type: general
      – SubjectFull: Female
        Type: general
      – SubjectFull: Humans
        Type: general
      – SubjectFull: Retrospective Studies
        Type: general
      – SubjectFull: Neoplasm Recurrence, Local
        Type: general
      – SubjectFull: Vagina
        Type: general
      – SubjectFull: Candidiasis, Vulvovaginal drug therapy
        Type: general
      – SubjectFull: Candidiasis, Vulvovaginal diagnosis
        Type: general
      – SubjectFull: Candidiasis, Vulvovaginal microbiology
        Type: general
    Titles:
      – TitleFull: Clinical and morphopathological assay in vulvovaginal candidiasis.
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: Manolea MM
      – PersonEntity:
          Name:
            NameFull: Istrate-Ofiţeru AM
      – PersonEntity:
          Name:
            NameFull: Săndulescu MS
      – PersonEntity:
          Name:
            NameFull: Camen IV
      – PersonEntity:
          Name:
            NameFull: Piciu IA
      – PersonEntity:
          Name:
            NameFull: Dijmărescu AL
      – PersonEntity:
          Name:
            NameFull: Vrabie SC
      – PersonEntity:
          Name:
            NameFull: Neamţu SD
      – PersonEntity:
          Name:
            NameFull: Obleagă CV
      – PersonEntity:
          Name:
            NameFull: Siminel MA
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 01
              M: 07
              Text: 2022 Jul-Sep
              Type: published
              Y: 2022
          Identifiers:
            – Type: issn-electronic
              Value: 2066-8279
          Numbering:
            – Type: volume
              Value: 63
            – Type: issue
              Value: 3
          Titles:
            – TitleFull: Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie
              Type: main
ResultId 1